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Items: 8

1.

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Mar 26. doi: 10.1158/2159-8290.CD-17-0867. [Epub ahead of print]

PMID:
29581176
2.

Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma.

Naschberger E, Liebl A, Schellerer VS, Schütz M, Britzen-Laurent N, Kölbel P, Schaal U, Haep L, Regensburger D, Wittmann T, Klein-Hitpass L, Rau TT, Dietel B, Méniel VS, Clarke AR, Merkel S, Croner RS, Hohenberger W, Stürzl M.

J Clin Invest. 2016 Nov 1;126(11):4187-4204. doi: 10.1172/JCI78260. Epub 2016 Oct 10.

3.

E-cadherin can limit the transforming properties of activating β-catenin mutations.

Huels DJ, Ridgway RA, Radulescu S, Leushacke M, Campbell AD, Biswas S, Leedham S, Serra S, Chetty R, Moreaux G, Parry L, Matthews J, Song F, Hedley A, Kalna G, Ceteci F, Reed KR, Meniel VS, Maguire A, Doyle B, Söderberg O, Barker N, Watson A, Larue L, Clarke AR, Sansom OJ.

EMBO J. 2015 Sep 14;34(18):2321-33. doi: 10.15252/embj.201591739. Epub 2015 Aug 3.

4.

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

Hammoudi A, Song F, Reed KR, Jenkins RE, Meniel VS, Watson AJ, Pritchard DM, Clarke AR, Jenkins JR.

Biochem Biophys Res Commun. 2013 Oct 25;440(3):364-70. doi: 10.1016/j.bbrc.2013.08.076. Epub 2013 Aug 31.

PMID:
23998936
5.

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M.

PLoS Genet. 2010 Jan 15;6(1):e1000816. doi: 10.1371/journal.pgen.1000816.

6.

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.

Reed KR, Athineos D, Meniel VS, Wilkins JA, Ridgway RA, Burke ZD, Muncan V, Clarke AR, Sansom OJ.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18919-23. doi: 10.1073/pnas.0805778105. Epub 2008 Nov 24. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1168.

7.

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.

Reed KR, Meniel VS, Marsh V, Cole A, Sansom OJ, Clarke AR.

BMC Cancer. 2008 Jun 5;8:162. doi: 10.1186/1471-2407-8-162.

8.

Myc deletion rescues Apc deficiency in the small intestine.

Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR.

Nature. 2007 Apr 5;446(7136):676-9. Epub 2007 Mar 21.

PMID:
17377531

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