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Items: 1 to 50 of 195

1.

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

Maia ARR, Linder S, Song JY, Vaarting C, Boon U, Pritchard CEJ, Velds A, Huijbers IJ, van Tellingen O, Jonkers J, Medema RH.

Br J Cancer. 2018 May 8. doi: 10.1038/s41416-018-0081-2. [Epub ahead of print]

PMID:
29736010
2.

SUMO targets the APC/C to regulate transition from metaphase to anaphase.

Eifler K, Cuijpers SAG, Willemstein E, Raaijmakers JA, El Atmioui D, Ovaa H, Medema RH, Vertegaal ACO.

Nat Commun. 2018 Mar 16;9(1):1119. doi: 10.1038/s41467-018-03486-4.

3.

Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation.

Halim VA, García-Santisteban I, Warmerdam DO, van den Broek B, Heck AJR, Mohammed S, Medema RH.

Mol Cell Proteomics. 2018 Feb 8. pii: mcp.RA118.000652. doi: 10.1074/mcp.RA118.000652. [Epub ahead of print]

4.

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

Raaijmakers JA, van Heesbeen RGHP, Blomen VA, Janssen LME, van Diemen F, Brummelkamp TR, Medema RH.

Cell Rep. 2018 Feb 6;22(6):1424-1438. doi: 10.1016/j.celrep.2018.01.034.

5.

TUBB3 overexpression has a negligible effect on the sensitivity to taxol in cultured cell lines.

Tame MA, Manjón AG, Belokhvostova D, Raaijmakers JA, Medema RH.

Oncotarget. 2017 May 10;8(42):71536-71547. doi: 10.18632/oncotarget.17740. eCollection 2017 Sep 22.

6.

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

van der Vaart B, Fischböck J, Mieck C, Pichler P, Mechtler K, Medema RH, Westermann S.

J Cell Biol. 2017 Nov 6;216(11):3471-3484. doi: 10.1083/jcb.201606080. Epub 2017 Sep 29.

7.

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

Hiruma Y, Koch A, Hazraty N, Tsakou F, Medema RH, Joosten RP, Perrakis A.

J Biol Chem. 2017 Sep 1;292(35):14496-14504. doi: 10.1074/jbc.M117.783555. Epub 2017 Jul 18.

PMID:
28726638
8.

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies.

Soto M, Raaijmakers JA, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F, Medema RH.

Cell Rep. 2017 Jun 20;19(12):2423-2431. doi: 10.1016/j.celrep.2017.05.055.

9.

ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.

Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, Helleday T, Medema RH, Macurek L, Lindqvist A.

EMBO J. 2017 Jul 14;36(14):2161-2176. doi: 10.15252/embj.201696082. Epub 2017 Jun 12.

PMID:
28607002
10.

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.

Haarhuis JHI, van der Weide RH, Blomen VA, Yáñez-Cuna JO, Amendola M, van Ruiten MS, Krijger PHL, Teunissen H, Medema RH, van Steensel B, Brummelkamp TR, de Wit E, Rowland BD.

Cell. 2017 May 4;169(4):693-707.e14. doi: 10.1016/j.cell.2017.04.013.

11.

Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines.

Libouban MAA, de Roos JADM, Uitdehaag JCM, Willemsen-Seegers N, Mainardi S, Dylus J, de Man J, Tops B, Meijerink JPP, Storchová Z, Buijsman RC, Medema RH, Zaman GJR.

Oncotarget. 2017 Jun 13;8(24):38309-38325. doi: 10.18632/oncotarget.16213.

12.

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.

Sansregret L, Patterson JO, Dewhurst S, López-García C, Koch A, McGranahan N, Chao WCH, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C.

Cancer Discov. 2017 Feb;7(2):218-233. doi: 10.1158/2159-8290.CD-16-0645. Epub 2017 Jan 9.

13.

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJA, de Rink I, Medema RH, Giepmans BNG, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.

Cancer Cell. 2016 Dec 12;30(6):986. doi: 10.1016/j.ccell.2016.11.008. No abstract available.

14.

Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora.

Bruinsma W, Aprelia M, García-Santisteban I, Kool J, Xu YJ, Medema RH.

Oncogene. 2017 Mar 30;36(13):1840-1848. doi: 10.1038/onc.2016.347. Epub 2016 Oct 10.

15.

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJ, de Rink I, Medema RH, Giepmans BN, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.

Cancer Cell. 2016 Oct 10;30(4):548-562. doi: 10.1016/j.ccell.2016.08.016. Epub 2016 Sep 29. Erratum in: Cancer Cell. 2016 Dec 12;30(6):986.

16.

HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets.

Omta WA, van Heesbeen RG, Pagliero RJ, van der Velden LM, Lelieveld D, Nellen M, Kramer M, Yeong M, Saeidi AM, Medema RH, Spruit M, Brinkkemper S, Klumperman J, Egan DA.

Assay Drug Dev Technol. 2016 Oct;14(8):439-452. Epub 2016 Sep 16.

PMID:
27636821
17.

Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.

Feringa FM, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, Medema RH.

Nat Commun. 2016 Aug 26;7:12618. doi: 10.1038/ncomms12618.

18.

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment.

Kongsema M, Zona S, Karunarathna U, Cabrera E, Man EP, Yao S, Shibakawa A, Khoo US, Medema RH, Freire R, Lam EW.

Oncogenesis. 2016 Aug 15;5(8):e252. doi: 10.1038/oncsis.2016.57.

19.

Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation.

van Heesbeen RGHP, Raaijmakers JA, Tanenbaum ME, Halim VA, Lelieveld D, Lieftink C, Heck AJR, Egan DA, Medema RH.

Chromosoma. 2017 Aug;126(4):473-486. doi: 10.1007/s00412-016-0607-4. Epub 2016 Jun 29.

20.

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

Vecchione L, Gambino V, Raaijmakers J, Schlicker A, Fumagalli A, Russo M, Villanueva A, Beerling E, Bartolini A, Mollevi DG, El-Murr N, Chiron M, Calvet L, Nicolazzi C, Combeau C, Henry C, Simon IM, Tian S, in 't Veld S, D'ario G, Mainardi S, Beijersbergen RL, Lieftink C, Linn S, Rumpf-Kienzl C, Delorenzi M, Wessels L, Salazar R, Di Nicolantonio F, Bardelli A, van Rheenen J, Medema RH, Tejpar S, Bernards R.

Cell. 2016 Apr 7;165(2):317-30. doi: 10.1016/j.cell.2016.02.059.

21.

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats.

Warmerdam DO, van den Berg J, Medema RH.

Cell Rep. 2016 Mar 22;14(11):2519-27. doi: 10.1016/j.celrep.2016.02.048. Epub 2016 Mar 10.

22.

Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest.

Bruinsma W, van den Berg J, Aprelia M, Medema RH.

EMBO Rep. 2016 May;17(5):659-70. doi: 10.15252/embr.201540767. Epub 2016 Mar 1.

23.

Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening.

Elbatsh AMO, Haarhuis JHI, Petela N, Chapard C, Fish A, Celie PH, Stadnik M, Ristic D, Wyman C, Medema RH, Nasmyth K, Rowland BD.

Mol Cell. 2016 Feb 18;61(4):575-588. doi: 10.1016/j.molcel.2016.01.025.

24.

Chromosome misalignments induce spindle-positioning defects.

Tame MA, Raaijmakers JA, Afanasyev P, Medema RH.

EMBO Rep. 2016 Mar;17(3):317-25. doi: 10.15252/embr.201541143. Epub 2016 Feb 4.

25.

Molecular basis underlying resistance to Mps1/TTK inhibitors.

Koch A, Maia A, Janssen A, Medema RH.

Oncogene. 2016 May 12;35(19):2518-28. doi: 10.1038/onc.2015.319. Epub 2015 Sep 14.

26.

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.

Maia AR, de Man J, Boon U, Janssen A, Song JY, Omerzu M, Sterrenburg JG, Prinsen MB, Willemsen-Seegers N, de Roos JA, van Doornmalen AM, Uitdehaag JC, Kops GJ, Jonkers J, Buijsman RC, Zaman GJ, Medema RH.

Ann Oncol. 2015 Oct;26(10):2180-92. doi: 10.1093/annonc/mdv293. Epub 2015 Jul 7.

PMID:
26153498
27.

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance.

Karunarathna U, Kongsema M, Zona S, Gong C, Cabrera E, Gomes AR, Man EP, Khongkow P, Tsang JW, Khoo US, Medema RH, Freire R, Lam EW.

Oncogene. 2016 Mar 17;35(11):1433-44. doi: 10.1038/onc.2015.208. Epub 2015 Jul 6.

28.

Spatial Separation of Plk1 Phosphorylation and Activity.

Bruinsma W, Aprelia M, Kool J, Macurek L, Lindqvist A, Medema RH.

Front Oncol. 2015 Jun 10;5:132. doi: 10.3389/fonc.2015.00132. eCollection 2015.

29.

The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA.

Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24.

30.

Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1.

Maia AF, Tanenbaum ME, Galli M, Lelieveld D, Egan DA, Gassmann R, Sunkel CE, van den Heuvel S, Medema RH.

Sci Data. 2015 May 12;2:150020. doi: 10.1038/sdata.2015.20. eCollection 2015.

31.

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance.

Khongkow P, Gomes AR, Gong C, Man EP, Tsang JW, Zhao F, Monteiro LJ, Coombes RC, Medema RH, Khoo US, Lam EW.

Oncogene. 2016 Feb 25;35(8):990-1002. doi: 10.1038/onc.2015.152. Epub 2015 May 11.

32.

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle.

Shaltiel IA, Krenning L, Bruinsma W, Medema RH.

J Cell Sci. 2015 Feb 15;128(4):607-20. doi: 10.1242/jcs.163766. Epub 2015 Jan 20. Review.

33.

Enter the nucleus to exit the cycle.

Krenning L, Medema RH.

Cell Cycle. 2014;13(17):2651-2. doi: 10.4161/15384101.2014.948783. No abstract available.

34.

USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.

Kim J, D'Annibale S, Magliozzi R, Low TY, Jansen P, Shaltiel IA, Mohammed S, Heck AJ, Medema RH, Guardavaccaro D.

Mol Cell Biol. 2014 Nov 15;34(22):4177-85. doi: 10.1128/MCB.00530-14. Epub 2014 Sep 8.

35.

Balanced activity of three mitotic motors is required for bipolar spindle assembly and chromosome segregation.

van Heesbeen RG, Tanenbaum ME, Medema RH.

Cell Rep. 2014 Aug 21;8(4):948-56. doi: 10.1016/j.celrep.2014.07.015. Epub 2014 Aug 7.

36.

A growing role for Aurora A in chromosome instability.

Maia AR, van Heesbeen RG, Medema RH.

Nat Cell Biol. 2014 Aug;16(8):739-41. doi: 10.1038/ncb3018.

PMID:
25082197
37.

Genomic stability: boosting cohesion corrects CIN.

Elbatsh AMO, Medema RH, Rowland BD.

Curr Biol. 2014 Jun 16;24(12):R571-R573. doi: 10.1016/j.cub.2014.05.009.

38.

Transient activation of p53 in G2 phase is sufficient to induce senescence.

Krenning L, Feringa FM, Shaltiel IA, van den Berg J, Medema RH.

Mol Cell. 2014 Jul 3;55(1):59-72. doi: 10.1016/j.molcel.2014.05.007. Epub 2014 Jun 5.

39.

Function and regulation of dynein in mitotic chromosome segregation.

Raaijmakers JA, Medema RH.

Chromosoma. 2014 Oct;123(5):407-22. doi: 10.1007/s00412-014-0468-7. Epub 2014 May 29. Review.

PMID:
24871939
40.

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle.

Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJ, Voest EE, Medema RH.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7313-8. doi: 10.1073/pnas.1322021111. Epub 2014 Apr 7.

41.

Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.

Schimmel J, Eifler K, Sigurðsson JO, Cuijpers SA, Hendriks IA, Verlaan-de Vries M, Kelstrup CD, Francavilla C, Medema RH, Olsen JV, Vertegaal AC.

Mol Cell. 2014 Mar 20;53(6):1053-66. doi: 10.1016/j.molcel.2014.02.001. Epub 2014 Feb 27.

42.

Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the S/G2 transition.

Akopyan K, Silva Cascales H, Hukasova E, Saurin AT, Müllers E, Jaiswal H, Hollman DA, Kops GJ, Medema RH, Lindqvist A.

Mol Cell. 2014 Mar 6;53(5):843-53. doi: 10.1016/j.molcel.2014.01.031. Epub 2014 Feb 27.

43.

Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning.

Tame MA, Raaijmakers JA, van den Broek B, Lindqvist A, Jalink K, Medema RH.

Cell Cycle. 2014;13(7):1162-70. doi: 10.4161/cc.28031. Epub 2014 Feb 10.

44.

Delaying mitotic exit downregulates FLIP expression and strongly sensitizes tumor cells to TRAIL.

Sánchez-Pérez T, Medema RH, López-Rivas A.

Oncogene. 2015 Jan 29;34(5):661-9. doi: 10.1038/onc.2013.601. Epub 2014 Feb 3.

PMID:
24488010
45.

Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis.

Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Medema RH, Hung MC, Huang S.

J Clin Invest. 2014 Feb;124(2):564-79. doi: 10.1172/JCI71104. Epub 2014 Jan 2.

46.

Bora and Aurora-A continue to activate Plk1 in mitosis.

Bruinsma W, Macurek L, Freire R, Lindqvist A, Medema RH.

J Cell Sci. 2014 Feb 15;127(Pt 4):801-11. doi: 10.1242/jcs.137216. Epub 2013 Dec 11.

47.

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.

Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes AR, Yagüe E, Monteiro LJ, Kongsema M, Zona S, Man EP, Tsang JW, Coombes RC, Wu KJ, Khoo US, Medema RH, Freire R, Lam EW.

Oncogene. 2014 Aug 7;33(32):4144-55. doi: 10.1038/onc.2013.457. Epub 2013 Oct 21.

48.

WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy.

Haarhuis JH, Elbatsh AM, van den Broek B, Camps D, Erkan H, Jalink K, Medema RH, Rowland BD.

Curr Biol. 2013 Oct 21;23(20):2071-7. doi: 10.1016/j.cub.2013.09.003. Epub 2013 Sep 19.

49.

Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation.

van Heesbeen RG, Raaijmakers JA, Tanenbaum ME, Medema RH.

Commun Integr Biol. 2013 May 1;6(3):e23841. doi: 10.4161/cib.23841.

50.

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.

Kleiblova P, Shaltiel IA, Benada J, Ševčík J, Pecháčková S, Pohlreich P, Voest EE, Dundr P, Bartek J, Kleibl Z, Medema RH, Macurek L.

J Cell Biol. 2013 May 13;201(4):511-21. doi: 10.1083/jcb.201210031. Epub 2013 May 6.

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