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Items: 1 to 50 of 117

1.

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.

Rocha EM, Smith GA, Park E, Cao H, Brown E, Hayes MA, Beagan J, McLean JR, Izen SC, Perez-Torres E, Hallett PJ, Isacson O.

Neurobiol Dis. 2015 Oct;82:495-503. doi: 10.1016/j.nbd.2015.09.009. Epub 2015 Sep 25.

2.

Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis.

Xiao S, MacNair L, McGoldrick P, McKeever PM, McLean JR, Zhang M, Keith J, Zinman L, Rogaeva E, Robertson J.

Ann Neurol. 2015 Oct;78(4):568-83. doi: 10.1002/ana.24469. Epub 2015 Aug 29.

PMID:
26174152
3.

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.

Rocha EM, Smith GA, Park E, Cao H, Graham AR, Brown E, McLean JR, Hayes MA, Beagan J, Izen SC, Perez-Torres E, Hallett PJ, Isacson O.

Antioxid Redox Signal. 2015 Aug 20;23(6):550-64. doi: 10.1089/ars.2015.6307. Epub 2015 Jul 29.

4.

Jump from pre-mutation to pathologic expansion in C9orf72.

Xi Z, van Blitterswijk M, Zhang M, McGoldrick P, McLean JR, Yunusova Y, Knock E, Moreno D, Sato C, McKeever PM, Schneider R, Keith J, Petrescu N, Fraser P, Tartaglia MC, Baker MC, Graff-Radford NR, Boylan KB, Dickson DW, Mackenzie IR, Rademakers R, Robertson J, Zinman L, Rogaeva E.

Am J Hum Genet. 2015 Jun 4;96(6):962-70. doi: 10.1016/j.ajhg.2015.04.016. Epub 2015 May 21.

5.

A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).

Smith GA, Rocha EM, Rooney T, Barneoud P, McLean JR, Beagan J, Osborn T, Coimbra M, Luo Y, Hallett PJ, Isacson O.

PLoS One. 2015 Mar 27;10(3):e0121072. doi: 10.1371/journal.pone.0121072. eCollection 2015.

6.

A two-hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25-interacting protein, SIP30.

Gentil BJ, McLean JR, Xiao S, Zhao B, Durham HD, Robertson J.

J Neurochem. 2014 Dec;131(5):588-601. doi: 10.1111/jnc.12928. Epub 2014 Sep 4.

7.

An efficient fluorescent protein-based multifunctional affinity purification approach in mammalian cells.

Ma H, McLean JR, Gould KL, McCollum D.

Methods Mol Biol. 2014;1177:175-91. doi: 10.1007/978-1-4939-1034-2_14.

PMID:
24943323
8.

ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.

McLean JR, Smith GA, Rocha EM, Osborn TM, Dib S, Hayes MA, Beagan JA, Brown TB, Lawson TF, Hallett PJ, Robertson J, Isacson O.

Exp Neurol. 2014 Nov;261:217-29. doi: 10.1016/j.expneurol.2014.05.024. Epub 2014 Jun 4.

PMID:
24907400
9.

Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection.

McLean JR, Smith GA, Rocha EM, Hayes MA, Beagan JA, Hallett PJ, Isacson O.

Neurosci Lett. 2014 Jul 25;576:73-8. doi: 10.1016/j.neulet.2014.05.044. Epub 2014 May 29.

10.

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.

Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJ.

Hum Mol Genet. 2014 Sep 1;23(17):4510-27. doi: 10.1093/hmg/ddu166. Epub 2014 Apr 12.

PMID:
24728190
11.

The utility of stroke volume variability as a predictor of fluid responsiveness in critically ill children: a pilot study.

McLean JR, Inwald DP.

Intensive Care Med. 2014 Feb;40(2):288-9. doi: 10.1007/s00134-013-3171-x. Epub 2013 Dec 5. No abstract available.

12.

Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.

Gupta S, Mana-Capelli S, McLean JR, Chen CT, Ray S, Gould KL, McCollum D.

Curr Biol. 2013 Feb 18;23(4):333-8. doi: 10.1016/j.cub.2013.01.014. Epub 2013 Feb 7.

13.

Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS, Broadus MR, McLean JR, Feoktistova A, Ren L, Gould KL.

Mol Cell Proteomics. 2013 May;12(5):1074-86. doi: 10.1074/mcp.M112.025924. Epub 2013 Jan 7.

14.

The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning.

Mana-Capelli S, McLean JR, Chen CT, Gould KL, McCollum D.

Mol Biol Cell. 2012 Dec;23(23):4592-600. doi: 10.1091/mbc.E12-07-0532. Epub 2012 Oct 19.

15.

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.

Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O.

Sci Transl Med. 2012 Jul 4;4(141):141ra90. doi: 10.1126/scitranslmed.3003985.

16.

α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.

Hallett PJ, McLean JR, Kartunen A, Langston JW, Isacson O.

Neurobiol Dis. 2012 Aug;47(2):258-67. doi: 10.1016/j.nbd.2012.04.009. Epub 2012 Apr 19.

17.

Predicting the fission yeast protein interaction network.

Pancaldi V, Saraç OS, Rallis C, McLean JR, Převorovský M, Gould K, Beyer A, Bähler J.

G3 (Bethesda). 2012 Apr;2(4):453-67. doi: 10.1534/g3.111.001560. Epub 2012 Apr 1.

18.

A highly efficient multifunctional tandem affinity purification approach applicable to diverse organisms.

Ma H, McLean JR, Chao LF, Mana-Capelli S, Paramasivam M, Hagstrom KA, Gould KL, McCollum D.

Mol Cell Proteomics. 2012 Aug;11(8):501-11. doi: 10.1074/mcp.O111.016246. Epub 2012 Apr 3.

19.
20.

SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS, Shao N, McLean JR, Sevugan M, Ren L, Chew TG, Bimbo A, Sharma R, Tang X, Gould KL, Balasubramanian MK.

Curr Biol. 2011 Dec 6;21(23):1968-78. doi: 10.1016/j.cub.2011.10.051. Epub 2011 Nov 23.

21.

Isoform-specific expression and ratio changes accompany oxidant-induced peripherin aggregation in a neuroblastoma cell line.

McLean JR, Robertson J.

Brain Res. 2011 Nov 8;1422:57-65. doi: 10.1016/j.brainres.2011.09.032. Epub 2011 Sep 22.

PMID:
21985957
22.

Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis.

Walia V, Yu Y, Cao D, Sun M, McLean JR, Hollier BG, Cheng J, Mani SA, Rao K, Premkumar L, Elble RC.

Oncogene. 2012 Apr 26;31(17):2237-46. doi: 10.1038/onc.2011.392. Epub 2011 Sep 12.

23.

N-termini of fungal CSL transcription factors are disordered, enriched in regulatory motifs and inhibit DNA binding in fission yeast.

Převorovský M, Atkinson SR, Ptáčková M, McLean JR, Gould K, Folk P, Půta F, Bähler J.

PLoS One. 2011;6(8):e23650. doi: 10.1371/journal.pone.0023650. Epub 2011 Aug 12.

24.

Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Ren L, McLean JR, Hazbun TR, Fields S, Vander Kooi C, Ohi MD, Gould KL.

PLoS One. 2011 Feb 28;6(2):e16719. doi: 10.1371/journal.pone.0016719. Erratum in: PLoS One. 2011;6(9). doi: 10.1371/annotation/62e74a1c-c922-495b-9aaf-eebfe6b85ff5.

25.

State of the APC/C: organization, function, and structure.

McLean JR, Chaix D, Ohi MD, Gould KL.

Crit Rev Biochem Mol Biol. 2011 Apr;46(2):118-36. doi: 10.3109/10409238.2010.541420. Epub 2011 Jan 24. Review.

26.

Survey of the phosphorylation status of the Schizosaccharomyces pombe deubiquitinating enzyme (DUB) family.

McLean JR, Kouranti I, Gould KL.

J Proteome Res. 2011 Mar 4;10(3):1208-15. doi: 10.1021/pr100985s. Epub 2011 Feb 4.

27.

A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Kouranti I, McLean JR, Feoktistova A, Liang P, Johnson AE, Roberts-Galbraith RH, Gould KL.

PLoS Biol. 2010 Sep 7;8(9). pii: e1000471. doi: 10.1371/journal.pbio.1000471.

28.

Randomized, controlled trial of insulin for acute poststroke hyperglycemia.

McCormick M, Hadley D, McLean JR, Macfarlane JA, Condon B, Muir KW.

Ann Neurol. 2010 May;67(5):570-8. doi: 10.1002/ana.21983.

PMID:
20437554
29.

Factors that influence helical preferences for singly charged gas-phase peptide ions: the effects of multiple potential charge-carrying sites.

McLean JR, McLean JA, Wu Z, Becker C, Pérez LM, Pace CN, Scholtz JM, Russell DH.

J Phys Chem B. 2010 Jan 21;114(2):809-16. doi: 10.1021/jp9105103.

30.

Defects in nuclear transport enhance segregation distortion.

McElroy JM, McLean RA, McLean JR.

Fly (Austin). 2008 Nov-Dec;2(6):280-90. Epub 2008 Nov 23. No abstract available.

PMID:
19077541
31.

An aggregate-inducing peripherin isoform generated through intron retention is upregulated in amyotrophic lateral sclerosis and associated with disease pathology.

Xiao S, Tjostheim S, Sanelli T, McLean JR, Horne P, Fan Y, Ravits J, Strong MJ, Robertson J.

J Neurosci. 2008 Feb 20;28(8):1833-40. doi: 10.1523/JNEUROSCI.3222-07.2008.

32.

A collision cross-section database of singly-charged peptide ions.

Tao L, McLean JR, McLean JA, Russell DH.

J Am Soc Mass Spectrom. 2007 Jul;18(7):1232-8. Epub 2007 Apr 15. Erratum in: J Am Soc Mass Spectrom. 2007 Sep;18(9):1727-8.

33.

Temporal profiles of neuronal degeneration, glial proliferation, and cell death in hNFL(+/+) and NFL(-/-) mice.

McLean JR, Sanelli TR, Leystra-Lantz C, He BP, Strong MJ.

Glia. 2005 Oct;52(1):59-69.

PMID:
15920739
34.
35.

Prediction of radiosensitivity by measurement of X-ray induced apoptosis in human blood using the comet assay.

Kizilian-Martel N, Wilkins RC, Mclean JR, Malone S, Raaphorst GP.

Anticancer Res. 2003 Sep-Oct;23(5A):3847-54.

PMID:
14666687
36.

Protection from solar simulated radiation-induced DNA damage in cultured human fibroblasts by three commercially available sunscreens.

Reinhardt P, Cybulski M, McNamee JP, McLean JR, Gorman W, Deslauriers Y.

Can J Physiol Pharmacol. 2003 Jul;81(7):690-5.

PMID:
12897816
37.

Prompt and delayed nonsteroidal anti-inflammatory drug-photoinduced DNA damage in peripheral blood mononuclear cells measured with the comet assays.

Vinette AL, McNamee JP, Bellier PV, McLean JR, Scaiano JC.

Photochem Photobiol. 2003 Apr;77(4):390-6.

PMID:
12733651
38.

A 60 Hz magnetic field does not affect the incidence of squamous cell carcinomas in SENCAR mice.

McLean JR, Thansandote A, McNamee JP, Tryphonas L, Lecuyer D, Gajda G.

Bioelectromagnetics. 2003 Feb;24(2):75-81.

PMID:
12524673
39.

DNA damage detection technique applying time-resolved fluorescence measurements.

Cosa G, Vinette AL, McLean JR, Scaiano JC.

Anal Chem. 2002 Dec 15;74(24):6163-9.

PMID:
12510734
40.

The effect of the ratio of CD4+ to CD8+ T-cells on radiation-induced apoptosis in human lymphocyte subpopulations.

Wilkins RC, Kutzner BC, Truong M, McLean JR.

Int J Radiat Biol. 2002 Aug;78(8):681-8.

PMID:
12194751
41.
42.

DNA damage and apoptosis in the immature mouse cerebellum after acute exposure to a 1 mT, 60 Hz magnetic field.

McNamee JP, Bellier PV, McLean JR, Marro L, Gajda GB, Thansandote A.

Mutat Res. 2002 Jan 15;513(1-2):121-33.

PMID:
11719097
43.

Differential apoptotic response to ionizing radiation in subpopulations of human white blood cells.

Wilkins RC, Wilkinson D, Maharaj HP, Bellier PV, Cybulski MB, McLean JR.

Mutat Res. 2002 Jan 15;513(1-2):27-36.

PMID:
11719087
44.
45.

Photophysical properties of fluorescent DNA-dyes bound to single- and double-stranded DNA in aqueous buffered solution.

Cosa G, Focsaneanu KS, McLean JR, McNamee JP, Scaiano JC.

Photochem Photobiol. 2001 Jun;73(6):585-99.

PMID:
11421063
46.

Comet assay: rapid processing of multiple samples.

McNamee JP, McLean JR, Ferrarotto CL, Bellier PV.

Mutat Res. 2000 Mar 3;466(1):63-9.

PMID:
10751727
47.

The use of silver-stained "comets" to visualize DNA damage and repair in normal and Xeroderma pigmentosum fibroblasts after exposure to simulated solar radiation.

Reinhardt-Poulin P, McLean JR, Deslauriers Y, Gorman W, Cabat S, Rouabhia M.

Photochem Photobiol. 2000 Apr;71(4):422-5.

PMID:
10824592
48.

Mutatect: a mouse tumour model for detecting radiation-induced mutations in vivo.

Birnboim HC, Wilkinson D, Sandhu JK, McLean JR, Ross W.

Mutat Res. 1999 Dec 6;430(2):275-80.

PMID:
10631342
49.

Silver-stained comet assay for detection of apoptosis.

Kizilian N, Wilkins RC, Reinhardt P, Ferrarotto C, McLean JR, McNamee JP.

Biotechniques. 1999 Nov;27(5):926-30. No abstract available.

PMID:
10572638

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