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Items: 31

1.

Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages.

Song G, Sun X, Hines RN, McCarver DG, Lake BG, Osimitz TG, Creek MR, Clewell HJ, Yoon M.

Drug Metab Dispos. 2017 May;45(5):468-475. doi: 10.1124/dmd.116.074583. Epub 2017 Feb 22.

PMID:
28228413
2.

Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.

Giebel NL, Shadley JD, McCarver DG, Dorko K, Gramignoli R, Strom SC, Yan K, Simpson PM, Hines RN.

Drug Metab Dispos. 2016 Jul;44(7):1027-37. doi: 10.1124/dmd.116.069344. Epub 2016 Feb 26.

3.

Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny.

Hines RN, Simpson PM, McCarver DG.

Drug Metab Dispos. 2016 Jul;44(7):959-66. doi: 10.1124/dmd.115.068957. Epub 2016 Jan 29.

4.

Human hepatic UGT2B15 developmental expression.

Divakaran K, Hines RN, McCarver DG.

Toxicol Sci. 2014 Sep;141(1):292-9. doi: 10.1093/toxsci/kfu126. Epub 2014 Jun 30.

5.

The effect of CYP2D6 polymorphisms on the response to pain treatment for pediatric sickle cell pain crisis.

Brousseau DC, McCarver DG, Drendel AL, Divakaran K, Panepinto JA.

J Pediatr. 2007 Jun;150(6):623-6.

6.

Identification and functional analysis of a novel human CYP2E1 far upstream enhancer.

Shadley JD, Divakaran K, Munson K, Hines RN, Douglas K, McCarver DG.

Mol Pharmacol. 2007 Jun;71(6):1630-9. Epub 2007 Mar 12.

7.

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.

Gaedigk A, Ndjountché L, Divakaran K, Dianne Bradford L, Zineh I, Oberlander TF, Brousseau DC, McCarver DG, Johnson JA, Alander SW, Wayne Riggs K, Steven Leeder J.

Clin Pharmacol Ther. 2007 Feb;81(2):242-51.

PMID:
17259947
8.

Pharmacogenomics and the future of drug therapy.

Hines RN, McCarver DG.

Pediatr Clin North Am. 2006 Aug;53(4):591-619. Review.

PMID:
16872995
9.

Population-based analysis of methadone distribution and metabolism using an age-dependent physiologically based pharmacokinetic model.

Yang F, Tong X, McCarver DG, Hines RN, Beard DA.

J Pharmacokinet Pharmacodyn. 2006 Aug;33(4):485-518. Epub 2006 Jun 7.

PMID:
16758333
10.

Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene.

Nong A, McCarver DG, Hines RN, Krishnan K.

Toxicol Appl Pharmacol. 2006 Jul 1;214(1):78-87. Epub 2006 Feb 7.

PMID:
16464483
11.

Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants.

Koukouritaki SB, Poch MT, Cabacungan ET, McCarver DG, Hines RN.

Mol Pharmacol. 2005 Aug;68(2):383-92. Epub 2005 Apr 27.

12.

Alcohol dehydrogenase 2*3 affects alterations in offspring facial morphology associated with maternal ethanol intake in pregnancy.

Das UG, Cronk CE, Martier SS, Simpson PM, McCarver DG.

Alcohol Clin Exp Res. 2004 Oct;28(10):1598-606.

PMID:
15597094
13.

Proximity of residence to trichloroethylene-emitting sites and increased risk of offspring congenital heart defects among older women.

Yauck JS, Malloy ME, Blair K, Simpson PM, McCarver DG.

Birth Defects Res A Clin Mol Teratol. 2004 Oct;70(10):808-14.

PMID:
15390315
14.
15.

Excess birth prevalence of Hypoplastic Left Heart syndrome in eastern Wisconsin for birth cohorts 1997-1999.

Cronk CE, Pelech AN, Malloy ME, McCarver DG.

Birth Defects Res A Clin Mol Teratol. 2004 Mar;70(3):114-20.

PMID:
15039925
16.

Completeness of state administrative databases for surveillance of congenital heart disease.

Cronk CE, Malloy ME, Pelech AN, Miller RE, Meyer SA, Cowell M, McCarver DG.

Birth Defects Res A Clin Mol Teratol. 2003 Sep;67(9):597-603.

PMID:
14703780
17.

Developmental expression of human hepatic CYP2C9 and CYP2C19.

Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, McCarver DG, Hines RN.

J Pharmacol Exp Ther. 2004 Mar;308(3):965-74. Epub 2003 Nov 21.

18.

Human hepatic CYP2E1 expression during development.

Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, Hines RN, McCarver DG.

J Pharmacol Exp Ther. 2003 Oct;307(1):402-7. Erratum in: J Pharmacol Exp Ther. 2004 Apr;309(1):439.

19.

Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6).

Hines RN, Luo Z, Hopp KA, Cabacungan ET, Koukouritaki SB, McCarver DG.

J Pharmacol Exp Ther. 2003 Sep;306(3):1210-8. Epub 2003 Jun 26.

20.

Trichloroethylene decreases heat shock protein 90 interactions with endothelial nitric oxide synthase: implications for endothelial cell proliferation.

Ou J, Ou Z, McCarver DG, Hines RN, Oldham KT, Ackerman AW, Pritchard KA Jr.

Toxicol Sci. 2003 May;73(1):90-7. Epub 2003 Mar 25.

PMID:
12657742
21.

Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis.

Zheng YM, Henne KR, Charmley P, Kim RB, McCarver DG, Cabacungan ET, Hines RN, Rettie AE.

Toxicol Appl Pharmacol. 2003 Jan 15;186(2):119-26.

PMID:
12639503
22.

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms.

McCarver DG, Hines RN.

J Pharmacol Exp Ther. 2002 Feb;300(2):361-6. Review.

23.

The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes.

Hines RN, McCarver DG.

J Pharmacol Exp Ther. 2002 Feb;300(2):355-60. Review.

24.

Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities.

Park CS, Kang JH, Chung WG, Yi HG, Pie JE, Park DK, Hines RN, McCarver DG, Cha YN.

Pharmacogenetics. 2002 Jan;12(1):77-80. No abstract available.

PMID:
11773868
25.
26.

Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.

Whetstine JR, Yueh MF, McCarver DG, Williams DE, Park CS, Kang JH, Cha YN, Dolphin CT, Shephard EA, Phillips IR, Hines RN.

Toxicol Appl Pharmacol. 2000 Nov 1;168(3):216-24.

PMID:
11042094
27.
28.

Knowledge and misconceptions among inner-city African-American mothers regarding alcohol and drug use.

Donnelly FM, Mowery JL, McCarver DG.

Am J Drug Alcohol Abuse. 1998 Nov;24(4):675-83.

PMID:
9849777
29.
30.

Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans.

McCarver DG, Thomasson HR, Martier SS, Sokol RJ, Li T.

J Pharmacol Exp Ther. 1997 Dec;283(3):1095-101.

31.

Genetic polymorphisms in human drug metabolic enzymes.

Miller MS, McCarver DG, Bell DA, Eaton DL, Goldstein JA.

Fundam Appl Toxicol. 1997 Nov;40(1):1-14. Review.

PMID:
9398483

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