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Items: 1 to 50 of 122

1.

Roswell Park Cancer Institute Symposium: molecular approaches to cancer therapeutics.

Mihich E, Nichol CA.

Cancer Res. 1997 Nov 15;57(22):5185-8. No abstract available.

2.

A tribute to Dr. Gerald Burr Grindey, 1940-1993.

Mihich E, Moran RG, Nichol CA.

Invest New Drugs. 1996;14(3):241-2. No abstract available.

PMID:
8958177
3.
4.

On the substrate specificity of bovine liver dihydrofolate reductase: new unconjugated dihydropterin substrates.

Smith GK, Banks SD, Bigham EC, Nichol CA.

Arch Biochem Biophys. 1987 May 1;254(2):416-20.

PMID:
3579311
5.

Synthetic analogues of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases.

Bigham EC, Smith GK, Reinhard JF Jr, Mallory WR, Nichol CA, Morrison RW Jr.

J Med Chem. 1987 Jan;30(1):40-5.

PMID:
2879918
6.
7.

Differences in the metabolism of the aromatic amino acid hydroxylase cofactor, tetrahydrobiopterin, in mutant mice with neurological and immunological defects.

Duch DS, Bowers SW, Woolf JH, Davisson MT, Maltais LJ, Nichol CA.

Biochem Genet. 1986 Oct;24(9-10):657-68.

PMID:
3778424
8.

Endocrine-dependent regulation of tetrahydrobiopterin levels and guanosine triphosphate cyclohydrolase activity.

Duch DS, Bowers SW, Nichol CA.

Mol Cell Endocrinol. 1986 Oct;47(3):209-16.

PMID:
3019798
9.

Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase.

Ozaki Y, Reinhard JF Jr, Nichol CA.

Biochem Biophys Res Commun. 1986 Jun 30;137(3):1106-11.

PMID:
3488060
10.

Regulation of tetrahydrobiopterin biosynthesis in cultured adrenal cortical tumor cells by adrenocorticotropin and adenosine 3',5'-cyclic monophosphate.

Duch DS, Woolf JH, Edelstein MP, Viveros OH, Abou-Donia MA, Nichol CA.

Endocrinology. 1986 May;118(5):1897-905.

PMID:
3009141
13.

Stimulation of retinal dopamine biosynthesis in vivo by exogenous tetrahydrobiopterin: relationship to tyrosine hydroxylase activation.

Iuvone PM, Reinhard JF Jr, Abou-Donia MM, Viveros OH, Nichol CA.

Brain Res. 1985 Dec 16;359(1-2):392-6.

PMID:
2866821
14.

Urinary biopterin and neopterin excretion and pituitary-adrenal activity in psychiatric patients.

Garbutt JC, Duch DS, Nichol CA, Woolf JH.

Psychiatry Res. 1985 Nov;16(3):181-7.

PMID:
4089052
15.

The C-6 proton of tetrahydrobiopterin is acquired from water, not NADPH, during de novo biosynthesis.

Smith GK, Cichetti JA, Chandrasurin P, Nichol CA.

J Biol Chem. 1985 May 10;260(9):5221-4.

16.

Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.

Nichol CA, Smith GK, Duch DS.

Annu Rev Biochem. 1985;54:729-64. Review. No abstract available.

PMID:
2862841
17.
18.

Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections.

Nathan HC, Bacchi CJ, Nichol CA, Duch DS, Mullaney EA, Hutner SH.

Am J Trop Med Hyg. 1984 Sep;33(5):845-50.

PMID:
6548337
19.
20.

Two new tetrahydropterin intermediates in the adrenal medullary de novo biosynthesis of tetrahydrobiopterin.

Smith GK, Nichol CA.

Biochem Biophys Res Commun. 1984 May 16;120(3):761-6.

PMID:
6732787
21.

Inhibitors of histamine metabolism in vitro and in vivo. Correlations with antitrypanosomal activity.

Duch DS, Bacchi CJ, Edelstein MP, Nichol CA.

Biochem Pharmacol. 1984 May 1;33(9):1547-53.

PMID:
6428421
22.

Urinary excretion of biopterin and neopterin in psychiatric disorders.

Duch DS, Woolf JH, Nichol CA, Davidson JR, Garbutt JC.

Psychiatry Res. 1984 Feb;11(2):83-9.

PMID:
6584938
24.

Biosynthesis of tetrahydrobiopterin in the presence of dihydrofolate reductase inhibitors.

Duch DS, Lee CL, Edelstein MP, Nichol CA.

Mol Pharmacol. 1983 Jul;24(1):103-8.

PMID:
6865919
25.

Hormonal regulation of guanosine triphosphate cyclohydrolase activity and biopterin levels in the rat adrenal cortex.

Abou-Donia MM, Duch DS, Nichol CA, Viveros OH.

Endocrinology. 1983 Jun;112(6):2088-94.

PMID:
6133742
26.

Determination of biopterin and other pterins in tissues and body fluids by high-performance liquid chromatography.

Woolf JH, Nichol CA, Duch DS.

J Chromatogr. 1983 May 13;274:398-402. No abstract available.

PMID:
6874847
27.

Analysis of folate cofactor levels in tissues using high-performance liquid chromatography.

Duch DS, Bowers SW, Nichol CA.

Anal Biochem. 1983 Apr 15;130(2):385-92.

PMID:
6688160
28.
30.

Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model.

Serano RD, Sigel CW, Nichol CA, Bigner DD.

Cancer Treat Rep. 1982 Jan;66(1):99-106.

PMID:
6272992
31.

Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex.

Viveros OH, Lee CL, Abou-Donia MM, Nixon JC, Nichol CA.

Science. 1981 Jul 17;213(4505):349-50.

PMID:
7017928
32.

Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice.

Bacchi CJ, Nathan HC, Hutner SH, Duch DS, Nichol CA.

Biochem Pharmacol. 1981 Apr 15;30(8):883-6. No abstract available.

PMID:
7247968
33.

Inhibition of histamine-metabolizing enzymes and elevation of histamine levels in tissues by lipid-soluble anticancer folate antagonists.

Duch DS, Edelstein MP, Nichol CA.

Mol Pharmacol. 1980 Jul;18(1):100-4. No abstract available.

PMID:
6774226
34.

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.

Grivsky EM, Lee S, Sigel CW, Duch DS, Nichol CA.

J Med Chem. 1980 Mar;23(3):327-9.

PMID:
6928967
36.

Elevation of brain histamine levels by diaminopyrimidine inhibitors of histamine N-methyl transferase.

Duch DS, Bowers SW, Nichol CA.

Biochem Pharmacol. 1978 May 15;27(10):1507-9. No abstract available.

PMID:
697892
37.

Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.

Cavallito JC, Nichol CA, Brenckman WD Jr, Deangelis RL, Stickney DR, Simmons WS, Sigel CW.

Drug Metab Dispos. 1978 May-Jun;6(3):329-37.

PMID:
26555
39.

Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.

Nichol CA, Cavallito JC, Woolley JL, Sigel CW.

Cancer Treat Rep. 1977 Jul;61(4):559-64.

PMID:
301777
40.

Specific TLC tissue residue determination of sulfadiazine following fluorescamine derivatization.

Sigel CW, Woolley JL Jr, Nichol CA.

J Pharm Sci. 1975 Jun;64(6):973-6.

PMID:
1133754
41.

Quantitative thin-layer chromatography of pyrimethamine and related diaminopyrimidines in body fluids and tissues.

DeAngelis RL, Simmons WS, Nichol CA.

J Chromatogr. 1975 Mar 19;106(1):41-9.

PMID:
168216
42.

Specific TLC determination of trimethoprim and sulfamethoxazole in plasma.

Sigel CW, Grace ME, Nichol CA, Hitchings GH.

J Pharm Sci. 1974 Aug;63(8):1212-5. No abstract available.

PMID:
4854354
43.

Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay.

Sigel CW, Grace ME, Nichol CA.

J Infect Dis. 1973 Nov;128:Suppl:580-3 p. No abstract available.

PMID:
4758049
44.

Long plasma half-life of pyrimethamine.

Nichol CA.

Lancet. 1973 Jul 21;2(7821):161. No abstract available.

PMID:
4124093
45.
46.

Interaction of drugs inhibiting different steps in the synthesis of DNA.

Grindey GB, Nichol CA.

Cancer Res. 1972 Mar;32(3):527-31. No abstract available.

47.

Combinations of drugs which interact as inhibitors of DNA biosynthesis.

Nichol CA, Grindey GB, Moran RG, Werkheiser WC.

Adv Enzyme Regul. 1972;10:63-80. No abstract available.

PMID:
4265901
48.

Mammalian deoxyuridine 5'-triphosphate pyrophosphatase.

Grindey GR, Nichol CA.

Biochim Biophys Acta. 1971 Jun 30;240(2):180-3. No abstract available.

PMID:
5105331
49.

A model system for detecting drug impairment of antitumor host defenses.

Mihich E, Bross I, Mihich RM, Nichol CA.

Cancer Res. 1970 May;30(5):1376-83. No abstract available.

50.

Effects of cortisol on DNA metabolism in the sensitive and resistant lines of mouse lymphoma P1798.

Rosen JM, Rosen F, Milholland RJ, Nichol CA.

Cancer Res. 1970 Apr;30(4):1129-36. No abstract available.

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