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Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis.

Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, Mikaelian I, Barry V, Firestein GS.

Biochem Pharmacol. 2018 Feb 6. pii: S0006-2952(18)30041-8. doi: 10.1016/j.bcp.2018.01.041. [Epub ahead of print]


Breast cancer targeting through inhibition of the endoplasmic reticulum-based apoptosis regulator Nrh/BCL2L10.

Nougarede A, Popgeorgiev N, Kassem L, Omarjee S, Borel S, Mikaelian I, Lopez J, Gadet R, Marcillat O, Treilleux I, Villoutreix BO, Rimokh R, Gillet G.

Cancer Res. 2018 Jan 12. pii: canres.0846.2017. doi: 10.1158/0008-5472.CAN-17-0846. [Epub ahead of print]


Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells.

Li L, Barry V, Daffis S, Niu C, Huntzicker E, French DM, Mikaelian I, Lanford RE, Delaney WE 4th, Fletcher SP.

J Hepatol. 2017 Dec 14. pii: S0168-8278(17)32490-X. doi: 10.1016/j.jhep.2017.12.008. [Epub ahead of print]


Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification.

Gherardi S, Ripoche D, Mikaelian I, Chanal M, Teinturier R, Goehrig D, Cordier-Bussat M, Zhang CX, Hennino A, Bertolino P.

Biochim Biophys Acta. 2017 Apr;1860(4):427-437. doi: 10.1016/j.bbagrm.2017.02.003. Epub 2017 Feb 12.


Syk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas.

Long AJ, Sampson E, McCarthy RW, Harris CM, Barnard M, Shi D, Conlon D, Caldwell R, Honor D, Wishart N, Hoemann M, Duggan L, Fritz D, Stedman C, O'Connor E, Mikaelian I, Schwartz A.

Toxicol Pathol. 2016 Oct;44(7):998-1012. doi: 10.1177/0192623316654015. Epub 2016 Jun 19.


Fc Receptor-mediated Effector Function Contributes to the Therapeutic Response of Anti-TNF Monoclonal Antibodies in a Mouse Model of Inflammatory Bowel Disease.

McRae BL, Levin AD, Wildenberg ME, Koelink PJ, Bousquet P, Mikaelian I, Sterman AS, Bryant S, D'Haens G, Kamath R, Salfeld J, van den Brink GR.

J Crohns Colitis. 2016 Jan;10(1):69-76. doi: 10.1093/ecco-jcc/jjv179. Epub 2015 Oct 1.


Temporal Patterns of Novel Circulating Biomarkers in IL-2-mediated Vascular Injury in the Rat.

Keirstead ND, Bertinetti-Lapatki C, Knapp D, Albassam M, Hughes V, Hong F, Roth AB, Mikaelian I.

Toxicol Pathol. 2015 Oct;43(7):984-94. doi: 10.1177/0192623315601245. Epub 2015 Sep 8.


Differential analysis of transient increases of serum cTnI in response to handling in rats.

Mikaelian I, Dunn ME, Mould DR, Hirkaler G, Geng W, Coluccio D, Nicklaus R, Singer T, Reddy M.

Pharmacol Res Perspect. 2013 Dec;1(2):e00011. doi: 10.1002/prp2.11. Epub 2013 Dec 5.


Combination of a discovery LC-MS/MS analysis and a label-free quantification for the characterization of an epithelial-mesenchymal transition signature.

Biarc J, Gonzalo P, Mikaelian I, Fattet L, Deygas M, Gillet G, Lemoine J, Rimokh R.

J Proteomics. 2014 Oct 14;110:183-94. doi: 10.1016/j.jprot.2014.05.026. Epub 2014 Jun 12.


Nonclinical safety biomarkers of drug-induced vascular injury: current status and blueprint for the future.

Mikaelian I, Cameron M, Dalmas DA, Enerson BE, Gonzalez RJ, Guionaud S, Hoffmann PK, King NM, Lawton MP, Scicchitano MS, Smith HW, Thomas RA, Weaver JL, Zabka TS; Vascular Injury Working Group of the Predictive Safety Consortium.

Toxicol Pathol. 2014 Jun;42(4):635-57. doi: 10.1177/0192623314525686. Epub 2014 Apr 28.


Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β-independent mechanism.

Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M.

Cancer Res. 2013 Nov 15;73(22):6621-31. doi: 10.1158/0008-5472.CAN-13-0560. Epub 2013 Sep 27.


Comparison of ketamine-xylazine and ketamine-dexmedetomidine anesthesia and intraperitoneal tolerance in rats.

Wellington D, Mikaelian I, Singer L.

J Am Assoc Lab Anim Sci. 2013 Jul;52(4):481-7.


TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling.

Fattet L, Ay AS, Bonneau B, Jallades L, Mikaelian I, Treilleux I, Gillet G, Hesling C, Rimokh R.

J Cell Sci. 2013 Aug 15;126(Pt 16):3713-23. doi: 10.1242/jcs.126748. Epub 2013 Jun 20.


Amniotic fluid glial fibrillary acidic protein (AF-GFAP), a biomarker of open neural tube defects.

Lopez J, Mikaelian I, Gonzalo P.

Prenat Diagn. 2013 Oct;33(10):990-5. doi: 10.1002/pd.4181. Epub 2013 Jul 28.


Calcineurin A versus NS5A-TP2/HD domain containing 2: a case study of site-directed low-frequency random mutagenesis for dissecting target specificity of peptide aptamers.

Dibenedetto S, Cluet D, Stebe PN, Baumle V, Léault J, Terreux R, Bickle M, Chassey BD, Mikaelian I, Colas P, Spichty M, Zoli M, Rudkin BB.

Mol Cell Proteomics. 2013 Jul;12(7):1939-52. doi: 10.1074/mcp.M112.024612. Epub 2013 Apr 10.


Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition.

Hesling C, Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R.

Development. 2013 Jan 1;140(1):167-75. doi: 10.1242/dev.085068. Epub 2012 Nov 15.


Frontiers in preclinical safety biomarkers: microRNAs and messenger RNAs.

Mikaelian I, Scicchitano M, Mendes O, Thomas RA, Leroy BE.

Toxicol Pathol. 2013 Jan;41(1):18-31. doi: 10.1177/0192623312448939. Epub 2012 Jun 1. Review.


Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction.

Deshiere A, Duchemin-Pelletier E, Spreux E, Ciais D, Combes F, Vandenbrouck Y, Couté Y, Mikaelian I, Giusiano S, Charpin C, Cochet C, Filhol O.

Oncogene. 2013 Mar 14;32(11):1373-83. doi: 10.1038/onc.2012.165. Epub 2012 May 7.


LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation.

Malek M, Guillaumot P, Huber AL, Lebeau J, Pétrilli V, Kfoury A, Mikaelian I, Renno T, Manié SN.

Cell Death Dis. 2012 Apr 19;3:e300. doi: 10.1038/cddis.2012.39.


Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.

Lopez J, Hesling C, Prudent J, Popgeorgiev N, Gadet R, Mikaelian I, Rimokh R, Gillet G, Gonzalo P.

Cell Death Differ. 2012 Sep;19(9):1459-69. doi: 10.1038/cdd.2012.21. Epub 2012 Mar 2.


Myocardial mononuclear cell infiltrates are not associated with increased serum cardiac troponin I in cynomolgus monkeys.

Dunn ME, Coluccio D, Zabka TS, Gopalakrishnan G, Hirkaler G, Geng W, Nicklaus R, Lipshultz SE, Doessegger L, Saladino BH, Singer T, Mikaelian I.

Toxicol Pathol. 2012 Jun;40(4):647-50. doi: 10.1177/0192623311436176. Epub 2012 Jan 31.


The complete pharmacokinetic profile of serum cardiac troponin I in the rat and the dog.

Dunn ME, Coluccio D, Hirkaler G, Mikaelian I, Nicklaus R, Lipshultz SE, Doessegger L, Reddy M, Singer T, Geng W.

Toxicol Sci. 2011 Oct;123(2):368-73. doi: 10.1093/toxsci/kfr190. Epub 2011 Jul 20.


Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells.

Hesling C, Fattet L, Teyre G, Jury D, Gonzalo P, Lopez J, Vanbelle C, Morel AP, Gillet G, Mikaelian I, Rimokh R.

EMBO Rep. 2011 Jul 1;12(7):665-72. doi: 10.1038/embor.2011.78.


Speed-difficulty trade-off in speech: Chinese versus English.

Latash ML, Sun Y, Latash EM, Mikaelian IL.

Exp Brain Res. 2011 Jun;211(2):193-205. doi: 10.1007/s00221-011-2664-5. Epub 2011 Apr 9.


Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers.

Garcia AI, Buisson M, Bertrand P, Rimokh R, Rouleau E, Lopez BS, Lidereau R, Mikaélian I, Mazoyer S.

EMBO Mol Med. 2011 May;3(5):279-90. doi: 10.1002/emmm.201100136. Epub 2011 Apr 5.


A logarithmic speed-difficulty trade-off in speech production.

Latash ML, Mikaelian IL.

Motor Control. 2011 Jan;15(1):52-67.


[Minimally invasive surgical accesses for the treatment of the acute cholecystitis].

Cherepanin AI, Galliamov EA, Biriukov AIu, Mikaelian IA, Fedorov DN.

Khirurgiia (Mosk). 2010;(12):31-7. Russian.


Proposal of Bisgaardia hudsonensis gen. nov., sp. nov. and an additional genomospecies, isolated from seals, as new members of the family Pasteurellaceae.

Foster G, Higgins R, Leclair D, Korczak BM, Mikaelian I, Patterson IA, Kuhnert P.

Int J Syst Evol Microbiol. 2011 Dec;61(Pt 12):3016-22. doi: 10.1099/ijs.0.028027-0. Epub 2011 Feb 4.


Serum cardiac troponin I concentrations transiently increase in rats given rosiglitazone.

Mikaelian I, Buness A, Hirkaler G, Fernandes R, Coluccio D, Geng W, Visalli T, Bachynsky MO, Berkofsky-Fessler W, Kanwal C, Hilton H, Nicklaus R, Hoflack JC, Dunn M, Sanders M, Giron M, Boyle BW, Singer T, Dick LS.

Toxicol Lett. 2011 Mar 5;201(2):110-5. doi: 10.1016/j.toxlet.2010.12.012. Epub 2010 Dec 21.


Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs.

Mikaelian I, Buness A, de Vera-Mudry MC, Kanwal C, Coluccio D, Rasmussen E, Char HW, Carvajal V, Hilton H, Funk J, Hoflack JC, Fielden M, Herting F, Dunn M, Suter-Dick L.

Toxicol Sci. 2010 Sep;117(1):144-51. doi: 10.1093/toxsci/kfq189. Epub 2010 Jul 12.


Time course characterization of serum cardiac troponins, heart fatty acid-binding protein, and morphologic findings with isoproterenol-induced myocardial injury in the rat.

Clements P, Brady S, York M, Berridge B, Mikaelian I, Nicklaus R, Gandhi M, Roman I, Stamp C, Davies D, McGill P, Williams T, Pettit S, Walker D; ILSI HESI Cardiac Troponins Working Group, Turton J.

Toxicol Pathol. 2010 Aug;38(5):703-14. doi: 10.1177/0192623310374969. Epub 2010 Jun 28.


How long does it take to describe what one sees? The first step using picture description tasks.

Latash ML, Mikaelian IL.

Hum Mov Sci. 2010 Jun;29(3):369-85. doi: 10.1016/j.humov.2009.11.004. Epub 2010 Apr 18.


Assessment of the toxicity of hydralazine in the rat using an ultrasensitive flow-based cardiac troponin I immunoassay.

Mikaelian I, Coluccio D, Hirkaler GM, Downing JC, Rasmussen E, Todd J, Estis J, Lu QA, Nicklaus R.

Toxicol Pathol. 2009 Dec;37(7):878-81. doi: 10.1177/0192623309351894.


Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.

Grelier G, Voirin N, Ay AS, Cox DG, Chabaud S, Treilleux I, Léon-Goddard S, Rimokh R, Mikaelian I, Venoux C, Puisieux A, Lasset C, Moyret-Lalle C.

Br J Cancer. 2009 Aug 18;101(4):673-83. doi: 10.1038/sj.bjc.6605193.


[The acute colon obstruction in a child, caused by spleen introversion and necrosis].

Cherepanin AI, Cheliadinova EV, Mikaelian IA.

Khirurgiia (Mosk). 2008;(7):54-5. Russian. No abstract available.


A RasGAP SH3 peptide aptamer inhibits RasGAP-Aurora interaction and induces caspase-independent tumor cell death.

Pamonsinlapatham P, Hadj-Slimane R, Raynaud F, Bickle M, Corneloup C, Barthelaix A, Lepelletier Y, Mercier P, Schapira M, Samson J, Mathieu AL, Hugo N, Moncorgé O, Mikaelian I, Dufour S, Garbay C, Colas P.

PLoS One. 2008 Aug 6;3(8):e2902. doi: 10.1371/journal.pone.0002902.


Metastatic cholangiocellular carcinoma and renal adenocarcinoma in a golden eagle (Aquila chrysaetos).

Mikaelian I, Patenaude R, Girard C, Martineau D.

Avian Pathol. 1998;27(3):321-5. doi: 10.1080/03079459808419345.


Temporal gene expression profiling indicates early up-regulation of interleukin-6 in isoproterenol-induced myocardial necrosis in rat.

Mikaelian I, Coluccio D, Morgan KT, Johnson T, Ryan AL, Rasmussen E, Nicklaus R, Kanwal C, Hilton H, Frank K, Fritzky L, Wheeldon EB.

Toxicol Pathol. 2008 Feb;36(2):256-64. doi: 10.1177/0192623307312696. Epub 2008 Apr 15.


Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors.

Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, Backlund MG, Yin Y, Khramtsov AI, Bastein R, Quackenbush J, Glazer RI, Brown PH, Green JE, Kopelovich L, Furth PA, Palazzo JP, Olopade OI, Bernard PS, Churchill GA, Van Dyke T, Perou CM.

Genome Biol. 2007;8(5):R76.


An antiproliferative genetic screening identifies a peptide aptamer that targets calcineurin and up-regulates its activity.

de Chassey B, Mikaelian I, Mathieu AL, Bickle M, Olivier D, Nègre D, Cosset FL, Rudkin BB, Colas P.

Mol Cell Proteomics. 2007 Mar;6(3):451-9. Epub 2006 Dec 4.


Expression of terminal differentiation proteins defines stages of mouse mammary gland development.

Mikaelian I, Hovick M, Silva KA, Burzenski LM, Shultz LD, Ackert-Bicknell CL, Cox GA, Sundberg JP.

Vet Pathol. 2006 Jan;43(1):36-49.


Systemic effects of arctic pollutants in beluga whales indicated by CYP1A1 expression.

Wilson JY, Cooke SR, Moore MJ, Martineau D, Mikaelian I, Metner DA, Lockhart WL, Stegeman JJ.

Environ Health Perspect. 2005 Nov;113(11):1594-9.


Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export.

Hiriart E, Gruffat H, Buisson M, Mikaelian I, Keppler S, Meresse P, Mercher T, Bernard OA, Sergeant A, Manet E.

J Biol Chem. 2005 Nov 4;280(44):36935-45. Epub 2005 Aug 29.


The Mouse Tumor Biology Database: integrated access to mouse cancer biology data.

Krupke D, Näf D, Vincent M, Allio T, Mikaelian I, Sundberg J, Bult C, Eppig J.

Exp Lung Res. 2005 Mar;31(2):259-70. Review.


Proteotypic classification of spontaneous and transgenic mammary neoplasms.

Mikaelian I, Blades N, Churchill GA, Fancher K, Knowles BB, Eppig JT, Sundberg JP.

Breast Cancer Res. 2004;6(6):R668-79. Epub 2004 Oct 6.


Spontaneous proliferative lesions and tumors of the uterus of captive African hedgehogs (Atelerix albiventris).

Mikaelian I, Reavill DR, Practice A.

J Zoo Wildl Med. 2004 Jun;35(2):216-20.


A universal transgene silencing method based on RNA interference.

Mangeot PE, Cosset FL, Colas P, Mikaelian I.

Nucleic Acids Res. 2004 Jul 12;32(12):e102.


Antibodies that label paraffin-embedded mouse tissues: a collaborative endeavor.

Mikaelian I, Nanney LB, Parman KS, Kusewitt DF, Ward JM, Näf D, Krupke DM, Eppig JT, Bult CJ, Seymour R, Ichiki T, Sundberg JP.

Toxicol Pathol. 2004 Mar-Apr;32(2):181-91.


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