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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.

Janas MM, Schlegel MK, Harbison CE, Yilmaz VO, Jiang Y, Parmar R, Zlatev I, Castoreno A, Xu H, Shulga-Morskaya S, Rajeev KG, Manoharan M, Keirstead ND, Maier MA, Jadhav V.

Nat Commun. 2018 Feb 19;9(1):723. doi: 10.1038/s41467-018-02989-4.


Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates.

Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S.

Mol Ther. 2018 Jan 4. pii: S1525-0016(18)30001-7. doi: 10.1016/j.ymthe.2017.12.021. [Epub ahead of print]


Molecular Characterization of Renal Cell Carcinoma: A Potential three microRNA Prognostic Signature.

Lokeshwar SD, Talukder A, Yates TJ, Hennig MJP, Garcia-Roig M, Lahorewala SS, Mullani NN, Klaassen Z, Kava BR, Manoharan M, Soloway MS, Lokeshwar V.

Cancer Epidemiol Biomarkers Prev. 2018 Feb 12. pii: cebp.0700.2017. doi: 10.1158/1055-9965.EPI-17-0700. [Epub ahead of print]


Molecular Dynamics Correctly Models the Unusual Major Conformation of the GAGU RNA Internal Loop and with NMR Reveals an Unusual Minor Conformation.

Spasic A, Kennedy SD, Needham L, Manoharan M, Kierzek R, Turner DH, Mathews D.

RNA. 2018 Feb 6. pii: rna.064527.117. doi: 10.1261/rna.064527.117. [Epub ahead of print]


Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.

Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG.

J Med Chem. 2018 Feb 8;61(3):734-744. doi: 10.1021/acs.jmedchem.7b01147. Epub 2018 Jan 27.


Malocclusion and dental caries experience among 8-9-year-old children in a city of South Indian region: A cross-sectional survey.

Disha P, Poornima P, Pai SM, Nagaveni NB, Roshan NM, Manoharan M.

J Educ Health Promot. 2017 Dec 4;6:98. doi: 10.4103/jehp.jehp_24_17. eCollection 2017.


Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression.

Willoughby JLS, Chan A, Sehgal A, Butler JS, Nair JK, Racie T, Shulga-Morskaya S, Nguyen T, Qian K, Yucius K, Charisse K, van Berkel TJC, Manoharan M, Rajeev KG, Maier MA, Jadhav V, Zimmermann TS.

Mol Ther. 2018 Jan 3;26(1):105-114. doi: 10.1016/j.ymthe.2017.08.019. Epub 2017 Sep 7.


Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.

Nair JK, Attarwala H, Sehgal A, Wang Q, Aluri K, Zhang X, Gao M, Liu J, Indrakanti R, Schofield S, Kretschmer P, Brown CR, Gupta S, Willoughby JLS, Boshar JA, Jadhav V, Charisse K, Zimmermann T, Fitzgerald K, Manoharan M, Rajeev KG, Akinc A, Hutabarat R, Maier MA.

Nucleic Acids Res. 2017 Nov 2;45(19):10969-10977. doi: 10.1093/nar/gkx818.


Hyaluronic acid family in bladder cancer: potential prognostic biomarkers and therapeutic targets.

Morera DS, Hennig MS, Talukder A, Lokeshwar SD, Wang J, Garcia-Roig M, Ortiz N, Yates TJ, Lopez LE, Kallifatidis G, Kramer MW, Jordan AR, Merseburger AS, Manoharan M, Soloway MS, Terris MK, Lokeshwar VB.

Br J Cancer. 2017 Nov 7;117(10):1507-1517. doi: 10.1038/bjc.2017.318. Epub 2017 Oct 3.


4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.

Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ.

J Am Chem Soc. 2017 Oct 18;139(41):14542-14555. doi: 10.1021/jacs.7b07582. Epub 2017 Oct 6.


Crystal structure of Middle East respiratory syndrome coronavirus helicase.

Hao W, Wojdyla JA, Zhao R, Han R, Das R, Zlatev I, Manoharan M, Wang M, Cui S.

PLoS Pathog. 2017 Jun 26;13(6):e1006474. doi: 10.1371/journal.ppat.1006474. eCollection 2017 Jun.


Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.

Schlegel MK, Foster DJ, Kel'in AV, Zlatev I, Bisbe A, Jayaraman M, Lackey JG, Rajeev KG, Charissé K, Harp J, Pallan PS, Maier MA, Egli M, Manoharan M.

J Am Chem Soc. 2017 Jun 28;139(25):8537-8546. doi: 10.1021/jacs.7b02694. Epub 2017 Jun 19.


Current Concepts of Epigenetics in Testicular Cancer.

la Rosa AH, Manoharan M, Goolam AS.

Indian J Surg Oncol. 2017 Jun;8(2):169-174. doi: 10.1007/s13193-016-0593-2. Epub 2017 Jan 13. Review.


Decipher test impacts decision making among patients considering adjuvant and salvage treatment after radical prostatectomy: Interim results from the Multicenter Prospective PRO-IMPACT study.

Gore JL, du Plessis M, Santiago-Jiménez M, Yousefi K, Thompson DJS, Karsh L, Lane BR, Franks M, Chen DYT, Bandyk M, Bianco FJ Jr, Brown G, Clark W, Kibel AS, Kim HL, Lowrance W, Manoharan M, Maroni P, Perrapato S, Sieber P, Trabulsi EJ, Waterhouse R, Davicioni E, Lotan Y, Lin DW.

Cancer. 2017 Aug 1;123(15):2850-2859. doi: 10.1002/cncr.30665. Epub 2017 Apr 19.


Prevalence and genetic mechanisms of antimicrobial resistance in Staphylococcus species: A multicentre report of the indian council of medical research antimicrobial resistance surveillance network.

Rajkumar S, Sistla S, Manoharan M, Sugumar M, Nagasundaram N, Parija SC, Ray P, Bakthavatchalam YD, Veeraraghavan B, Kapil A, Walia K, Ohri VC.

Indian J Med Microbiol. 2017 Jan-Mar;35(1):53-60. doi: 10.4103/ijmm.IJMM_16_427.


Is early morning flowering an effective trait to minimize heat stress damage during flowering in rice?

Bheemanahalli R, Sathishraj R, Manoharan M, Sumanth HN, Muthurajan R, Ishimaru T, Krishna JS.

Field Crops Res. 2017 Mar 1;203:238-242. doi: 10.1016/j.fcr.2016.11.011.


A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo.

Lee JB, Zhang K, Tam YY, Quick J, Tam YK, Lin PJ, Chen S, Liu Y, Nair JK, Zlatev I, Rajeev KG, Manoharan M, Rennie PS, Cullis PR.

Mol Ther Nucleic Acids. 2016;5:e348. doi: 10.1038/mtna.2016.43.


Comparative analysis of the root transcriptomes of cultivated sweetpotato (Ipomoea batatas [L.] Lam) and its wild ancestor (Ipomoea trifida [Kunth] G. Don).

Ponniah SK, Thimmapuram J, Bhide K, Kalavacharla VK, Manoharan M.

BMC Plant Biol. 2017 Jan 13;17(1):9. doi: 10.1186/s12870-016-0950-x.


siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L.

Nucleic Acids Res. 2017 May 5;45(8):5008. doi: 10.1093/nar/gkw1298. No abstract available.


Orbital Crossings Activated through Electron Injection: Opening Communication between Orthogonal Orbitals in Anionic C1-C5 Cyclizations of Enediynes.

Peterson PW, Shevchenko N, Breiner B, Manoharan M, Lufti F, Delaune J, Kingsley M, Kovnir K, Alabugin IV.

J Am Chem Soc. 2016 Dec 7;138(48):15617-15628. Epub 2016 Nov 28.


siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L.

Nucleic Acids Res. 2017 Apr 7;45(6):3528-3536. doi: 10.1093/nar/gkw1171.


Predictive models and risk of biopsy progression in active surveillance patients.

Iremashvili V, Manoharan M, Kava BR, Parekh DJ, Punnen S.

Urol Oncol. 2017 Feb;35(2):37.e1-37.e8. doi: 10.1016/j.urolonc.2016.08.015. Epub 2016 Sep 28.


Effect of newer antioxidants on the bond strength of composite on bleached enamel.

Manoharan M, Shashibhushan KK, Poornima P, Naik SN, Patil D, Shruthi AS.

J Indian Soc Pedod Prev Dent. 2016 Oct-Dec;34(4):391-6. doi: 10.4103/0970-4388.191430.


The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation.

Mobin MB, Gerstberger S, Teupser D, Campana B, Charisse K, Heim MH, Manoharan M, Tuschl T, Stoffel M.

Nat Commun. 2016 Sep 26;7:12848. doi: 10.1038/ncomms12848.


Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge.

Ahuja SK, Manoharan MS, Harper NL, Jimenez F, Hobson BD, Martinez H, Ingale P, Liu YG, Carrillo A, Lou Z, Kellog DL, Ahuja SS, Rather CG, Esch RE, Ramirez DA, Clark RA, Nadeau K, Andrews CP, Jacobs RL, He W.

J Allergy Clin Immunol. 2017 Mar;139(3):844-854. doi: 10.1016/j.jaci.2016.08.019. Epub 2016 Sep 19.


Can nomograms improve our ability to select candidates for active surveillance for prostate cancer?

Iremashvili V, Manoharan M, Parekh DJ, Punnen S.

Prostate Cancer Prostatic Dis. 2016 Dec;19(4):385-389. doi: 10.1038/pcan.2016.27. Epub 2016 Jul 19.


Is It Time to Revisit the Role of Prostate-specific Antigen Kinetics in Active Surveillance for Prostate Cancer?

Iremashvili V, Kava BR, Manoharan M, Parekh DJ, Punnen S.

Urology. 2016 Sep;95:139-44. doi: 10.1016/j.urology.2016.04.016. Epub 2016 Apr 26.


5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V.

Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28.


Classification of Protein Kinases Influenced by Conservation of Substrate Binding Residues.

Janaki C, Srinivasan N, Manoharan M.

Methods Mol Biol. 2016;1415:301-13. doi: 10.1007/978-1-4939-3572-7_15.


Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.

Butler JS, Chan A, Costelha S, Fishman S, Willoughby JL, Borland TD, Milstein S, Foster DJ, Gonçalves P, Chen Q, Qin J, Bettencourt BR, Sah DW, Alvarez R, Rajeev KG, Manoharan M, Fitzgerald K, Meyers RE, Nochur SV, Saraiva MJ, Zimmermann TS.

Amyloid. 2016 Jun;23(2):109-18. doi: 10.3109/13506129.2016.1160882. Epub 2016 Mar 31.


Robotic Partial Nephrectomy with the Da Vinci Xi.

Kallingal GJ, Swain S, Darwiche F, Punnen S, Manoharan M, Gonzalgo ML, Parekh DJ.

Adv Urol. 2016;2016:9675095. doi: 10.1155/2016/9675095. Epub 2016 Feb 9.


Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.

Kel'in AV, Zlatev I, Harp J, Jayaraman M, Bisbe A, O'Shea J, Taneja N, Manoharan RM, Khan S, Charisse K, Maier MA, Egli M, Rajeev KG, Manoharan M.

J Org Chem. 2016 Mar 18;81(6):2261-79. doi: 10.1021/acs.joc.5b02375. Epub 2016 Mar 4.


Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis.

Blair TC, Manoharan M, Rawlings-Rhea SD, Tagge I, Kohama SG, Hollister-Smith J, Ferguson B, Woltjer RL, Frederick MC, Pollaro J, Rooney WD, Sherman LS, Bourdette DN, Wong SW.

J Neuroimmunol. 2016 Feb 15;291:1-10. doi: 10.1016/j.jneuroim.2015.11.026. Epub 2015 Dec 2.


Prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in active surveillance patients.

Iremashvili V, Barney SL, Manoharan M, Kava BR, Parekh DJ, Punnen S.

Int J Urol. 2016 Apr;23(4):313-7. doi: 10.1111/iju.13048. Epub 2016 Jan 13.


Sequence Analysis and Evolutionary Studies of Reelin Proteins.

Manoharan M, Muhammad SA, Sowdhamini R.

Bioinform Biol Insights. 2015 Dec 20;9:187-93. doi: 10.4137/BBI.S26530. eCollection 2015.


5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M.

ACS Chem Biol. 2016 Apr 15;11(4):953-60. doi: 10.1021/acschembio.5b00654. Epub 2016 Jan 13.


Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification.

Chan A, Liebow A, Yasuda M, Gan L, Racie T, Maier M, Kuchimanchi S, Foster D, Milstein S, Charisse K, Sehgal A, Manoharan M, Meyers R, Fitzgerald K, Simon A, Desnick RJ, Querbes W.

Mol Ther Nucleic Acids. 2015 Nov 3;4:e263. doi: 10.1038/mtna.2015.36.


Method for the determination of chromium in feed matrix by HPLC.

Umesh B, Rajendran RM, Manoharan MT.

Poult Sci. 2015 Nov;94(11):2805-15. doi: 10.3382/ps/pev238.


Gene stacking in plant cell using recombinases for gene integration and nucleases for marker gene deletion.

Nandy S, Zhao S, Pathak BP, Manoharan M, Srivastava V.

BMC Biotechnol. 2015 Oct 9;15:93. doi: 10.1186/s12896-015-0212-2.


Epigenetics application in the diagnosis and treatment of bladder cancer.

Harb-de la Rosa A, Acker M, Kumar RA, Manoharan M.

Can J Urol. 2015 Oct;22(5):7947-51. Review.


Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.

Gornalusse GG, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan MS, Avadhanam N, Murthy KK, Martinez H, Molano Murillo A, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich-Koretskaya L, Abdool Karim S, Martin JN, Deeks SG, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndung'u T, Hunt PW, He W, Ahuja SK.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4762-71. doi: 10.1073/pnas.1423228112. Epub 2015 Aug 11.


The role of epigenetics in kidney malignancies.

la Rosa AH, Acker M, Swain S, Manoharan M.

Cent European J Urol. 2015;68(2):157-64. doi: 10.5173/ceju.2015.453. Epub 2015 Apr 20. Review.


Identification of siRNA delivery enhancers by a chemical library screen.

Gilleron J, Paramasivam P, Zeigerer A, Querbes W, Marsico G, Andree C, Seifert S, Amaya P, Stöter M, Koteliansky V, Waldmann H, Fitzgerald K, Kalaidzidis Y, Akinc A, Maier MA, Manoharan M, Bickle M, Zerial M.

Nucleic Acids Res. 2015 Sep 18;43(16):7984-8001. doi: 10.1093/nar/gkv762. Epub 2015 Jul 28.


Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.

Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J.

Nat Biotechnol. 2015 Aug;33(8):870-6. doi: 10.1038/nbt.3298. Epub 2015 Jul 20.


Genome-Wide Profiling of Histone Modifications (H3K9me2 and H4K12ac) and Gene Expression in Rust (Uromyces appendiculatus) Inoculated Common Bean (Phaseolus vulgaris L.).

Ayyappan V, Kalavacharla V, Thimmapuram J, Bhide KP, Sripathi VR, Smolinski TG, Manoharan M, Thurston Y, Todd A, Kingham B.

PLoS One. 2015 Jul 13;10(7):e0132176. doi: 10.1371/journal.pone.0132176. eCollection 2015.


Operative technique and early experience for robotic-assisted laparoscopic nephroureterectomy (RALNU) using da Vinci Xi.

Darwiche F, Swain S, Kallingal G, Punnen S, Manoharan M, Parekh DJ, Gonzalgo ML.

Springerplus. 2015 Jun 27;4:298. doi: 10.1186/s40064-015-1076-6. eCollection 2015.


Cockroach sensitization mitigates allergic rhinoconjunctivitis symptom severity in patients allergic to house dust mites and pollen.

He W, Jimenez F, Martinez H, Harper NL, Manoharan MS, Carrillo A, Ingale P, Liu YG, Ahuja SS, Clark RA, Rather CG, Ramirez DA, Andrews CP, Jacobs RL, Ahuja SK.

J Allergy Clin Immunol. 2015 Sep;136(3):658-66. doi: 10.1016/j.jaci.2015.02.041. Epub 2015 May 28.


Neoadjuvant Radiotherapy Improves Survival in Patients With T2b/T3 Bladder Cancer: A Population-Based Analysis.

Diaz DA, Pollack A, Reis IM, Mahmoud O, Gonzalgo ML, Ishkanian A, Fernandez G, Manoharan M, Abramowitz MC.

Clin Genitourin Cancer. 2015 Aug;13(4):378-384.e1. doi: 10.1016/j.clgc.2015.02.014. Epub 2015 Mar 5.


Prognostic significance of cystoscopy findings following neoadjuvant chemotherapy for muscle-invasive bladder cancer.

Mansour AM, Soloway MS, Eldefrawy A, Singal R, Joshi S, Manoharan M.

Can J Urol. 2015 Apr;22(2):7690-7.


An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.

Sehgal A, Barros S, Ivanciu L, Cooley B, Qin J, Racie T, Hettinger J, Carioto M, Jiang Y, Brodsky J, Prabhala H, Zhang X, Attarwala H, Hutabarat R, Foster D, Milstein S, Charisse K, Kuchimanchi S, Maier MA, Nechev L, Kandasamy P, Kel'in AV, Nair JK, Rajeev KG, Manoharan M, Meyers R, Sorensen B, Simon AR, Dargaud Y, Negrier C, Camire RM, Akinc A.

Nat Med. 2015 May;21(5):492-7. doi: 10.1038/nm.3847. Epub 2015 Apr 13.


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