Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 40

1.

A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation.

Kernfeld EM, Genga RMJ, Neherin K, Magaletta ME, Xu P, Maehr R.

Immunity. 2018 Jun 5. pii: S1074-7613(18)30184-5. doi: 10.1016/j.immuni.2018.04.015. [Epub ahead of print]

PMID:
29884461
2.

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Aug 4;23(8):1004. doi: 10.1038/nm0817-1004a. No abstract available.

3.

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Feb 7;23(2):264. doi: 10.1038/nm0217-264a. No abstract available.

PMID:
28170374
4.

Using an Inducible CRISPR-dCas9-KRAB Effector System to Dissect Transcriptional Regulation in Human Embryonic Stem Cells.

Parsi KM, Hennessy E, Kearns N, Maehr R.

Methods Mol Biol. 2017;1507:221-233.

PMID:
27832543
5.

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2016 Dec;22(12):1482-1487. doi: 10.1038/nm.4203. Epub 2016 Oct 31. Erratum in: Nat Med. 2017 Aug 4;23 (8):1004. Nat Med. 2017 Feb 7;23 (2):264.

6.

Controlling transcription in human pluripotent stem cells using CRISPR-effectors.

Genga RM, Kearns NA, Maehr R.

Methods. 2016 May 15;101:36-42. doi: 10.1016/j.ymeth.2015.10.014. Epub 2015 Oct 23. Review.

7.

Transcriptional Regulation with CRISPR/Cas9 Effectors in Mammalian Cells.

Pham H, Kearns NA, Maehr R.

Methods Mol Biol. 2016;1358:43-57. doi: 10.1007/978-1-4939-3067-8_3.

PMID:
26463376
8.

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

Kearns NA, Pham H, Tabak B, Genga RM, Silverstein NJ, Garber M, Maehr R.

Nat Methods. 2015 May;12(5):401-403. doi: 10.1038/nmeth.3325. Epub 2015 Mar 16.

9.

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.

Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA.

Elife. 2014 Sep 16;3:e02809. doi: 10.7554/eLife.02809.

10.

De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts.

Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ.

Cell Rep. 2014 Mar 27;6(6):1046-1058. doi: 10.1016/j.celrep.2014.02.013. Epub 2014 Mar 6.

11.

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells.

Kearns NA, Genga RM, Enuameh MS, Garber M, Wolfe SA, Maehr R.

Development. 2014 Jan;141(1):219-23. doi: 10.1242/dev.103341.

12.

Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules.

Kearns NA, Genga RM, Ziller M, Kapinas K, Peters H, Brehm MA, Meissner A, Maehr R.

Stem Cell Res. 2013 Nov;11(3):1003-12. doi: 10.1016/j.scr.2013.06.007. Epub 2013 Jun 29.

13.

Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.

Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA.

Stem Cells. 2013 Dec;31(12):2833-41. doi: 10.1002/stem.1445.

14.

Wnt signaling specifies and patterns intestinal endoderm.

Sherwood RI, Maehr R, Mazzoni EO, Melton DA.

Mech Dev. 2011 Sep-Dec;128(7-10):387-400. doi: 10.1016/j.mod.2011.07.005. Epub 2011 Aug 10.

15.

iPS cells in type 1 diabetes research and treatment.

Maehr R.

Clin Pharmacol Ther. 2011 May;89(5):750-3. doi: 10.1038/clpt.2011.1. Epub 2011 Mar 23. Review. No abstract available.

PMID:
21430661
16.

The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.

Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME.

Cell. 2010 Mar 5;140(5):704-16. doi: 10.1016/j.cell.2010.01.026.

17.

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.

Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K.

Genes Dev. 2010 Feb 1;24(3):312-26. doi: 10.1101/gad.1833510.

18.

Generation of pluripotent stem cells from patients with type 1 diabetes.

Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15768-73. doi: 10.1073/pnas.0906894106. Epub 2009 Aug 31.

19.

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.

Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA.

Cell Stem Cell. 2009 Apr 3;4(4):348-58. doi: 10.1016/j.stem.2009.01.014.

20.

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D.

Nat Chem Biol. 2009 Apr;5(4):258-65. doi: 10.1038/nchembio.154. Epub 2009 Mar 15.

PMID:
19287398
21.

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA.

Nat Biotechnol. 2008 Nov;26(11):1269-75. doi: 10.1038/nbt.1502. Epub 2008 Oct 12.

PMID:
18849973
22.

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.

Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Barrett TA, Weissleder R, Khazaie K.

PLoS One. 2008 Aug 13;3(8):e2916. doi: 10.1371/journal.pone.0002916. Erratum in: PLoS ONE.2008;3(10).doi.org/10.1371/annotation/499b225f-e661-4124-aa2f-60bef89bd14a.. Plough, Hidde L [corrected to Ploegh, Hidde L].

23.

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.

Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA.

Nat Biotechnol. 2008 Jul;26(7):795-7. doi: 10.1038/nbt1418. Epub 2008 Jun 22.

PMID:
18568017
24.

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.

Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ.

Nature. 2008 Mar 20;452(7185):370-4. doi: 10.1038/nature06780.

25.

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.

Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, Kopito RR.

EMBO J. 2007 Jun 6;26(11):2693-706. Epub 2007 May 10.

26.

AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells.

Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh HL.

J Immunol. 2007 Feb 15;178(4):2192-203.

27.

Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.

Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, Ploegh HL.

ACS Chem Biol. 2006 Dec 20;1(11):713-23.

PMID:
17184136
28.
29.

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.

Maehr R, Mintern JD, Herman AE, Lennon-Duménil AM, Mathis D, Benoist C, Ploegh HL.

J Clin Invest. 2005 Oct;115(10):2934-43. Epub 2005 Sep 22.

30.

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

Maehr R, Hang HC, Mintern JD, Kim YM, Cuvillier A, Nishimura M, Yamada K, Shirahama-Noda K, Hara-Nishimura I, Ploegh HL.

J Immunol. 2005 Jun 1;174(11):7066-74.

31.
32.

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.

van Swieten PF, Maehr R, van den Nieuwendijk AM, Kessler BM, Reich M, Wong CS, Kalbacher H, Leeuwenburgh MA, Driessen C, van der Marel GA, Ploegh HL, Overkleeft HS.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3131-4.

PMID:
15149659
33.

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.

Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4566-71. Epub 2004 Mar 16.

34.

Functional proteomics of the active cysteine protease content in Drosophila S2 cells.

Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM.

Mol Cell Proteomics. 2003 Nov;2(11):1188-97. Epub 2003 Sep 16.

35.

Invariant chain controls the activity of extracellular cathepsin L.

Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM.

J Exp Med. 2002 Nov 4;196(9):1263-9.

36.

The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP).

Vugmeyster Y, Borodovsky A, Maurice MM, Maehr R, Furman MH, Ploegh HL.

Mol Immunol. 2002 Nov;39(7-8):431-41.

PMID:
12413694
37.

Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.

Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C.

J Exp Med. 2002 Aug 19;196(4):529-40.

38.

Comparative pharmacology of cisatracurium (51W89), atracurium, and five isomers in cats.

Wastila WB, Maehr RB, Turner GL, Hill DA, Savarese JJ.

Anesthesiology. 1996 Jul;85(1):169-77.

PMID:
8694363
39.

Approaches to short-acting neuromuscular blocking agents: nonsymmetrical bis-tetrahydroisoquinolinium mono- and diesters.

Dhar NC, Maehr RB, Masterson LA, Midgley JM, Stenlake JB, Wastila WB.

J Med Chem. 1996 Jan 19;39(2):556-61.

PMID:
8558527
40.

High-performance liquid chromatographic analysis of doxacurium, a new long-acting neuromuscular blocker.

DeAngelis R, Loebs P, Maehr R, Savarese J, Welch R.

J Chromatogr. 1990 Feb 23;525(2):389-400.

PMID:
2139440

Supplemental Content

Support Center