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Items: 1 to 50 of 105

1.

Intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency.

van Rijn JM, Ardy RC, Kuloğlu Z, Härter B, van Haaften-Visser DY, van der Doef HPJ, van Hoesel M, Kansu A, van Vugt AHM, Ng M, Kokke FTM, Krolo A, Başaran MK, Kaya NG, Ünlüsoy Aksu A, Dalgıç B, Ozcay F, Baris Z, Kain R, Stigter ECA, Lichtenbelt KD, Massink MPG, Duran KJ, Verheij JBGM, Lugtenberg D, Nikkels PGJ, Brouwer HGF, Verkade HJ, Scheenstra R, Spee B, Nieuwenhuis EES, Coffer PJ, Janecke AR, van Haaften G, Houwen RHJ, Müller T, Middendorp S, Boztug K.

Gastroenterology. 2018 Mar 28. pii: S0016-5085(18)30347-0. doi: 10.1053/j.gastro.2018.03.040. [Epub ahead of print]

2.

Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease.

Schneeberger K, Roth S, Nieuwenhuis EES, Middendorp S.

Dis Model Mech. 2018 Feb 13;11(2). pii: dmm031088. doi: 10.1242/dmm.031088. Review.

3.

Chromatin Conformation Links Distal Target Genes to CKD Loci.

Brandt MM, Meddens CA, Louzao-Martinez L, van den Dungen NAM, Lansu NR, Nieuwenhuis EES, Duncker DJ, Verhaar MC, Joles JA, Mokry M, Cheng C.

J Am Soc Nephrol. 2018 Feb;29(2):462-476. doi: 10.1681/ASN.2016080875. Epub 2017 Nov 1.

PMID:
29093029
4.

Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization.

Haitjema S, Meddens CA, van der Laan SW, Kofink D, Harakalova M, Tragante V, Foroughi Asl H, van Setten J, Brandt MM, Bis JC, O'Donnell C, Cheng C, Hoefer IE, Waltenberger J, Biessen E, Jukema JW, Doevendans PA, Nieuwenhuis EE, Erdmann J, Björkegren JL, Pasterkamp G, Asselbergs FW, den Ruijter HM, Mokry M.

Circ Cardiovasc Genet. 2017 Apr;10(2). pii: e001664. doi: 10.1161/CIRCGENETICS.116.001664.

5.

Ankyrin repeat and zinc-finger domain-containing 1 mutations are associated with infantile-onset inflammatory bowel disease.

van Haaften-Visser DY, Harakalova M, Mocholi E, van Montfrans JM, Elkadri A, Rieter E, Fiedler K, van Hasselt PM, Triffaux EMM, van Haelst MM, Nijman IJ, Kloosterman WP, Nieuwenhuis EES, Muise AM, Cuppen E, Houwen RHJ, Coffer PJ.

J Biol Chem. 2017 May 12;292(19):7904-7920. doi: 10.1074/jbc.M116.772038. Epub 2017 Mar 16.

PMID:
28302725
6.

Oxazolone-Induced Intestinal Inflammation in Adult Zebrafish.

Brugman S, Nieuwenhuis EES.

Methods Mol Biol. 2017;1559:311-318. doi: 10.1007/978-1-4939-6786-5_21.

PMID:
28063053
7.

The Value of a Checklist for Child Abuse in Out-of-Hours Primary Care: To Screen or Not to Screen.

Schouten MC, van Stel HF, Verheij TJ, Houben ML, Russel IM, Nieuwenhuis EE, van de Putte EM.

PLoS One. 2017 Jan 3;12(1):e0165641. doi: 10.1371/journal.pone.0165641. eCollection 2017.

8.

Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease.

Meddens CA, Harakalova M, van den Dungen NA, Foroughi Asl H, Hijma HJ, Cuppen EP, Björkegren JL, Asselbergs FW, Nieuwenhuis EE, Mokry M.

Genome Biol. 2016 Nov 30;17(1):247.

9.

Extensive Association of Common Disease Variants with Regulatory Sequence.

Mokry M, Harakalova M, Asselbergs FW, de Bakker PI, Nieuwenhuis EE.

PLoS One. 2016 Nov 22;11(11):e0165893. doi: 10.1371/journal.pone.0165893. eCollection 2016.

10.

[Systematic detection of physical child abuse at emergency rooms].

Sittig JS, Uiterwaal CS, Moons KG, Russel IM, Nievelstein RA, Nieuwenhuis EE, van de Putte EM.

Ned Tijdschr Geneeskd. 2016;160(0):D672. Dutch.

PMID:
27848908
11.

A screening protocol for child abuse at out-of-hours primary care locations: a descriptive study.

Schouten MC, van Stel HF, Verheij TJ, Nieuwenhuis EE, van de Putte EM.

BMC Fam Pract. 2016 Nov 8;17(1):155.

12.

Tissue-specific mutation accumulation in human adult stem cells during life.

Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R.

Nature. 2016 Oct 13;538(7624):260-264. doi: 10.1038/nature19768. Epub 2016 Oct 3.

13.

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis.

Dekkers JF, Berkers G, Kruisselbrink E, Vonk A, de Jonge HR, Janssens HM, Bronsveld I, van de Graaf EA, Nieuwenhuis EE, Houwen RH, Vleggaar FP, Escher JC, de Rijke YB, Majoor CJ, Heijerman HG, de Winter-de Groot KM, Clevers H, van der Ent CK, Beekman JM.

Sci Transl Med. 2016 Jun 22;8(344):344ra84. doi: 10.1126/scitranslmed.aad8278.

PMID:
27334259
14.

Novel approaches: Tissue engineering and stem cells--In vitro modelling of the gut.

van Rijn JM, Schneeberger K, Wiegerinck CL, Nieuwenhuis EE, Middendorp S.

Best Pract Res Clin Gastroenterol. 2016 Apr;30(2):281-93. doi: 10.1016/j.bpg.2016.03.005. Epub 2016 Mar 15. Review.

PMID:
27086891
15.

Value of systematic detection of physical child abuse at emergency rooms: a cross-sectional diagnostic accuracy study.

Sittig JS, Uiterwaal CS, Moons KG, Russel IM, Nievelstein RA, Nieuwenhuis EE, van de Putte EM.

BMJ Open. 2016 Mar 22;6(3):e010788. doi: 10.1136/bmjopen-2015-010788.

16.

Autoimmune disease-associated gene expression is reduced by BET-inhibition.

Peeters JG, Vervoort SJ, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Mokry M, van Loosdregt J.

Genom Data. 2015 Nov 7;7:14-7. doi: 10.1016/j.gdata.2015.11.004. eCollection 2016 Mar.

17.

Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.

van den Broek T, Delemarre EM, Janssen WJ, Nievelstein RA, Broen JC, Tesselaar K, Borghans JA, Nieuwenhuis EE, Prakken BJ, Mokry M, Jansen NJ, van Wijk F.

J Clin Invest. 2016 Mar 1;126(3):1126-36. doi: 10.1172/JCI84997. Epub 2016 Feb 22.

18.

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM.

Nature. 2015 Dec 24;528(7583):560-564. doi: 10.1038/nature16460. Epub 2015 Dec 9.

19.

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.

Schneeberger K, Vogel GF, Teunissen H, van Ommen DD, Begthel H, El Bouazzaoui L, van Vugt AH, Beekman JM, Klumperman J, Müller T, Janecke A, Gerner P, Huber LA, Hess MW, Clevers H, van Es JH, Nieuwenhuis EE, Middendorp S.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12408-13. doi: 10.1073/pnas.1516672112. Epub 2015 Sep 21.

20.

Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.

Peeters JG, Vervoort SJ, Tan SC, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Creyghton MP, Coffer PJ, Mokry M, van Loosdregt J.

Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17.

21.

An extensively hydrolysed casein-based formula for infants with cows' milk protein allergy: tolerance/hypo-allergenicity and growth catch-up.

Dupont C, Hol J, Nieuwenhuis EE; Cow's Milk Allergy Modified by Elimination and Lactobacilli study group.

Br J Nutr. 2015 Apr 14;113(7):1102-12. doi: 10.1017/S000711451500015X. Epub 2015 Mar 17.

PMID:
25781481
22.

T lymphocytes control microbial composition by regulating the abundance of Vibrio in the zebrafish gut.

Brugman S, Schneeberger K, Witte M, Klein MR, van den Bogert B, Boekhorst J, Timmerman HM, Boes ML, Kleerebezem M, Nieuwenhuis EE.

Gut Microbes. 2014;5(6):737-47. doi: 10.4161/19490976.2014.972228.

23.

Long-term culture of genome-stable bipotent stem cells from adult human liver.

Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H.

Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18.

24.

Deficiency in macrophage-stimulating protein results in spontaneous intestinal inflammation and increased susceptibility toward epithelial damage in zebrafish.

Witte M, Huitema LF, Nieuwenhuis EE, Brugman S.

Zebrafish. 2014 Dec;11(6):542-50. doi: 10.1089/zeb.2014.1023.

PMID:
25353089
25.

Human buccal epithelium acquires microbial hyporesponsiveness at birth, a role for secretory leukocyte protease inhibitor.

Menckeberg CL, Hol J, Simons-Oosterhuis Y, Raatgeep HR, de Ruiter LF, Lindenbergh-Kortleve DJ, Korteland-van Male AM, El Aidy S, van Lierop PP, Kleerebezem M, Groeneweg M, Kraal G, Elink-Schuurman BE, de Jongste JC, Nieuwenhuis EE, Samsom JN.

Gut. 2015 Jun;64(6):884-93. doi: 10.1136/gutjnl-2013-306149. Epub 2014 Jul 23.

PMID:
25056659
26.

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

Farin HF, Karthaus WR, Kujala P, Rakhshandehroo M, Schwank G, Vries RG, Kalkhoven E, Nieuwenhuis EE, Clevers H.

J Exp Med. 2014 Jun 30;211(7):1393-405. doi: 10.1084/jem.20130753.

27.

Loss of syntaxin 3 causes variant microvillus inclusion disease.

Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, Klumperman J, Clevers H, Nieuwenhuis EE, Houwen RH, van Haaften G, Hess MW, Huber LA, Stapelbroek JM, Müller T, Middendorp S.

Gastroenterology. 2014 Jul;147(1):65-68.e10. doi: 10.1053/j.gastro.2014.04.002. Epub 2014 Apr 12.

PMID:
24726755
28.

Adult stem cells in the small intestine are intrinsically programmed with their location-specific function.

Middendorp S, Schneeberger K, Wiegerinck CL, Mokry M, Akkerman RD, van Wijngaarden S, Clevers H, Nieuwenhuis EE.

Stem Cells. 2014 May;32(5):1083-91. doi: 10.1002/stem.1655.

29.

FOXO3 selectively amplifies enhancer activity to establish target gene regulation.

Eijkelenboom A, Mokry M, Smits LM, Nieuwenhuis EE, Burgering BM.

Cell Rep. 2013 Dec 26;5(6):1664-78. doi: 10.1016/j.celrep.2013.11.031. Epub 2013 Dec 19.

30.

Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium.

Mokry M, Middendorp S, Wiegerinck CL, Witte M, Teunissen H, Meddens CA, Cuppen E, Clevers H, Nieuwenhuis EE.

Gastroenterology. 2014 Apr;146(4):1040-7. doi: 10.1053/j.gastro.2013.12.003. Epub 2013 Dec 12.

PMID:
24333384
31.

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.

Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H.

Cell Stem Cell. 2013 Dec 5;13(6):653-8. doi: 10.1016/j.stem.2013.11.002.

32.

T lymphocyte-dependent and -independent regulation of Cxcl8 expression in zebrafish intestines.

Brugman S, Witte M, Scholman RC, Klein MR, Boes M, Nieuwenhuis EE.

J Immunol. 2014 Jan 1;192(1):484-91. doi: 10.4049/jimmunol.1301865. Epub 2013 Nov 25.

33.

Gene expression analysis of peripheral cells for subclassification of pediatric inflammatory bowel disease in remission.

van Lierop PP, Swagemakers SM, de Bie CI, Middendorp S, van Baarlen P, Samsom JN, van Ijcken WF, Escher JC, van der Spek PJ, Nieuwenhuis EE.

PLoS One. 2013 Nov 18;8(11):e79549. doi: 10.1371/journal.pone.0079549. eCollection 2013.

34.

Evaluation of suspected child abuse at the ED; implementation of American Academy of Pediatrics guidelines in the Netherlands.

Sittig JS, Post ED, Russel IM, van Dijk IA, Nieuwenhuis EE, van de Putte EM.

Am J Emerg Med. 2014 Jan;32(1):64-6. doi: 10.1016/j.ajem.2013.08.038. Epub 2013 Oct 5.

PMID:
24099714
35.

Canonical Wnt signaling negatively modulates regulatory T cell function.

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ.

Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15.

36.

FOXP1 acts through a negative feedback loop to suppress FOXO-induced apoptosis.

van Boxtel R, Gomez-Puerto C, Mokry M, Eijkelenboom A, van der Vos KE, Nieuwenhuis EE, Burgering BM, Lam EW, Coffer PJ.

Cell Death Differ. 2013 Sep;20(9):1219-29. doi: 10.1038/cdd.2013.81. Epub 2013 Jul 5.

37.

A functional CFTR assay using primary cystic fibrosis intestinal organoids.

Dekkers JF, Wiegerinck CL, de Jonge HR, Bronsveld I, Janssens HM, de Winter-de Groot KM, Brandsma AM, de Jong NW, Bijvelds MJ, Scholte BJ, Nieuwenhuis EE, van den Brink S, Clevers H, van der Ent CK, Middendorp S, Beekman JM.

Nat Med. 2013 Jul;19(7):939-45. doi: 10.1038/nm.3201. Epub 2013 Jun 2.

PMID:
23727931
38.

A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barré syndrome.

Louwen R, Horst-Kreft D, de Boer AG, van der Graaf L, de Knegt G, Hamersma M, Heikema AP, Timms AR, Jacobs BC, Wagenaar JA, Endtz HP, van der Oost J, Wells JM, Nieuwenhuis EE, van Vliet AH, Willemsen PT, van Baarlen P, van Belkum A.

Eur J Clin Microbiol Infect Dis. 2013 Feb;32(2):207-26. doi: 10.1007/s10096-012-1733-4. Epub 2012 Sep 4.

PMID:
22945471
39.

Natural killer T cells in adipose tissue prevent insulin resistance.

Schipper HS, Rakhshandehroo M, van de Graaf SF, Venken K, Koppen A, Stienstra R, Prop S, Meerding J, Hamers N, Besra G, Boon L, Nieuwenhuis EE, Elewaut D, Prakken B, Kersten S, Boes M, Kalkhoven E.

J Clin Invest. 2012 Sep;122(9):3343-54. doi: 10.1172/JCI62739. Epub 2012 Aug 6.

40.

Campylobacter jejuni translocation across intestinal epithelial cells is facilitated by ganglioside-like lipooligosaccharide structures.

Louwen R, Nieuwenhuis EE, van Marrewijk L, Horst-Kreft D, de Ruiter L, Heikema AP, van Wamel WJ, Wagenaar JA, Endtz HP, Samsom J, van Baarlen P, Akhmanova A, van Belkum A.

Infect Immun. 2012 Sep;80(9):3307-18. doi: 10.1128/IAI.06270-11. Epub 2012 Jul 9.

41.

Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice.

El Aidy S, van Baarlen P, Derrien M, Lindenbergh-Kortleve DJ, Hooiveld G, Levenez F, Doré J, Dekker J, Samsom JN, Nieuwenhuis EE, Kleerebezem M.

Mucosal Immunol. 2012 Sep;5(5):567-79. doi: 10.1038/mi.2012.32. Epub 2012 May 23.

PMID:
22617837
42.

Child abuse inventory at emergency rooms: CHAIN-ER rationale and design.

Sittig JS, Uiterwaal CS, Moons KG, Nieuwenhuis EE, van de Putte EM.

BMC Pediatr. 2011 Oct 18;11:91. doi: 10.1186/1471-2431-11-91.

43.

Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells.

Du Pré MF, Kozijn AE, van Berkel LA, ter Borg MN, Lindenbergh-Kortleve D, Jensen LT, Kooy-Winkelaar Y, Koning F, Boon L, Nieuwenhuis EE, Sollid LM, Fugger L, Samsom JN.

Gastroenterology. 2011 Aug;141(2):610-20, 620.e1-2. doi: 10.1053/j.gastro.2011.04.048. Epub 2011 Apr 28.

PMID:
21683079
44.

Myelin ingestion alters macrophage antigen-presenting function in vitro and in vivo.

van Zwam M, Samsom JN, Nieuwenhuis EE, Melief MJ, Wierenga-Wolf AF, Dijke IE, Talens S, van Meurs M, Voerman JS, Boven LA, Laman JD.

J Leukoc Biol. 2011 Jul;90(1):123-32. doi: 10.1189/jlb.1209813. Epub 2011 Apr 12.

PMID:
21486907
45.

Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

Buschard K, Hansen AK, Jensen K, Lindenbergh-Kortleve DJ, de Ruiter LF, Krohn TC, Hufeldt MR, Vogensen FK, Aasted B, Osterbye T, Roep BO, de Haar C, Nieuwenhuis EE.

PLoS One. 2011 Apr 1;6(4):e17931. doi: 10.1371/journal.pone.0017931.

46.

Development of inflammatory bowel disease in patients with juvenile idiopathic arthritis treated with etanercept.

van Dijken TD, Vastert SJ, Gerloni VM, Pontikaki I, Linnemann K, Girschick H, Armbrust W, Minden K, Prince FH, Kokke FT, Nieuwenhuis EE, Horneff G, Wulffraat NM.

J Rheumatol. 2011 Jul;38(7):1441-6. doi: 10.3899/jrheum.100809. Epub 2011 Apr 1.

PMID:
21459936
47.

CD62L(neg)CD38⁺ expression on circulating CD4⁺ T cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls.

du Pré MF, van Berkel LA, Ráki M, van Leeuwen MA, de Ruiter LF, Broere F, Ter Borg MN, Lund FE, Escher JC, Lundin KE, Sollid LM, Kraal G, Nieuwenhuis EE, Samsom JN.

Am J Gastroenterol. 2011 Jun;106(6):1147-59. doi: 10.1038/ajg.2011.24. Epub 2011 Mar 8.

48.

Anti-inflammatory actions of phosphatidylinositol.

van Dieren JM, Simons-Oosterhuis Y, Raatgeep HC, Lindenbergh-Kortleve DJ, Lambers ME, van der Woude CJ, Kuipers EJ, Snoek GT, Potman R, Hammad H, Lambrecht BN, Samsom JN, Nieuwenhuis EE.

Eur J Immunol. 2011 Apr;41(4):1047-57. doi: 10.1002/eji.201040899. Epub 2011 Mar 1.

49.

Overlap, common features, and essential differences in pediatric granulomatous inflammatory bowel disease.

Damen GM, van Krieken JH, Hoppenreijs E, van Os E, Tolboom JJ, Warris A, Yntema JB, Nieuwenhuis EE, Escher JC.

J Pediatr Gastroenterol Nutr. 2010 Dec;51(6):690-7. doi: 10.1097/MPG.0b013e3181dc0d73. Review.

PMID:
20683205
50.

TLR4-mediated sensing of Campylobacter jejuni by dendritic cells is determined by sialylation.

Kuijf ML, Samsom JN, van Rijs W, Bax M, Huizinga R, Heikema AP, van Doorn PA, van Belkum A, van Kooyk Y, Burgers PC, Luider TM, Endtz HP, Nieuwenhuis EE, Jacobs BC.

J Immunol. 2010 Jul 1;185(1):748-55. doi: 10.4049/jimmunol.0903014. Epub 2010 Jun 4.

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