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Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.


Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository.

Bonnet-Serrano F, Diedisheim M, Mallone R, Larger E.

PLoS One. 2018 Jan 19;13(1):e0191528. doi: 10.1371/journal.pone.0191528. eCollection 2018.


Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.

James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S, Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R; Immunology of Diabetes Society T Cell Workshop Committee.

Diabetologia. 2018 Mar;61(3):658-670. doi: 10.1007/s00125-017-4508-8. Epub 2017 Dec 1.


Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients.

Masat E, Laforêt P, De Antonio M, Corre G, Perniconi B, Taouagh N, Mariampillai K, Amelin D, Mauhin W, Hogrel JY, Caillaud C, Ronzitti G, Puzzo F, Kuranda K, Colella P, Mallone R, Benveniste O, Mingozzi F; French Pompe Registry Study Group.

Sci Rep. 2016 Nov 4;6:36182. doi: 10.1038/srep36182.


Loss of immune tolerance to IL-2 in type 1 diabetes.

Pérol L, Lindner JM, Caudana P, Nunez NG, Baeyens A, Valle A, Sedlik C, Loirat D, Boyer O, Créange A, Cohen JL, Rogner UC, Yamanouchi J, Marchant M, Leber XC, Scharenberg M, Gagnerault MC, Mallone R, Battaglia M, Santamaria P, Hartemann A, Traggiai E, Piaggio E.

Nat Commun. 2016 Oct 6;7:13027. doi: 10.1038/ncomms13027.


β-cell Mass in Nondiabetic Autoantibody-Positive Subjects: An Analysis Based on the Network for Pancreatic Organ Donors Database.

Diedisheim M, Mallone R, Boitard C, Larger E.

J Clin Endocrinol Metab. 2016 Apr;101(4):1390-7. doi: 10.1210/jc.2015-3756. Epub 2016 Feb 1.


Priming of Qualitatively Superior Human Effector CD8+ T Cells Using TLR8 Ligand Combined with FLT3 Ligand.

Lissina A, Briceño O, Afonso G, Larsen M, Gostick E, Price DA, Mallone R, Appay V.

J Immunol. 2016 Jan 1;196(1):256-263. doi: 10.4049/jimmunol.1501140. Epub 2015 Nov 25.


Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes.

Xu X, Gu Y, Bian L, Shi Y, Cai Y, Chen Y, Chen H, Qian L, Wu X, Xu K, Mallone R, Davidson HW, Yu L, She J, Zhang M, Yang T.

Vaccine. 2016 Feb 3;34(6):854-62. doi: 10.1016/j.vaccine.2015.10.108. Epub 2015 Nov 3.


Reduced naïve CD8(+) T-cell priming efficacy in elderly adults.

Briceño O, Lissina A, Wanke K, Afonso G, von Braun A, Ragon K, Miquel T, Gostick E, Papagno L, Stiasny K, Price DA, Mallone R, Sauce D, Karrer U, Appay V.

Aging Cell. 2016 Feb;15(1):14-21. doi: 10.1111/acel.12384. Epub 2015 Oct 15.


Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes.

Culina S, Gupta N, Boisgard R, Afonso G, Gagnerault MC, Dimitrov J, Østerbye T, Justesen S, Luce S, Attias M, Kyewski B, Buus S, Wong FS, Lacroix-Desmazes S, Mallone R.

Diabetes. 2015 Oct;64(10):3532-42. doi: 10.2337/db15-0024. Epub 2015 Apr 27.


Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance.

Gupta N, Culina S, Meslier Y, Dimitrov J, Arnoult C, Delignat S, Gangadharan B, Lecerf M, Justesen S, Gouilleux-Gruart V, Salomon BL, Scott DW, Kaveri SV, Mallone R, Lacroix-Desmazes S.

Sci Transl Med. 2015 Feb 18;7(275):275ra21. doi: 10.1126/scitranslmed.aaa1957.


Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, Long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D.

J Autoimmun. 2015 Apr;58:48-58. doi: 10.1016/j.jaut.2015.01.001. Epub 2015 Jan 26.


Of bugs and men: antigen-fortified Lactoccoccus lactis for type 1 diabetes immunotherapy.

Mallone R, Culina S.

Diabetes. 2014 Aug;63(8):2603-5. doi: 10.2337/db14-0587. No abstract available.


A rapid lateral flow immunoassay for the detection of tyrosine phosphatase-like protein IA-2 autoantibodies in human serum.

Kikkas I, Mallone R, Larger E, Volland H, Morel N.

PLoS One. 2014 Jul 21;9(7):e103088. doi: 10.1371/journal.pone.0103088. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e106611.


Infectious triggers in type 1 diabetes: is there a case for epitope mimicry?

Afonso G, Mallone R.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:82-8. doi: 10.1111/dom.12166. Review.


MHC class II tetramers made from isolated recombinant α and β chains refolded with affinity-tagged peptides.

Braendstrup P, Justesen S, Osterbye T, Nielsen LL, Mallone R, Vindeløv L, Stryhn A, Buus S.

PLoS One. 2013 Sep 2;8(9):e73648. doi: 10.1371/journal.pone.0073648. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/97cabee9-2a2a-4bd6-a417-a2075e56a8d4. PLoS One. 2013;8(12). doi:10.1371/annotation/9375e7cb-92f1-4a83-adaf-c11f284ceee0.


A simple and fast non-radioactive bridging immunoassay for insulin autoantibodies.

Kikkas I, Mallone R, Tubiana-Rufi N, Chevenne D, Carel JC, Créminon C, Volland H, Boitard C, Morel N.

PLoS One. 2013 Jul 29;8(7):e69021. doi: 10.1371/journal.pone.0069021. Print 2013.


Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes.

Pihl M, Akerman L, Axelsson S, Chéramy M, Hjorth M, Mallone R, Ludvigsson J, Casas R.

Clin Exp Immunol. 2013 Jun;172(3):394-402. doi: 10.1111/cei.12078.


Biomarkers for immune intervention trials in type 1 diabetes.

Mallone R, Roep BO.

Clin Immunol. 2013 Dec;149(3):286-96. doi: 10.1016/j.clim.2013.02.009. Epub 2013 Feb 27. Review.


Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB).

Vaughan K, Peters B, Mallone R, von Herrath M, Roep BO, Sette A.

Immunome Res. 2013;9(1). doi: 10.4172/1745-7580.1000063.


Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency.

Iglesias MC, Briceno O, Gostick E, Moris A, Meaudre C, Price DA, Ungeheuer MN, Saez-Cirion A, Mallone R, Appay V.

Immunol Lett. 2013 Jan;149(1-2):119-22. doi: 10.1016/j.imlet.2012.10.002. Epub 2012 Oct 13.


Insulin and type 1 diabetes: immune connections.

Culina S, Brezar V, Mallone R.

Eur J Endocrinol. 2013 Jan 17;168(2):R19-31. doi: 10.1530/EJE-12-0693. Print 2013 Feb. Review.


HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes.

Scotto M, Afonso G, Østerbye T, Larger E, Luce S, Raverdy C, Novelli G, Bruno G, Gonfroy-Leymarie C, Launay O, Lemonnier FA, Buus S, Carel JC, Boitard C, Mallone R.

Diabetes. 2012 Oct;61(10):2546-55.


Immune biomarkers in immunotherapeutic trials for type 1 diabetes: cui prodest?

Culina S, Mallone R.

Diabetes Metab. 2012 Nov;38(5):379-85. doi: 10.1016/j.diabet.2012.05.005. Epub 2012 Jul 31. Review.


Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome.

Boita M, Rolla G, Mallone R, Martinuzzi E, Heffler E, Circosta P, Elia AR, Cignetti A, Caillat-Zucman S, de Menthon M, Guida G.

Clin Exp Rheumatol. 2012 Jan-Feb;30(1 Suppl 70):S57-61. Epub 2012 May 14.


Short-term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice.

Brezar V, Culina S, Gagnerault MC, Mallone R.

Eur J Immunol. 2012 Jun;42(6):1553-61. doi: 10.1002/eji.201242394.


Three sensitive assays do not provide evidence for circulating HuD-specific T cells in the blood of patients with paraneoplastic neurological syndromes with anti-Hu antibodies.

de Jongste AH, de Graaf MT, Martinuzzi E, van den Broek PD, Kraan J, Lamers CH, Mallone R, Gratama JW, Sillevis Smitt PA.

Neuro Oncol. 2012 Jul;14(7):841-8. doi: 10.1093/neuonc/nos118. Epub 2012 May 15.


Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients.

Scotto M, Afonso G, Larger E, Raverdy C, Lemonnier FA, Carel JC, Dubois-Laforgue D, Baz B, Levy D, Gautier JF, Launay O, Bruno G, Boitard C, Sechi LA, Hutton JC, Davidson HW, Mallone R.

Diabetologia. 2012 Jul;55(7):2026-31. doi: 10.1007/s00125-012-2543-z. Epub 2012 Apr 20.


T cells recognizing a peptide contaminant undetectable by mass spectrometry.

Brezar V, Culina S, Østerbye T, Guillonneau F, Chiappetta G, Verdier Y, Vinh J, Wong FS, Buus S, Mallone R.

PLoS One. 2011;6(12):e28866. doi: 10.1371/journal.pone.0028866. Epub 2011 Dec 14.


Long-lasting immune responses 4 years after GAD-alum treatment in children with type 1 diabetes.

Axelsson S, Chéramy M, Hjorth M, Pihl M, Akerman L, Martinuzzi E, Mallone R, Ludvigsson J, Casas R.

PLoS One. 2011;6(12):e29008. doi: 10.1371/journal.pone.0029008. Epub 2011 Dec 12.


Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls.

Brooks-Worrell B, Tree T, Mannering SI, Durinovic-Bello I, James E, Gottlieb P, Wong S, Zhou Z, Yang L, Cilio CM, Reichow J, Menart B, Rutter R, Schreiner R, Pham M, Petrich de Marquesini L, Lou O, Scotto M, Mallone R, Schloot NC; T-Cell Workshop Committee, Immunology of Diabetes Society.

Diabetes Metab Res Rev. 2011 Nov;27(8):737-45. doi: 10.1002/dmrr.1245.


Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative.

James EA, Mallone R, Schloot NC, Gagnerault MC, Thorpe J, Fitzgerald-Miller L, Reichow J, Wagner R, Pham MN, Jospe N, Lou O, Gottlieb PA, Brooks-Worrell BM, Durinovic-Belló I; T-Cell Workshop Committee, Immunology of Diabetes Society.

Diabetes Metab Res Rev. 2011 Nov;27(8):727-36. doi: 10.1002/dmrr.1244.


Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative.

Mallone R, Scotto M, Janicki CN, James EA, Fitzgerald-Miller L, Wagner R, Gottlieb P, Thorpe J, Jospe N, Durinovic-Bellò I, Boitard C, Lou O, Dayan CM, Wong FS; T-Cell Workshop Committee, Immunology of Diabetes Society.

Diabetes Metab Res Rev. 2011 Nov;27(8):720-6. doi: 10.1002/dmrr.1243.


Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients.

Masala S, Paccagnini D, Cossu D, Brezar V, Pacifico A, Ahmed N, Mallone R, Sechi LA.

PLoS One. 2011;6(10):e26931. doi: 10.1371/journal.pone.0026931. Epub 2011 Oct 27.


Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.

Luce S, Lemonnier F, Briand JP, Coste J, Lahlou N, Muller S, Larger E, Rocha B, Mallone R, Boitard C.

Diabetes. 2011 Dec;60(12):3289-99. doi: 10.2337/db11-0270. Epub 2011 Oct 13.


To B or not to B: (anti)bodies of evidence on the crime scene of type 1 diabetes?

Mallone R, Brezar V.

Diabetes. 2011 Aug;60(8):2020-2. doi: 10.2337/db11-0700. No abstract available.


T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives.

Mallone R, Brezar V, Boitard C.

Clin Dev Immunol. 2011;2011:513210. doi: 10.1155/2011/513210. Epub 2011 Jul 19. Review.


Pathogenic and regulatory T cells in type 1 diabetes: losing self-control, restoring it, and how to take the temperature.

Culina S, Mallone R.

Curr Diab Rep. 2011 Oct;11(5):426-33. doi: 10.1007/s11892-011-0209-8. Review.


acDCs enhance human antigen-specific T-cell responses.

Martinuzzi E, Afonso G, Gagnerault MC, Naselli G, Mittag D, Combadière B, Boitard C, Chaput N, Zitvogel L, Harrison LC, Mallone R.

Blood. 2011 Aug 25;118(8):2128-37. doi: 10.1182/blood-2010-12-326231. Epub 2011 Jun 28.


Beyond the hormone: insulin as an autoimmune target in type 1 diabetes.

Brezar V, Carel JC, Boitard C, Mallone R.

Endocr Rev. 2011 Oct;32(5):623-69. doi: 10.1210/er.2011-0010. Epub 2011 Jun 23. Review.


Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks?

Culina S, Boitard C, Mallone R.

Clin Dev Immunol. 2011;2011:286248. doi: 10.1155/2011/286248. Epub 2011 May 14.


Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay.

Diana J, Brezar V, Beaudoin L, Dalod M, Mellor A, Tafuri A, von Herrath M, Boitard C, Mallone R, Lehuen A.

J Exp Med. 2011 Apr 11;208(4):729-45. doi: 10.1084/jem.20101692. Epub 2011 Mar 28.


Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes.

Fourlanos S, Perry C, Gellert SA, Martinuzzi E, Mallone R, Butler J, Colman PG, Harrison LC.

Diabetes. 2011 Apr;60(4):1237-45. doi: 10.2337/db10-1360. Epub 2011 Feb 9.


Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society.

Mallone R, Mannering SI, Brooks-Worrell BM, Durinovic-Belló I, Cilio CM, Wong FS, Schloot NC; T-Cell Workshop Committee, Immunology of Diabetes Society.

Clin Exp Immunol. 2011 Jan;163(1):33-49. doi: 10.1111/j.1365-2249.2010.04272.x. Epub 2010 Oct 5. Review.


Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes.

Mannering SI, Wong FS, Durinovic-Belló I, Brooks-Worrell B, Tree TI, Cilio CM, Schloot NC, Mallone R; Immunology of Diabetes Society T-Cell Workshop Committee.

Clin Exp Immunol. 2010 Nov;162(2):197-209. doi: 10.1111/j.1365-2249.2010.04237.x. Epub 2010 Sep 15. Review.


21-Hydroxylase epitopes are targeted by CD8 T cells in autoimmune Addison's disease.

Rottembourg D, Deal C, Lambert M, Mallone R, Carel JC, Lacroix A, Caillat-Zucman S, le Deist F.

J Autoimmun. 2010 Dec;35(4):309-15. doi: 10.1016/j.jaut.2010.07.001. Epub 2010 Aug 3.


Critical parameters in blood processing for T-cell assays: validation on ELISpot and tetramer platforms.

Afonso G, Scotto M, Renand A, Arvastsson J, Vassilieff D, Cilio CM, Mallone R.

J Immunol Methods. 2010 Jul 31;359(1-2):28-36. doi: 10.1016/j.jim.2010.05.005.


Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells.

Madec AM, Mallone R, Afonso G, Abou Mrad E, Mesnier A, Eljaafari A, Thivolet C.

Diabetologia. 2009 Jul;52(7):1391-9. doi: 10.1007/s00125-009-1374-z. Epub 2009 May 7.


Measurement of CD8 T cell responses in human type 1 diabetes.

Martinuzzi E, Lemonnier FA, Boitard C, Mallone R.

Ann N Y Acad Sci. 2008 Dec;1150:61-7. doi: 10.1196/annals.1447.015. Review.


T cells in the pathogenesis of type 1 diabetes.

Mallone R, van Endert P.

Curr Diab Rep. 2008 Apr;8(2):101-6. Review.


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