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Items: 1 to 50 of 224

1.

A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.

Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM.

PLoS Pathog. 2018 Mar 5;14(3):e1006806. doi: 10.1371/journal.ppat.1006806. eCollection 2018 Mar.

2.

Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.

Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ.

J Immunol. 2018 Feb 1;200(3):1124-1132. doi: 10.4049/jimmunol.1701364. Epub 2017 Dec 20.

PMID:
29263212
3.

IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection.

Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ.

AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S81-S92. doi: 10.1089/aid.2017.0160.

PMID:
29140110
4.

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.

Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG.

PLoS Med. 2017 Nov 7;14(11):e1002417. doi: 10.1371/journal.pmed.1002417. eCollection 2017 Nov.

5.

Defining total-body AIDS-virus burden with implications for curative strategies.

Estes JD, Kityo C, Ssali F, Swainson L, Makamdop KN, Del Prete GQ, Deeks SG, Luciw PA, Chipman JG, Beilman GJ, Hoskuldsson T, Khoruts A, Anderson J, Deleage C, Jasurda J, Schmidt TE, Hafertepe M, Callisto SP, Pearson H, Reimann T, Schuster J, Schoephoerster J, Southern P, Perkey K, Shang L, Wietgrefe SW, Fletcher CV, Lifson JD, Douek DC, McCune JM, Haase AT, Schacker TW.

Nat Med. 2017 Nov;23(11):1271-1276. doi: 10.1038/nm.4411. Epub 2017 Oct 2.

PMID:
28967921
6.

Glut1 Expression Level on Inflammatory Monocytes is Associated With Markers of Cardiovascular Disease Risk in HIV-Infected Individuals.

Anzinger JJ, Butterfield TR, Gouillou M, McCune JM, Crowe SM, Palmer CS.

J Acquir Immune Defic Syndr. 2018 Feb 1;77(2):e28-e30. doi: 10.1097/QAI.0000000000001559. No abstract available.

PMID:
28961681
7.

Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection.

Palmer CS, Duette GA, Wagner MCE, Henstridge DC, Saleh S, Pereira C, Zhou J, Simar D, Lewin SR, Ostrowski M, McCune JM, Crowe SM.

FEBS Lett. 2017 Oct;591(20):3319-3332. doi: 10.1002/1873-3468.12843. Epub 2017 Oct 11.

8.

Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells.

Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR.

Cell Rep. 2017 Jul 25;20(4):984-998. doi: 10.1016/j.celrep.2017.06.087.

9.

Transancestral mapping and genetic load in systemic lupus erythematosus.

Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ.

Nat Commun. 2017 Jul 17;8:16021. doi: 10.1038/ncomms16021.

10.

Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals.

Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M.

Gut Microbes. 2017 Sep 3;8(5):440-450. doi: 10.1080/19490976.2017.1334034. Epub 2017 May 25.

11.

Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression.

Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM.

AIDS Res Hum Retroviruses. 2017 Jul;33(7):658-667. doi: 10.1089/AID.2016.0324. Epub 2017 Apr 25.

PMID:
28335609
12.

Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages.

Trang K, Raposo RA, Lowe MM, Krow-Lucal ER, Yonemoto W, Cabido VD, SenGupta D, McCune JM.

Viral Immunol. 2017 Apr;30(3):142-148. doi: 10.1089/vim.2016.0160. Epub 2017 Feb 2.

13.

Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling.

Bronevetsky Y, Burt TD, McCune JM.

J Immunol. 2016 Dec 1;197(11):4344-4350. Epub 2016 Oct 28.

14.

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC.

Pathog Immun. 2016 Spring;1(1):154-164.

15.

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood.

Palmer CS, Anzinger JJ, Butterfield TR, McCune JM, Crowe SM.

J Vis Exp. 2016 Aug 12;(114). doi: 10.3791/54255.

PMID:
27584036
16.

Henry Kunkel and the teaching of patient-oriented research.

McCune JM.

Clin Immunol. 2016 Nov;172:27-28. doi: 10.1016/j.clim.2016.07.014. Epub 2016 Aug 15. No abstract available.

PMID:
27538773
17.

Impact of early cART in the gut during acute HIV infection.

Deleage C, Schuetz A, Alvord WG, Johnston L, Hao XP, Morcock DR, Rerknimitr R, Fletcher JL, Puttamaswin S, Phanuphak N, Dewar R, McCune JM, Sereti I, Robb M, Kim JH, Schacker TW, Hunt P, Lifson JD, Ananworanich J, Estes JD.

JCI Insight. 2016 Jul 7;1(10). pii: e87065.

18.

Defining HIV and SIV Reservoirs in Lymphoid Tissues.

Deleage C, Wietgrefe SW, Del Prete G, Morcock DR, Hao XP, Piatak M Jr, Bess J, Anderson JL, Perkey KE, Reilly C, McCune JM, Haase AT, Lifson JD, Schacker TW, Estes JD.

Pathog Immun. 2016 Spring;1(1):68-106.

19.

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.

Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM.

J Clin Invest. 2016 Jul 1;126(7):2745-56. doi: 10.1172/JCI85996. Epub 2016 Jun 20.

20.

Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing.

Cunyat F, Rainho JN, West B, Swainson L, McCune JM, Stevenson M.

J Virol. 2016 Jun 24;90(14):6255-6262. doi: 10.1128/JVI.00231-16. Print 2016 Jul 15.

21.

Immunologic profiles distinguish aviremic HIV-infected adults.

Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW.

AIDS. 2016 Jun 19;30(10):1553-62. doi: 10.1097/QAD.0000000000001049.

22.

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.

Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch SV, McCune JM.

Cell Rep. 2015 Nov 24;13(8):1589-97. doi: 10.1016/j.celrep.2015.10.026. Epub 2015 Nov 12.

23.

Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease.

Ladell K, Hazenberg MD, Fitch M, Emson C, McEvoy-Hein Asgarian BK, Mold JE, Miller C, Busch R, Price DA, Hellerstein MK, McCune JM.

J Immunol. 2015 Nov 1;195(9):4096-105. doi: 10.4049/jimmunol.1500799. Epub 2015 Sep 28.

24.

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques.

Ortiz AM, Klase ZA, DiNapoli SR, Vujkovic-Cvijin I, Carmack K, Perkins MR, Calantone N, Vinton CL, Riddick NE, Gallagher J, Klatt NR, McCune JM, Estes JD, Paiardini M, Brenchley JM.

Mucosal Immunol. 2016 Mar;9(2):458-67. doi: 10.1038/mi.2015.75. Epub 2015 Aug 19.

25.

Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge.

Baker CA, Swainson L, Lin DL, Wong S, Hartigan-O'Connor DJ, Lifson JD, Tarantal AF, McCune JM.

Sci Transl Med. 2015 Aug 12;7(300):300ra125. doi: 10.1126/scitranslmed.aac5547.

26.

Immune mechanisms at the maternal-fetal interface: perspectives and challenges.

PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune JM, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga K.

Nat Immunol. 2015 Apr;16(4):328-34. doi: 10.1038/ni.3131. No abstract available.

27.

The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial.

Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW.

PLoS One. 2014 Dec 29;9(12):e116306. doi: 10.1371/journal.pone.0116306. eCollection 2014.

28.

Gut epithelial barrier and systemic inflammation during chronic HIV infection.

Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW.

AIDS. 2015 Jan 2;29(1):43-51. doi: 10.1097/QAD.0000000000000511.

29.

Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjects.

Palmer CS, Anzinger JJ, Zhou J, Gouillou M, Landay A, Jaworowski A, McCune JM, Crowe SM.

J Immunol. 2014 Dec 1;193(11):5595-603. doi: 10.4049/jimmunol.1303092. Epub 2014 Nov 3.

30.

Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease.

Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM.

AIDS Res Ther. 2014 Aug 5;11:27. doi: 10.1186/1742-6405-11-27. eCollection 2014.

31.

Distinct functional programs in fetal T and myeloid lineages.

Krow-Lucal ER, McCune JM.

Front Immunol. 2014 Jul 7;5:314. doi: 10.3389/fimmu.2014.00314. eCollection 2014. Review. No abstract available.

32.

Programmed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV disease.

Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG.

AIDS. 2014 Jul 31;28(12):1749-58. doi: 10.1097/QAD.0000000000000314.

33.

Myeloid-lymphoid ontogeny in the rhesus monkey (Macaca mulatta).

Batchelder CA, Duru N, Lee CI, Baker CA, Swainson L, Mccune JM, Tarantal AF.

Anat Rec (Hoboken). 2014 Aug;297(8):1392-406. doi: 10.1002/ar.22943. Epub 2014 May 28.

34.

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.

Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG.

PLoS Pathog. 2014 May 15;10(5):e1004078. doi: 10.1371/journal.ppat.1004078. eCollection 2014 May.

35.

Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging.

Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW.

PLoS One. 2014 Feb 27;9(2):e89444. doi: 10.1371/journal.pone.0089444. eCollection 2014.

36.

The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.

Byakwaga H, Boum Y 2nd, Huang Y, Muzoora C, Kembabazi A, Weiser SD, Bennett J, Cao H, Haberer JE, Deeks SG, Bangsberg DR, McCune JM, Martin JN, Hunt PW.

J Infect Dis. 2014 Aug 1;210(3):383-91. doi: 10.1093/infdis/jiu115. Epub 2014 Feb 28.

37.

Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.

Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW.

J Infect Dis. 2014 Aug 1;210(3):374-82. doi: 10.1093/infdis/jiu109. Epub 2014 Feb 28.

38.

Distinct functional programming of human fetal and adult monocytes.

Krow-Lucal ER, Kim CC, Burt TD, McCune JM.

Blood. 2014 Mar 20;123(12):1897-904. doi: 10.1182/blood-2013-11-536094. Epub 2014 Feb 11.

39.

Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.

Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM.

PLoS One. 2014 Feb 3;9(2):e87877. doi: 10.1371/journal.pone.0087877. eCollection 2014.

40.

Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease.

Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, Deeks SG, McCune JM.

PLoS One. 2014 Jan 21;9(1):e85613. doi: 10.1371/journal.pone.0085613. eCollection 2014.

41.

Analysis of maternal microchimerism in rhesus monkeys (Macaca mulatta) using real-time quantitative PCR amplification of MHC polymorphisms.

Bakkour S, Baker CA, Tarantal AF, Wen L, Busch MP, Lee TH, McCune JM.

Chimerism. 2014 Jan-Mar;5(1):6-15. doi: 10.4161/chim.27778. Epub 2014 Jan 17.

42.

Higher CD27+CD8+ T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4+ T cell recovery in treated HIV infection.

Seu L, Ortiz GM, Epling L, Sinclair E, Swainson LA, Bajpai UD, Huang Y, Deeks SG, Hunt PW, Martin JN, McCune JM.

PLoS One. 2013 Dec 31;8(12):e84091. doi: 10.1371/journal.pone.0084091. eCollection 2013.

43.

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection.

Palmer CS, Ostrowski M, Gouillou M, Tsai L, Yu D, Zhou J, Henstridge DC, Maisa A, Hearps AC, Lewin SR, Landay A, Jaworowski A, McCune JM, Crowe SM.

AIDS. 2014 Jan 28;28(3):297-309. doi: 10.1097/QAD.0000000000000128.

44.

Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.

Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM.

J Infect Dis. 2014 May 15;209(10):1602-12. doi: 10.1093/infdis/jit801. Epub 2013 Dec 10.

45.

Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG.

PLoS Pathog. 2013;9(10):e1003691. doi: 10.1371/journal.ppat.1003691. Epub 2013 Oct 10.

46.

Discordance between peripheral and colonic markers of inflammation during suppressive ART.

Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM.

J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):133-41. doi: 10.1097/01.qai.0000437172.08127.0b.

47.

Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial.

Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG.

J Infect Dis. 2013 Nov 1;208(9):1436-42. doi: 10.1093/infdis/jit453. Epub 2013 Aug 23.

48.

Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size.

Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher CD, Hecht FM, Deeks SG.

J Infect Dis. 2013 Oct 15;208(8):1202-11. doi: 10.1093/infdis/jit311. Epub 2013 Jul 12.

49.

Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism.

Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM.

Sci Transl Med. 2013 Jul 10;5(193):193ra91. doi: 10.1126/scitranslmed.3006438. Erratum in: Sci Transl Med. 2017 Nov 8;9(415):.

50.

IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.

Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM.

Int Immunol. 2013 Aug;25(8):471-83. doi: 10.1093/intimm/dxt012. Epub 2013 May 8.

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