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Multiscale simulation of the interaction of calreticulin-thrombospondin-1 complex with a model membrane microdomain.

Wang L, Murphy-Ullrich JE, Song Y.

J Biomol Struct Dyn. 2018 Feb 15:1-12. doi: 10.1080/07391102.2018.1433065. [Epub ahead of print]


Thrombospondins: Purification of human platelet thrombospondin-1.

Sipes JM, Murphy-Ullrich JE, Roberts DD.

Methods Cell Biol. 2018;143:347-369. doi: 10.1016/bs.mcb.2017.08.021. Epub 2017 Nov 6.


Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.

Murphy-Ullrich JE, Suto MJ.

Matrix Biol. 2017 Dec 27. pii: S0945-053X(17)30359-1. doi: 10.1016/j.matbio.2017.12.009. [Epub ahead of print] Review.


The role of the endoplasmic reticulum protein calreticulin in mediating TGF-β-stimulated extracellular matrix production in fibrotic disease.

Owusu BY, Zimmerman KA, Murphy-Ullrich JE.

J Cell Commun Signal. 2018 Mar;12(1):289-299. doi: 10.1007/s12079-017-0426-2. Epub 2017 Oct 28. Review.


Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation.

Zimmerman KA, Xing D, Pallero MA, Lu A, Ikawa M, Black L, Hoyt KL, Kabarowski JH, Michalak M, Murphy-Ullrich JE.

J Vasc Res. 2015;52(5):306-20. doi: 10.1159/000443884. Epub 2016 Feb 25.


Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma.

Lu A, Pallero MA, Lei W, Hong H, Yang Y, Suto MJ, Murphy-Ullrich JE.

Am J Pathol. 2016 Mar;186(3):678-90. doi: 10.1016/j.ajpath.2015.11.003. Epub 2016 Jan 20.


High-Magnitude and/or High-Frequency Mechanical Strain Promotes Peripapillary Scleral Myofibroblast Differentiation.

Qu J, Chen H, Zhu L, Ambalavanan N, Girkin CA, Murphy-Ullrich JE, Downs JC, Zhou Y.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7821-30. doi: 10.1167/iovs.15-17848.


The Thrombospondin1-TGF-β Pathway and Glaucoma.

Murphy-Ullrich JE, Downs JC.

J Ocul Pharmacol Ther. 2015 Sep;31(7):371-5. doi: 10.1089/jop.2015.0016. Epub 2015 May 29.


Hyperglycemic arterial disturbed flow niche as an in vitro model of atherosclerosis.

Patibandla PK, Rogers AJ, Giridharan GA, Pallero MA, Murphy-Ullrich JE, Sethu P.

Anal Chem. 2014 Nov 4;86(21):10948-54. doi: 10.1021/ac503294p. Epub 2014 Oct 17.


Molecular insight into the effect of lipid bilayer environments on thrombospondin-1 and calreticulin interactions.

Wang L, Murphy-Ullrich JE, Song Y.

Biochemistry. 2014 Oct 14;53(40):6309-22. doi: 10.1021/bi500662v. Epub 2014 Sep 26.


Revisiting the matricellular concept.

Murphy-Ullrich JE, Sage EH.

Matrix Biol. 2014 Jul;37:1-14. doi: 10.1016/j.matbio.2014.07.005. Epub 2014 Jul 24. Review.


The role of matricellular proteins in glaucoma.

Wallace DM, Murphy-Ullrich JE, Downs JC, O'Brien CJ.

Matrix Biol. 2014 Jul;37:174-82. doi: 10.1016/j.matbio.2014.03.007. Epub 2014 Apr 12. Review.


Calreticulin regulates transforming growth factor-β-stimulated extracellular matrix production.

Zimmerman KA, Graham LV, Pallero MA, Murphy-Ullrich JE.

J Biol Chem. 2013 May 17;288(20):14584-98. doi: 10.1074/jbc.M112.447243. Epub 2013 Apr 5.


CD36, but not G2A, modulates efferocytosis, inflammation, and fibrosis following bleomycin-induced lung injury.

Parks BW, Black LL, Zimmerman KA, Metz AE, Steele C, Murphy-Ullrich JE, Kabarowski JH.

J Lipid Res. 2013 Apr;54(4):1114-23. doi: 10.1194/jlr.M035352. Epub 2013 Feb 6.


Thrombospondin-1 in early flow-related remodeling of mesenteric arteries from young normotensive and spontaneously hypertensive rats.

Lemkens P, Boari G, Fazzi G, Janssen G, Murphy-Ullrich J, Schiffers P, De Mey J.

Open Cardiovasc Med J. 2012;6:50-9. doi: 10.2174/1874192401206010050. Epub 2012 May 18.


Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation.

Bailey Dubose K, Zayzafoon M, Murphy-Ullrich JE.

Biochem Biophys Res Commun. 2012 Jun 8;422(3):488-93. doi: 10.1016/j.bbrc.2012.05.020. Epub 2012 May 11.


Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms.

Sweetwyne MT, Murphy-Ullrich JE.

Matrix Biol. 2012 Apr;31(3):178-86. doi: 10.1016/j.matbio.2012.01.006. Epub 2012 Jan 14. Review.


Thrombospondins in physiology and disease: new tricks for old dogs.

Murphy-Ullrich JE, Iozzo RV.

Matrix Biol. 2012 Apr;31(3):152-4. doi: 10.1016/j.matbio.2012.01.002. Epub 2012 Jan 12. Review. No abstract available.


Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy.

Lu A, Miao M, Schoeb TR, Agarwal A, Murphy-Ullrich JE.

Am J Pathol. 2011 Jun;178(6):2573-86. doi: 10.1016/j.ajpath.2011.02.039.


Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation.

Garg P, Yang S, Liu A, Pallero MA, Buchsbaum DJ, Mosher DF, Murphy-Ullrich JE, Goldblum SE.

Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L79-90. doi: 10.1152/ajplung.00287.2010. Epub 2011 Apr 29.


Molecular and structural insight into the role of key residues of thrombospondin-1 and calreticulin in thrombospondin-1-calreticulin binding.

Yan Q, Murphy-Ullrich JE, Song Y.

Biochemistry. 2011 Feb 1;50(4):566-73. doi: 10.1021/bi101639y. Epub 2011 Jan 4.


Human cytomegalovirus induces TGF-β1 activation in renal tubular epithelial cells after epithelial-to-mesenchymal transition.

Shimamura M, Murphy-Ullrich JE, Britt WJ.

PLoS Pathog. 2010 Nov 4;6(11):e1001170. doi: 10.1371/journal.ppat.1001170.


TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine.

Maheshwari A, Kelly DR, Nicola T, Ambalavanan N, Jain SK, Murphy-Ullrich J, Athar M, Shimamura M, Bhandari V, Aprahamian C, Dimmitt RA, Serra R, Ohls RK.

Gastroenterology. 2011 Jan;140(1):242-53. doi: 10.1053/j.gastro.2010.09.043. Epub 2010 Sep 24.


The calreticulin-binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodeling.

Sweetwyne MT, Pallero MA, Lu A, Van Duyn Graham L, Murphy-Ullrich JE.

Am J Pathol. 2010 Oct;177(4):1710-24. doi: 10.2353/ajpath.2010.090903. Epub 2010 Aug 19.


Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy.

Diers AR, Dranka BP, Ricart KC, Oh JY, Johnson MS, Zhou F, Pallero MA, Bodenstine TM, Murphy-Ullrich JE, Welch DR, Landar A.

Biochem J. 2010 Aug 15;430(1):69-78. doi: 10.1042/BJ20091193.


Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation.

Zhou Y, Hagood JS, Lu B, Merryman WD, Murphy-Ullrich JE.

J Biol Chem. 2010 Jul 16;285(29):22382-93. doi: 10.1074/jbc.M110.126227. Epub 2010 May 12.


Structural insight into the role of thrombospondin-1 binding to calreticulin in calreticulin-induced focal adhesion disassembly.

Yan Q, Murphy-Ullrich JE, Song Y.

Biochemistry. 2010 May 4;49(17):3685-94. doi: 10.1021/bi902067f.


Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cells.

Wang S, Lincoln TM, Murphy-Ullrich JE.

Am J Physiol Cell Physiol. 2010 May;298(5):C1188-97. doi: 10.1152/ajpcell.00330.2009. Epub 2010 Feb 17.


Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrix.

Van Duyn Graham L, Sweetwyne MT, Pallero MA, Murphy-Ullrich JE.

J Biol Chem. 2010 Mar 5;285(10):7067-78. doi: 10.1074/jbc.M109.006841. Epub 2009 Dec 31.


Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis.

Pallero MA, Talbert Roden M, Chen YF, Anderson PG, Lemons J, Brott BC, Murphy-Ullrich JE.

J Vasc Res. 2010;47(4):309-22. doi: 10.1159/000265565. Epub 2009 Dec 16.


Calreticulin: non-endoplasmic reticulum functions in physiology and disease.

Gold LI, Eggleton P, Sweetwyne MT, Van Duyn LB, Greives MR, Naylor SM, Michalak M, Murphy-Ullrich JE.

FASEB J. 2010 Mar;24(3):665-83. doi: 10.1096/fj.09-145482. Epub 2009 Nov 25. Review.


Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1.

Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR.

Cancer Res. 2009 Jul 1;69(13):5374-82. doi: 10.1158/0008-5472.CAN-09-0186. Epub 2009 Jun 23.


Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation.

Liu A, Garg P, Yang S, Gong P, Pallero MA, Annis DS, Liu Y, Passaniti A, Mann D, Mosher DF, Murphy-Ullrich JE, Goldblum SE.

J Biol Chem. 2009 Mar 6;284(10):6389-402. doi: 10.1074/jbc.M809198200. Epub 2009 Jan 7.


Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.

Zhou Y, Koli K, Hagood JS, Miao M, Mavalli M, Rifkin DB, Murphy-Ullrich JE.

Am J Pathol. 2009 Jan;174(1):21-33. doi: 10.2353/ajpath.2009.080620. Epub 2008 Dec 4.


The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endothelia.

Liu A, Mosher DF, Murphy-Ullrich JE, Goldblum SE.

Microvasc Res. 2009 Jan;77(1):13-20. doi: 10.1016/j.mvr.2008.08.008. Epub 2008 Oct 1. Review.


Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis.

Pallero MA, Elzie CA, Chen J, Mosher DF, Murphy-Ullrich JE.

FASEB J. 2008 Nov;22(11):3968-79. doi: 10.1096/fj.07-104802. Epub 2008 Jul 24.


LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.

Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK.

Physiol Rev. 2008 Jul;88(3):887-918. doi: 10.1152/physrev.00033.2007. Review.


Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung.

Ambalavanan N, Nicola T, Hagood J, Bulger A, Serra R, Murphy-Ullrich J, Oparil S, Chen YF.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L86-95. doi: 10.1152/ajplung.00534.2007. Epub 2008 May 16.


Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditions.

Ambalavanan N, Nicola T, Li P, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF.

Pediatr Res. 2008 Jan;63(1):26-32.


The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.

Komalavilas P, Penn RB, Flynn CR, Thresher J, Lopes LB, Furnish EJ, Guo M, Pallero MA, Murphy-Ullrich JE, Brophy CM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L69-78. Epub 2007 Nov 9.


A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II.

Belmadani S, Bernal J, Wei CC, Pallero MA, Dell'italia L, Murphy-Ullrich JE, Berecek KH.

Am J Pathol. 2007 Sep;171(3):777-89. Epub 2007 Jul 19.


Endothelin-1 mediates hypoxia-induced increases in vascular collagen in the newborn mouse lung.

Ambalavanan N, Li P, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF.

Pediatr Res. 2007 May;61(5 Pt 1):559-64.


Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I.

Rege TA, Pallero MA, Gomez C, Grenett HE, Murphy-Ullrich JE, Hagood JS.

Exp Cell Res. 2006 Nov 15;312(19):3752-67. Epub 2006 Sep 12.


Function-blocking antithrombospondin-1 monoclonal antibodies.

Annis DS, Murphy-Ullrich JE, Mosher DF.

J Thromb Haemost. 2006 Feb;4(2):459-68.


Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions.

Zhou Y, Poczatek MH, Berecek KH, Murphy-Ullrich JE.

Biochem Biophys Res Commun. 2006 Jan 13;339(2):633-41. Epub 2005 Nov 18.


Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen.

Vayalil PK, Olman M, Murphy-Ullrich JE, Postlethwait EM, Liu RM.

Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L937-45. Epub 2005 Oct 28.


Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte.

Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM.

Cell. 2005 Oct 21;123(2):321-34.


Endothelin-A receptor blockade prevents and partially reverses neonatal hypoxic pulmonary vascular remodeling.

Ambalavanan N, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF.

Pediatr Res. 2005 May;57(5 Pt 1):631-6. Epub 2005 Mar 17.


Activation of Latent TGF-β1 by Thrombospondin-1 is a Major Component of Wound Repair.

Nör JE, Dipietro L, Murphy-Ullrich JE, Hynes RO, Lawler J, Polverini PJ.

Oral Biosci Med. 2005;2(2):153-161.


Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics.

Dreiza CM, Brophy CM, Komalavilas P, Furnish EJ, Joshi L, Pallero MA, Murphy-Ullrich JE, von Rechenberg M, Ho YS, Richardson B, Xu N, Zhen Y, Peltier JM, Panitch A.

FASEB J. 2005 Feb;19(2):261-3. Epub 2004 Dec 14.


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