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Items: 18


A genome editing approach to study cancer stem cells in human tumors.

Cortina C, Turon G, Stork D, Hernando-Momblona X, Sevillano M, Aguilera M, Tosi S, Merlos-Suárez A, Stephan-Otto Attolini C, Sancho E, Batlle E.

EMBO Mol Med. 2017 Jul;9(7):869-879. doi: 10.15252/emmm.201707550.


Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression.

Forn M, Díez-Villanueva A, Merlos-Suárez A, Muñoz M, Lois S, Carriò E, Jordà M, Bigas A, Batlle E, Peinado MA.

PLoS One. 2015 May 1;10(5):e0123263. doi: 10.1371/journal.pone.0123263. eCollection 2015.


Iro/IRX transcription factors negatively regulate Dpp/TGF-β pathway activity during intestinal tumorigenesis.

Martorell Ò, Barriga FM, Merlos-Suárez A, Stephan-Otto Attolini C, Casanova J, Batlle E, Sancho E, Casali A.

EMBO Rep. 2014 Nov;15(11):1210-8. doi: 10.15252/embr.201438622. Epub 2014 Oct 8.


Conserved mechanisms of tumorigenesis in the Drosophila adult midgut.

Martorell Ò, Merlos-Suárez A, Campbell K, Barriga FM, Christov CP, Miguel-Aliaga I, Batlle E, Casanova J, Casali A.

PLoS One. 2014 Feb 6;9(2):e88413. doi: 10.1371/journal.pone.0088413. eCollection 2014.


Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells.

Forn M, Muñoz M, Tauriello DV, Merlos-Suárez A, Rodilla V, Bigas A, Batlle E, Jordà M, Peinado MA.

Mol Oncol. 2013 Dec;7(6):1129-41. doi: 10.1016/j.molonc.2013.08.008. Epub 2013 Aug 30.


The circadian molecular clock creates epidermal stem cell heterogeneity.

Janich P, Pascual G, Merlos-Suárez A, Batlle E, Ripperger J, Albrecht U, Cheng HY, Obrietan K, Di Croce L, Benitah SA.

Nature. 2011 Nov 9;480(7376):209-14. doi: 10.1038/nature10649.


Isolation and in vitro expansion of human colonic stem cells.

Jung P, Sato T, Merlos-Suárez A, Barriga FM, Iglesias M, Rossell D, Auer H, Gallardo M, Blasco MA, Sancho E, Clevers H, Batlle E.

Nat Med. 2011 Sep 4;17(10):1225-7. doi: 10.1038/nm.2470.


The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse.

Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Muñoz P, Clevers H, Sancho E, Mangues R, Batlle E.

Cell Stem Cell. 2011 May 6;8(5):511-24. doi: 10.1016/j.stem.2011.02.020. Epub 2011 Mar 17.


Eph-ephrin signalling in adult tissues and cancer.

Merlos-Suárez A, Batlle E.

Curr Opin Cell Biol. 2008 Apr;20(2):194-200. doi: 10.1016/ Epub 2008 Mar 18. Review.


A neural survival factor is a candidate oncogene in breast cancer.

Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, Bae YK, Monitto CL, Merlos-Suarez A, Chan J, Hulette CM, Richardson A, Morton CC, Marks J, Duyao M, Hruban R, Gabrielson E, Gelman R, Polyak K.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10931-6. Epub 2003 Sep 2.


Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.

Borroto A, Ruiz-Paz S, de la Torre TV, Borrell-Pages M, Merlos-Suarez A, Pandiella A, Blobel CP, Baselga J, Arribas J.

J Biol Chem. 2003 Jul 11;278(28):25933-9. Epub 2003 Apr 24. Erratum in: J Biol Chem. 2004 Jan 23;279(4):3119.


Shedding of plasma membrane proteins.

Arribas J, Merlos-Suárez A.

Curr Top Dev Biol. 2003;54:125-44. Review. No abstract available.


Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme.

Merlos-Suárez A, Ruiz-Paz S, Baselga J, Arribas J.

J Biol Chem. 2001 Dec 21;276(51):48510-7. Epub 2001 Oct 12.


Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.

Velasco G, Cal S, Merlos-Suárez A, Ferrando AA, Alvarez S, Nakano A, Arribas J, López-Otín C.

Cancer Res. 2000 Feb 15;60(4):877-82.


A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.

Fernández-Larrea J, Merlos-Suárez A, Ureña JM, Baselga J, Arribas J.

Mol Cell. 1999 Apr;3(4):423-33.


Mechanisms controlling the shedding of transmembrane molecules.

Merlos-Suárez A, Arribas J.

Biochem Soc Trans. 1999 Feb;27(2):243-6. Review. No abstract available.


Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing.

Merlos-Suárez A, Fernández-Larrea J, Reddy P, Baselga J, Arribas J.

J Biol Chem. 1998 Sep 18;273(38):24955-62.

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