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Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study.

Gramatzki D, Roth P, Rushing EJ, Weller J, Andratschke N, Hofer S, Korol D, Regli L, Pangalu A, Pless M, Oberle J, Bernays R, Moch H, Rohrmann S, Weller M.

Ann Oncol. 2018 Mar 30. doi: 10.1093/annonc/mdy106. [Epub ahead of print]


Targeted next-generation-sequencing for reliable detection of targetable rearrangements in lung adenocarcinoma-a single center retrospective study.

Velizheva NP, Rechsteiner MP, Valtcheva N, Freiberger SN, Wong CE, Vrugt B, Zhong Q, Wagner U, Moch H, Hillinger S, Schmitt-Opitz I, Soltermann A, Wild PJ, Tischler V.

Pathol Res Pract. 2018 Apr;214(4):572-578. doi: 10.1016/j.prp.2018.02.001. Epub 2018 Feb 16.


Comprehensive immunohistochemical analysis of PD-L1 shows scarce expression in castration-resistant prostate cancer.

Fankhauser CD, Schüffler PJ, Gillessen S, Omlin A, Rupp NJ, Rueschoff JH, Hermanns T, Poyet C, Sulser T, Moch H, Wild PJ.

Oncotarget. 2017 Dec 4;9(12):10284-10293. doi: 10.18632/oncotarget.22888. eCollection 2018 Feb 13.


Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJG, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K.

Nat Med. 2018 May;24(4):463-473. doi: 10.1038/nm.4494. Epub 2018 Mar 12.


PD-L1 is a positive prognostic factor in squamous cell carcinoma of the nasal vestibule.

Vital D, Holzmann D, Huber GF, Moch H, Morand GB, Ikenberg K.

Rhinology. 2018 Feb 21. doi: 10.4193/Rhin17.215. [Epub ahead of print]


Morphological clues to the appropriate recognition of hereditary renal neoplasms.

Moch H, Ohashi R, Gandhi JS, Amin MB.

Semin Diagn Pathol. 2018 Feb 14. pii: S0740-2570(18)30005-4. doi: 10.1053/j.semdp.2018.01.005. [Epub ahead of print] Review.


Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features.

Rechsteiner M, Dedes K, Fink D, Pestalozzi B, Sobottka B, Moch H, Wild P, Varga Z.

J Cancer Res Clin Oncol. 2018 Feb 17. doi: 10.1007/s00432-018-2609-5. [Epub ahead of print]


Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer.

Posch F, Silina K, Leibl S, Mündlein A, Moch H, Siebenhüner A, Samaras P, Riedl J, Stotz M, Szkandera J, Stöger H, Pichler M, Stupp R, van den Broek M, Schraml P, Gerger A, Petrausch U, Winder T.

Oncoimmunology. 2017 Dec 18;7(2):e1378844. doi: 10.1080/2162402X.2017.1378844. eCollection 2018.


Biomarker discovery for renal cancer stem cells.

Corrò C, Moch H.

J Pathol Clin Res. 2018 Jan 17;4(1):3-18. doi: 10.1002/cjp2.91. eCollection 2018 Jan. Review.


Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma.

Silina K, Soltermann A, Movahedian Attar F, Casanova R, Uckeley ZM, Thut H, Wandres M, Isajevs S, Cheng PF, Curioni Fontecedro A, Foukas P, Levesque MP, Moch H, Linē A, van den Broek M.

Cancer Res. 2017 Dec 26. pii: canres.1987.2017. doi: 10.1158/0008-5472.CAN-17-1987. [Epub ahead of print]


NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Singer J, Ruscheweyh HJ, Hofmann AL, Thurnherr T, Singer F, Toussaint NC, Ng CKY, Piscuoglio S, Beisel C, Christofori G, Dummer R, Hall MN, Krek W, Levesque MP, Manz MG, Moch H, Papassotiropoulos A, Stekhoven DJ, Wild P, Wüst T, Rinn B, Beerenwinkel N.

Bioinformatics. 2018 Jan 1;34(1):107-108. doi: 10.1093/bioinformatics/btx540.


[Establishment of a living biobank : Improved guidance of precision cancer care with in vitro and in vivo cancer models].

Pauli C, Moch H, Rubin MA.

Pathologe. 2017 Nov;38(Suppl 2):160-168. doi: 10.1007/s00292-017-0346-1. Review. German.


Neue und vielversprechende molekulare Therapieoptionen in verschiedenen Subtypen des Nierenzellkarzinoms.

Rupp NJ, Mischo A, Moch H.

Ther Umsch. 2017 Sep;74(4):171-179. doi: 10.1024/0040-5930/a000901. Review. German. No abstract available.


A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, Böhm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, Kähne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Altés S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, Hüser N, Davis RJ, Müllhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A.

Cancer Cell. 2017 Sep 11;32(3):342-359.e10. doi: 10.1016/j.ccell.2017.08.010.


Computed Tomography Radiomics Predicts HPV Status and Local Tumor Control After Definitive Radiochemotherapy in Head and Neck Squamous Cell Carcinoma.

Bogowicz M, Riesterer O, Ikenberg K, Stieb S, Moch H, Studer G, Guckenberger M, Tanadini-Lang S.

Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):921-928. doi: 10.1016/j.ijrobp.2017.06.002. Epub 2017 Jun 15.


Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

Janouskova H, El Tekle G, Bellini E, Udeshi ND, Rinaldi A, Ulbricht A, Bernasocchi T, Civenni G, Losa M, Svinkina T, Bielski CM, Kryukov GV, Cascione L, Napoli S, Enchev RI, Mutch DG, Carney ME, Berchuck A, Winterhoff BJN, Broaddus RR, Schraml P, Moch H, Bertoni F, Catapano CV, Peter M, Carr SA, Garraway LA, Wild PJ, Theurillat JP.

Nat Med. 2017 Sep;23(9):1046-1054. doi: 10.1038/nm.4372. Epub 2017 Aug 14.


[Clinical autopsies in Switzerland : A status report].

Rodewald AK, Bode P, Cathomas G, Moch H.

Pathologe. 2017 Sep;38(5):416-421. doi: 10.1007/s00292-017-0323-8. Review. German.


SOX2 Gene Amplification and Overexpression is Linked to HPV-positive Vulvar Carcinomas.

Gut A, Moch H, Choschzick M.

Int J Gynecol Pathol. 2018 Jan;37(1):68-73. doi: 10.1097/PGP.0000000000000388.


The presence of aberrant p53 pattern is a negative prognostic predictor in squamous cell carcinoma of the nasal vestibule.

Vital D, Huber GF, Holzmann D, Moch H, Ikenberg K.

Eur Arch Otorhinolaryngol. 2017 Sep;274(9):3503-3512. doi: 10.1007/s00405-017-4659-8. Epub 2017 Jul 1.


Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.

Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ.

Nat Med. 2017 Jul;23(7):869-877. doi: 10.1038/nm.4343. Epub 2017 May 29.


Circulating Tumor Cells: A Reliable Biomarker for Prostate Cancer Treatment Assessment?

Ciccarese C, Montironi R, Fiorentino M, Martignoni G, Brunelli M, Iacovelli R, Lopez-Beltran A, Cheng L, Scarpelli M, Moch H, Tortora G, Massari F.

Curr Drug Metab. 2017;18(8):692-699. doi: 10.2174/1389200218666170518163549.


Urinary Biomarkers for Prostate Cancer.

Giunchi F, Ciccarese C, Montironi R, Scarpelli M, Lopez-Beltran A, Cheng L, Moch H, Massari F, Fiorentino M.

Curr Drug Metab. 2017 Oct 16;18(8):723-726. doi: 10.2174/1389200218666170518161140.


Targeting the Programmed Cell Death-1 Pathway in Genitourinary Tumors: Current Progress and Future Perspectives.

Mann SA, Lopez-Beltran A, Massari F, Pili R, Fiorentino M, Koch MO, Kaimakliotis HZ, Wang L, Scarpelli M, Ciccarese C, Moch H, Montironi R, Cheng L.

Curr Drug Metab. 2017 Oct 16;18(8):700-711. doi: 10.2174/1389200218666170518162500.


Mirna Expression in Bladder Cancer and Their Potential Role in Clinical Practice.

Blanca A, Cheng L, Montironi R, Moch H, Massari F, Fiorentino M, Raspollini MR, Scarpelli M, Lopez-Beltran A.

Curr Drug Metab. 2017 Oct 16;18(8):712-722. doi: 10.2174/1389200218666170518164507.


An Immune Atlas of Clear Cell Renal Cell Carcinoma.

Chevrier S, Levine JH, Zanotelli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, van den Broek M, Beisel C, Stadler MB, Gedye C, Reis B, Pe'er D, Bodenmiller B.

Cell. 2017 May 4;169(4):736-749.e18. doi: 10.1016/j.cell.2017.04.016.


Negative LC3b immunoreactivity in cancer cells is an independent prognostic predictor of prostate cancer specific death.

Mortezavi A, Salemi S, Rupp NJ, Rüschoff JH, Hermanns T, Poyet C, Randazzo M, Simon HU, Moch H, Sulser T, Wild P, Eberli D.

Oncotarget. 2017 May 9;8(19):31765-31774. doi: 10.18632/oncotarget.15986.


p16INK4a : A surrogate marker of high-risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule.

Vital D, Holzmann D, Huber GF, Soyka MB, Moch H, Zimmermann DR, Ikenberg K.

Head Neck. 2017 Jul;39(7):1392-1398. doi: 10.1002/hed.24767. Epub 2017 Mar 28.


Morphoproteomic Characterization of Lung Squamous Cell Carcinoma Fragmentation, a Histological Marker of Increased Tumor Invasiveness.

Casanova R, Xia D, Rulle U, Nanni P, Grossmann J, Vrugt B, Wettstein R, Ballester R, Astolfo A, Weder W, Moch H, Stampanoni M, Beck AH, Soltermann A.

Cancer Res. 2017 May 15;77(10):2585-2593. doi: 10.1158/0008-5472.CAN-16-2363. Epub 2017 Mar 31. Erratum in: Cancer Res. 2018 Feb 1;78(3):841.


Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists.

Williamson SR, Gadde R, Trpkov K, Hirsch MS, Srigley JR, Reuter VE, Cheng L, Kunju LP, Barod R, Rogers CG, Delahunt B, Hes O, Eble JN, Zhou M, McKenney JK, Martignoni G, Fleming S, Grignon DJ, Moch H, Gupta NS.

Hum Pathol. 2017 May;63:149-156. doi: 10.1016/j.humpath.2017.03.004. Epub 2017 Mar 14.


A curated collection of tissue microarray images and clinical outcome data of prostate cancer patients.

Zhong Q, Guo T, Rechsteiner M, Rüschoff JH, Rupp N, Fankhauser C, Saba K, Mortezavi A, Poyet C, Hermanns T, Zhu Y, Moch H, Aebersold R, Wild PJ.

Sci Data. 2017 Mar 14;4:170014. doi: 10.1038/sdata.2017.14.


Detecting circulating tumor DNA in renal cancer: An open challenge.

Corrò C, Hejhal T, Poyet C, Sulser T, Hermanns T, Winder T, Prager G, Wild PJ, Frew I, Moch H, Rechsteiner M.

Exp Mol Pathol. 2017 Apr;102(2):255-261. doi: 10.1016/j.yexmp.2017.02.009. Epub 2017 Feb 23.


Prominent Oncogenic Roles of EVI1 in Breast Carcinoma.

Wang H, Schaefer T, Konantz M, Braun M, Varga Z, Paczulla AM, Reich S, Jacob F, Perner S, Moch H, Fehm TN, Kanz L, Schulze-Osthoff K, Lengerke C.

Cancer Res. 2017 Apr 15;77(8):2148-2160. doi: 10.1158/0008-5472.CAN-16-0593. Epub 2017 Feb 16.


Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing - a case report.

Valtcheva N, Lang FM, Noske A, Samartzis EP, Schmidt AM, Bellini E, Fink D, Moch H, Rechsteiner M, Dedes KJ, Wild PJ.

BMC Cancer. 2017 Jan 19;17(1):66. doi: 10.1186/s12885-017-3054-6.


Prognostic Role of Preoperative Serum Lipid Levels in Patients Undergoing Radical Prostatectomy for Clinically Localized Prostate Cancer.

Wettstein MS, Saba K, Umbehr MH, Murtola TJ, Fankhauser CD, Adank JP, Hofmann M, Sulser T, Hermanns T, Moch H, Wild P, Poyet C.

Prostate. 2017 Apr;77(5):549-556. doi: 10.1002/pros.23296. Epub 2017 Jan 17.


Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.

Brandt S, Samartzis EP, Zimmermann AK, Fink D, Moch H, Noske A, Dedes KJ.

BMC Cancer. 2017 Jan 10;17(1):44. doi: 10.1186/s12885-016-3026-2.


VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma.

Razafinjatovo CF, Stiehl D, Deininger E, Rechsteiner M, Moch H, Schraml P.

Oncotarget. 2017 Feb 7;8(6):10199-10212. doi: 10.18632/oncotarget.14372.


Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers.

Hofmann AL, Behr J, Singer J, Kuipers J, Beisel C, Schraml P, Moch H, Beerenwinkel N.

BMC Bioinformatics. 2017 Jan 3;18(1):8. doi: 10.1186/s12859-016-1417-7.


Value of postmortem studies in deceased neonatal and pediatric intensive care unit patients.

Widmann R, Caduff R, Giudici L, Zhong Q, Vogetseder A, Arlettaz R, Frey B, Moch H, Bode PK.

Virchows Arch. 2017 Feb;470(2):217-223. doi: 10.1007/s00428-016-2056-0. Epub 2016 Dec 14.


MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients.

Lukamowicz-Rajska M, Mittmann C, Prummer M, Zhong Q, Bedke J, Hennenlotter J, Stenzl A, Mischo A, Bihr S, Schmidinger M, Vogl U, Blume I, Karlo C, Schraml P, Moch H.

Oncotarget. 2016 Nov 29;7(48):78433-78447. doi: 10.18632/oncotarget.12618.


Cytology smears as excellent starting material for next-generation sequencing-based molecular testing of patients with adenocarcinoma of the lung.

Velizheva NP, Rechsteiner MP, Wong CE, Zhong Q, Rössle M, Bode B, Moch H, Soltermann A, Wild PJ, Tischler V.

Cancer Cytopathol. 2017 Jan;125(1):30-40. doi: 10.1002/cncy.21771. Epub 2016 Sep 16.


Detection of CCNE1/URI (19q12) amplification by in situ hybridisation is common in high grade and type II endometrial cancer.

Noske A, Brandt S, Valtcheva N, Wagner U, Zhong Q, Bellini E, Fink D, Obermann EC, Moch H, Wild PJ.

Oncotarget. 2017 Feb 28;8(9):14794-14805. doi: 10.18632/oncotarget.11605.


Discretization of Gene Expression Data Unmasks Molecular Subgroups Recurring in Different Human Cancer Types.

Beleut M, Soeldner R, Egorov M, Guenther R, Dehler S, Morys-Wortmann C, Moch H, Henco K, Schraml P.

PLoS One. 2016 Aug 18;11(8):e0161514. doi: 10.1371/journal.pone.0161514. eCollection 2016.


Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance.

Razafinjatovo C, Bihr S, Mischo A, Vogl U, Schmidinger M, Moch H, Schraml P.

BMC Cancer. 2016 Aug 17;16:638. doi: 10.1186/s12885-016-2688-0.


Similar lymphocytic infiltration pattern in primary breast cancer and their corresponding distant metastases.

Sobottka B, Pestalozzi B, Fink D, Moch H, Varga Z.

Oncoimmunology. 2016 May 5;5(6):e1153208. doi: 10.1080/2162402X.2016.1153208. eCollection 2016 Jun.


Interleukin-33 in human gliomas: Expression and prognostic significance.

Gramatzki D, Frei K, Cathomas G, Moch H, Weller M, Mertz KD.

Oncol Lett. 2016 Jul;12(1):445-452. Epub 2016 May 25.


[The WHO/ISUP grading system for renal carcinoma].

Moch H.

Pathologe. 2016 Jul;37(4):355-60. doi: 10.1007/s00292-016-0171-y. German.


Accelerating the Development and Validation of New Value-Based Diagnostics by Leveraging Biobanks.

Schneider D, Riegman PH, Cronin M, Negrouk A, Moch H, Balling R, Penault-Llorca F, Zatloukal K, Horgan D.

Public Health Genomics. 2016;19(3):160-9. doi: 10.1159/000446534. Epub 2016 Jun 1.


Cutaneous Melanoma with Brain Metastasis: Report of 193 Patients with New Observations.

Gugger A, Barnhill RL, Seifert B, Dehler S, Moch H, Lugassy C, Marques-Maggio E, Rushing EJ, Mihic-Probst D.

PLoS One. 2016 May 23;11(5):e0156115. doi: 10.1371/journal.pone.0156115. eCollection 2016.


Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity.

Zhong Q, Rüschoff JH, Guo T, Gabrani M, Schüffler PJ, Rechsteiner M, Liu Y, Fuchs TJ, Rupp NJ, Fankhauser C, Buhmann JM, Perner S, Poyet C, Blattner M, Soldini D, Moch H, Rubin MA, Noske A, Rüschoff J, Haffner MC, Jochum W, Wild PJ.

Sci Rep. 2016 Apr 7;6:24146. doi: 10.1038/srep24146.


The Microphthalmia-Associated Transcription Factor p.E318K Mutation Does Not Play a Major Role in Sporadic Renal Cell Tumors from Caucasian Patients.

Stoehr CG, Walter B, Denzinger S, Ghiorzo P, Sturm RA, Hinze R, Moch H, Junker K, Hartmann A, Stoehr R.

Pathobiology. 2016;83(4):165-9. doi: 10.1159/000443311. Epub 2016 Mar 22.

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