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Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma.

Porcu C, Antonucci L, Barbaro B, Illi B, Nasi S, Martini M, Licata A, Miele L, Grieco A, Balsano C.

Oncotarget. 2018 Jan 20;9(10):9325-9343. doi: 10.18632/oncotarget.24282. eCollection 2018 Feb 6.


Treatment of early stage chronic hepatitis C virus infection.

Ponziani FR, Miele L, Tortora A, Furnari M, Bodini G, Pompili M, Gasbarrini A, Giannini EG.

Expert Rev Clin Pharmacol. 2018 Mar 9:1-6. doi: 10.1080/17512433.2018.1447923. [Epub ahead of print]


Gut microbiome composition in lean patients with NASH is associated with liver damage independent of caloric intake: A prospective pilot study.

Duarte SMB, Stefano JT, Miele L, Ponziani FR, Souza-Basqueira M, Okada LSRR, de Barros Costa FG, Toda K, Mazo DFC, Sabino EC, Carrilho FJ, Gasbarrini A, Oliveira CP.

Nutr Metab Cardiovasc Dis. 2018 Apr;28(4):369-384. doi: 10.1016/j.numecd.2017.10.014. Epub 2017 Oct 26.


ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models.

Guo S, Zhang C, Bratton M, Mottamal M, Liu J, Ma P, Zheng S, Zhong Q, Yang L, Wiese TE, Wu Y, Ellis MJ, Matossian M, Burow ME, Miele L, Houtman R, Wang G.

Oncotarget. 2018 Jan 8;9(6):6924-6937. doi: 10.18632/oncotarget.24023. eCollection 2018 Jan 23.


A novel patient-derived xenograft model for claudin-low triple-negative breast cancer.

Matossian MD, Burks HE, Bowles AC, Elliott S, Hoang VT, Sabol RA, Pashos NC, O'Donnell B, Miller KS, Wahba BM, Bunnell BA, Moroz K, Zea AH, Jones SD, Ochoa AC, Al-Khami AA, Hossain F, Riker AI, Rhodes LV, Martin EC, Miele L, Burow ME, Collins-Burow BM.

Breast Cancer Res Treat. 2018 Feb 1. doi: 10.1007/s10549-018-4685-2. [Epub ahead of print]


Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma.

Ponziani FR, Spinelli I, Rinninella E, Cerrito L, Saviano A, Avolio AW, Basso M, Miele L, Riccardi L, Zocco MA, Annicchiarico BE, Garcovich M, Biolato M, Marrone G, De Gaetano AM, Iezzi R, Giuliante F, Vecchio FM, Agnes S, Addolorato G, Siciliano M, Rapaccini GL, Grieco A, Gasbarrini A, Pompili M.

World J Hepatol. 2017 Dec 28;9(36):1322-1331. doi: 10.4254/wjh.v9.i36.1322.


Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway.

Kumar D, Haldar S, Gorain M, Kumar S, Mulani FA, Yadav AS, Miele L, Thulasiram HV, Kundu GC.

BMC Cancer. 2018 Jan 8;18(1):52. doi: 10.1186/s12885-017-3876-2.


The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.

Dai L, Smith CD, Foroozesh M, Miele L, Qin Z.

Int J Cancer. 2017 Dec 26. doi: 10.1002/ijc.31234. [Epub ahead of print]


Nonalcoholic fatty liver disease in patients with psoriasis: A consequence of systemic inflammatory burden?

Prussick RB, Miele L.

Br J Dermatol. 2017 Dec 13. doi: 10.1111/bjd.16239. [Epub ahead of print] Review.


Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells.

Man J, Yu X, Huang H, Zhou W, Xiang C, Huang H, Miele L, Liu Z, Bebek G, Bao S, Yu JS.

Cell Stem Cell. 2018 Jan 4;22(1):104-118.e6. doi: 10.1016/j.stem.2017.10.005. Epub 2017 Nov 30.


Farmers' Market Utilization among Supplemental Nutrition Assistance Program Recipients in New Orleans, Louisiana: Preliminary Findings.

Nuss H, Skizim M, Afaneh H, Miele L, Sothern M.

Ethn Dis. 2017 Nov 9;27(Suppl 1):295-302. doi: 10.18865/ed.27.S1.295. eCollection 2017.


Preventing liver fibrosis in patients with NAFLD and the road ahead.

Nobili V, Miele L, Alisi A.

Expert Rev Gastroenterol Hepatol. 2017 Dec;11(12):1081-1083. doi: 10.1080/17474124.2017.1389276. Epub 2017 Oct 16. No abstract available.


Gut microbiota, obesity and metabolic disorders.

Federico A, Dallio M, DI Sarno R, Giorgio V, Miele L.

Minerva Gastroenterol Dietol. 2017 Dec;63(4):337-344. doi: 10.23736/S1121-421X.17.02376-5.


Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance.

Sierra RA, Trillo-Tinoco J, Mohamed E, Yu L, Achyut BR, Arbab A, Bradford JW, Osborne BA, Miele L, Rodriguez PC.

Cancer Res. 2017 Oct 15;77(20):5628-5638. doi: 10.1158/0008-5472.CAN-17-0357. Epub 2017 Sep 13.


Estrogen receptor β-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis.

Fortini F, Vieceli Dalla Sega F, Caliceti C, Aquila G, Pannella M, Pannuti A, Miele L, Ferrari R, Rizzo P.

J Biol Chem. 2017 Nov 3;292(44):18178-18191. doi: 10.1074/jbc.M117.790121. Epub 2017 Sep 11.


Enhanced liver fibrosis test as a reliable tool for assessing fibrosis in nonalcoholic fatty liver disease in a clinical setting.

Miele L, De Michele T, Marrone G, Antonietta Isgrò M, Basile U, Cefalo C, Biolato M, Maria Vecchio F, Lodovico Rapaccini G, Gasbarrini A, Zuppi C, Grieco A.

Int J Biol Markers. 2017 Oct 31;32(4):e397-e402. doi: 10.5301/ijbm.5000292.


Ancestry as a potential modifier of gene expression in breast tumors from Colombian women.

Serrano-Gómez SJ, Sanabria-Salas MC, Garay J, Baddoo MC, Hernández-Suarez G, Mejía JC, García O, Miele L, Fejerman L, Zabaleta J.

PLoS One. 2017 Aug 23;12(8):e0183179. doi: 10.1371/journal.pone.0183179. eCollection 2017.


Acellular Dermal Matrix Versus Inferior Deepithelialized Flap Breast Reconstruction: Equivalent Outcomes, with Increased Cost.

Hon HH, Mubang RN, Wernick BD, Freedman SF, Stoltzfus JC, Miele LF, Stawicki SP, Morrissey WM Jr.

Plast Reconstr Surg Glob Open. 2017 Jun 28;5(6):e1382. doi: 10.1097/GOX.0000000000001382. eCollection 2017 Jun.


Elevated Hemoglobin Level Is Associated With Advanced Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease.

Giorgio V, Mosca A, Alterio A, Alisi A, Grieco A, Nobili V, Miele L.

J Pediatr Gastroenterol Nutr. 2017 Aug;65(2):150-155. doi: 10.1097/MPG.0000000000001614.


Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.

Donati B, Pietrelli A, Pingitore P, Dongiovanni P, Caddeo A, Walker L, Baselli G, Pelusi S, Rosso C, Vanni E, Daly A, Mancina RM, Grieco A, Miele L, Grimaudo S, Craxi A, Petta S, De Luca L, Maier S, Soardo G, Bugianesi E, Colli F, Romagnoli R, Anstee QM, Reeves HL, Fracanzani AL, Fargion S, Romeo S, Valenti L.

Cancer Med. 2017 Aug;6(8):1930-1940. doi: 10.1002/cam4.1078. Epub 2017 Jul 4.


MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals.

Donati B, Dongiovanni P, Romeo S, Meroni M, McCain M, Miele L, Petta S, Maier S, Rosso C, De Luca L, Vanni E, Grimaudo S, Romagnoli R, Colli F, Ferri F, Mancina RM, Iruzubieta P, Craxi A, Fracanzani AL, Grieco A, Corradini SG, Aghemo A, Colombo M, Soardo G, Bugianesi E, Reeves H, Anstee QM, Fargion S, Valenti L.

Sci Rep. 2017 Jul 3;7(1):4492. doi: 10.1038/s41598-017-04991-0.


Liver transplantation for intermediate hepatocellular carcinoma: An adaptive approach.

Biolato M, Marrone G, Miele L, Gasbarrini A, Grieco A.

World J Gastroenterol. 2017 May 14;23(18):3195-3204. doi: 10.3748/wjg.v23.i18.3195.


γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.

Ran Y, Hossain F, Pannuti A, Lessard CB, Ladd GZ, Jung JI, Minter LM, Osborne BA, Miele L, Golde TE.

EMBO Mol Med. 2017 Jul;9(7):950-966. doi: 10.15252/emmm.201607265.


Assessing the Racial and Ethnic Disparities in Breast Cancer Mortality in the United States.

Yedjou CG, Tchounwou PB, Payton M, Miele L, Fonseca DD, Lowe L, Alo RA.

Int J Environ Res Public Health. 2017 May 5;14(5). pii: E486. doi: 10.3390/ijerph14050486. Review.


Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study.

Aquila G, Fortini C, Pannuti A, Delbue S, Pannella M, Morelli MB, Caliceti C, Castriota F, de Mattei M, Ongaro A, Pellati A, Ferrante P, Miele L, Tavazzi L, Ferrari R, Rizzo P, Cremonesi A.

J Transl Med. 2017 May 4;15(1):98. doi: 10.1186/s12967-017-1199-3.


An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes.

Hicks C, Ramani R, Sartor O, Bhalla R, Miele L, Dlamini Z, Gumede N.

Biomark Insights. 2017 Mar 16;12:1177271917695810. doi: 10.1177/1177271917695810. eCollection 2017.


Watery stools and metabolic acidosis.

Ferrari MC, Miele L, Guidi L, Rindi G, Rocchi C, Castaldi P, Alfieri S, Gasbarrini A, Grieco A, Rapaccini G.

Intern Emerg Med. 2017 Jun;12(4):487-492. doi: 10.1007/s11739-017-1656-2. Epub 2017 Apr 5. No abstract available.


Liver transplantation for drug-induced acute liver failure.

Biolato M, Araneo C, Marrone G, Liguori A, Miele L, Ponziani FR, Gasbarrini A, Grieco A.

Eur Rev Med Pharmacol Sci. 2017 Mar;21(1 Suppl):37-45. Review.


Fatty liver and drugs: the two sides of the same coin.

Miele L, Liguori A, Marrone G, Biolato M, Araneo C, Vaccaro FG, Gasbarrini A, Grieco A.

Eur Rev Med Pharmacol Sci. 2017 Mar;21(1 Suppl):86-94.


Drug-induced liver injury 2017: the diagnosis is not easy but always to keep in mind.

Marrone G, Vaccaro FG, Biolato M, Miele L, Liguori A, Araneo C, Ponziani FR, Mores N, Gasbarrini A, Grieco A.

Eur Rev Med Pharmacol Sci. 2017 Mar;21(1 Suppl):122-134.


Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.

Gnani D, Romito I, Artuso S, Chierici M, De Stefanis C, Panera N, Crudele A, Ceccarelli S, Carcarino E, D'Oria V, Porru M, Giorda E, Ferrari K, Miele L, Villa E, Balsano C, Pasini D, Furlanello C, Locatelli F, Nobili V, Rota R, Leonetti C, Alisi A.

Cell Death Differ. 2017 May;24(5):889-902. doi: 10.1038/cdd.2017.34. Epub 2017 Mar 24.


The NAFL Risk Score: A simple scoring model to predict 4-y risk for non-alcoholic fatty liver.

Zhou YJ, Zheng JN, Liu WY, Miele L, Vitale A, Van Poucke S, Zou TT, Fang DH, Shen S, Zhang DC, Zheng MH.

Clin Chim Acta. 2017 May;468:17-24. doi: 10.1016/j.cca.2017.01.021. Epub 2017 Jan 19.


Serum alkaline phosphatase, a risk factor for non-alcoholic fatty liver, but only for women in their 30s and 40s: evidence from a large cohort study.

Zhou YJ, Zou H, Zheng JN, Zou TT, Vitale A, Miele L, Van Poucke S, Liu WY, Shen S, Zhang DC, Shi KQ, Zheng MH.

Expert Rev Gastroenterol Hepatol. 2017 Mar;11(3):269-276. doi: 10.1080/17474124.2017.1283984. Epub 2017 Jan 27.


Advancing the Science of Health Disparities Through Research on the Social Determinants of Health.

Fouad MN, Oates GR, Scarinci IC, Demark-Wahnefried W, Hamby BW, Bateman LB, Estrada JJ, Payton M, Sims M, Miele L, Partridge EE.

Am J Prev Med. 2017 Jan;52(1S1):S1-S4. doi: 10.1016/j.amepre.2016.09.032. No abstract available.


Pathophysiology of Non Alcoholic Fatty Liver Disease.

Petta S, Gastaldelli A, Rebelos E, Bugianesi E, Messa P, Miele L, Svegliati-Baroni G, Valenti L, Bonino F.

Int J Mol Sci. 2016 Dec 11;17(12). pii: E2082. Review.


Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression.

Sorrentino C, Miele L, Porta A, Pinto A, Morello S.

Oncotarget. 2016 Sep 27;7(39):64274-64288. doi: 10.18632/oncotarget.11729.


Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD).

Liu J, Zheng S, Akerstrom VL, Yuan C, Ma Y, Zhong Q, Zhang C, Zhang Q, Guo S, Ma P, Skripnikova EV, Bratton MR, Pannuti A, Miele L, Wiese TE, Wang G.

J Med Chem. 2016 Sep 8;59(17):8134-40. doi: 10.1021/acs.jmedchem.6b00753. Epub 2016 Aug 29.


The Metabolic Role of Gut Microbiota in the Development of Nonalcoholic Fatty Liver Disease and Cardiovascular Disease.

Sanduzzi Zamparelli M, Compare D, Coccoli P, Rocco A, Nardone OM, Marrone G, Gasbarrini A, Grieco A, Nardone G, Miele L.

Int J Mol Sci. 2016 Jul 29;17(8). pii: E1225. doi: 10.3390/ijms17081225. Review.


Autoimmunity and lymphoproliferation markers in naïve HCV-RNA positive patients without clinical evidences of autoimmune/lymphoproliferative disorders.

Gulli F, Basile U, Gragnani L, Fognani E, Napodano C, Colacicco L, Miele L, De Matthaeis N, Cattani P, Zignego AL, Rapaccini GL.

Dig Liver Dis. 2016 Aug;48(8):927-33. doi: 10.1016/j.dld.2016.05.013. Epub 2016 May 24.


High prevalence of luminal B breast cancer intrinsic subtype in Colombian women.

Serrano-Gomez SJ, Sanabria-Salas MC, Hernández-Suarez G, García O, Silva C, Romero A, Mejía JC, Miele L, Fejerman L, Zabaleta J.

Carcinogenesis. 2016 Jul;37(7):669-676. doi: 10.1093/carcin/bgw043. Epub 2016 Apr 16.


Notch Signaling in Neuroendocrine Tumors.

Crabtree JS, Singleton CS, Miele L.

Front Oncol. 2016 Apr 14;6:94. doi: 10.3389/fonc.2016.00094. eCollection 2016. Review.


Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia.

Hicks C, Sitthi-Amorn J, Douglas J, Ramani R, Miele L, Vijayakumar V, Karlson C, Chipeta J, Megason G.

Clin Med Insights Oncol. 2016 Mar 14;10:5-15. doi: 10.4137/CMO.S18180. eCollection 2016.


Serum From Advanced Heart Failure Patients Promotes Angiogenic Sprouting and Affects the Notch Pathway in Human Endothelial Cells.

Pannella M, Caliceti C, Fortini F, Aquila G, Vieceli Dalla Sega F, Pannuti A, Fortini C, Morelli MB, Fucili A, Francolini G, Voltan R, Secchiero P, Dinelli G, Leoncini E, Ferracin M, Hrelia S, Miele L, Rizzo P.

J Cell Physiol. 2016 Dec;231(12):2700-10. doi: 10.1002/jcp.25373. Epub 2016 Apr 4.


Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility.

Su RW, Strug MR, Jeong JW, Miele L, Fazleabas AT.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2300-5. doi: 10.1073/pnas.1520441113. Epub 2016 Feb 8.


Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.

Eslam M, Mangia A, Berg T, Chan HL, Irving WL, Dore GJ, Abate ML, Bugianesi E, Adams LA, Najim MA, Miele L, Weltman M, Mollison L, Cheng W, Riordan S, Fischer J, Romero-Gomez M, Spengler U, Nattermann J, Rahme A, Sheridan D, Booth DR, McLeod D, Powell E, Liddle C, Douglas MW, van der Poorten D, George J; International Liver Disease Genetics Consortium.

Hepatology. 2016 Jul;64(1):34-46. doi: 10.1002/hep.28475. Epub 2016 Mar 30.


Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib.

Mazzoccoli G, Miele L, Oben J, Grieco A, Vinciguerra M.

Curr Drug Targets. 2016;17(7):783-99. Review.


Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.

Verginelli F, Adesso L, Limon I, Alisi A, Gueguen M, Panera N, Giorda E, Raimondi L, Ciarapica R, Campese AF, Screpanti I, Stifani S, Kitajewski J, Miele L, Rota R, Locatelli F.

Oncotarget. 2015 Dec 22;6(41):43216-29. doi: 10.18632/oncotarget.6456.


Nonalcoholic fatty liver disease as trigger of cardiovascular and metabolic complication in metabolic syndrome.

Miele L, Gasbarrini G, Giorgio V, Gasbarrini A, Grieco A.

Intern Emerg Med. 2016 Feb;11(1):3-10. doi: 10.1007/s11739-015-1346-x. Epub 2015 Nov 24. No abstract available.


FibroGENE: A gene-based model for staging liver fibrosis.

Eslam M, Hashem AM, Romero-Gomez M, Berg T, Dore GJ, Mangia A, Chan HLY, Irving WL, Sheridan D, Abate ML, Adams LA, Weltman M, Bugianesi E, Spengler U, Shaker O, Fischer J, Mollison L, Cheng W, Nattermann J, Riordan S, Miele L, Kelaeng KS, Ampuero J, Ahlenstiel G, McLeod D, Powell E, Liddle C, Douglas MW, Booth DR, George J; International Liver Disease Genetics Consortium (ILDGC).

J Hepatol. 2016 Feb;64(2):390-398. doi: 10.1016/j.jhep.2015.11.008. Epub 2015 Dec 1.


Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk.

Miele L, Giorgio V, Alberelli MA, De Candia E, Gasbarrini A, Grieco A.

Curr Cardiol Rep. 2015 Dec;17(12):120. doi: 10.1007/s11886-015-0671-z. Review.


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