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Proteomics reveals novel Protein associations with early endosomes in an Epidermal Growth Factor-dependent manner.

Gosney JA, Wilkey DW, Merchant ML, Ceresa BP.

J Biol Chem. 2018 Mar 9. pii: jbc.RA117.000632. doi: 10.1074/jbc.RA117.000632. [Epub ahead of print]


Automated microbeam observation environment for biological analysis-Custom portable environmental control applied to a vertical microbeam system.

England MJ, Bigelow AW, Merchant MJ, Velliou E, Welch D, Brenner DJ, Kirkby KJ.

Sens Actuators B Chem. 2017 Feb;239:1134-1143. doi: 10.1016/j.snb.2016.08.076. Epub 2016 Aug 16.


Antibacterial properties of plasma from the prairie rattlesnake (Crotalus viridis).

Baker SJ, Merchant ME.

Dev Comp Immunol. 2018 Mar 3;84:273-278. doi: 10.1016/j.dci.2018.03.002. [Epub ahead of print]


Risk Factors Including Age, Stage and Anatomic Location that Impact the Outcomes of Patients with Synovial Sarcoma.

Pan M, Merchant M.

Med Sci (Basel). 2018 Mar 6;6(1). pii: E21. doi: 10.3390/medsci6010021.


In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density.

Henthorn NT, Warmenhoven JW, Sotiropoulos M, Mackay RI, Kirkby NF, Kirkby KJ, Merchant MJ.

Sci Rep. 2018 Feb 8;8(1):2654. doi: 10.1038/s41598-018-21111-8.


Abstract ID: 171 A Monte Carlo study to reduce range uncertainty in proton beam therapy via prompt gamma-ray detection.

Panaino C, Taylor MJ, MacKay R, Merchant MJ, Price T, Pheonix B, Green S.

Phys Med. 2018 Jan;45 Suppl 1:S2. doi: 10.1016/j.ejmp.2017.11.027.


Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Merchant M, Moffat J, Schaefer G, Chan J, Wang X, Orr C, Cheng J, Hunsaker T, Shao L, Wang SJ, Wagle MC, Lin E, Haverty PM, Shahidi-Latham S, Ngu H, Solon M, Eastham-Anderson J, Koeppen H, Huang SA, Schwarz J, Belvin M, Kirouac D, Junttila MR.

PLoS One. 2018 Jan 25;13(1):e0192059. doi: 10.1371/journal.pone.0192059. eCollection 2018.


Insights into the Proteome of Gastrointestinal Stromal Tumors-Derived Exosomes Reveals New Potential Diagnostic Biomarkers.

Atay S, Wilkey DW, Milhem M, Merchant M, Godwin AK.

Mol Cell Proteomics. 2018 Mar;17(3):495-515. doi: 10.1074/mcp.RA117.000267. Epub 2017 Dec 14.


First-trimester vaginal microbiome diversity: A potential indicator of preterm delivery risk.

Haque MM, Merchant M, Kumar PN, Dutta A, Mande SS.

Sci Rep. 2017 Nov 23;7(1):16145. doi: 10.1038/s41598-017-16352-y.


Modelling direct DNA damage for gold nanoparticle enhanced proton therapy.

Sotiropoulos M, Henthorn NT, Warmenhoven JW, Mackay RI, Kirkby KJ, Merchant MJ.

Nanoscale. 2017 Nov 30;9(46):18413-18422. doi: 10.1039/c7nr07310k.


Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery.

Merchant ML, Rood IM, Deegens JKJ, Klein JB.

Nat Rev Nephrol. 2017 Dec;13(12):731-749. doi: 10.1038/nrneph.2017.148. Epub 2017 Oct 30. Review.


LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease.

Larsen CP, Trivin-Avillach C, Coles P, Collins AB, Merchant M, Ma H, Wilkey DW, Ambruzs JM, Messias NC, Cossey LN, Rosales IA, Wooldridge T, Walker PD, Colvin RB, Klein J, Salant DJ, Beck LH Jr..

J Am Soc Nephrol. 2018 Feb;29(2):644-653. doi: 10.1681/ASN.2017060664. Epub 2017 Oct 26.


Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Merchant M, Moffat J, Schaefer G, Chan J, Wang X, Orr C, Cheng J, Hunsaker T, Shao L, Wang SJ, Wagle MC, Lin E, Haverty PM, Shahidi-Latham S, Ngu H, Solon M, Eastham-Anderson J, Koeppen H, Huang SA, Schwarz J, Belvin M, Kirouac D, Junttila MR.

PLoS One. 2017 Oct 5;12(10):e0185862. doi: 10.1371/journal.pone.0185862. eCollection 2017. Erratum in: PLoS One. 2018 Jan 25;13(1):e0192059.


Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins.

Hudson SV, Dolin CE, Poole LG, Massey VL, Wilkey D, Beier JI, Merchant ML, Frieboes HB, Arteel GE.

Sci Rep. 2017 Sep 29;7(1):12444. doi: 10.1038/s41598-017-12691-y.


Knee Alignment Is Quantitatively Related to Periarticular Bone Morphometry and Density, Especially in Patients With Osteoarthritis.

Lo GH, Merchant MG, Driban JB, Duryea J, Price LL, Eaton CB, McAlindon TE.

Arthritis Rheumatol. 2018 Feb;70(2):212-221. doi: 10.1002/art.40325. Epub 2018 Jan 9.


Statistical analysis of ADCs and clinical biomarkers in detecting acute renal transplant rejection.

Hollis E, Shehata M, Abou El-Ghar M, Ghazal M, El-Diasty T, Merchant M, Switala AE, El-Baz A.

Br J Radiol. 2017 Dec;90(1080):20170125. doi: 10.1259/bjr.20170125. Epub 2017 Sep 13.


GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Romero FA, Murray J, Lai KW, Tsui V, Albrecht BK, An L, Beresini MH, de Leon Boenig G, Bronner SM, Chan EW, Chen KX, Chen Z, Choo EF, Clagg K, Clark K, Crawford TD, Cyr P, de Almeida Nagata D, Gascoigne KE, Grogan JL, Hatzivassiliou G, Huang W, Hunsaker TL, Kaufman S, Koenig SG, Li R, Li Y, Liang X, Liao J, Liu W, Ly J, Maher J, Masui C, Merchant M, Ran Y, Taylor AM, Wai J, Wang F, Wei X, Yu D, Zhu BY, Zhu X, Magnuson S.

J Med Chem. 2017 Nov 22;60(22):9162-9183. doi: 10.1021/acs.jmedchem.7b00796. Epub 2017 Sep 21.


Erratum: Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S.

NPJ Syst Biol Appl. 2017 Sep 4;3:25. doi: 10.1038/s41540-017-0026-z. eCollection 2017.


Voice Outcomes of Adults Diagnosed with Pediatric Vocal Fold Nodules and Impact of Speech Therapy.

Song BH, Merchant M, Schloegel L.

Otolaryngol Head Neck Surg. 2017 Nov;157(5):824-829. doi: 10.1177/0194599817726285. Epub 2017 Aug 22.


Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.

Jin L, Garcia J, Chan E, de la Cruz C, Segal E, Merchant M, Kharbanda S, Raisner R, Haverty PM, Modrusan Z, Ly J, Choo E, Kaufman S, Beresini MH, Romero FA, Magnuson S, Gascoigne KE.

Cancer Res. 2017 Oct 15;77(20):5564-5575. doi: 10.1158/0008-5472.CAN-17-0314. Epub 2017 Aug 17.


Nanodosimetric Simulation of Direct Ion-Induced DNA Damage Using Different Chromatin Geometry Models.

Henthorn NT, Warmenhoven JW, Sotiropoulos M, Mackay RI, Kirkby KJ, Merchant MJ.

Radiat Res. 2017 Dec;188(6):690-703. doi: 10.1667/RR14755.1. Epub 2017 Aug 9.


Crocodylian nuclear factor kappa B.

Merchant M, Morkotinis V, Hale A, White M, Moran C.

Comp Biochem Physiol B Biochem Mol Biol. 2017 Nov;213:28-34. doi: 10.1016/j.cbpb.2017.07.009. Epub 2017 Jul 29. Review.


Dynamic measurement of the optical properties of bovine enamel demineralization models using four-dimensional optical coherence tomography.

Aden A, Anthony A, Brigi C, Merchant MS, Siraj H, Tomlins PH.

J Biomed Opt. 2017 Jul 1;22(7):76020. doi: 10.1117/1.JBO.22.7.076020.


Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus.

Wheelock KM, Cai J, Looker HC, Merchant ML, Nelson RG, Fufaa GD, Weil EJ, Feldman HI, Vasan RS, Kimmel PL, Rovin BH, Mauer M, Klein JB; CKD Biomarkers Consortium.

PLoS One. 2017 Jul 10;12(7):e0180964. doi: 10.1371/journal.pone.0180964. eCollection 2017.


Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S.

NPJ Syst Biol Appl. 2017 Jun 2;3:14. doi: 10.1038/s41540-017-0016-1. eCollection 2017. Erratum in: NPJ Syst Biol Appl. 2017 Sep 4;3:25.


Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma.

Sahu N, Chan E, Chu F, Pham T, Koeppen H, Forrest W, Merchant M, Settleman J.

Mol Cancer Ther. 2017 Sep;16(9):1729-1738. doi: 10.1158/1535-7163.MCT-17-0009. Epub 2017 Jun 15.


Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues.

Majzner RG, Simon JS, Grosso JF, Martinez D, Pawel BR, Santi M, Merchant MS, Geoerger B, Hezam I, Marty V, Vielh P, Daugaard M, Sorensen PH, Mackall CL, Maris JM.

Cancer. 2017 Oct 1;123(19):3807-3815. doi: 10.1002/cncr.30724. Epub 2017 Jun 13.


Corrigendum to "Low dose ouabain stimulates Na-K ATPase 〈alpha〉 1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells" [Biochim. Biophys. Acta 1863/11 (2016) 2624-2636].

Ketchem CJ, Conner CD, Murray RD, DuPlessis M, Lederer ED, Wilkey D, Merchant M, Khundmiri SJ.

Biochim Biophys Acta. 2017 Oct;1864(10):1922. doi: 10.1016/j.bbamcr.2017.06.002. Epub 2017 Jun 13. No abstract available.


Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.

Shields KM, Tooley JG, Petkowski JJ, Wilkey DW, Garbett NC, Merchant ML, Cheng A, Schaner Tooley CE.

Protein Sci. 2017 Aug;26(8):1639-1652. doi: 10.1002/pro.3202. Epub 2017 Jun 11.


Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.

Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ.

Am J Physiol Cell Physiol. 2017 Aug 1;313(2):C197-C206. doi: 10.1152/ajpcell.00219.2016. Epub 2017 May 17.


Changes in the buccolingual inclination of first molars with growth in untreated subjects: A longitudinal study.

Sayania B, Merchant M, Josephs P, Chung CH.

Angle Orthod. 2017 Sep;87(5):681-687. doi: 10.2319/120716-878.1. Epub 2017 May 8.


Detection of a synthetic sex steroid in the American crocodile (Crocodylus acutus): Evidence for a novel environmental androgen.

Murray CM, Merchant M, Easter M, Padilla S, Garrigós DB, Sasa Marin M, Guyer C.

Chemosphere. 2017 Aug;180:125-129. doi: 10.1016/j.chemosphere.2017.04.020. Epub 2017 Apr 5.


Biomarkers of lupus nephritis histology and flare: deciphering the relevant amidst the noise.

Birmingham DJ, Merchant M, Waikar SS, Nagaraja H, Klein JB, Rovin BH.

Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i71-i79. doi: 10.1093/ndt/gfw300. Review.


Host FIH-Mediated Asparaginyl Hydroxylation of Translocated Legionella pneumophila Effectors.

Price C, Merchant M, Jones S, Best A, Von Dwingelo J, Lawrenz MB, Alam N, Schueler-Furman O, Kwaik YA.

Front Cell Infect Microbiol. 2017 Mar 6;7:54. doi: 10.3389/fcimb.2017.00054. eCollection 2017.


Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.

Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2486-E2493. doi: 10.1073/pnas.1615372114. Epub 2017 Mar 7.


MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, Deng Z, Kumar A, Zhang L, Merchant ML, Yan J, Miller DM, Zhang HG.

Nat Commun. 2017 Feb 17;8:14448. doi: 10.1038/ncomms14448.


Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis.

McLeish KR, Merchant ML, Creed TM, Tandon S, Barati MT, Uriarte SM, Ward RA.

J Leukoc Biol. 2017 Jul;102(1):19-29. doi: 10.1189/jlb.3HI0716-293RR. Epub 2017 Jan 17.


The hepatic "matrisome" responds dynamically to injury: Characterization of transitional changes to the extracellular matrix in mice.

Massey VL, Dolin CE, Poole LG, Hudson SV, Siow DL, Brock GN, Merchant ML, Wilkey DW, Arteel GE.

Hepatology. 2017 Mar;65(3):969-982. doi: 10.1002/hep.28918. Epub 2016 Dec 30.


Crapemyrtle Bark Scale: A New Threat for Crapemyrtles, a Popular Landscape Plant in the U.S.

Wang Z, Chen Y, Gu M, Vafaie E, Merchant M, Diaz R.

Insects. 2016 Dec 16;7(4). pii: E78. doi: 10.3390/insects7040078. Review.


Characterization of glomerular extracellular matrix by proteomic analysis of laser-captured microdissected glomeruli.

Hobeika L, Barati MT, Caster DJ, McLeish KR, Merchant ML.

Kidney Int. 2017 Feb;91(2):501-511. doi: 10.1016/j.kint.2016.09.044. Epub 2016 Dec 15.


SDF-1 Blockade Enhances Anti-VEGF Therapy of Glioblastoma and Can Be Monitored by MRI.

Deng L, Stafford JH, Liu SC, Chernikova SB, Merchant M, Recht L, Martin Brown J.

Neoplasia. 2017 Jan;19(1):1-7. doi: 10.1016/j.neo.2016.11.010. Epub 2016 Dec 7.


Over-expression of insulin-response element binding protein-1 (IRE-BP1) in mouse pancreatic islets increases expression of RACK1 and TCTP: Beta cell markers of high glucose sensitivity.

Villafuerte BC, Barati MT, Rane MJ, Isaacs S, Li M, Wilkey DW, Merchant ML.

Biochim Biophys Acta. 2017 Feb;1865(2):186-194. doi: 10.1016/j.bbapap.2016.10.015. Epub 2016 Nov 3.


Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.

Crawford TD, Romero FA, Lai KW, Tsui V, Taylor AM, de Leon Boenig G, Noland CL, Murray J, Ly J, Choo EF, Hunsaker TL, Chan EW, Merchant M, Kharbanda S, Gascoigne KE, Kaufman S, Beresini MH, Liao J, Liu W, Chen KX, Chen Z, Conery AR, Côté A, Jayaram H, Jiang Y, Kiefer JR, Kleinheinz T, Li Y, Maher J, Pardo E, Poy F, Spillane KL, Wang F, Wang J, Wei X, Xu Z, Xu Z, Yen I, Zawadzke L, Zhu X, Bellon S, Cummings R, Cochran AG, Albrecht BK, Magnuson S.

J Med Chem. 2016 Dec 8;59(23):10549-10563. Epub 2016 Sep 28.


Titanium Surgical Tacks: Are They Safe? Do They Work?

Shatkin-Margolis A, Merchant M, Margulies RU, Ramm O.

Female Pelvic Med Reconstr Surg. 2017 Jan/Feb;23(1):36-38.


Evidence that vitronectin is a potent migration-enhancing factor for cancer cells chaperoned by fibrinogen: a novel view of the metastasis of cancer cells to low-fibrinogen lymphatics and body cavities.

Schneider G, Bryndza E, Poniewierska-Baran A, Serwin K, Suszynska M, Sellers ZP, Merchant ML, Kaliappan A, Ratajczak J, Kucia M, Garbett NC, Ratajczak MZ.

Oncotarget. 2016 Oct 25;7(43):69829-69843. doi: 10.18632/oncotarget.12003.


Structure-function aspects of the Porphyromonas gingivalis tyrosine kinase Ptk1.

Liu C, Miller DP, Wang Y, Merchant M, Lamont RJ.

Mol Oral Microbiol. 2017 Aug;32(4):314-323. doi: 10.1111/omi.12173. Epub 2016 Sep 25.


Low dose ouabain stimulates NaK ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells.

Ketchem CJ, Conner CD, Murray RD, DuPlessis M, Lederer ED, Wilkey D, Merchant M, Khundmiri SJ.

Biochim Biophys Acta. 2016 Nov;1863(11):2624-2636. doi: 10.1016/j.bbamcr.2016.07.008. Epub 2016 Aug 3. Erratum in: Biochim Biophys Acta. 2017 Oct;1864(10 ):1922.


Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs.

Sahu N, Stephan JP, Cruz DD, Merchant M, Haley B, Bourgon R, Classon M, Settleman J.

Nat Commun. 2016 Aug 3;7:12351. doi: 10.1038/ncomms12351.


Methyltestosterone alters sex determination in the American alligator (Alligator mississippiensis).

Murray CM, Easter M, Merchant M, Rheubert JL, Wilson KA, Cooper A, Mendonça M, Wibbels T, Marin MS, Guyer C.

Gen Comp Endocrinol. 2016 Sep 15;236:63-69. doi: 10.1016/j.ygcen.2016.07.007. Epub 2016 Jul 9.


Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.

Shukla N, Somwar R, Smith RS, Ambati S, Munoz S, Merchant M, D'Arcy P, Wang X, Kobos R, Antczak C, Bhinder B, Shum D, Radu C, Yang G, Taylor BS, Ng CK, Weigelt B, Khodos I, de Stanchina E, Reis-Filho JS, Ouerfelli O, Linder S, Djaballah H, Ladanyi M.

Cancer Res. 2016 Aug 1;76(15):4525-34. doi: 10.1158/0008-5472.CAN-16-1040. Epub 2016 Jun 2.

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