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Biol Lett. 2018 Mar;14(3). pii: 20180006. doi: 10.1098/rsbl.2018.0006.

Cationic antimicrobial peptides do not change recombination frequency in Escherichia coli.

Author information

1
Evolutionary Biology, Institut für Biologie, Freie Universität Berlin, Berlin, Germany a.rojas@fu-berlin.de.
2
Evolutionary Biology, Institut für Biologie, Freie Universität Berlin, Berlin, Germany.
3
Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

Abstract

Cationic antimicrobial peptides are ubiquitous immune effectors of multicellular organisms. We previously reported, that in contrast to most of the classic antibiotics, cationic antimicrobial peptides (AMPs) do not increase mutation rates in E. coli Here, we provide new evidence showing that AMPs do not stimulate or enhance bacterial DNA recombination in the surviving fractions. Recombination accelerates evolution of antibiotic resistance. Our findings have implications for our understanding of host-microbe interactions, the evolution of innate immune defences, and shed new light on the dynamic of antimicrobial-resistance evolution.

KEYWORDS:

antibiotic resistance; cationic antimicrobial peptides; homologous recombination

PMID:
29563281
PMCID:
PMC5897613
[Available on 2019-03-01]
DOI:
10.1098/rsbl.2018.0006

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