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Items: 7

1.

Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.

Iwai K, Yaguchi M, Nishimura K, Yamamoto Y, Tamura T, Nakata D, Dairiki R, Kawakita Y, Mizojiri R, Ito Y, Asano M, Maezaki H, Nakayama Y, Kaishima M, Hayashi K, Teratani M, Miyakawa S, Iwatani M, Miyamoto M, Klein MG, Lane W, Snell G, Tjhen R, He X, Pulukuri S, Nomura T.

EMBO Mol Med. 2018 May 16. pii: e8289. doi: 10.15252/emmm.201708289. [Epub ahead of print]

2.

Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors.

Mizojiri R, Asano M, Tomita D, Banno H, Nii N, Sasaki M, Sumi H, Satoh Y, Yamamoto Y, Moriya T, Satomi Y, Maezaki H.

J Med Chem. 2018 Feb 8;61(3):1098-1117. doi: 10.1021/acs.jmedchem.7b01547. Epub 2018 Jan 5.

PMID:
29232514
3.

Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors.

Mizojiri R, Nakata D, Satoh Y, Morishita D, Shibata S, Iwatani-Yoshihara M, Kosugi Y, Kosaka M, Takeda J, Sasaki S, Takami K, Fukuda K, Kamaura M, Sasaki S, Arai R, Cary DR, Imaeda Y.

ACS Med Chem Lett. 2017 Sep 8;8(10):1077-1082. doi: 10.1021/acsmedchemlett.7b00283. eCollection 2017 Oct 12.

PMID:
29057054
4.

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.

Hirose H, Yamasaki T, Ogino M, Mizojiri R, Tamura-Okano Y, Yashiro H, Muraki Y, Nakano Y, Sugama J, Hata A, Iwasaki S, Watanabe M, Maekawa T, Kasai S.

Bioorg Med Chem. 2017 Aug 1;25(15):4175-4193. doi: 10.1016/j.bmc.2017.06.007. Epub 2017 Jun 9.

PMID:
28642028
5.

Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety.

Hirashima S, Oka T, Ikegashira K, Noji S, Yamanaka H, Hara Y, Goto H, Mizojiri R, Niwa Y, Noguchi T, Ando I, Ikeda S, Hashimoto H.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3181-6. Epub 2007 Mar 14.

PMID:
17383878
7.

Highly Enantio- and Diastereoselective Synthesis of 2-Substituted 1-Bicyclo[3.1.0]hexanols.

Mizojiri R, Urabe H, Sato F.

Angew Chem Int Ed Engl. 1998 Oct 16;37(19):2666-2668. doi: 10.1002/(SICI)1521-3773(19981016)37:19<2666::AID-ANIE2666>3.0.CO;2-K.

PMID:
29711618

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