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Items: 28


Simulated ablation for detection of cells impacting paracrine signalling in histology analysis.

Taylor-King JP, Baratchart E, Dhawan A, Coker EA, Rye IH, Russnes H, Chapman SJ, Basanta D, Marusyk A.

Math Med Biol. 2018 Feb 14. doi: 10.1093/imammb/dqx022. [Epub ahead of print]


Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer.

Dhawan A, Nichol D, Kinose F, Abazeed ME, Marusyk A, Haura EB, Scott JG.

Sci Rep. 2017 Apr 27;7(1):1232. doi: 10.1038/s41598-017-00791-8.


Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells.

Tavera-Mendoza LE, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, Cameron LA, Ficarro SB, Marto JA, Klawitter J, Brown M.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2186-E2194. doi: 10.1073/pnas.1615015114. Epub 2017 Feb 27.


Somatic clonal evolution: A selection-centric perspective.

Scott J, Marusyk A.

Biochim Biophys Acta. 2017 Apr;1867(2):139-150. doi: 10.1016/j.bbcan.2017.01.006. Epub 2017 Feb 2. Review.


Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes.

Marusyk A, Tabassum DP, Janiszewska M, Place AE, Trinh A, Rozhok AI, Pyne S, Guerriero JL, Shu S, Ekram M, Ishkin A, Cahill DP, Nikolsky Y, Chan TA, Rimawi MF, Hilsenbeck S, Schiff R, Osborne KC, Letai A, Polyak K.

Cancer Res. 2016 Nov 15;76(22):6495-6506. doi: 10.1158/0008-5472.CAN-16-1457. Epub 2016 Sep 26.


Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.

Su Y, Subedee A, Bloushtain-Qimron N, Savova V, Krzystanek M, Li L, Marusyk A, Tabassum DP, Zak A, Flacker MJ, Li M, Lin JJ, Sukumar S, Suzuki H, Long H, Szallasi Z, Gimelbrant A, Maruyama R, Polyak K.

Cell Rep. 2015 Jun 16;11(10):1549-63. doi: 10.1016/j.celrep.2015.05.011. Epub 2015 Jun 4.


MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis.

Cuiffo BG, Campagne A, Bell GW, Lembo A, Orso F, Lien EC, Bhasin MK, Raimo M, Hanson SE, Marusyk A, El-Ashry D, Hematti P, Polyak K, Mechta-Grigoriou F, Mariani O, Volinia S, Vincent-Salomon A, Taverna D, Karnoub AE.

Cell Stem Cell. 2014 Dec 4;15(6):762-74. doi: 10.1016/j.stem.2014.10.001. Epub 2014 Oct 16.


Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.

Marusyk A, Tabassum DP, Altrock PM, Almendro V, Michor F, Polyak K.

Nature. 2014 Oct 2;514(7520):54-8. doi: 10.1038/nature13556. Epub 2014 Jul 30.


Cancer: Clonal cooperation.

Polyak K, Marusyk A.

Nature. 2014 Apr 3;508(7494):52-3. doi: 10.1038/508052a. No abstract available.


Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.

Almendro V, Cheng YK, Randles A, Itzkovitz S, Marusyk A, Ametller E, Gonzalez-Farre X, Muñoz M, Russnes HG, Helland A, Rye IH, Borresen-Dale AL, Maruyama R, van Oudenaarden A, Dowsett M, Jones RL, Reis-Filho J, Gascon P, Gönen M, Michor F, Polyak K.

Cell Rep. 2014 Feb 13;6(3):514-27. doi: 10.1016/j.celrep.2013.12.041. Epub 2014 Jan 23.


Targeting Akt3 signaling in triple-negative breast cancer.

Chin YR, Yoshida T, Marusyk A, Beck AH, Polyak K, Toker A.

Cancer Res. 2014 Feb 1;74(3):964-73. doi: 10.1158/0008-5472.CAN-13-2175. Epub 2013 Dec 12.


Cancer. Cancer cell phenotypes, in fifty shades of grey.

Marusyk A, Polyak K.

Science. 2013 Feb 1;339(6119):528-9. doi: 10.1126/science.1234415. No abstract available.


Cellular heterogeneity and molecular evolution in cancer.

Almendro V, Marusyk A, Polyak K.

Annu Rev Pathol. 2013 Jan 24;8:277-302. doi: 10.1146/annurev-pathol-020712-163923. Epub 2012 Oct 22. Review.


Intra-tumour heterogeneity: a looking glass for cancer?

Marusyk A, Almendro V, Polyak K.

Nat Rev Cancer. 2012 Apr 19;12(5):323-34. doi: 10.1038/nrc3261. Review.


Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.

Lyons TR, O'Brien J, Borges VF, Conklin MW, Keely PJ, Eliceiri KW, Marusyk A, Tan AC, Schedin P.

Nat Med. 2011 Aug 7;17(9):1109-15. doi: 10.1038/nm.2416.


Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?

Henry CJ, Marusyk A, DeGregori J.

Aging (Albany NY). 2011 Jun;3(6):643-56. Review.


The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K.

J Clin Invest. 2011 Jul;121(7):2723-35. doi: 10.1172/JCI44745.


Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.

Henry CJ, Marusyk A, Zaberezhnyy V, Adane B, DeGregori J.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21713-8. doi: 10.1073/pnas.1005486107. Epub 2010 Nov 22.


Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.

Fleenor CJ, Marusyk A, DeGregori J.

Cell Cycle. 2010 Aug 1;9(15):3005-11. Epub 2010 Aug 7.


Irradiation selects for p53-deficient hematopoietic progenitors.

Marusyk A, Porter CC, Zaberezhnyy V, DeGregori J.

PLoS Biol. 2010 Mar 2;8(3):e1000324. doi: 10.1371/journal.pbio.1000324.


Tumor heterogeneity: causes and consequences.

Marusyk A, Polyak K.

Biochim Biophys Acta. 2010 Jan;1805(1):105-17. doi: 10.1016/j.bbcan.2009.11.002. Epub 2009 Nov 18. Review.


Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.

Marusyk A, Casás-Selves M, Henry CJ, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J.

Cancer Res. 2009 Sep 15;69(18):7262-9. doi: 10.1158/0008-5472.CAN-09-0604. Epub 2009 Sep 8.


Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.

Marusyk A, DeGregori J.

Biochim Biophys Acta. 2008 Jan;1785(1):1-11. Epub 2007 Oct 12. Review.


Replicational stress selects for p53 mutation.

Marusyk A, DeGregori J.

Cell Cycle. 2007 Sep 1;6(17):2148-51. Epub 2007 Jul 10.


p53 mediates senescence-like arrest induced by chronic replicational stress.

Marusyk A, Wheeler LJ, Mathews CK, DeGregori J.

Mol Cell Biol. 2007 Aug;27(15):5336-51. Epub 2007 May 21.


Building a better model of cancer.

Marusyk A, DeGregori J.

Cell Div. 2006 Oct 18;1:24.


Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

Bilousova G, Marusyk A, Porter CC, Cardiff RD, DeGregori J.

PLoS Biol. 2005 Dec;3(12):e401. Epub 2005 Nov 15.


Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

Jiang X, Huang F, Marusyk A, Sorkin A.

Mol Biol Cell. 2003 Mar;14(3):858-70.

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