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Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene.

Middleton SJ, Kneller EM, Chen S, Ogiwara I, Montal M, Yamakawa K, McHugh TJ.

Nat Neurosci. 2018 Jun 4. doi: 10.1038/s41593-018-0163-8. [Epub ahead of print]


Developing a virtual fracture clinic for hand and wrist injuries.

Evans D, Hardman J, Middleton SD, Anakwe RE.

J Hand Surg Eur Vol. 2018 Jan 1:1753193418778472. doi: 10.1177/1753193418778472. [Epub ahead of print] No abstract available.


The largest survivorship and clinical outcomes study of the fixed bearing Stryker Triathlon Partial Knee Replacement - A multi-surgeon, single centre cohort study with a minimum of two years of follow-up.

Middleton SWF, Schranz PJ, Mandalia VI, Toms AD.

Knee. 2018 May 3. pii: S0968-0160(18)30167-4. doi: 10.1016/j.knee.2018.04.002. [Epub ahead of print]


Sleep disordered breathing controlled by CPAP and sFlt-1 in a pregnant patient with chronic hypertension: Case report and literature review.

Daly A, Robertson A, Bobek G, Middleton S, Sullivan C, Hennessy A.

Obstet Med. 2018 Mar;11(1):32-34. doi: 10.1177/1753495X17708949. Epub 2017 Sep 13.


Back to Basics: Adherence With Guidelines for Glucose and Temperature Control in an American Comprehensive Stroke Center Sample.

Alexandrov AW, Palazzo P, Biby S, Doerr A, Dusenbury W, Young R, Lindstrom A, Grove M, Tsivgoulis G, Middleton S, Alexandrov AV.

J Neurosci Nurs. 2018 Jun;50(3):131-137. doi: 10.1097/JNN.0000000000000358.


What do randomized controlled trials say about virtual rehabilitation in stroke? A systematic literature review and meta-analysis of upper-limb and cognitive outcomes.

Aminov A, Rogers JM, Middleton S, Caeyenberghs K, Wilson PH.

J Neuroeng Rehabil. 2018 Mar 27;15(1):29. doi: 10.1186/s12984-018-0370-2.


Graft versus host disease after multivisceral transplantation: A UK center experience and update on management.

Sharkey LM, Peacock S, Russell NK, Middleton SJ, Butler AJ.

Clin Transplant. 2018 May;32(5):e13239. doi: 10.1111/ctr.13239. Epub 2018 Apr 16.


Mid-term survivorship and clinical outcomes of the Avon patellofemoral joint replacement.

Middleton SWF, Toms AD, Schranz PJ, Mandalia VI.

Knee. 2018 Mar;25(2):323-328. doi: 10.1016/j.knee.2018.01.007. Epub 2018 Feb 21.


Evaluation of hospital outcomes: the relation between length-of-stay, readmission, and mortality in a large international administrative database.

Lingsma HF, Bottle A, Middleton S, Kievit J, Steyerberg EW, Marang-van de Mheen PJ.

BMC Health Serv Res. 2018 Feb 14;18(1):116. doi: 10.1186/s12913-018-2916-1.


Quality of Life Is Poorer for Patients With Stroke Who Require an Interpreter: An Observational Australian Registry Study.

Kilkenny MF, Lannin NA, Anderson CS, Dewey HM, Kim J, Barclay-Moss K, Levi C, Faux S, Hill K, Grabsch B, Middleton S, Thrift AG, Grimley R, Donnan G, Cadilhac DA; AuSCR Consortium.

Stroke. 2018 Mar;49(3):761-764. doi: 10.1161/STROKEAHA.117.019771. Epub 2018 Feb 9.


Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.

Dawes JM, Weir GA, Middleton SJ, Patel R, Chisholm KI, Pettingill P, Peck LJ, Sheridan J, Shakir A, Jacobson L, Gutierrez-Mecinas M, Galino J, Walcher J, Kühnemund J, Kuehn H, Sanna MD, Lang B, Clark AJ, Themistocleous AC, Iwagaki N, West SJ, Werynska K, Carroll L, Trendafilova T, Menassa DA, Giannoccaro MP, Coutinho E, Cervellini I, Tewari D, Buckley C, Leite MI, Wildner H, Zeilhofer HU, Peles E, Todd AJ, McMahon SB, Dickenson AH, Lewin GR, Vincent A, Bennett DL.

Neuron. 2018 Feb 21;97(4):806-822.e10. doi: 10.1016/j.neuron.2018.01.033. Epub 2018 Feb 8.


Prescription of antihypertensive medication at discharge influences survival following stroke.

Andrew NE, Kim J, Thrift AG, Kilkenny MF, Lannin NA, Anderson CS, Donnan GA, Hill K, Middleton S, Levi C, Faux S, Grimley R, Gange N, Geraghty R, Ermel S, Cadilhac DA; Australian Stroke Clinical Registry Consortium.

Neurology. 2018 Feb 27;90(9):e745-e753. doi: 10.1212/WNL.0000000000005023. Epub 2018 Jan 31.


PIVOT: platform for interactive analysis and visualization of transcriptomics data.

Zhu Q, Fisher SA, Dueck H, Middleton S, Khaladkar M, Kim J.

BMC Bioinformatics. 2018 Jan 5;19(1):6. doi: 10.1186/s12859-017-1994-0.


Complex Regional Pain Syndrome after Total Knee Arthroplasty is Rare and Misdiagnosis Potentially Hazardous-Prospective Study of the New Diagnostic Criteria in 100 Patients with No Cases Identified.

Kosy JD, Middleton SWF, Bradley BM, Stroud RM, Phillips JRA, Toms AD.

J Knee Surg. 2018 Jan 2. doi: 10.1055/s-0037-1615746. [Epub ahead of print]


Treatment and Outcomes of Working Aged Adults with Stroke: Results from a National Prospective Registry.

Lannin NA, Anderson CS, Kim J, Kilkenny M, Bernhardt J, Levi C, Dewey HM, Bladin C, Hand P, Castley H, Hill K, Faux S, Grimley R, Grabsch B, Middleton S, Donnan G, Cadilhac DA.

Neuroepidemiology. 2017;49(3-4):113-120. doi: 10.1159/000484141. Epub 2017 Nov 14.


Influence of stroke coordinators on delivery of acute stroke care and hospital outcomes: An observational study.

Purvis T, Kilkenny MF, Middleton S, Cadilhac DA.

Int J Stroke. 2017 Jan 1:1747493017741382. doi: 10.1177/1747493017741382. [Epub ahead of print]


Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source.

Weir GA, Middleton SJ, Clark AJ, Daniel T, Khovanov N, McMahon SB, Bennett DL.

Brain. 2017 Oct 1;140(10):2570-2585. doi: 10.1093/brain/awx201.


Acute single channel EEG predictors of cognitive function after stroke.

Aminov A, Rogers JM, Johnstone SJ, Middleton S, Wilson PH.

PLoS One. 2017 Oct 2;12(10):e0185841. doi: 10.1371/journal.pone.0185841. eCollection 2017.


Chemotherapy-free, triple combination of obinutuzumab, venetoclax and idasanutlin: antitumor activity in xenograft models of non-Hodgkin lymphoma.

Herting F, Friess T, Umaña P, Middleton S, Klein C.

Leuk Lymphoma. 2018 Jun;59(6):1482-1485. doi: 10.1080/10428194.2017.1376740. Epub 2017 Sep 15. No abstract available.


Improving quality and outcomes of stroke care in hospitals: Protocol and statistical analysis plan for the Stroke123 implementation study.

Cadilhac DA, Andrew NE, Kilkenny MF, Hill K, Grabsch B, Lannin NA, Thrift AG, Anderson CS, Donnan GA, Middleton S, Grimley R.

Int J Stroke. 2018 Jan;13(1):96-106. doi: 10.1177/1747493017730741. Epub 2017 Sep 15.


Predictors of Daily Pain Medication Use in Individuals with Recurrent Back Pain.

Sturgeon JA, Hah JM, Sharifzadeh Y, Middleton SK, Rico T, Johnson KA, Mackey SC.

Int J Behav Med. 2018 Apr;25(2):252-258. doi: 10.1007/s12529-017-9686-8.


Multi-level spine endoscopy: A review of available evidence and case report.

Middleton SD, Wagner R, Gibson JNA.

EFORT Open Rev. 2017 Jul 12;2(7):317-323. doi: 10.1302/2058-5241.2.160087. eCollection 2017 Jul.


International Uptake of a Proven Intervention to Reduce Death and Dependency in Acute Stroke: A Cross-Sectional Survey Following the QASC Trial.

Middleton S, Bruch D, Martinez-Garduno C, Dale S, McNamara M.

Worldviews Evid Based Nurs. 2017 Dec;14(6):447-454. doi: 10.1111/wvn.12253. Epub 2017 Aug 14.


Improving discharge care: the potential of a new organisational intervention to improve discharge after hospitalisation for acute stroke, a controlled before-after pilot study.

Cadilhac DA, Andrew NE, Stroil Salama E, Hill K, Middleton S, Horton E, Meade I, Kuhle S, Nelson MR, Grimley R; Australian Stroke Clinical Registry Consortium.

BMJ Open. 2017 Aug 4;7(8):e016010. doi: 10.1136/bmjopen-2017-016010.


Statistical analysis plan for the Head Position in Stroke Trial (HeadPoST): An international cluster cross-over randomized trial.

Billot L, Woodward M, Arima H, Hackett ML, Muñoz Venturelli P, Lavados PM, Brunser A, Peng B, Cui L, Song L, Heritier S, Jan S, Middleton S, Olavarría VV, Lim J, Robinson T, Pontes-Neto O, Watkins C, Anderson CS.

Int J Stroke. 2017 Aug;12(6):667-670. doi: 10.1177/1747493017701943. Epub 2017 Mar 24.


Development of a theory-informed implementation intervention to improve the triage, treatment and transfer of stroke patients in emergency departments using the Theoretical Domains Framework (TDF): the T3 Trial.

Craig LE, Taylor N, Grimley R, Cadilhac DA, McInnes E, Phillips R, Dale S, O'Connor D, Levi C, Fitzgerald M, Considine J, Grimshaw JM, Gerraty R, Cheung NW, Ward J, Middleton S.

Implement Sci. 2017 Jul 17;12(1):88. doi: 10.1186/s13012-017-0616-6.


Decortication and osteotomy for the correction of multiplanar deformity in the treatment of malunion in adult diaphyseal femoral deformity: a case series and technique description.

Middleton S, Walker RW, Norton M.

Eur J Orthop Surg Traumatol. 2018 Jan;28(1):117-120. doi: 10.1007/s00590-017-2008-7. Epub 2017 Jun 28.


Congenital deafness is associated with specific somatosensory deficits in adolescents.

Moshourab R, Bégay V, Wetzel C, Walcher J, Middleton S, Gross M, Lewin GR.

Sci Rep. 2017 Jun 26;7(1):4251. doi: 10.1038/s41598-017-04074-0.


Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke.

Anderson CS, Arima H, Lavados P, Billot L, Hackett ML, Olavarría VV, Muñoz Venturelli P, Brunser A, Peng B, Cui L, Song L, Rogers K, Middleton S, Lim JY, Forshaw D, Lightbody CE, Woodward M, Pontes-Neto O, De Silva HA, Lin RT, Lee TH, Pandian JD, Mead GE, Robinson T, Watkins C; HeadPoST Investigators and Coordinators.

N Engl J Med. 2017 Jun 22;376(25):2437-2447. doi: 10.1056/NEJMoa1615715.


Vocal palsy increases the risk of lower respiratory tract infection in low-risk, low-morbidity patients undergoing thyroidectomy for benign disease: A big data analysis.

Nouraei SAR, Allen J, Kaddour H, Middleton SE, Aylin P, Darzi A, Tolley NS.

Clin Otolaryngol. 2017 Dec;42(6):1259-1266. doi: 10.1111/coa.12913. Epub 2017 Jul 20.


Discharge on the day of surgery following unicompartmental knee arthroplasty within the United Kingdom NHS.

Bradley B, Middleton S, Davis N, Williams M, Stocker M, Hockings M, Isaac DL.

Bone Joint J. 2017 Jun;99-B(6):788-792. doi: 10.1302/0301-620X.99B6.BJJ-2016-0540.R2.


Mapping workforce configuration and operational models in Australian emergency departments: a national survey.

Gardner G, Gardner A, Middleton S, Considine J, Fitzgerald G, Christofis L, Doubrovsky A, Adams M, O'Connell J.

Aust Health Rev. 2017 May 18. doi: 10.1071/AH16231. [Epub ahead of print]


Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability.

Boehringer R, Polygalov D, Huang AJY, Middleton SJ, Robert V, Wintzer ME, Piskorowski RA, Chevaleyre V, McHugh TJ.

Neuron. 2017 May 3;94(3):642-655.e9. doi: 10.1016/j.neuron.2017.04.014.


Risk-adjusted hospital mortality rates for stroke: evidence from the Australian Stroke Clinical Registry (AuSCR).

Cadilhac DA, Kilkenny MF, Levi CR, Lannin NA, Thrift AG, Kim J, Grabsch B, Churilov L, Dewey HM, Hill K, Faux SG, Grimley R, Castley H, Hand PJ, Wong A, Herkes GK, Gill M, Crompton D, Middleton S, Donnan GA, Anderson CS.

Med J Aust. 2017 May 1;206(8):345-350.


Complete fold annotation of the human proteome using a novel structural feature space.

Middleton SA, Illuminati J, Kim J.

Sci Rep. 2017 Apr 13;7:46321. doi: 10.1038/srep46321.


Using thoughtful questions as a new pedagogy for teaching patient-centred care.

Buist M, Middleton S, Moore R.

Med Educ. 2017 May;51(5):558-559. doi: 10.1111/medu.13324. No abstract available.


Mortality Reduction for Fever, Hyperglycemia, and Swallowing Nurse-Initiated Stroke Intervention: QASC Trial (Quality in Acute Stroke Care) Follow-Up.

Middleton S, Coughlan K, Mnatzaganian G, Low Choy N, Dale S, Jammali-Blasi A, Levi C, Grimshaw JM, Ward J, Cadilhac DA, McElduff P, Hiller JE, D'Este C.

Stroke. 2017 May;48(5):1331-1336. doi: 10.1161/STROKEAHA.116.016038. Epub 2017 Apr 7.


Impact of the method and success of pharyngeal reconstruction on the outcome of treating laryngeal and hypopharyngeal cancers with pharyngolaryngectomy: A national analysis.

Nouraei SA, Dias A, Kanona H, Vokes D, O'Flynn P, Clarke PM, Middleton SE, Darzi A, Aylin P, Jallali N.

J Plast Reconstr Aesthet Surg. 2017 May;70(5):628-638. doi: 10.1016/j.bjps.2016.12.009. Epub 2017 Jan 9.


The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts.

Kim H, Walsh MC, Takegahara N, Middleton SA, Shin HI, Kim J, Choi Y.

Sci Rep. 2017 Mar 15;7(1):196. doi: 10.1038/s41598-017-00139-2.


Quality of Acute Care and Long-Term Quality of Life and Survival: The Australian Stroke Clinical Registry.

Cadilhac DA, Andrew NE, Lannin NA, Middleton S, Levi CR, Dewey HM, Grabsch B, Faux S, Hill K, Grimley R, Wong A, Sabet A, Butler E, Bladin CF, Bates TR, Groot P, Castley H, Donnan GA, Anderson CS; Australian Stroke Clinical Registry Consortium.

Stroke. 2017 Apr;48(4):1026-1032. doi: 10.1161/STROKEAHA.116.015714. Epub 2017 Mar 3.


Effectiveness of a 'Do not interrupt' bundled intervention to reduce interruptions during medication administration: a cluster randomised controlled feasibility study.

Westbrook JI, Li L, Hooper TD, Raban MZ, Middleton S, Lehnbom EC.

BMJ Qual Saf. 2017 Sep;26(9):734-742. doi: 10.1136/bmjqs-2016-006123. Epub 2017 Feb 23.


Barriers and enablers to adherence to anticoagulation in heart failure with atrial fibrillation: patient and provider perspectives.

Ferguson C, Inglis SC, Newton PJ, Middleton S, Macdonald PS, Davidson PM.

J Clin Nurs. 2017 Dec;26(23-24):4325-4334. doi: 10.1111/jocn.13759. Epub 2017 Mar 31.


Testing a systematic approach to identify and prioritise barriers to successful implementation of a complex healthcare intervention.

Craig LE, Churilov L, Olenko L, Cadilhac DA, Grimley R, Dale S, Martinez-Garduno C, McInnes E, Considine J, Grimshaw JM, Middleton S.

BMC Med Res Methodol. 2017 Feb 7;17(1):24. doi: 10.1186/s12874-017-0298-4.


Medium-term patient-reported outcomes after total hip replacement for displaced hip fractures.

Middleton SD, McNiven N, Anakwe RE, Jenkins PJ, Aitken SA, Keating JF, Moran M.

Eur J Orthop Surg Traumatol. 2017 Oct;27(7):917-921. doi: 10.1007/s00590-017-1907-y. Epub 2017 Jan 25.


Regional variation in acute stroke care organisation.

Muñoz Venturelli P, Robinson T, Lavados PM, Olavarría VV, Arima H, Billot L, Hackett ML, Lim JY, Middleton S, Pontes-Neto O, Peng B, Cui L, Song L, Mead G, Watkins C, Lin RT, Lee TH, Pandian J, de Silva HA, Anderson CS; HeadPoST Investigators.

J Neurol Sci. 2016 Dec 15;371:126-130. doi: 10.1016/j.jns.2016.10.026. Epub 2016 Oct 18.


Acrometastasis following colorectal cancer: A case report and review of literature.

Agha K, Akbari K, Abbas SH, Middleton S, McGrath D.

Int J Surg Case Rep. 2016;29:158-161. doi: 10.1016/j.ijscr.2016.10.078. Epub 2016 Nov 10.


Aetiology of hospital setting adverse events 2: 'clinical futile cycles'.

Buist M, Middleton S.

Br J Hosp Med (Lond). 2016 Nov 2;77(11):C175-C178. No abstract available.


Aetiology of hospital setting adverse events 1: limitations of the 'Swiss cheese' model.

Buist M, Middleton S.

Br J Hosp Med (Lond). 2016 Nov 2;77(11):C170-C174. No abstract available.


Nontraumatic Testicular Pain due to Sacroiliac-Joint Dysfunction: A Case Report.

Leone JE, Middleton S.

J Athl Train. 2016 Aug;51(8):651-657. Epub 2016 Sep 14.

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