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Items: 10


ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells.

Piao S, Ojha R, Rebecca VW, Samanta A, Ma XH, Mcafee Q, Nicastri MC, Buckley M, Brown E, Winkler JD, Gimotty PA, Amaravadi RK.

Autophagy. 2017;13(12):2056-2071. doi: 10.1080/15548627.2017.1377377. Epub 2017 Oct 5.


A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK.

Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12.


A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.

Rosenfeld MR, Ye X, Supko JG, Desideri S, Grossman SA, Brem S, Mikkelson T, Wang D, Chang YC, Hu J, McAfee Q, Fisher J, Troxel AB, Piao S, Heitjan DF, Tan KS, Pontiggia L, O'Dwyer PJ, Davis LE, Amaravadi RK.

Autophagy. 2014 Aug;10(8):1359-68. doi: 10.4161/auto.28984. Epub 2014 May 20.


Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

Ma XH, Piao SF, Dey S, McAfee Q, Karakousis G, Villanueva J, Hart LS, Levi S, Hu J, Zhang G, Lazova R, Klump V, Pawelek JM, Xu X, Xu W, Schuchter LM, Davies MA, Herlyn M, Winkler J, Koumenis C, Amaravadi RK.

J Clin Invest. 2014 Mar;124(3):1406-17. doi: 10.1172/JCI70454. Epub 2014 Feb 24.


Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.

McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T, Sepulveda AR, Davis LE, Winkler JD, Amaravadi RK.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8. doi: 10.1073/pnas.1118193109. Epub 2012 May 7.


Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma.

Ma XH, Piao S, Wang D, McAfee QW, Nathanson KL, Lum JJ, Li LZ, Amaravadi RK.

Clin Cancer Res. 2011 May 15;17(10):3478-89. doi: 10.1158/1078-0432.CCR-10-2372. Epub 2011 Feb 15.


Identification, regulation and anti-proliferative role of the NPR-C receptor in gastric epithelial cells.

Gower WR Jr, Carter GM, McAfee Q, Solivan SM.

Mol Cell Biochem. 2006 Dec;293(1-2):103-18. Epub 2006 Jun 20.


Novel therapeutic approach for cancer using four cardiovascular hormones.

Vesely DL, Clark LC, Garces AH, McAfee QW, Soto J, Gower WR Jr.

Eur J Clin Invest. 2004 Oct;34(10):674-82.


Four peptides decrease the number of human pancreatic adenocarcinoma cells.

Vesely BA, McAfee Q, Gower WR Jr, Vesely DL.

Eur J Clin Invest. 2003 Nov;33(11):998-1005.


Gastric atrial natriuretic peptide regulates endocrine secretion in antrum and fundus of human and rat stomach.

Gower WR Jr, Premaratne S, McCuen RW, Arimura A, McAfee Q, Schubert ML.

Am J Physiol Gastrointest Liver Physiol. 2003 Apr;284(4):G638-45.

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