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Management of Triple-Negative Breast Cancer in Older Patients: How Is It Different?

Shachar SS, Jolly TA, Jones E, Muss HB.

Oncology (Williston Park). 2018 Feb 15;32(2):58-63. Review.


The incremental value of a geriatric assessment-derived three-item scale on estimating overall survival in older adults with cancer.

Nishijima TF, Deal AM, Lund JL, Nyrop KA, Muss HB, Sanoff HK.

J Geriatr Oncol. 2018 Feb 7. pii: S1879-4068(18)30022-5. doi: 10.1016/j.jgo.2018.01.007. [Epub ahead of print]


Chemotherapy Toxicity Risk Score for Treatment Decisions in Older Adults with Advanced Solid Tumors.

Nishijima TF, Deal AM, Williams GR, Sanoff HK, Nyrop KA, Muss HB.

Oncologist. 2018 Jan 25. pii: theoncologist.2017-0559. doi: 10.1634/theoncologist.2017-0559. [Epub ahead of print]


Quality of Life From Canadian Cancer Trials Group MA.17R: A Randomized Trial of Extending Adjuvant Letrozole to 10 Years.

Lemieux J, Brundage MD, Parulekar WR, Goss PE, Ingle JN, Pritchard KI, Celano P, Muss H, Gralow J, Strasser-Weippl K, Whelan K, Tu D, Whelan TJ.

J Clin Oncol. 2018 Feb 20;36(6):563-571. doi: 10.1200/JCO.2017.75.7500. Epub 2018 Jan 12.


Patient-Reported Comorbidity and Survival in Older Adults with Cancer.

Williams GR, Deal AM, Lund JL, Chang Y, Muss HB, Pergolotti M, Guerard EJ, Shachar SS, Wang Y, Kenzik K, Sanoff HK.

Oncologist. 2017 Dec 14. pii: theoncologist.2017-0404. doi: 10.1634/theoncologist.2017-0404. [Epub ahead of print]


The impact of actual body weight-based chemotherapy dosing and body size on adverse events and outcome in older patients with breast cancer: Results from Cancer and Leukemia Group B (CALGB) trial 49907 (Alliance A151436).

Morrison VA, McCall L, Muss HB, Jatoi A, Cohen HJ, Cirrincione CT, Ligibel JA, Lafky JM, Hurria A.

J Geriatr Oncol. 2017 Dec 7. pii: S1879-4068(17)30245-X. doi: 10.1016/j.jgo.2017.11.007. [Epub ahead of print]


The impact of skeletal muscle on the pharmacokinetics and toxicity of 5-fluorouracil in colorectal cancer.

Williams GR, Deal AM, Shachar SS, Walko CM, Patel JN, O'Neil B, McLeod HL, Weinberg MS, Choi SK, Muss HB, Sanoff HK.

Cancer Chemother Pharmacol. 2018 Feb;81(2):413-417. doi: 10.1007/s00280-017-3487-2. Epub 2017 Nov 20.


Beyond sarcopenia: Characterization and integration of skeletal muscle quantity and radiodensity in a curable breast cancer population.

Weinberg MS, Shachar SS, Muss HB, Deal AM, Popuri K, Yu H, Nyrop KA, Alston SM, Williams GR.

Breast J. 2017 Nov 15. doi: 10.1111/tbj.12952. [Epub ahead of print]


Measuring and understanding adherence in a home-based exercise intervention during chemotherapy for early breast cancer.

Nyrop KA, Deal AM, Choi SK, Wagoner CW, Lee JT, Wood A, Anders C, Carey LA, Dees EC, Jolly TA, Reeder-Hayes KE, Muss HB.

Breast Cancer Res Treat. 2018 Feb;168(1):43-55. doi: 10.1007/s10549-017-4565-1. Epub 2017 Nov 9.


Potential Medication-Related Problems in Older Breast, Colon, and Lung Cancer Patients in the United States.

Lund JL, Sanoff HK, Peacock Hinton S, Muss HB, Pate V, Stürmer T.

Cancer Epidemiol Biomarkers Prev. 2018 Jan;27(1):41-49. doi: 10.1158/1055-9965.EPI-17-0523. Epub 2017 Oct 4.


Weight gain in hormone receptor-positive (HR+) early-stage breast cancer: is it menopausal status or something else?

Nyrop KA, Deal AM, Lee JT, Muss HB, Choi SK, Wheless A, Carey LA, Shachar SS.

Breast Cancer Res Treat. 2018 Jan;167(1):235-248. doi: 10.1007/s10549-017-4501-4. Epub 2017 Sep 14.


Frailty and skeletal muscle in older adults with cancer.

Williams GR, Deal AM, Muss HB, Weinberg MS, Sanoff HK, Guerard EJ, Nyrop KA, Pergolotti M, Shachar SS.

J Geriatr Oncol. 2018 Jan;9(1):68-73. doi: 10.1016/j.jgo.2017.08.002. Epub 2017 Aug 24.


Lymphedema, musculoskeletal events and arm function in older patients receiving adjuvant chemotherapy for breast cancer (Alliance A171302).

Hopkins JO, Allred J, Hurria A, Jatoi A, Lafky JM, Cohen H, Hudis C, Winer E, Mandelblatt J, Partridge A, Carey L, Muss HB.

Breast Cancer Res Treat. 2017 Dec;166(3):793-808. doi: 10.1007/s10549-017-4454-7. Epub 2017 Aug 20.


The use of psychological supportive care services and psychotropic drugs in patients with early-stage breast cancer: a comparison between two institutions on two continents.

Kaidar-Person O, Meattini I, Deal AM, Francolini G, Carta G, Terzo L, Camporeale J, Muss H, Marks LB, Livi L, Mayer DK, Zagar TM.

Med Oncol. 2017 Aug;34(8):144. doi: 10.1007/s12032-017-1003-5. Epub 2017 Jul 19.


Learning from big data: are we undertreating older women with high-risk breast cancer?

Sparano JA, Muss H.

NPJ Breast Cancer. 2016 Jun 8;2:16019. doi: 10.1038/npjbcancer.2016.19. eCollection 2016. No abstract available.


Comparative "nocebo effects" in older patients enrolled in cancer therapeutic trials: Observations from a 446-patient cohort.

Foster JC, Le-Rademacher JG, Feliciano JL, Gajra A, Seisler DK, DeMatteo R, Lafky JM, Hurria A, Muss HB, Cohen HJ, Jatoi A.

Cancer. 2017 Nov 1;123(21):4193-4198. doi: 10.1002/cncr.30867. Epub 2017 Jul 12.


Randomized Controlled Trial of a Home-Based Walking Program to Reduce Moderate to Severe Aromatase Inhibitor-Associated Arthralgia in Breast Cancer Survivors.

Nyrop KA, Callahan LF, Cleveland RJ, Arbeeva LL, Hackney BS, Muss HB.

Oncologist. 2017 Oct;22(10):1238-1249. doi: 10.1634/theoncologist.2017-0174. Epub 2017 Jul 11.


Frailty Index Developed From a Cancer-Specific Geriatric Assessment and the Association With Mortality Among Older Adults With Cancer.

Guerard EJ, Deal AM, Chang Y, Williams GR, Nyrop KA, Pergolotti M, Muss HB, Sanoff HK, Lund JL.

J Natl Compr Canc Netw. 2017 Jul;15(7):894-902. doi: 10.6004/jnccn.2017.0122.


The Effects of Exercise on Patient-Reported Outcomes and Performance-Based Physical Function in Adults With Acute Leukemia Undergoing Induction Therapy.

Bryant AL, Deal AM, Battaglini CL, Phillips B, Pergolotti M, Coffman E, Foster MC, Wood WA, Bailey C, Hackney AC, Mayer DK, Muss HB, Reeve BB.

Integr Cancer Ther. 2017 Mar 1:1534735417699881. doi: 10.1177/1534735417699881. [Epub ahead of print]


Evaluating the association between adjuvant chemotherapy and function-related adverse events among older patients with early stage breast cancer.

Mariano C, Lund JL, Peacock Hinton S, Htoo P, Muss H, Reeder-Hayes KE.

J Geriatr Oncol. 2017 Jul;8(4):242-248. doi: 10.1016/j.jgo.2017.05.005. Epub 2017 Jun 7.


Skeletal muscle measures and physical function in older adults with cancer: sarcopenia or myopenia?

Williams GR, Deal AM, Muss HB, Weinberg MS, Sanoff HK, Nyrop KA, Pergolotti M, Shachar SS.

Oncotarget. 2017 May 16;8(20):33658-33665. doi: 10.18632/oncotarget.16866.


Data Linkage to Improve Geriatric Oncology Research: A Feasibility Study.

Lund JL, Meyer AM, Deal AM, Choi BJ, Chang Y, Williams GR, Pergolotti M, Guerard EJ, Muss HB, Sanoff HK.

Oncologist. 2017 Aug;22(8):1002-1005. doi: 10.1634/theoncologist.2016-0418. Epub 2017 Apr 13.


Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance).

Mandelblatt JS, Cai L, Luta G, Kimmick G, Clapp J, Isaacs C, Pitcher B, Barry W, Winer E, Sugarman S, Hudis C, Muss H, Cohen HJ, Hurria A.

Breast Cancer Res Treat. 2017 Jul;164(1):107-117. doi: 10.1007/s10549-017-4222-8. Epub 2017 Mar 31.


Activities, function, and health-related quality of life (HRQOL) of older adults with cancer.

Pergolotti M, Deal AM, Williams GR, Bryant AL, Bensen JT, Muss HB, Reeve BB.

J Geriatr Oncol. 2017 Jul;8(4):249-254. doi: 10.1016/j.jgo.2017.02.009. Epub 2017 Mar 9.


Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503).

Kimmick GG, Major B, Clapp J, Sloan J, Pitcher B, Ballman K, Barginear M, Freedman RA, Artz A, Klepin HD, Lafky JM, Hopkins J, Winer E, Hudis C, Muss H, Cohen H, Jatoi A, Hurria A, Mandelblatt J.

Breast Cancer Res Treat. 2017 Jun;163(2):391-398. doi: 10.1007/s10549-017-4188-6. Epub 2017 Mar 10.


Safety and Tolerability of PD-1/PD-L1 Inhibitors Compared with Chemotherapy in Patients with Advanced Cancer: A Meta-Analysis.

Nishijima TF, Shachar SS, Nyrop KA, Muss HB.

Oncologist. 2017 Apr;22(4):470-479. doi: 10.1634/theoncologist.2016-0419. Epub 2017 Mar 8. Review.


Frailty and inflammatory markers in older adults with cancer.

Nishijima TF, Deal AM, Williams GR, Guerard EJ, Nyrop KA, Muss HB.

Aging (Albany NY). 2017 Mar 8;9(3):650-664. doi: 10.18632/aging.101162.


Geriatric Assessment as a Predictor of Tolerance, Quality of Life, and Outcomes in Older Patients With Head and Neck Cancers and Lung Cancers Receiving Radiation Therapy.

VanderWalde NA, Deal AM, Comitz E, Stravers L, Muss H, Reeve BB, Basch E, Tepper J, Chera B.

Int J Radiat Oncol Biol Phys. 2017 Jul 15;98(4):850-857. doi: 10.1016/j.ijrobp.2016.11.048. Epub 2016 Dec 2.


Multidisciplinary Management of Breast Cancer During Pregnancy.

Shachar SS, Gallagher K, McGuire K, Zagar TM, Faso A, Muss HB, Sweeting R, Anders CK.

Oncologist. 2017 Mar;22(3):324-334. doi: 10.1634/theoncologist.2016-0208. Epub 2017 Feb 23. Review.


Weight changes in postmenopausal breast cancer survivors over 2 years of endocrine therapy: a retrospective chart review.

Nyrop KA, Deal AM, Lee JT, Muss HB, Choi SK, Dixon S, Wheless A, Carey LA, Shachar SS.

Breast Cancer Res Treat. 2017 Apr;162(2):375-388. doi: 10.1007/s10549-017-4106-y. Epub 2017 Feb 2.


Body Composition as a Predictor of Toxicity in Patients Receiving Anthracycline and Taxane-Based Chemotherapy for Early-Stage Breast Cancer.

Shachar SS, Deal AM, Weinberg M, Williams GR, Nyrop KA, Popuri K, Choi SK, Muss HB.

Clin Cancer Res. 2017 Jul 15;23(14):3537-3543. doi: 10.1158/1078-0432.CCR-16-2266. Epub 2017 Jan 31.


Biopsy of breast cancer metastases: patient characteristics and survival.

Shachar SS, Mashiach T, Fried G, Drumea K, Shafran N, Muss HB, Bar-Sela G.

BMC Cancer. 2017 Jan 4;17(1):7. doi: 10.1186/s12885-016-3014-6.


Accrual of Older Patients With Breast Cancer to Alliance Systemic Therapy Trials Over Time: Protocol A151527.

Freedman RA, Foster JC, Seisler DK, Lafky JM, Muss HB, Cohen HJ, Mandelblatt J, Winer EP, Hudis CA, Partridge AH, Carey LA, Cirrincione C, Moreno-Aspitia A, Kimmick G, Jatoi A, Hurria A.

J Clin Oncol. 2017 Feb;35(4):421-431. doi: 10.1200/JCO.2016.69.4182. Epub 2016 Dec 19.


Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J.

Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15.


Surveillance Mammography in Older Patients With Breast Cancer-Can We Ever Stop?: A Review.

Freedman RA, Keating NL, Partridge AH, Muss HB, Hurria A, Winer EP.

JAMA Oncol. 2017 Mar 1;3(3):402-409. doi: 10.1001/jamaoncol.2016.3931. Review.


Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511).

Freedman RA, Seisler DK, Foster JC, Sloan JA, Lafky JM, Kimmick GG, Hurria A, Cohen HJ, Winer EP, Hudis CA, Partridge AH, Carey LA, Jatoi A, Klepin HD, Citron M, Berry DA, Shulman LN, Buzdar AU, Suman VJ, Muss HB.

Breast Cancer Res Treat. 2017 Jan;161(2):363-373. doi: 10.1007/s10549-016-4051-1. Epub 2016 Nov 19.


Vaginal Estrogens and Aromatase Inhibitors: How Safe Is Safe Enough?

Reeder-Hayes K, Muss HB.

JAMA Oncol. 2017 Mar 1;3(3):305-306. doi: 10.1001/jamaoncol.2016.3934. No abstract available.


Adrenal Hormone and Metabolic Biomarker Responses to 30 min of Intermittent Cycling Exercise in Breast Cancer Survivors.

Evans ES, Hackney AC, Pebole MM, McMurray RG, Muss HB, Deal AM, Battaglini CL.

Int J Sports Med. 2016 Nov;37(12):921-929. Epub 2016 Aug 4.


Platelet phenotype changes associated with breast cancer and its treatment.

Holmes CE, Levis JE, Schneider DJ, Bambace NM, Sharma D, Lal I, Wood ME, Muss HB.

Platelets. 2016 Nov;27(7):703-711. Epub 2016 May 2.


Comprehensive Geriatric Assessment-Guided Therapy Does Improve Outcomes of Older Patients With Advanced Lung Cancer.

Gajra A, Loh KP, Hurria A, Muss H, Maggiore R, Dale W, Klepin HD, Magnuson A, Lichtman SM, Williams GR, Shahrokhni A, Mohile SG.

J Clin Oncol. 2016 Nov 20;34(33):4047-4048. doi: 10.1200/JCO.2016.67.5926. Epub 2016 Sep 30. No abstract available.


Skeletal Muscle Measures as Predictors of Toxicity, Hospitalization, and Survival in Patients with Metastatic Breast Cancer Receiving Taxane-Based Chemotherapy.

Shachar SS, Deal AM, Weinberg M, Nyrop KA, Williams GR, Nishijima TF, Benbow JM, Muss HB.

Clin Cancer Res. 2017 Feb 1;23(3):658-665. doi: 10.1158/1078-0432.CCR-16-0940. Epub 2016 Aug 3.


A phase II trial of bendamustine in combination with rituximab in older patients with previously untreated diffuse large B-cell lymphoma.

Park SI, Grover NS, Olajide O, Asch AS, Wall JG, Richards KL, Sobol AL, Deal AM, Ivanova A, Foster MC, Muss HB, Shea TC.

Br J Haematol. 2016 Oct;175(2):281-289. doi: 10.1111/bjh.14232. Epub 2016 Jul 22.


Long-term trajectories of self-reported cognitive function in a cohort of older survivors of breast cancer: CALGB 369901 (Alliance).

Mandelblatt JS, Clapp JD, Luta G, Faul LA, Tallarico MD, McClendon TD, Whitley JA, Cai L, Ahles TA, Stern RA, Jacobsen PB, Small BJ, Pitcher BN, Dura-Fernandis E, Muss HB, Hurria A, Cohen HJ, Isaacs C.

Cancer. 2016 Jul 22. doi: 10.1002/cncr.30208. [Epub ahead of print]


Targeted Therapies in Older Adults With Breast Cancer: What Do We Know?

Strulov Shachar S, Hurria A, Muss HB.

J Clin Oncol. 2016 Oct 1;34(28):3486-8. doi: 10.1200/JCO.2016.68.8242. Epub 2016 Jul 18. No abstract available.


Weight gain during adjuvant endocrine treatment for early-stage breast cancer: What is the evidence?

Nyrop KA, Williams GR, Muss HB, Shachar SS.

Breast Cancer Res Treat. 2016 Jul;158(2):203-17. doi: 10.1007/s10549-016-3874-0. Epub 2016 Jun 24. Review.


Cachexia in patients with cancer.

Williams GR, Muss HB, Shachar SS.

Lancet Oncol. 2016 Jun;17(6):e220. doi: 10.1016/S1470-2045(16)00167-4. No abstract available.


Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years.

Goss PE, Ingle JN, Pritchard KI, Robert NJ, Muss H, Gralow J, Gelmon K, Whelan T, Strasser-Weippl K, Rubin S, Sturtz K, Wolff AC, Winer E, Hudis C, Stopeck A, Beck JT, Kaur JS, Whelan K, Tu D, Parulekar WR.

N Engl J Med. 2016 Jul 21;375(3):209-19. doi: 10.1056/NEJMoa1604700. Epub 2016 Jun 5.


Cancer Treatment as an Accelerated Aging Process: Assessment, Biomarkers, and Interventions.

Hurria A, Jones L, Muss HB.

Am Soc Clin Oncol Educ Book. 2016;35:e516-22. doi: 10.14694/EDBK_156160. Review.


Endocrine Therapy for Hormone Receptor-Positive Metastatic Breast Cancer: American Society of Clinical Oncology Guideline.

Rugo HS, Rumble RB, Macrae E, Barton DL, Connolly HK, Dickler MN, Fallowfield L, Fowble B, Ingle JN, Jahanzeb M, Johnston SR, Korde LA, Khatcheressian JL, Mehta RS, Muss HB, Burstein HJ.

J Clin Oncol. 2016 Sep 1;34(25):3069-103. doi: 10.1200/JCO.2016.67.1487. Epub 2016 May 23.


Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer.

Hurria A, Mohile S, Gajra A, Klepin H, Muss H, Chapman A, Feng T, Smith D, Sun CL, De Glas N, Cohen HJ, Katheria V, Doan C, Zavala L, Levi A, Akiba C, Tew WP.

J Clin Oncol. 2016 Jul 10;34(20):2366-71. doi: 10.1200/JCO.2015.65.4327. Epub 2016 May 16.

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