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Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.

Tang S, Fang Y, Huang G, Xu X, Padilla-Banks E, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X.

EMBO J. 2017 Nov 2;36(21):3175-3193. doi: 10.15252/embj.201796708. Epub 2017 Oct 11.


Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization.

Cheng J, Liu C, Hu K, Greenberg A, Wu D, Ausman LM, McBurney MW, Wang XD.

Biochim Biophys Acta. 2017 Nov;1863(11):2783-2790. doi: 10.1016/j.bbadis.2017.08.004. Epub 2017 Aug 5.


Reversible modulation of SIRT1 activity in a mouse strain.

Clark-Knowles KV, He X, Jardine K, Coulombe J, Dewar-Darch D, Caron AZ, Gray DA, McBurney MW.

PLoS One. 2017 Mar 8;12(3):e0173002. doi: 10.1371/journal.pone.0173002. eCollection 2017.


Sirt1-deficiency causes defective protein quality control.

Tomita T, Hamazaki J, Hirayama S, McBurney MW, Yashiroda H, Murata S.

Sci Rep. 2015 Jul 29;5:12613. doi: 10.1038/srep12613.


The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance.

Chuprin A, Avin A, Goldfarb Y, Herzig Y, Levi B, Jacob A, Sela A, Katz S, Grossman M, Guyon C, Rathaus M, Cohen HY, Sagi I, Giraud M, McBurney MW, Husebye ES, Abramson J.

Nat Immunol. 2015 Jul;16(7):737-45. doi: 10.1038/ni.3194. Epub 2015 May 25.


Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH on osteoblasts.

Fei Y, Shimizu E, McBurney MW, Partridge NC.

J Biol Chem. 2015 Mar 27;290(13):8373-82. doi: 10.1074/jbc.M114.602763. Epub 2015 Jan 28.


Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.

Di Sante G, Wang L, Wang C, Jiao X, Casimiro MC, Chen K, Pestell TG, Yaman I, Di Rocco A, Sun X, Horio Y, Powell MJ, He X, McBurney MW, Pestell RG.

Mol Endocrinol. 2015 Feb;29(2):200-12. doi: 10.1210/me.2014-1228. Epub 2014 Dec 29.


Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.

Di Sante G, Pestell TG, Casimiro MC, Bisetto S, Powell MJ, Lisanti MP, Cordon-Cardo C, Castillo-Martin M, Bonal DM, Debattisti V, Chen K, Wang L, He X, McBurney MW, Pestell RG.

Am J Pathol. 2015 Jan;185(1):266-79. doi: 10.1016/j.ajpath.2014.09.014.


Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity.

Clark-Knowles KV, Dewar-Darch D, Jardine KE, McBurney MW.

PLoS One. 2014 Nov 7;9(11):e112406. doi: 10.1371/journal.pone.0112406. eCollection 2014.


SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation.

Tang S, Huang G, Fan W, Chen Y, Ward JM, Xu X, Xu Q, Kang A, McBurney MW, Fargo DC, Hu G, Baumgart-Vogt E, Zhao Y, Li X.

Mol Cell. 2014 Sep 18;55(6):843-855. doi: 10.1016/j.molcel.2014.07.011. Epub 2014 Aug 21.


SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.

Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L816-28. doi: 10.1152/ajplung.00323.2013. Epub 2014 Mar 14.


The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome.

Caron AZ, He X, Mottawea W, Seifert EL, Jardine K, Dewar-Darch D, Cron GO, Harper ME, Stintzi A, McBurney MW.

FASEB J. 2014 Mar;28(3):1306-16. doi: 10.1096/fj.13-243568. Epub 2013 Dec 2.


SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.

Clark-Knowles KV, Dewar-Darch D, Jardine KE, McBurney MW.

PLoS One. 2013 Nov 21;8(11):e82106. doi: 10.1371/journal.pone.0082106. eCollection 2013.


SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.

Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 1;305(9):L615-24. doi: 10.1152/ajplung.00249.2012. Epub 2013 Sep 13.


SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.

McBurney MW, Clark-Knowles KV, Caron AZ, Gray DA.

Genes Cancer. 2013 Mar;4(3-4):125-34. doi: 10.1177/1947601912474893.


SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD.

Aging Cell. 2014 Feb;13(1):193-6. doi: 10.1111/acel.12151. Epub 2013 Nov 19.


Silent information regulator 1 protects the brain against cerebral ischemic damage.

Hernández-Jiménez M, Hurtado O, Cuartero MI, Ballesteros I, Moraga A, Pradillo JM, McBurney MW, Lizasoain I, Moro MA.

Stroke. 2013 Aug;44(8):2333-7. doi: 10.1161/STROKEAHA.113.001715. Epub 2013 May 30.


Sirt1-deficient mice exhibit an altered cartilage phenotype.

Gabay O, Zaal KJ, Sanchez C, Dvir-Ginzberg M, Gagarina V, Song Y, He XH, McBurney MW.

Joint Bone Spine. 2013 Dec;80(6):613-20. doi: 10.1016/j.jbspin.2013.01.001. Epub 2013 Apr 13.


Identification of a SIRT1 mutation in a family with type 1 diabetes.

Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, Zulewski H, Geier A, Cermak JM, Elliott P, Ellis JL, Westphal C, Knobel U, Eloranta JJ, Kerr-Conte J, Pattou F, Konrad D, Matter CM, Fontana A, Rogler G, Schlapbach R, Regairaz C, Carballido JM, Glaser B, McBurney MW, Pociot F, Sinclair DA, Donath MY.

Cell Metab. 2013 Mar 5;17(3):448-455. doi: 10.1016/j.cmet.2013.02.001.


Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model.

Gabay O, Sanchez C, Dvir-Ginzberg M, Gagarina V, Zaal KJ, Song Y, He XH, McBurney MW.

Arthritis Rheum. 2013 Jan;65(1):159-66. doi: 10.1002/art.37750.


SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I.

J Clin Invest. 2012 Jun;122(6):2032-45. doi: 10.1172/JCI60132. Epub 2012 May 1.


NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells.

Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, Fujita N, Tanimura A, Sudo T, Tanaka H, McBurney MW, Matsumura I, Kanakura Y.

Biochem Biophys Res Commun. 2012 Feb 24;418(4):811-7. doi: 10.1016/j.bbrc.2012.01.109. Epub 2012 Jan 28.


A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction.

Fusco S, Ripoli C, Podda MV, Ranieri SC, Leone L, Toietta G, McBurney MW, Schütz G, Riccio A, Grassi C, Galeotti T, Pani G.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):621-6. doi: 10.1073/pnas.1109237109. Epub 2011 Dec 21.


Sirtuin 1 in immune regulation and autoimmunity.

Kong S, McBurney MW, Fang D.

Immunol Cell Biol. 2012 Jan;90(1):6-13. doi: 10.1038/icb.2011.102. Epub 2011 Nov 22. Review.


SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice.

Seifert EL, Caron AZ, Morin K, Coulombe J, He XH, Jardine K, Dewar-Darch D, Boekelheide K, Harper ME, McBurney MW.

FASEB J. 2012 Feb;26(2):555-66. doi: 10.1096/fj.11-193979. Epub 2011 Oct 17.


WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis.

Wu J, Zhang F, Yan M, Wu D, Yu Q, Zhang Y, Zhou B, McBurney MW, Zhai Q.

Diabetes. 2011 Dec;60(12):3197-207. doi: 10.2337/db11-0232. Epub 2011 Oct 13.


SIRT1-mediated acute cardioprotection.

Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente L, Rahman I, Brookes PS.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1506-12. doi: 10.1152/ajpheart.00587.2011. Epub 2011 Aug 19.


SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

Huber JL, McBurney MW, Distefano PS, McDonagh T.

Future Med Chem. 2010 Dec;2(12):1751-9. doi: 10.4155/fmc.10.257.


SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons.

Panossian L, Fenik P, Zhu Y, Zhan G, McBurney MW, Veasey S.

J Neurosci. 2011 Mar 16;31(11):4025-36. doi: 10.1523/JNEUROSCI.5166-10.2011.


Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.

Powell MJ, Casimiro MC, Cordon-Cardo C, He X, Yeow WS, Wang C, McCue PA, McBurney MW, Pestell RG.

Cancer Res. 2011 Feb 1;71(3):964-75. doi: 10.1158/0008-5472.CAN-10-3172. Epub 2010 Dec 28.


Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP.

Arnold DE, Gagne C, Niknejad N, McBurney MW, Dimitroulakos J.

Mol Cell Biochem. 2010 Dec;345(1-2):1-11. doi: 10.1007/s11010-010-0553-z. Epub 2010 Aug 9.


SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.

Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.

PLoS One. 2010 Jul 23;5(7):e11755. doi: 10.1371/journal.pone.0011755.


SIRT1 is essential for normal cognitive function and synaptic plasticity.

Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD.

J Neurosci. 2010 Jul 21;30(29):9695-707. doi: 10.1523/JNEUROSCI.0027-10.2010.


Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD.

Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I.

Arch Biochem Biophys. 2010 Aug 15;500(2):203-9. doi: 10.1016/ Epub 2010 May 20.


SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis.

Stein S, Lohmann C, Schäfer N, Hofmann J, Rohrer L, Besler C, Rothgiesser KM, Becher B, Hottiger MO, Borén J, McBurney MW, Landmesser U, Lüscher TF, Matter CM.

Eur Heart J. 2010 Sep;31(18):2301-9. doi: 10.1093/eurheartj/ehq107. Epub 2010 Apr 23.


Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice.

Boily G, He XH, Jardine K, McBurney MW.

Exp Cell Res. 2010 Aug 1;316(13):2189-93. doi: 10.1016/j.yexcr.2010.04.012. Epub 2010 Apr 20.


AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.

Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW, Kim MK, Viollet B, Chung JH.

Diabetes. 2010 Mar;59(3):554-63. doi: 10.2337/db09-0482. Epub 2009 Nov 23.


The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.

Zhang J, Lee SM, Shannon S, Gao B, Chen W, Chen A, Divekar R, McBurney MW, Braley-Mullen H, Zaghouani H, Fang D.

J Clin Invest. 2009 Oct;119(10):3048-58. doi: 10.1172/JCI38902.


Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes.

El Ramy R, Magroun N, Messadecq N, Gauthier LR, Boussin FD, Kolthur-Seetharam U, Schreiber V, McBurney MW, Sassone-Corsi P, Dantzer F.

Cell Mol Life Sci. 2009 Oct;66(19):3219-34. doi: 10.1007/s00018-009-0105-4. Epub 2009 Aug 12.


SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.

Boily G, He XH, Pearce B, Jardine K, McBurney MW.

Oncogene. 2009 Aug 13;28(32):2882-93. doi: 10.1038/onc.2009.147. Epub 2009 Jun 8.


sirt1-null mice develop an autoimmune-like condition.

Sequeira J, Boily G, Bazinet S, Saliba S, He X, Jardine K, Kennedy C, Staines W, Rousseaux C, Mueller R, McBurney MW.

Exp Cell Res. 2008 Oct 1;314(16):3069-74. doi: 10.1016/j.yexcr.2008.07.011. Epub 2008 Jul 23.


SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons.

Li Y, Xu W, McBurney MW, Longo VD.

Cell Metab. 2008 Jul;8(1):38-48. doi: 10.1016/j.cmet.2008.05.004.


Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.

Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V.

Dev Cell. 2008 May;14(5):661-73. doi: 10.1016/j.devcel.2008.02.004.


SirT1 regulates energy metabolism and response to caloric restriction in mice.

Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J, Evans M, Harper ME, McBurney MW.

PLoS One. 2008 Mar 12;3(3):e1759. doi: 10.1371/journal.pone.0001759.


Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation.

Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M.

Cell Host Microbe. 2008 Mar 13;3(3):158-67. doi: 10.1016/j.chom.2008.02.002.


Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription.

Ghosh HS, Spencer JV, Ng B, McBurney MW, Robbins PD.

Biochem J. 2007 Nov 15;408(1):105-11.


Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage.

Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P.

Cell Cycle. 2006 Apr;5(8):873-7. Epub 2006 Apr 17.


SirT1 fails to affect p53-mediated biological functions.

Kamel C, Abrol M, Jardine K, He X, McBurney MW.

Aging Cell. 2006 Feb;5(1):81-8.


A local mechanism mediates NAD-dependent protection of axon degeneration.

Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z.

J Cell Biol. 2005 Aug 1;170(3):349-55. Epub 2005 Jul 25.


The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals.

Lemieux ME, Yang X, Jardine K, He X, Jacobsen KX, Staines WA, Harper ME, McBurney MW.

Mech Ageing Dev. 2005 Oct;126(10):1097-105.


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