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Items: 1 to 50 of 107

1.

Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin.

Kim SY, Jones DR, Kang JY, Yun CH, Miller GP.

Xenobiotica. 2018 Mar 28:1-7. doi: 10.1080/00498254.2018.1451668. [Epub ahead of print]

PMID:
29543105
2.

Computationally Assessing the Bioactivation of Drugs by N-Dealkylation.

Dang NL, Hughes TB, Miller GP, Swamidass SJ.

Chem Res Toxicol. 2018 Feb 19;31(2):68-80. doi: 10.1021/acs.chemrestox.7b00191. Epub 2018 Feb 6.

PMID:
29355304
3.

Toxicological Implications of Mitochondrial Localization of CYP2E1.

Hartman JH, Miller GP, Meyer JN.

Toxicol Res (Camb). 2017;6(3):273-289. doi: 10.1039/C7TX00020K. Epub 2017 Mar 14.

4.

Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases.

Barnette DA, Johnson BP, Pouncey DL, Nshimiyimana R, Desrochers LP, Goodwin TE, Miller GP.

Drug Metab Dispos. 2017 Sep;45(9):1000-1007. doi: 10.1124/dmd.117.075929. Epub 2017 Jun 23.

PMID:
28646078
5.

Microchannel plate detector detection efficiency to monoenergetic electrons between 3 and 28 keV.

Blase RC, Benke RR, Miller GP, Pickens KS, Waite JH.

Rev Sci Instrum. 2017 May;88(5):053302. doi: 10.1063/1.4983338.

PMID:
28571456
6.

Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes.

Dang NL, Hughes TB, Miller GP, Swamidass SJ.

Chem Res Toxicol. 2017 Apr 17;30(4):1046-1059. doi: 10.1021/acs.chemrestox.6b00336. Epub 2017 Mar 14.

7.

1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice.

Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G.

Toxicology. 2017 Mar 1;378:114-124. doi: 10.1016/j.tox.2017.01.005. Epub 2017 Jan 9.

8.

Modeling Reactivity to Biological Macromolecules with a Deep Multitask Network.

Hughes TB, Dang NL, Miller GP, Swamidass SJ.

ACS Cent Sci. 2016 Aug 24;2(8):529-37. doi: 10.1021/acscentsci.6b00162. Epub 2016 Jul 29.

9.

Modeling Epoxidation of Drug-like Molecules with a Deep Machine Learning Network.

Hughes TB, Miller GP, Swamidass SJ.

ACS Cent Sci. 2015 Jul 22;1(4):168-80. doi: 10.1021/acscentsci.5b00131. Epub 2015 Jun 9.

10.

Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.

Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis L, Pouncey DL, Miller GP, Eoff RL.

Chem Res Toxicol. 2016 Jan 19;29(1):101-8. doi: 10.1021/acs.chemrestox.5b00452. Epub 2015 Dec 30.

11.

Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates.

Hartman JH, Martin HC, Caro AA, Pearce AR, Miller GP.

Toxicology. 2015 Dec 2;338:47-58. doi: 10.1016/j.tox.2015.10.001. Epub 2015 Oct 14.

12.

Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures.

Hartman JH, Letzig LG, Roberts DW, James LP, Fifer EK, Miller GP.

Biochem Pharmacol. 2015 Oct 1;97(3):341-9. doi: 10.1016/j.bcp.2015.07.026. Epub 2015 Jul 28.

13.

Site of reactivity models predict molecular reactivity of diverse chemicals with glutathione.

Hughes TB, Miller GP, Swamidass SJ.

Chem Res Toxicol. 2015 Apr 20;28(4):797-809. doi: 10.1021/acs.chemrestox.5b00017. Epub 2015 Mar 16.

14.

Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations.

Levy JW, Hartman JH, Perry MD Jr, Miller GP.

J Mol Graph Model. 2015 Mar;56:43-52. doi: 10.1016/j.jmgm.2014.11.013. Epub 2014 Dec 6.

15.

Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites.

Pugh CP, Pouncey DL, Hartman JH, Nshimiyimana R, Desrochers LP, Goodwin TE, Boysen G, Miller GP.

Arch Biochem Biophys. 2014 Dec 15;564:244-53. doi: 10.1016/j.abb.2014.10.006. Epub 2014 Oct 19.

16.

Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity.

Hartman JH, Miller GP, Boysen G.

Toxicology. 2014 Apr 6;318:51-8. doi: 10.1016/j.tox.2014.02.003. Epub 2014 Feb 18.

17.

CYP2E1 hydroxylation of aniline involves negative cooperativity.

Hartman JH, Knott K, Miller GP.

Biochem Pharmacol. 2014 Feb 1;87(3):523-33. doi: 10.1016/j.bcp.2013.12.003. Epub 2013 Dec 15.

PMID:
24345333
18.

Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites.

Pianalto KM, Hartman JH, Boysen G, Miller GP.

Toxicol Lett. 2013 Nov 25;223(2):221-7. doi: 10.1016/j.toxlet.2013.08.025. Epub 2013 Sep 8.

19.

Interfacial shear stress between single-walled carbon nanotubes and gold surfaces with and without an alkanethiol monolayer.

Pan H, Wu YC, Adams GG, Miller GP, McGruer NE.

J Colloid Interface Sci. 2013 Oct 1;407:133-9. doi: 10.1016/j.jcis.2013.06.021. Epub 2013 Jul 11.

PMID:
23906860
20.

Structure of pyrazole derivatives impact their affinity, stoichiometry, and cooperative interactions for CYP2E1 complexes.

Hartman JH, Bradley AM, Laddusaw RM, Perry MD Jr, Miller GP.

Arch Biochem Biophys. 2013 Sep 1;537(1):12-20. doi: 10.1016/j.abb.2013.06.011. Epub 2013 Jun 27.

21.

Predicting CYP2C19 catalytic parameters for enantioselective oxidations using artificial neural networks and a chirality code.

Hartman JH, Cothren SD, Park SH, Yun CH, Darsey JA, Miller GP.

Bioorg Med Chem. 2013 Jul 1;21(13):3749-59. doi: 10.1016/j.bmc.2013.04.044. Epub 2013 Apr 22.

22.

Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.

Kim SY, Kang JY, Hartman JH, Park SH, Jones DR, Yun CH, Boysen G, Miller GP.

Drug Metab Lett. 2012 Sep 1;6(3):157-64.

23.

Cooperative effects for CYP2E1 differ between styrene and its metabolites.

Hartman JH, Boysen G, Miller GP.

Xenobiotica. 2013 Sep;43(9):755-64. doi: 10.3109/00498254.2012.760764. Epub 2013 Jan 18.

24.

CYP2E1 metabolism of styrene involves allostery.

Hartman JH, Boysen G, Miller GP.

Drug Metab Dispos. 2012 Oct;40(10):1976-83. doi: 10.1124/dmd.112.046698. Epub 2012 Jul 17.

25.

An improved synthesis of pentacene: rapid access to a benchmark organic semiconductor.

Pramanik C, Miller GP.

Molecules. 2012 Apr 20;17(4):4625-33. doi: 10.3390/molecules17044625.

26.

The role of ERp44 in maturation of serotonin transporter protein.

Freyaldenhoven S, Li Y, Kocabas AM, Ziu E, Ucer S, Ramanagoudr-Bhojappa R, Miller GP, Kilic F.

J Biol Chem. 2012 May 18;287(21):17801-11. doi: 10.1074/jbc.M112.345058. Epub 2012 Mar 26.

27.

Probing intramolecular CH-π interactions in o-quinodimethane adducts of [60]fullerene using variable temperature NMR.

Kopreski RP, Briggs JB, Lin W, Jazdzyk M, Miller GP.

J Org Chem. 2012 Feb 3;77(3):1308-15. doi: 10.1021/jo201921h. Epub 2012 Jan 20.

PMID:
22263627
28.

Open-shell singlet character of stable derivatives of nonacene, hexacene and teranthene.

Gao X, Hodgson JL, Jiang DE, Zhang SB, Nagase S, Miller GP, Chen Z.

Org Lett. 2011 Jul 1;13(13):3316-9. doi: 10.1021/ol201004u. Epub 2011 Jun 7.

PMID:
21648416
29.

Assays and applications in warfarin metabolism: what we know, how we know it and what we need to know.

Jones DR, Miller GP.

Expert Opin Drug Metab Toxicol. 2011 Jul;7(7):857-74. doi: 10.1517/17425255.2011.576247. Epub 2011 Apr 12. Review.

PMID:
21480820
30.

Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma.

Jones DR, Boysen G, Miller GP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1056-62. doi: 10.1016/j.jchromb.2011.03.022. Epub 2011 Mar 21. Erratum in: J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Mar 1;919-920:61.

PMID:
21470921
31.

Highly ordered assembly of single-domain dichloropentacene over large areas on vicinal gold surfaces.

Wang J, Kaur I, Diaconescu B, Tang JM, Miller GP, Pohl K.

ACS Nano. 2011 Mar 22;5(3):1792-7. doi: 10.1021/nn102468p. Epub 2011 Feb 14.

PMID:
21319850
32.

Warfarin therapy: how the less interesting half just got interesting.

Miller GP.

J Thromb Haemost. 2010 Dec;8(12):2705-7. doi: 10.1111/j.1538-7836.2010.04097.x. No abstract available.

33.

Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.

Jones DR, Kim SY, Boysen G, Yun CH, Miller GP.

Drug Metab Lett. 2010 Dec;4(4):213-9.

PMID:
20615193
34.

Double displacement: An improved bioorthogonal reaction strategy for templated nucleic acid detection.

Kleinbaum DJ, Miller GP, Kool ET.

Bioconjug Chem. 2010 Jun 16;21(6):1115-20. doi: 10.1021/bc100165h.

35.

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Jones DR, Kim SY, Guderyon M, Yun CH, Moran JH, Miller GP.

Chem Res Toxicol. 2010 May 17;23(5):939-45. doi: 10.1021/tx1000283.

36.

Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners.

Jang HH, Jamakhandi AP, Sullivan SZ, Yun CH, Hollenberg PF, Miller GP.

Biochim Biophys Acta. 2010 Jun;1804(6):1285-93. doi: 10.1016/j.bbapap.2010.02.003. Epub 2010 Feb 10.

37.

Design, synthesis, and characterization of a persistent nonacene derivative.

Kaur I, Jazdzyk M, Stein NN, Prusevich P, Miller GP.

J Am Chem Soc. 2010 Feb 3;132(4):1261-3. doi: 10.1021/ja9095472.

PMID:
20055388
38.

Warfarin and UDP-glucuronosyltransferases: writing a new chapter of metabolism.

Jones DR, Moran JH, Miller GP.

Drug Metab Rev. 2010 Feb;42(1):55-61. doi: 10.3109/03602530903209395.

PMID:
19788348
39.

Field-assisted nanopatterning of metals, metal oxides and metal salts.

Liu JF, Miller GP.

Nanotechnology. 2009 Feb 4;20(5):055303. doi: 10.1088/0957-4484/20/5/055303. Epub 2009 Jan 9.

PMID:
19417344
40.

Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans.

Miller GP, Jones DR, Sullivan SZ, Mazur A, Owen SN, Mitchell NC, Radominska-Pandya A, Moran JH.

Chem Res Toxicol. 2009 Jul;22(7):1239-45. doi: 10.1021/tx900031z.

41.

Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids.

Mazur A, Lichti CF, Prather PL, Zielinska AK, Bratton SM, Gallus-Zawada A, Finel M, Miller GP, Radomińska-Pandya A, Moran JH.

Drug Metab Dispos. 2009 Jul;37(7):1496-504. doi: 10.1124/dmd.109.026898. Epub 2009 Apr 1.

42.

Molecular self-assembly of functionalized fullerenes on a metal surface.

Diaconescu B, Yang T, Berber S, Jazdzyk M, Miller GP, Tománek D, Pohl K.

Phys Rev Lett. 2009 Feb 6;102(5):056102. Epub 2009 Feb 5.

PMID:
19257526
43.

Exploiting substituent effects for the synthesis of a photooxidatively resistant heptacene derivative.

Kaur I, Stein NN, Kopreski RP, Miller GP.

J Am Chem Soc. 2009 Mar 18;131(10):3424-5. doi: 10.1021/ja808881x.

PMID:
19243093
44.

1,2-Dimethyl-4,5-diphenyl-benzene determined on a Bruker SMART X2S benchtop crystallographic system.

Briggs JB, Jazdzyk MD, Miller GP.

Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 30;65(Pt 5):o1171. doi: 10.1107/S1600536809015311.

45.

2,3-Bis(bromo-meth-yl)-1,4-diphenyl-benzene.

Briggs JB, Jazdzyk MD, Miller GP.

Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 4;66(Pt 1):o12. doi: 10.1107/S1600536809050764.

46.

2,5-Dichloro-thio-phene 1,1-dioxide.

Briggs JB, Jia W, Jazdzyk MD, Miller GP.

Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 28;65(Pt 12):o3258. doi: 10.1107/S1600536809050776.

47.

Substituent effects in pentacenes: gaining control over HOMO-LUMO gaps and photooxidative resistances.

Kaur I, Jia W, Kopreski RP, Selvarasah S, Dokmeci MR, Pramanik C, McGruer NE, Miller GP.

J Am Chem Soc. 2008 Dec 3;130(48):16274-86. doi: 10.1021/ja804515y.

PMID:
19006312
48.

Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin.

Miller GP, Lichti CF, Zielinska AK, Mazur A, Bratton SM, Gallus-Zawada A, Finel M, Moran JH, Radominska-Pandya A.

Drug Metab Dispos. 2008 Nov;36(11):2211-8. doi: 10.1124/dmd.108.022863. Epub 2008 Aug 25.

49.

Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective.

Miller GP.

Expert Opin Drug Metab Toxicol. 2008 Aug;4(8):1053-64. doi: 10.1517/17425255.4.8.1053 . Review.

PMID:
18680440
50.

5'-Iodination of solid-phase-linked oligodeoxyribonucleotides.

Kool ET, Miller GP.

Curr Protoc Nucleic Acid Chem. 2003 Nov;Chapter 4:Unit 4.19. doi: 10.1002/0471142700.nc0419s14.

PMID:
18428909

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