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Items: 9


Long chain n-3 fatty acids attenuate oncogenic KRas-driven proliferation by altering plasma membrane nanoscale proteolipid composition.

Fuentes NR, Mlih M, Barhoumi R, Fan YY, Hardin P, Steele TJ, Behmer S, Prior IA, Karpac J, Chapkin RS.

Cancer Res. 2018 May 16. pii: canres.0324.2018. doi: 10.1158/0008-5472.CAN-18-0324. [Epub ahead of print]


Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.

Jaoude AA, Badiqué L, Mlih M, Awan S, Guo S, Lemle A, Abboud C, Foppolo S, Host L, Terrand J, Justiniano H, Herz J, Matz RL, Boucher P.

Sci Rep. 2018 Mar 14;8(1):4501. doi: 10.1038/s41598-018-22819-3.


Convergent Signaling Pathways Controlled by LRP1 (Receptor-related Protein 1) Cytoplasmic and Extracellular Domains Limit Cellular Cholesterol Accumulation.

El Asmar Z, Terrand J, Jenty M, Host L, Mlih M, Zerr A, Justiniano H, Matz RL, Boudier C, Scholler E, Garnier JM, Bertaccini D, Thiersé D, Schaeffer C, Van Dorsselaer A, Herz J, Bruban V, Boucher P.

J Biol Chem. 2016 Mar 4;291(10):5116-27. doi: 10.1074/jbc.M116.714485. Epub 2016 Jan 19.


Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy.

Mohamed IA, Gadeau AP, Fliegel L, Lopaschuk G, Mlih M, Abdulrahman N, Fillmore N, Mraiche F.

PLoS One. 2015 Apr 17;10(4):e0123318. doi: 10.1371/journal.pone.0123318. eCollection 2015.


Na+/H+ exchanger isoform 1 induced cardiomyocyte hypertrophy involves activation of p90 ribosomal s6 kinase.

Jaballah M, Mohamed IA, Alemrayat B, Al-Sulaiti F, Mlih M, Mraiche F.

PLoS One. 2015 Apr 1;10(4):e0122230. doi: 10.1371/journal.pone.0122230. eCollection 2015.


Na(+)/H (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4.

Mlih M, Abdulrahman N, Gadeau AP, Mohamed IA, Jaballah M, Mraiche F.

Mol Cell Biochem. 2015 Jun;404(1-2):211-20. doi: 10.1007/s11010-015-2380-8. Epub 2015 Mar 11.


The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.

Mlih M, Host L, Martin S, Niederhoffer N, Monassier L, Terrand J, Messaddeq N, Radke M, Gotthardt M, Bruban V, Kober F, Bernard M, Canet-Soulas E, Abt-Jijon F, Boucher P, Matz RL.

J Biol Chem. 2015 Jan 23;290(4):2419-30. doi: 10.1074/jbc.M114.597377. Epub 2014 Dec 8.


The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells.

Woldt E, Terrand J, Mlih M, Matz RL, Bruban V, Coudane F, Foppolo S, El Asmar Z, Chollet ME, Ninio E, Bednarczyk A, Thiersé D, Schaeffer C, Van Dorsselaer A, Boudier C, Wahli W, Chambon P, Metzger D, Herz J, Boucher P.

Nat Commun. 2012;3:1077. doi: 10.1038/ncomms2087.


Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor.

Woldt E, Matz RL, Terrand J, Mlih M, Gracia C, Foppolo S, Martin S, Bruban V, Ji J, Velot E, Herz J, Boucher P.

J Biol Chem. 2011 May 13;286(19):16775-82. doi: 10.1074/jbc.M110.212878. Epub 2011 Mar 22.

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