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Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by iPSC Modeling.

Kiskin FN, Chang CH, Huang CJZ, Kwieder B, Cheung C, Dunmore BJ, Serrano F, Sinha S, Morrell NW, Rana AA.

Am J Respir Crit Care Med. 2018 Mar 16. doi: 10.1164/rccm.201801-0049LE. [Epub ahead of print] No abstract available.


miR-322-5p targets IGF-1 and is suppressed in the heart of rats with pulmonary hypertension.

Connolly M, Garfield BE, Crosby A, Morrell NW, Wort SJ, Kemp PR.

FEBS Open Bio. 2018 Jan 24;8(3):339-348. doi: 10.1002/2211-5463.12369. eCollection 2018 Mar.


A novel piperidine identified by stem cell based screening attenuates pulmonary arterial hypertension via regulating BMP2 and PTGS2 levels.

Xing Y, Zhao S, Wei Q, Gong S, Zhao X, Zhou F, Ai-Lamki R, Ortmann D, Du M, Pedersen R, Shang G, Si S, Morrell NW, Yang J.

Eur Respir J. 2018 Feb 15. pii: 1702229. doi: 10.1183/13993003.02229-2017. [Epub ahead of print]


Silicone Metacarpophalangeal Arthroplasty for Osteoarthritis: Long-Term Results.

Morrell NT, Weiss AC.

J Hand Surg Am. 2018 Mar;43(3):229-233. doi: 10.1016/j.jhsa.2017.10.010. Epub 2017 Nov 14.


Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.

Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC.


Light curves of the neutron star merger GW170817/SSS17a: Implications for r-process nucleosynthesis.

Drout MR, Piro AL, Shappee BJ, Kilpatrick CD, Simon JD, Contreras C, Coulter DA, Foley RJ, Siebert MR, Morrell N, Boutsia K, Di Mille F, Holoien TW, Kasen D, Kollmeier JA, Madore BF, Monson AJ, Murguia-Berthier A, Pan YC, Prochaska JX, Ramirez-Ruiz E, Rest A, Adams C, Alatalo K, Bañados E, Baughman J, Beers TC, Bernstein RA, Bitsakis T, Campillay A, Hansen TT, Higgs CR, Ji AP, Maravelias G, Marshall JL, Bidin CM, Prieto JL, Rasmussen KC, Rojas-Bravo C, Strom AL, Ulloa N, Vargas-González J, Wan Z, Whitten DD.

Science. 2017 Dec 22;358(6370):1570-1574. doi: 10.1126/science.aaq0049. Epub 2017 Oct 16.


Early spectra of the gravitational wave source GW170817: Evolution of a neutron star merger.

Shappee BJ, Simon JD, Drout MR, Piro AL, Morrell N, Prieto JL, Kasen D, Holoien TW, Kollmeier JA, Kelson DD, Coulter DA, Foley RJ, Kilpatrick CD, Siebert MR, Madore BF, Murguia-Berthier A, Pan YC, Prochaska JX, Ramirez-Ruiz E, Rest A, Adams C, Alatalo K, Bañados E, Baughman J, Bernstein RA, Bitsakis T, Boutsia K, Bravo JR, Di Mille F, Higgs CR, Ji AP, Maravelias G, Marshall JL, Placco VM, Prieto G, Wan Z.

Science. 2017 Dec 22;358(6370):1574-1578. doi: 10.1126/science.aaq0186. Epub 2017 Oct 16.


Electromagnetic evidence that SSS17a is the result of a binary neutron star merger.

Kilpatrick CD, Foley RJ, Kasen D, Murguia-Berthier A, Ramirez-Ruiz E, Coulter DA, Drout MR, Piro AL, Shappee BJ, Boutsia K, Contreras C, Di Mille F, Madore BF, Morrell N, Pan YC, Prochaska JX, Rest A, Rojas-Bravo C, Siebert MR, Simon JD, Ulloa N.

Science. 2017 Dec 22;358(6370):1583-1587. doi: 10.1126/science.aaq0073. Epub 2017 Oct 16.


Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.

Hadinnapola C, Bleda M, Haimel M, Screaton N, Swift A, Dorfmüller P, Preston SD, Southwood M, Hernandez-Sanchez J, Martin J, Treacy C, Yates K, Bogaard H, Church C, Coghlan G, Condliffe R, Corris PA, Gibbs S, Girerd B, Holden S, Humbert M, Kiely DG, Lawrie A, Machado R, MacKenzie Ross R, Moledina S, Montani D, Newnham M, Peacock A, Pepke-Zaba J, Rayner-Matthews P, Shamardina O, Soubrier F, Southgate L, Suntharalingam J, Toshner M, Trembath R, Vonk Noordegraaf A, Wilkins MR, Wort SJ, Wharton J; NIHR BioResource–Rare Diseases Consortium; UK National Cohort Study of Idiopathic and Heritable PAH, Gräf S, Morrell NW.

Circulation. 2017 Nov 21;136(21):2022-2033. doi: 10.1161/CIRCULATIONAHA.117.028351. Epub 2017 Sep 28.


Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.

Zhang H, Wang D, Li M, Plecitá-Hlavatá L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Ježek P, Morrell NW, Hu CJ, Stenmark KR.

Circulation. 2017 Dec 19;136(25):2468-2485. doi: 10.1161/CIRCULATIONAHA.117.028069. Epub 2017 Sep 26.


Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.

Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW.

Circulation. 2017 Dec 19;136(25):2451-2467. doi: 10.1161/CIRCULATIONAHA.117.028034. Epub 2017 Sep 26.


Role of the Aryl Hydrocarbon Receptor in Sugen 5416-induced Experimental Pulmonary Hypertension.

Dean A, Gregorc T, Docherty CK, Harvey KY, Nilsen M, Morrell NW, MacLean MR.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):320-330. doi: 10.1165/rcmb.2017-0260OC.


Clinical trial protocol for TRANSFORM-UK: A therapeutic open-label study of tocilizumab in the treatment of pulmonary arterial hypertension.

Hernández-Sánchez J, Harlow L, Church C, Gaine S, Knightbridge E, Bunclark K, Gor D, Bedding A, Morrell N, Corris P, Toshner M.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217735820. doi: 10.1177/2045893217735820. Epub 2017 Sep 28.


Correction for Bagarova et al., "Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation".

Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CSC, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB.

Mol Cell Biol. 2017 Sep 12;37(19). pii: e00284-17. doi: 10.1128/MCB.00284-17. Print 2017 Oct 1. No abstract available.


Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling.

Pickworth J, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey PM, Gladson S, Shay S, Morrell NW, Francis SE, West JD, Lawrie A.

Pulm Circ. 2017 Oct-Dec;7(4):768-776. doi: 10.1177/2045893217729096. Epub 2017 Sep 22.


A 3D tri-culture system reveals that activin receptor-like kinase 5 and connective tissue growth factor drive human glomerulosclerosis.

Waters JP, Richards YC, Skepper JN, Southwood M, Upton PD, Morrell NW, Pober JS, Bradley JR.

J Pathol. 2017 Nov;243(3):390-400. doi: 10.1002/path.4960. Epub 2017 Oct 3.


Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation.

Chen X, Orriols M, Walther FJ, Laghmani EH, Hoogeboom AM, Hogen-Esch ACB, Hiemstra PS, Folkerts G, Goumans MTH, Ten Dijke P, Morrell NW, Wagenaar GTM.

Front Physiol. 2017 Jul 13;8:486. doi: 10.3389/fphys.2017.00486. eCollection 2017.


Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis.

Collum SD, Chen NY, Hernandez AM, Hanmandlu A, Sweeney H, Mertens TCJ, Weng T, Luo F, Molina JG, Davies J, Horan IP, Morrell NW, Amione-Guerra J, Al-Jabbari O, Youker K, Sun W, Rajadas J, Bollyky PL, Akkanti BH, Jyothula S, Sinha N, Guha A, Karmouty-Quintana H.

Br J Pharmacol. 2017 Oct;174(19):3284-3301. doi: 10.1111/bph.13947. Epub 2017 Aug 17.


Haplotype phasing of whole human genomes using bead-based barcode partitioning in a single tube.

Zhang F, Christiansen L, Thomas J, Pokholok D, Jackson R, Morrell N, Zhao Y, Wiley M, Welch E, Jaeger E, Granat A, Norberg SJ, Halpern A, C Rogert M, Ronaghi M, Shendure J, Gormley N, Gunderson KL, Steemers FJ.

Nat Biotechnol. 2017 Sep;35(9):852-857. doi: 10.1038/nbt.3897. Epub 2017 Jun 26.


Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2.

Mitrofan CG, Appleby SL, Nash GB, Mallat Z, Chilvers ER, Upton PD, Morrell NW.

J Biol Chem. 2017 Aug 18;292(33):13714-13726. doi: 10.1074/jbc.M117.778506. Epub 2017 Jun 23.


A sex-specific reconstitution bias in the competitive CD45.1/CD45.2 congenic bone marrow transplant model.

Jafri S, Moore SD, Morrell NW, Ormiston ML.

Sci Rep. 2017 Jun 14;7(1):3495. doi: 10.1038/s41598-017-03784-9.


The Pulmonary Vascular Research Institute celebrates its first decade.

Yuan JX, Morrell NW, Stenmark KR, Lang IM, Butrous G, Reynolds ME.

Pulm Circ. 2017 Apr-Jun;7(2):283-284. doi: 10.1177/2045893217713107. No abstract available.


Ventriculo-arterial coupling detects occult RV dysfunction in chronic thromboembolic pulmonary vascular disease.

Axell RG, Messer SJ, White PA, McCabe C, Priest A, Statopoulou T, Drozdzynska M, Viscasillas J, Hinchy EC, Hampton-Till J, Alibhai HI, Morrell N, Pepke-Zaba J, Large SR, Hoole SP.

Physiol Rep. 2017 Apr;5(7). pii: e13227. doi: 10.14814/phy2.13227.


Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.

Yang P, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, Upton PD, Crosby A, Sawiak SJ, Carpenter TA, Glen RC, Morrell NW, Maguire JJ, Davenport AP.

Circulation. 2017 Mar 21;135(12):1160-1173. doi: 10.1161/CIRCULATIONAHA.116.023218. Epub 2017 Jan 30.


Team Approach: Repair and Rehabilitation Following Flexor Tendon Lacerations.

Morrell NT, Hulvey A, Elsinger J, Zhang G, Shafritz AB.

JBJS Rev. 2017 Jan 10;5(1). pii: 01874474-201701000-00003. doi: 10.2106/JBJS.RVW.16.00013. No abstract available.


Scapholunate and perilunate injuries in the athlete.

Morrell NT, Moyer A, Quinlan N, Shafritz AB.

Curr Rev Musculoskelet Med. 2017 Mar;10(1):45-52. doi: 10.1007/s12178-017-9383-x. Review.


Our readership grows by leaps and bounds.

Yuan JX, Morrell NW, Stenmark KR, Butrous G, Reynolds ME.

Pulm Circ. 2016 Dec;6(4):405-406. doi: 10.1086/688929. No abstract available.


Pulmonary veno-occlusive disease: characterising a rare but important disease.

Hadinnapola C, Morrell NW.

Lancet Respir Med. 2017 Feb;5(2):89-90. doi: 10.1016/S2213-2600(16)30466-0. Epub 2017 Jan 11. No abstract available.


TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

Hurst LA, Dunmore BJ, Long L, Crosby A, Al-Lamki R, Deighton J, Southwood M, Yang X, Nikolic MZ, Herrera B, Inman GJ, Bradley JR, Rana AA, Upton PD, Morrell NW.

Nat Commun. 2017 Jan 13;8:14079. doi: 10.1038/ncomms14079.


Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.

Rhodes CJ, Ghataorhe P, Wharton J, Rue-Albrecht KC, Hadinnapola C, Watson G, Bleda M, Haimel M, Coghlan G, Corris PA, Howard LS, Kiely DG, Peacock AJ, Pepke-Zaba J, Toshner MR, Wort SJ, Gibbs JS, Lawrie A, Gräf S, Morrell NW, Wilkins MR.

Circulation. 2017 Jan 31;135(5):460-475. doi: 10.1161/CIRCULATIONAHA.116.024602. Epub 2016 Nov 21.


Prof. Almaz A. Aldashev (1953-2016).

Wilkins MR, Morrell NW.

Eur Respir J. 2016 Oct;48(4):990-991. doi: 10.1183/13993003.01316-2016. No abstract available.


Towards a molecular classification of pulmonary arterial hypertension.

Gräf S, Morrell NW.

Eur Respir J. 2016 Oct;48(4):987-989. doi: 10.1183/13993003.01550-2016. No abstract available.


Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium.

Appleby SL, Mitrofan CG, Crosby A, Hoenderdos K, Lodge K, Upton PD, Yates CM, Nash GB, Chilvers ER, Morrell NW.

J Immunol. 2016 Oct 15;197(8):3302-3314. doi: 10.4049/jimmunol.1601219. Epub 2016 Sep 19.


Regulation of the ALK1 ligands, BMP9 and BMP10.

Li W, Salmon RM, Jiang H, Morrell NW.

Biochem Soc Trans. 2016 Aug 15;44(4):1135-41. doi: 10.1042/BST20160083. Review.


Tenosynovitis of the Hand and Wrist: A Critical Analysis Review.

Blood TD, Morrell NT, Weiss AP.

JBJS Rev. 2016 Mar 29;4(3). pii: 01874474-201603000-00001. doi: 10.2106/JBJS.RVW.O.00061. No abstract available.


HIF2α-arginase axis is essential for the development of pulmonary hypertension.

Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8801-6. doi: 10.1073/pnas.1602978113. Epub 2016 Jul 18.


Disrupted Endothelial Cell Layer and Exposed Extracellular Matrix Proteins Promote Capture of Late Outgrowth Endothelial Progenitor Cells.

Zhao J, Mitrofan CG, Appleby SL, Morrell NW, Lever AM.

Stem Cells Int. 2016;2016:1406304. doi: 10.1155/2016/1406304. Epub 2016 Jun 16.


In Reply.

Pidgeon TS, Morrell NT, Wilson AT, DaSilva MF.

J Hand Surg Am. 2016 Apr;41(4):574-6. doi: 10.1016/j.jhsa.2016.01.016. No abstract available.


MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.

Rothman AM, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen RM, Guth-Gundel S, Southwood M, Morrell NW, Thomas M, Francis SE, Rowlands DJ, Lawrie A.

J Clin Invest. 2016 Jul 1;126(7):2495-508. doi: 10.1172/JCI83361. Epub 2016 May 23.


Regulation and function of miR-214 in pulmonary arterial hypertension.

Stevens HC, Deng L, Grant JS, Pinel K, Thomas M, Morrell NW, MacLean MR, Baker AH, Denby L.

Pulm Circ. 2016 Mar;6(1):109-17. doi: 10.1086/685079.


Erratum: Carpal Tunnel Release: Do We Understand the Biomechanical Consequences?

Morrell NT, Harris AP, Skjong C, Akelman E.

J Wrist Surg. 2016 May;5(2):167. doi: 10.1055/s-0036-1580088. Epub 2016 Mar 4.


A randomized preference trial to inform personalization of a parent training program implemented in community mental health clinics.

He Y, Gewirtz A, Lee S, Morrell N, August G.

Transl Behav Med. 2016 Mar;6(1):73-80. doi: 10.1007/s13142-015-0366-4.


Astronomy. ASASSN-15lh: A highly super-luminous supernova.

Dong S, Shappee BJ, Prieto JL, Jha SW, Stanek KZ, Holoien TW, Kochanek CS, Thompson TA, Morrell N, Thompson IB, Basu U, Beacom JF, Bersier D, Brimacombe J, Brown JS, Bufano F, Chen P, Conseil E, Danilet AB, Falco E, Grupe D, Kiyota S, Masi G, Nicholls B, Olivares E F, Pignata G, Pojmanski G, Simonian GV, Szczygiel DM, Woźniak PR.

Science. 2016 Jan 15;351(6270):257-60. doi: 10.1126/science.aac9613.


BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis.

Evans JD, Girerd B, Montani D, Wang XJ, Galiè N, Austin ED, Elliott G, Asano K, Grünig E, Yan Y, Jing ZC, Manes A, Palazzini M, Wheeler LA, Nakayama I, Satoh T, Eichstaedt C, Hinderhofer K, Wolf M, Rosenzweig EB, Chung WK, Soubrier F, Simonneau G, Sitbon O, Gräf S, Kaptoge S, Di Angelantonio E, Humbert M, Morrell NW.

Lancet Respir Med. 2016 Feb;4(2):129-37. doi: 10.1016/S2213-2600(15)00544-5. Epub 2016 Jan 19.


Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood.

Ormiston ML, Toshner MR, Kiskin FN, Huang CJ, Groves E, Morrell NW, Rana AA.

J Vis Exp. 2015 Dec 23;(106):e53384. doi: 10.3791/53384.


The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension.

Ormiston ML, Upton PD, Li W, Morrell NW.

Glob Cardiol Sci Pract. 2015 Nov 17;2015(4):47. doi: 10.5339/gcsp.2015.47. eCollection 2015.


The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells.

Jiang H, Salmon RM, Upton PD, Wei Z, Lawera A, Davenport AP, Morrell NW, Li W.

J Biol Chem. 2016 Feb 5;291(6):2954-66. doi: 10.1074/jbc.M115.683292. Epub 2015 Dec 2.


Targeting BMP signalling in cardiovascular disease and anaemia.

Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD.

Nat Rev Cardiol. 2016 Feb;13(2):106-20. doi: 10.1038/nrcardio.2015.156. Epub 2015 Oct 13. Review.


Caveolae protect endothelial cells from membrane rupture during increased cardiac output.

Cheng JP, Mendoza-Topaz C, Howard G, Chadwick J, Shvets E, Cowburn AS, Dunmore BJ, Crosby A, Morrell NW, Nichols BJ.

J Cell Biol. 2015 Oct 12;211(1):53-61. doi: 10.1083/jcb.201504042.


Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects.

Machado RD, Southgate L, Eichstaedt CA, Aldred MA, Austin ED, Best DH, Chung WK, Benjamin N, Elliott CG, Eyries M, Fischer C, Gräf S, Hinderhofer K, Humbert M, Keiles SB, Loyd JE, Morrell NW, Newman JH, Soubrier F, Trembath RC, Viales RR, Grünig E.

Hum Mutat. 2015 Dec;36(12):1113-27. doi: 10.1002/humu.22904. Epub 2015 Oct 12. Review.

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