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Items: 1 to 50 of 159

1.

Chemopreventive efficacy of the cyclooxygenase-2 (Cox-2) inhibitor, celecoxib, is predicted by adenoma expression of Cox-2 and 15-PGDH.

Wang J, Cho NL, Zauber AG, Hsu M, Dawson D, Srivastava A, Mitchell-Richards KA, Markowitz SD, Bertagnolli MM.

Cancer Epidemiol Biomarkers Prev. 2018 May 16. pii: cebp.0573.2017. doi: 10.1158/1055-9965.EPI-17-0573. [Epub ahead of print]

PMID:
29769213
2.

Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing.

Cooper GS, Markowitz SD, Chen Z, Tuck M, Willis JE, Berger BM, Brenner DE, Li L.

Dig Dis Sci. 2018 Jun;63(6):1449-1453. doi: 10.1007/s10620-018-5001-z. Epub 2018 Mar 7.

PMID:
29516325
3.

A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independent of age, transplant dose, and G-CSF support.

Desai A, Zhang Y, Park Y, Dawson DM, Larusch GA, Kasturi L, Wald D, Ready JM, Gerson SL, Markowitz SD.

Haematologica. 2018 Feb 22. pii: haematol.2017.178376. doi: 10.3324/haematol.2017.178376. [Epub ahead of print]

4.

Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus.

Moinova HR, LaFramboise T, Lutterbaugh JD, Chandar AK, Dumot J, Faulx A, Brock W, De la Cruz Cabrera O, Guda K, Barnholtz-Sloan JS, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Thota PN, Willis JE, Chak A, Markowitz SD.

Sci Transl Med. 2018 Jan 17;10(424). pii: eaao5848. doi: 10.1126/scitranslmed.aao5848.

5.

Genomic regions associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study.

Sun X, Chandar AK, Canto MI, Thota PN, Brock M, Shaheen NJ, Beer DG, Wang JS, Falk GW, Iyer PG, Abrams JA, Venkat-Ramani M, Veigl M, Miron A, Willis J, Patil DT, Nalbantoglu I, Guda K, Markowitz SD, Zhu X, Elston R, Chak A.

PLoS One. 2017 Oct 26;12(10):e0184962. doi: 10.1371/journal.pone.0184962. eCollection 2017.

6.

A nonrandomized trial of vitamin D supplementation for Barrett's esophagus.

Cummings LC, Thota PN, Willis JE, Chen Y, Cooper GS, Furey N, Bednarchik B, Alashkar BM, Dumot J, Faulx AL, Fink SP, Kresak AM, Abusneineh B, Barnholtz-Sloan J, Leahy P, Veigl ML, Chak A, Markowitz SD.

PLoS One. 2017 Sep 18;12(9):e0184928. doi: 10.1371/journal.pone.0184928. eCollection 2017.

7.

Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2).

Kim J, Do EJ, Moinova H, Bae SM, Kang JY, Hong SM, Fink SP, Joo J, Suh YA, Jang SJ, Hwang SW, Park SH, Yang DH, Ye BD, Byeon JS, Choe J, Yang SK, Markowitz SD, Kim SY, Myung SJ.

Neoplasia. 2017 Oct;19(10):805-816. doi: 10.1016/j.neo.2017.07.003. Epub 2017 Sep 5.

8.

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.

Kishore AH, Liang H, Kanchwala M, Xing C, Ganesh T, Akgul Y, Posner B, Ready JM, Markowitz SD, Word RA.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6427-E6436. doi: 10.1073/pnas.1704945114. Epub 2017 Jul 17.

9.

Cancer bypasses the lymph nodes.

Markowitz SD.

Science. 2017 Jul 7;357(6346):35-36. doi: 10.1126/science.aan8299. No abstract available.

PMID:
28684492
10.

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.

Antczak MI, Zhang Y, Wang C, Doran J, Naidoo J, Voruganti S, Williams NS, Markowitz SD, Ready JM.

J Med Chem. 2017 May 11;60(9):3979-4001. doi: 10.1021/acs.jmedchem.7b00271. Epub 2017 Apr 25.

11.

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome.

Cohen AJ, Saiakhova A, Corradin O, Luppino JM, Lovrenert K, Bartels CF, Morrow JJ, Mack SC, Dhillon G, Beard L, Myeroff L, Kalady MF, Willis J, Bradner JE, Keri RA, Berger NA, Pruett-Miller SM, Markowitz SD, Scacheri PC.

Nat Commun. 2017 Feb 7;8:14400. doi: 10.1038/ncomms14400.

12.

ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial.

Drew DA, Chin SM, Gilpin KK, Parziale M, Pond E, Schuck MM, Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP 3rd, Freedman M, Gala M, Garber JJ, Huttenhower C, Kedrin D, Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK, Staller K, Wang M, Chan AT.

Trials. 2017 Feb 1;18(1):50. doi: 10.1186/s13063-016-1744-z.

13.

Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.

Kim HB, Kim M, Park YS, Park I, Kim T, Yang SY, Cho CJ, Hwang D, Jung JH, Markowitz SD, Hwang SW, Yang SK, Lim DS, Myung SJ.

Gastroenterology. 2017 Feb;152(3):616-630. doi: 10.1053/j.gastro.2016.11.005. Epub 2016 Nov 15.

14.

Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.

Morris SM, Davison J, Carter KT, O'Leary RM, Trobridge P, Knoblaugh SE, Myeroff LL, Markowitz SD, Brett BT, Scheetz TE, Dupuy AJ, Starr TK, Grady WM.

Int J Cancer. 2017 Feb 15;140(4):853-863. doi: 10.1002/ijc.30491. Epub 2016 Nov 7.

15.

Adverse Clinical Outcome Associated With Mutations That Typify African American Colorectal Cancers.

Wang Z, Li L, Guda K, Chen Z, Barnholtz-Sloan J, Park YS, Markowitz SD, Willis J.

J Natl Cancer Inst. 2016 Aug 31;108(12). pii: djw164. doi: 10.1093/jnci/djw164. Print 2016 Dec.

16.

Phase I/II study of azacitidine and capecitabine/oxaliplatin (CAPOX) in refractory CIMP-high metastatic colorectal cancer: evaluation of circulating methylated vimentin.

Overman MJ, Morris V, Moinova H, Manyam G, Ensor J, Lee MS, Eng C, Kee B, Fogelman D, Shroff RT, LaFramboise T, Mazard T, Feng T, Hamilton S, Broom B, Lutterbaugh J, Issa JP, Markowitz SD, Kopetz S.

Oncotarget. 2016 Oct 11;7(41):67495-67506. doi: 10.18632/oncotarget.11317.

17.

RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas.

Blum AE, Venkitachalam S, Guo Y, Kieber-Emmons AM, Ravi L, Chandar AK, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Barnholtz-Sloan JS, Markowitz SD, Willis JE, Shyr Y, Chak A, Varadan V, Guda K.

Cancer Res. 2016 Oct 1;76(19):5628-5633. Epub 2016 Aug 8.

18.

Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia.

Fecteau RE, Kong J, Kresak A, Brock W, Song Y, Fujioka H, Elston R, Willis JE, Lynch JP, Markowitz SD, Guda K, Chak A.

JAMA Oncol. 2016 Oct 1;2(10):1333-1339. doi: 10.1001/jamaoncol.2016.2054.

19.

Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.

Venkitachalam S, Revoredo L, Varadan V, Fecteau RE, Ravi L, Lutterbaugh J, Markowitz SD, Willis JE, Gerken TA, Guda K.

Sci Rep. 2016 Mar 23;6:23642. doi: 10.1038/srep23642.

20.

Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm.

Sun X, Elston RC, Barnholtz-Sloan JS, Falk GW, Grady WM, Faulx A, Mittal SK, Canto M, Shaheen NJ, Wang JS, Iyer PG, Abrams JA, Tian YD, Willis JE, Guda K, Markowitz SD, Chandar A, Warfe JM, Brock W, Chak A.

Cancer Epidemiol Biomarkers Prev. 2016 May;25(5):727-35. doi: 10.1158/1055-9965.EPI-15-0832. Epub 2016 Feb 29.

21.

A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis.

Markowitz SD, Nock NL, Schmit SL, Stadler ZK, Joseph V, Zhang L, Willis JE, Scacheri P, Veigl M, Adams MD, Raskin L, Sullivan JF, Stratton K, Shia J, Ellis N, Rennert HS, Manschreck C, Li L, Offit K, Elston RC, Rennert G, Gruber SB.

PLoS One. 2016 Jan 11;11(1):e0146435. doi: 10.1371/journal.pone.0146435. eCollection 2016.

22.

Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial.

Thomas SS, Makar KW, Li L, Zheng Y, Yang P, Levy L, Rudolph RY, Lampe PD, Yan M, Markowitz SD, Bigler J, Lampe JW, Potter JD.

Genom Data. 2015 Sep 1;6:154-8. doi: 10.1016/j.gdata.2015.08.029. eCollection 2015 Dec.

23.

Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus.

Yu M, O'Leary RM, Kaz AM, Morris SM, Carter KT, Chak A, Chandar A, Willis JE, Moinova HR, Markowitz SD, Brenner DE, Anandabapasathy S, Westerhoff M, Wong CJ, Shaheen NJ, Chen Y, Barnholtz-Sloan JS, Grady WM.

Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12):1890-7. doi: 10.1158/1055-9965.EPI-15-0370. Epub 2015 Nov 6.

24.

Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival.

Fink SP, Myeroff LL, Kariv R, Platzer P, Xin B, Mikkola D, Lawrence E, Morris N, Nosrati A, Willson JK, Willis J, Veigl M, Barnholtz-Sloan JS, Wang Z, Markowitz SD.

Oncotarget. 2015 Oct 13;6(31):30500-15. doi: 10.18632/oncotarget.5921.

25.

Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.

Zhao J, Bulek K, Gulen MF, Zepp JA, Karagkounis G, Martin BN, Zhou H, Yu M, Liu X, Huang E, Fox PL, Kalady MF, Markowitz SD, Li X.

Gastroenterology. 2015 Dec;149(7):1860-1871.e8. doi: 10.1053/j.gastro.2015.08.051. Epub 2015 Sep 5.

26.

DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.

Merry CR, Forrest ME, Sabers JN, Beard L, Gao XH, Hatzoglou M, Jackson MW, Wang Z, Markowitz SD, Khalil AM.

Hum Mol Genet. 2015 Nov 1;24(21):6240-53. doi: 10.1093/hmg/ddv343. Epub 2015 Aug 25.

27.

ENVE: a novel computational framework characterizes copy-number mutational landscapes in colorectal cancers from African American patients.

Varadan V, Singh S, Nosrati A, Ravi L, Lutterbaugh J, Barnholtz-Sloan JS, Markowitz SD, Willis JE, Guda K.

Genome Med. 2015 Jul 20;7:69. doi: 10.1186/s13073-015-0192-9. eCollection 2015.

28.

MethyLight droplet digital PCR for detection and absolute quantification of infrequently methylated alleles.

Yu M, Carter KT, Makar KW, Vickers K, Ulrich CM, Schoen RE, Brenner D, Markowitz SD, Grady WM.

Epigenetics. 2015;10(9):803-9. doi: 10.1080/15592294.2015.1068490. Epub 2015 Jul 17.

29.

TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.

Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD.

Science. 2015 Jun 12;348(6240):aaa2340. doi: 10.1126/science.aaa2340.

30.

Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD, Willis JE.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2853. doi: 10.1073/pnas.1505059112. Epub 2015 May 4. No abstract available.

31.

Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial.

Thomas SS, Makar KW, Li L, Zheng Y, Yang P, Levy L, Rudolph RY, Lampe PD, Yan M, Markowitz SD, Bigler J, Lampe JW, Potter JD.

BMC Med Genet. 2015 Mar 24;16:18. doi: 10.1186/s12881-015-0161-6.

32.

IL-33 activates tumor stroma to promote intestinal polyposis.

Maywald RL, Doerner SK, Pastorelli L, De Salvo C, Benton SM, Dawson EP, Lanza DG, Berger NA, Markowitz SD, Lenz HJ, Nadeau JH, Pizarro TT, Heaney JD.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2487-96. doi: 10.1073/pnas.1422445112. Epub 2015 Apr 27.

33.

Novel recurrently mutated genes in African American colon cancers.

Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD, Willis JE.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1149-54. doi: 10.1073/pnas.1417064112. Epub 2015 Jan 12.

34.

Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.

Fink SP, Dawson DM, Zhang Y, Kresak A, Lawrence EG, Yang P, Chen Y, Barnholtz-Sloan JS, Willis JE, Kopelovich L, Markowitz SD.

Carcinogenesis. 2015 Feb;36(2):291-8. doi: 10.1093/carcin/bgu241. Epub 2014 Dec 10.

35.

The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening.

Grady WM, Markowitz SD.

Dig Dis Sci. 2015 Mar;60(3):762-72. doi: 10.1007/s10620-014-3444-4. Epub 2014 Dec 10. Review.

36.

Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis.

Li Y, Tu Z, Qian S, Fung JJ, Markowitz SD, Kusner LL, Kaminski HJ, Lu L, Lin F.

J Immunol. 2014 Sep 1;193(5):2127-34. doi: 10.4049/jimmunol.1400857. Epub 2014 Jul 23.

37.

Supraventricular tachycardia during pediatric anesthesia: a case series and qualitative analysis.

Cripe CC, Patel AR, Markowitz SD, Behringer TS, Litman RS.

J Clin Anesth. 2014 Jun;26(4):257-63. doi: 10.1016/j.jclinane.2013.11.020. Epub 2014 Jun 2.

PMID:
24882607
38.

Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.

Guda K, Fink SP, Milne GL, Molyneaux N, Ravi L, Lewis SM, Dannenberg AJ, Montgomery CG, Zhang S, Willis J, Wiesner GL, Markowitz SD.

Cancer Prev Res (Phila). 2014 Aug;7(8):805-12. doi: 10.1158/1940-6207.CAPR-14-0108. Epub 2014 May 16.

39.

Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.

Choi SH, Kim BG, Robinson J, Fink S, Yan M, Sporn MB, Markowitz SD, Letterio JJ.

J Clin Invest. 2014 Jun;124(6):2472-82. doi: 10.1172/JCI69672. Epub 2014 May 16.

40.

Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.

Luo Y, Wong CJ, Kaz AM, Dzieciatkowski S, Carter KT, Morris SM, Wang J, Willis JE, Makar KW, Ulrich CM, Lutterbaugh JD, Shrubsole MJ, Zheng W, Markowitz SD, Grady WM.

Gastroenterology. 2014 Aug;147(2):418-29.e8. doi: 10.1053/j.gastro.2014.04.039. Epub 2014 Apr 30.

41.

Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).

Fink SP, Yamauchi M, Nishihara R, Jung S, Kuchiba A, Wu K, Cho E, Giovannucci E, Fuchs CS, Ogino S, Markowitz SD, Chan AT.

Sci Transl Med. 2014 Apr 23;6(233):233re2. doi: 10.1126/scitranslmed.3008481.

42.

GNAS mutations identify a set of right-sided, RAS mutant, villous colon cancers.

Fecteau RE, Lutterbaugh J, Markowitz SD, Willis J, Guda K.

PLoS One. 2014 Jan 30;9(1):e87966. doi: 10.1371/journal.pone.0087966. eCollection 2014.

43.

NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer.

Luo Y, Kaz AM, Kanngurn S, Welsch P, Morris SM, Wang J, Lutterbaugh JD, Markowitz SD, Grady WM.

PLoS Genet. 2013;9(7):e1003552. doi: 10.1371/journal.pgen.1003552. Epub 2013 Jul 11.

44.

Two Distinct Categories of Focal Deletions in Cancer Genomes.

Rajaram M, Zhang J, Wang T, Li J, Kuscu C, Qi H, Kato M, Grubor V, Weil RJ, Helland A, Borrenson-Dale AL, Cho KR, Levine DA, Houghton AN, Wolchok JD, Myeroff L, Markowitz SD, Lowe SW, Zhang M, Krasnitz A, Lucito R, Mu D, Powers RS.

PLoS One. 2013 Jun 21;8(6):e66264. doi: 10.1371/journal.pone.0066264. Print 2013.

45.

Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility.

Thompson CL, Fink SP, Lutterbaugh JD, Elston RC, Veigl ML, Markowitz SD, Li L.

PLoS One. 2013 May 22;8(5):e64122. doi: 10.1371/journal.pone.0064122. Print 2013.

46.

Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.

Hao Y, Wang C, Cao B, Hirsch BM, Song J, Markowitz SD, Ewing RM, Sedwick D, Liu L, Zheng W, Wang Z.

Cancer Cell. 2013 May 13;23(5):583-93. doi: 10.1016/j.ccr.2013.03.021. Epub 2013 May 2.

47.

Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention.

Fink SP, Yang DH, Barnholtz-Sloan JS, Ryu YM, Mikkola D, Potter JD, Lampe JW, Markowitz SD, Myung SJ.

Dig Dis Sci. 2013 Sep;58(9):2615-22. doi: 10.1007/s10620-013-2670-5. Epub 2013 Apr 27.

48.

Inhibition of 15-hydroxyprostaglandin dehydrogenase by Helicobacter pylori in human gastric carcinogenesis.

Ryu YM, Myung SJ, Park YS, Yang DH, Song HJ, Jeong JY, Lee SM, Song M, Kim DH, Lee HJ, Park SK, Fink SP, Markowitz SD, Jung KW, Kim KJ, Ye BD, Byeon JS, Jung HY, Yang SK, Kim JH.

Cancer Prev Res (Phila). 2013 Apr;6(4):349-59. doi: 10.1158/1940-6207.CAPR-12-0389. Epub 2013 Feb 19.

49.

Global mutational profiling of formalin-fixed human colon cancers from a pathology archive.

Adams MD, Veigl ML, Wang Z, Molyneux N, Sun S, Guda K, Yu X, Markowitz SD, Willis J.

Mod Pathol. 2012 Dec;25(12):1599-608. doi: 10.1038/modpathol.2012.121. Epub 2012 Aug 10.

50.

Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.

Zhang P, Guo A, Possemato A, Wang C, Beard L, Carlin C, Markowitz SD, Polakiewicz RD, Wang Z.

Oncogene. 2013 Apr 18;32(16):2087-95. doi: 10.1038/onc.2012.220. Epub 2012 Jun 18.

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