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Items: 1 to 50 of 86

1.

IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer.

Zhang Y, Wester L, He J, Geiger T, Moerkens M, Siddappa R, Helmijr JA, Timmermans MM, Look MP, van Deurzen CHM, Martens JWM, Pont C, de Graauw M, Danen EHJ, Berns EMJJ, Meerman JHN, Jansen MPHM, van de Water B.

Oncogene. 2018 Apr;37(14):1869-1884. doi: 10.1038/s41388-017-0027-9. Epub 2018 Jan 22.

PMID:
29353882
2.

Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues.

Di Z, Klop MJ, Rogkoti VM, Le Dévédec SE, van de Water B, Verbeek FJ, Price LS, Meerman JH.

PLoS One. 2014 Oct 7;9(10):e109688. doi: 10.1371/journal.pone.0109688. eCollection 2014.

3.
4.

β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer.

Truong HH, Xiong J, Ghotra VP, Nirmala E, Haazen L, Le Dévédec SE, Balcioğlu HE, He S, Snaar-Jagalska BE, Vreugdenhil E, Meerman JH, van de Water B, Danen EH.

Sci Signal. 2014 Feb 11;7(312):ra15. doi: 10.1126/scisignal.2004751.

PMID:
24518294
5.

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.

Carreras Puigvert J, von Stechow L, Siddappa R, Pines A, Bahjat M, Haazen LC, Olsen JV, Vrieling H, Meerman JH, Mullenders LH, van de Water B, Danen EH.

Sci Signal. 2013 Jan 22;6(259):ra5. doi: 10.1126/scisignal.2003208.

PMID:
23354688
6.

Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening.

Di Z, Herpers B, Fredriksson L, Yan K, van de Water B, Verbeek FJ, Meerman JH.

PLoS One. 2012;7(12):e52337. doi: 10.1371/journal.pone.0052337. Epub 2012 Dec 27.

7.

Temporal and functional dynamics of the transcriptome during nerve growth factor-induced differentiation.

Dijkmans TF, van Hooijdonk LW, Schouten TG, Kamphorst JT, Vellinga AC, Meerman JH, Fitzsimons CP, de Kloet ER, Vreugdenhil E.

J Neurochem. 2008 Jun 1;105(6):2388-403. doi: 10.1111/j.1471-4159.2008.05338.x.

8.

Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening.

Van Liempd SM, Kool J, Meerman JH, Irth H, Vermeulen NP.

Chem Res Toxicol. 2007 Dec;20(12):1825-32. Epub 2007 Nov 1.

PMID:
17975887
9.

Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures.

Kool J, Eggink M, van Rossum H, van Liempd SM, van Elswijk DA, Irth H, Commandeur JN, Meerman JH, Vermeulen NP.

J Biomol Screen. 2007 Apr;12(3):396-405. Epub 2007 Mar 22.

PMID:
17379858
10.

Screening the oxidative potential of several mono- and di-halogenated biphenyls and biphenyl ethers in rat hepatocytes.

Gurer-Orhan H, Orhan H, Vermeulen NP, Meerman JH.

Comb Chem High Throughput Screen. 2006 Jul;9(6):449-54.

PMID:
16842226
11.

Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen.

Kool J, Ramautar R, van Liempd SM, Beckman J, de Kanter FJ, Meerman JH, Schenk T, Irth H, Commandeur JN, Vermeulen NP.

J Med Chem. 2006 Jun 1;49(11):3287-92.

PMID:
16722647
12.

Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes.

Orhan H, Gurer-Orhan H, Vriese E, Vermeulen NP, Meerman JH.

Toxicol In Vitro. 2006 Sep;20(6):1005-13. Epub 2006 Feb 20.

PMID:
16488111
13.

Bioactivation of dibrominated biphenyls by cytochrome P450 activity to metabolites with estrogenic activity and estrogen sulfotransferase inhibition capacity.

van Lipzig MM, Commandeur JN, de Kanter FJ, Damsten MC, Vermeulen NP, Maat E, Groot EJ, Brouwer A, Kester MH, Visser TJ, Meerman JH.

Chem Res Toxicol. 2005 Nov;18(11):1691-700.

PMID:
16300378
14.

The chemical interaction between the estrogen receptor and monohydroxybenzo[a]pyrene derivatives studied by fluorescence line-narrowing spectroscopy.

Bader AN, van Dongen MM, van Lipzig MM, Kool J, Meerman JH, Ariese F, Gooijer C.

Chem Res Toxicol. 2005 Sep;18(9):1405-12.

PMID:
16167832
15.

Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.

Kool J, van Liempd SM, Ramautar R, Schenk T, Meerman JH, Irth H, Commandeur JN, Vermeulen NP.

J Biomol Screen. 2005 Aug;10(5):427-36.

PMID:
16093552
16.

Development and validation of a microsomal online cytochrome P450 bioreactor coupled to solid-phase extraction and reversed-phase liquid chromatography.

van Liempd SM, Kool J, Reinen J, Schenk T, Meerman JH, Irth H, Vermeulen NP.

J Chromatogr A. 2005 May 20;1075(1-2):205-12.

PMID:
15974134
18.

Evaluation of a multi-parameter biomarker set for oxidative damage in man: increased urinary excretion of lipid, protein and DNA oxidation products after one hour of exercise.

Orhan H, van Holland B, Krab B, Moeken J, Vermeulen NP, Hollander P, Meerman JH.

Free Radic Res. 2004 Dec;38(12):1269-79.

PMID:
15763951
19.

Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.

van Lipzig MM, Vermeulen NP, Gusinu R, Legler J, Frank H, Seidel A, Meerman JH.

Environ Toxicol Pharmacol. 2005 Jan;19(1):41-55. doi: 10.1016/j.etap.2004.03.010.

PMID:
21783461
20.

Prediction of ligand binding affinity and orientation of xenoestrogens to the estrogen receptor by molecular dynamics simulations and the linear interaction energy method.

van Lipzig MM, ter Laak AM, Jongejan A, Vermeulen NP, Wamelink M, Geerke D, Meerman JH.

J Med Chem. 2004 Feb 12;47(4):1018-30.

PMID:
14761204
21.

Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography-tandem mass spectrometry as non-invasive biomarkers for oxidative damage.

Orhan H, Vermeulen NP, Tump C, Zappey H, Meerman JH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 25;799(2):245-54.

PMID:
14670743
22.

Blockage of transcription as a trigger for p53 accumulation by 2-acetylaminofluorene DNA-adducts.

van Gijssel HE, Mullenders LH, van Oosterwijk MF, Meerman JH.

Life Sci. 2003 Aug 22;73(14):1759-71.

PMID:
12888115
23.
24.

Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays.

Murk AJ, Legler J, van Lipzig MM, Meerman JH, Belfroid AC, Spenkelink A, van der Burg B, Rijs GB, Vethaak D.

Environ Toxicol Chem. 2002 Jan;21(1):16-23.

PMID:
11808534
25.

Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin.

Venhorst J, Onderwater RC, Meerman JH, Vermeulen NP, Commandeur JN.

Eur J Pharm Sci. 2000 Dec;12(2):151-8.

PMID:
11102743
26.

Simulations of the estrogen receptor ligand-binding domain: affinity of natural ligands and xenoestrogens.

Oostenbrink BC, Pitera JW, van Lipzig MM, Meerman JH, van Gunsteren WF.

J Med Chem. 2000 Nov 30;43(24):4594-605. Erratum in: J Med Chem 2001 Mar 29;44(7):1124.

PMID:
11101351
27.

Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity.

Venhorst J, Onderwater RC, Meerman JH, Commandeur JN, Vermeulen NP.

Drug Metab Dispos. 2000 Dec;28(12):1524-32.

28.

Loss of nuclear p53 protein in preneoplastic rat hepatocytes is accompanied by Mdm2 and Bcl-2 overexpression and by defective response to DNA damage in vivo.

Van Gijssel HE, Ohlson LC, Torndal UB, Mulder GJ, Eriksson LC, Porsch-Hällström I, Meerman JH.

Hepatology. 2000 Oct;32(4 Pt 1):701-10.

PMID:
11003613
29.
30.

Urinary excretion of biomarkers for radical-induced damage in rats treated with NDMA or diquat and the effects of calcium carbimide co-administration.

de Zwart LL, Vermeulen NP, Hermanns RC, Commandeur JN, Salemink PJ, Meerman JH.

Chem Biol Interact. 1999 Jan 29;117(2):151-72.

PMID:
10190574
31.

Biomarkers of free radical damage applications in experimental animals and in humans.

de Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP.

Free Radic Biol Med. 1999 Jan;26(1-2):202-26. Review.

PMID:
9890655
32.

Lack of mammalian mutagenicity of the potent bacterial mutagen tris(2,3-dibromopropyl) phosphate and its metabolite 2-bromoacrolein.

van Beerendonk GJ, Klein JC, Tijdens RB, Lichtenauer-Kaligis EG, Tasseron-de Jong JG, Meerman JH.

Mutat Res. 1998 Jul 31;415(3):201-11.

PMID:
9714806
33.

Urinary excretion of biomarkers of oxidative kidney damage induced by ferric nitrilotriacetate.

Hermanns RC, de Zwart LL, Salemink PJ, Commandeur JN, Vermeulen NP, Meerman JH.

Toxicol Sci. 1998 Jun;43(2):241-9.

PMID:
9710965
35.

Evaluation of urinary biomarkers for radical-induced liver damage in rats treated with carbon tetrachloride.

de Zwart LL, Hermanns RC, Meerman JH, Commandeur JN, Salemink PJ, Vermeulen NP.

Toxicol Appl Pharmacol. 1998 Jan;148(1):71-82.

PMID:
9465266
36.

Excretion of multiple urinary biomarkers for radical induced damage in rats treated with three different nephrotoxic compounds.

De Zwart LL, Hermanns RC, Meerman JH, Commandeur JN, Salem Ink PJ, Vermeulen NP.

Biomarkers. 1998;3(4-5):347-65. doi: 10.1080/135475098231156.

PMID:
23899362
37.

Electrochemical detection and quantification of the acetylated and deacetylated C8-deoxyguanosine DNA adducts induced by 2-acetylaminofluorene.

Bol SA, de Groot AJ, Tijdens RB, Meerman JH, Mullenders LH, van Zeeland AA.

Anal Biochem. 1997 Aug 15;251(1):24-31.

PMID:
9300078
38.

Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection.

De Zwart LL, Venhorst J, Groot M, Commandeur JN, Hermanns RC, Meerman JH, Van Baar BL, Vermeulen NP.

J Chromatogr B Biomed Sci Appl. 1997 Jul 4;694(2):277-87.

PMID:
9252041
39.
40.

Disposition in rat of [2-3H]-trans-4-hydroxy-2,3-nonenal, a product of lipid peroxidation.

de Zwart LL, Hermanns RC, Meerman JH, Commandeur JN, Vermeulen NP.

Xenobiotica. 1996 Oct;26(10):1087-100.

PMID:
8905921
41.

Deuterium isotope effect on the metabolism of the flame retardant tris(2,3-dibromopropyl) phosphate in the isolated perfused rat liver.

Van Beerendonk GJ, Pearson PG, Meijer DK, Mulder GJ, Nelson SD, Meerman JH.

Fundam Appl Toxicol. 1995 Nov;28(1):111-7.

PMID:
8566475
42.

Comparative toxicity of (+)-(R)- and (-)-(S)-1,2-dibromo-3-chloropropane.

Kouzi SA, Søderlund EJ, Dybing E, Meerman JH, Nelson SD.

Chirality. 1995;7(5):359-64.

PMID:
7495641
43.

Metabolism and genotoxicity of the halogenated alkyl compound tris(2,3-dibromopropyl)phosphate.

van Beerendonk GJ, Nelson SD, Meerman JH.

Hum Exp Toxicol. 1994 Dec;13(12):861-5. Review.

PMID:
7718306
44.

Metabolic activation routes of arylamines and their genotoxic effects.

Meerman JH, van de Poll ML.

Environ Health Perspect. 1994 Oct;102 Suppl 6:153-9.

45.

Sulphation of N-hydroxy-4-aminobiphenyl and N-hydroxy-4-acetylaminobiphenyl by human foetal and neonatal sulphotransferase.

Gilissen RA, Hume R, Meerman JH, Coughtrie MW.

Biochem Pharmacol. 1994 Aug 17;48(4):837-40.

PMID:
8080456
46.
47.

Genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate in the rat and Drosophila: effects of deuterium substitution.

van Beerendonk GJ, Nivard MJ, Vogel EW, Nelson SD, Meerman JH.

Carcinogenesis. 1994 Jun;15(6):1197-202.

PMID:
8020156
48.

Blocking of in vitro DNA replication by deoxycytidine adducts of the mutagen and clastogen 2-bromoacrolein.

van Beerendonk GJ, van Gog FB, Vrieling H, Pearson PG, Nelson SD, Meerman JH.

Cancer Res. 1994 Feb 1;54(3):679-84.

49.

Sulfation of aromatic hydroxamic acids and hydroxylamines by multiple forms of human liver sulfotransferases.

Gilissen RA, Bamforth KJ, Stavenuiter JF, Coughtrie MW, Meerman JH.

Carcinogenesis. 1994 Jan;15(1):39-45.

PMID:
8293546
50.

Formation of thymidine, cyclic deoxyguanosine and cyclic deoxycytidine adducts of the mutagen 2-bromoacrolein and their role in mutagenicity and clastogenicity.

Meerman JH, van Beerendonk GJ, Nelson SD.

IARC Sci Publ. 1994;(125):449-52. Review. No abstract available.

PMID:
7806337

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