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Brain penetrant kinase inhibitors: Learning from kinase neuroscience discovery.

Shi Y, Mader M.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):1981-1991. doi: 10.1016/j.bmcl.2018.05.007. Epub 2018 May 4. Review.


Use of Guideline-Recommended Treatments for PTSD Among Community-Based Providers in Texas and Vermont: Implications for the Veterans Choice Program.

Finley EP, Mader M, Haro EK, Noël PH, Bernardy N, Rosen CS, Bollinger M, Garcia HA, Sherrieb K, Pugh MJV.

J Behav Health Serv Res. 2018 May 10. doi: 10.1007/s11414-018-9613-z. [Epub ahead of print]


Assessing the ability of chloroplast and nuclear DNA gene markers to verify the geographic origin of Jatoba (Hymenaea courbaril L.) timber.

Chaves CL, Degen B, Pakull B, Mader M, Honorio E, Ruas P, Tysklind N, Sebbenn AM.

J Hered. 2018 Apr 16. doi: 10.1093/jhered/esy017. [Epub ahead of print]


Cutaneous squamous cell carcinoma associated with Zalophus californianus papillomavirus 1 in a California sea lion.

Luff JA, Burns RE, Mader M, Priest KD, Tuttle AD.

J Vet Diagn Invest. 2018 Apr 1:1040638718769702. doi: 10.1177/1040638718769702. [Epub ahead of print]


River recharge versus O2 supply from the unsaturated zone in shallow riparian groundwater: A case study from the Selke River (Germany).

Mader M, Roberts AM, Porst D, Schmidt C, Trauth N, van Geldern R, Barth JAC.

Sci Total Environ. 2018 Sep 1;634:374-381. doi: 10.1016/j.scitotenv.2018.03.230. Epub 2018 Apr 6.


Ultraporous, Compressible, Wettable Polylactide/Polycaprolactone Sponges for Tissue Engineering.

Mader M, Jérôme V, Freitag R, Agarwal S, Greiner A.

Biomacromolecules. 2018 May 14;19(5):1663-1673. doi: 10.1021/acs.biomac.8b00434. Epub 2018 Apr 10.


Complete Chloroplast Genome Sequences of Four Meliaceae Species and Comparative Analyses.

Mader M, Pakull B, Blanc-Jolivet C, Paulini-Drewes M, Bouda ZH, Degen B, Small I, Kersten B.

Int J Mol Sci. 2018 Mar 1;19(3). pii: E701. doi: 10.3390/ijms19030701.


Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer.

Kluth M, Jung S, Habib O, Eshagzaiy M, Heinl A, Amschler N, Masser S, Mader M, Runte F, Barow P, Frogh S, Omari J, Möller-Koop C, Hube-Magg C, Weischenfeldt J, Korbel J, Steurer S, Krech T, Huland H, Graefen M, Minner S, Sauter G, Schlomm T, Simon R.

Oncotarget. 2017 Nov 11;8(65):108923-108935. doi: 10.18632/oncotarget.22408. eCollection 2017 Dec 12.


Characteristics Associated With Utilization of VA and Non-VA Care Among Iraq and Afghanistan Veterans With Post-Traumatic Stress Disorder.

Finley EP, Mader M, Bollinger MJ, Haro EK, Garcia HA, Huynh AK, Pugh JA, Pugh MJ.

Mil Med. 2017 Nov;182(11):e1892-e1903. doi: 10.7205/MILMED-D-17-00074.


Prior malignancies in patients harboring glioblastoma: an institutional case-study of 2164 patients.

Zacharia BE, DiStefano N, Mader MM, Chohan MO, Ogilvie S, Brennan C, Gutin P, Tabar V.

J Neurooncol. 2017 Sep;134(2):245-251. doi: 10.1007/s11060-017-2512-y. Epub 2017 May 27. Review.


Stable isotope mass balances versus concentration differences of dissolved inorganic carbon - implications for tracing carbon turnover in reservoirs.

Barth JAC, Mader M, Nenning F, van Geldern R, Friese K.

Isotopes Environ Health Stud. 2017 Aug;53(4):413-426. doi: 10.1080/10256016.2017.1282478. Epub 2017 Feb 13.


Community Clinicians and the Veterans Choice Program for PTSD Care: Understanding Provider Interest During Early Implementation.

Finley EP, Noël PH, Mader M, Haro E, Bernardy N, Rosen CS, Bollinger M, Garcia H, Sherrieb K, Pugh MJV.

Med Care. 2017 Jul;55 Suppl 7 Suppl 1:S61-S70. doi: 10.1097/MLR.0000000000000668.


Physiological Ripples Associated with Sleep Spindles Differ in Waveform Morphology from Epileptic Ripples.

Bruder JC, Dümpelmann M, Piza DL, Mader M, Schulze-Bonhage A, Jacobs-Le Van J.

Int J Neural Syst. 2017 Nov;27(7):1750011. doi: 10.1142/S0129065717500113. Epub 2016 Nov 2.


A High-Resolution Analysis on the Meteorological Influences on Spontaneous Intracerebral Hemorrhage Incidence.

Neidert MC, Sprenger M, Mader M, Esposito G, Hosp JA, Bozinov O, Regli L, Burkhardt JK.

World Neurosurg. 2017 Feb;98:695-703.e19. doi: 10.1016/j.wneu.2016.12.006. Epub 2016 Dec 10.


Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.

Apgar JR, Mader M, Agostinelli R, Benard S, Bialek P, Johnson M, Gao Y, Krebs M, Owens J, Parris K, St Andre M, Svenson K, Morris C, Tchistiakova L.

MAbs. 2016 Oct;8(7):1302-1318. Epub 2016 Sep 13.


Validation of a Blood Stability Score as an easy-to-use blood sample quality index.

Robinson N, Kirchbichler A, Banuls O, Mader M, Aikin R, Sottas PE, D'Onofrio G.

Int J Lab Hematol. 2016 Dec;38(6):685-693. doi: 10.1111/ijlh.12557. Epub 2016 Aug 30.


Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth.

Smith MC, Mader MM, Cook JA, Iversen P, Ajamie R, Perkins E, Bloem L, Yip YY, Barda DA, Waid PP, Zeckner DJ, Young DA, Sanchez-Felix M, Donoho GP, Wacheck V.

Mol Cancer Ther. 2016 Oct;15(10):2344-2356. Epub 2016 Jul 20.


Development of Molecular Markers for Determining Continental Origin of Wood from White Oaks (Quercus L. sect. Quercus).

Schroeder H, Cronn R, Yanbaev Y, Jennings T, Mader M, Degen B, Kersten B.

PLoS One. 2016 Jun 28;11(6):e0158221. doi: 10.1371/journal.pone.0158221. eCollection 2016.


The AVICH Score: A Novel Grading System to Predict Clinical Outcome in Arteriovenous Malformation-Related Intracerebral Hemorrhage.

Neidert MC, Lawton MT, Mader M, Seifert B, Valavanis A, Regli L, Bozinov O, Burkhardt JK.

World Neurosurg. 2016 Aug;92:292-297. doi: 10.1016/j.wneu.2016.04.080. Epub 2016 May 2.


Beyond PAINs: Chemotype Sensitivity of Protein Methyltransferases in Screens.

Gao C, Margolis BJ, Strelow JM, Vidler LR, Mader MM.

ACS Med Chem Lett. 2015 Nov 19;7(2):156-61. doi: 10.1021/acsmedchemlett.5b00375. eCollection 2016 Feb 11.


Two Canine Papillomaviruses Associated With Metastatic Squamous Cell Carcinoma in Two Related Basenji Dogs.

Luff J, Rowland P, Mader M, Orr C, Yuan H.

Vet Pathol. 2016 Nov;53(6):1160-1163. Epub 2016 Mar 4.


Genome Sequences of Populus tremula Chloroplast and Mitochondrion: Implications for Holistic Poplar Breeding.

Kersten B, Faivre Rampant P, Mader M, Le Paslier MC, Bounon R, Berard A, Vettori C, Schroeder H, Leplé JC, Fladung M.

PLoS One. 2016 Jan 22;11(1):e0147209. doi: 10.1371/journal.pone.0147209. eCollection 2016.


Filter-less submicron hydrodynamic size sorting.

Fouet M, Mader MA, Iraïn S, Yanha Z, Naillon A, Cargou S, Gué AM, Joseph P.

Lab Chip. 2016 Feb 21;16(4):720-33. doi: 10.1039/c5lc00941c. Epub 2016 Jan 18.


Corrigendum: The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887c. No abstract available.


The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. No abstract available. Erratum in: Nat Chem Biol. 2015 Nov;11(11):887. Nat Chem Biol. 2015 Aug;11(8):541. Roth, Brian [Corrected to Roth, Bryan] and Frederiksen, Mathias [Added].


A scanning cavity microscope.

Mader M, Reichel J, Hänsch TW, Hunger D.

Nat Commun. 2015 Jun 24;6:7249. doi: 10.1038/ncomms8249.


Networks: On the relation of bi- and multivariate measures.

Mader W, Mader M, Timmer J, Thiel M, Schelter B.

Sci Rep. 2015 Jun 4;5:10805. doi: 10.1038/srep10805.


Complete genome sequence of canine papillomavirus type 16.

Luff J, Mader M, Britton M, Fass J, Rowland P, Orr C, Schlegel R, Yuan H.

Genome Announc. 2015 May 7;3(3). pii: e00404-15. doi: 10.1128/genomeA.00404-15.


LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.

Nguyen H, Allali-Hassani A, Antonysamy S, Chang S, Chen LH, Curtis C, Emtage S, Fan L, Gheyi T, Li F, Liu S, Martin JR, Mendel D, Olsen JB, Pelletier L, Shatseva T, Wu S, Zhang FF, Arrowsmith CH, Brown PJ, Campbell RM, Garcia BA, Barsyte-Lovejoy D, Mader M, Vedadi M.

J Biol Chem. 2015 May 29;290(22):13641-53. doi: 10.1074/jbc.M114.626861. Epub 2015 Mar 30.


Genetic stability of Schmallenberg virus in vivo during an epidemic, and in vitro, when passaged in the highly susceptible porcine SK-6 cell line.

Hofmann MA, Mader M, Flückiger F, Renzullo S.

Vet Microbiol. 2015 Mar 23;176(1-2):97-108. doi: 10.1016/j.vetmic.2015.01.010. Epub 2015 Jan 15.


Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.

Steven S, Hausding M, Kröller-Schön S, Mader M, Mikhed Y, Stamm P, Zinßius E, Pfeffer A, Welschof P, Agdauletova S, Sudowe S, Li H, Oelze M, Schulz E, Klein T, Münzel T, Daiber A.

Basic Res Cardiol. 2015 Mar;110(2):6. doi: 10.1007/s00395-015-0465-x. Epub 2015 Jan 20.


Description of the response of a new multi-parametric brain sensor to physiological and pathophysiological challenges in the cortex of juvenile pigs.

Leidorf A, Mader MM, Hecker A, Heimann A, Alessandri B, Mayr P, Kempski O, Wöbker G.

Turk Neurosurg. 2014;24(6):913-22. doi: 10.5137/1019-5149.JTN.11808-14.1.


The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity.

Oelze M, Kröller-Schön S, Welschof P, Jansen T, Hausding M, Mikhed Y, Stamm P, Mader M, Zinßius E, Agdauletova S, Gottschlich A, Steven S, Schulz E, Bottari SP, Mayoux E, Münzel T, Daiber A.

PLoS One. 2014 Nov 17;9(11):e112394. doi: 10.1371/journal.pone.0112394. eCollection 2014.


Electrical stimulation for cortical mapping reduces the density of high frequency oscillations.

Jacobs J, Golla T, Mader M, Schelter B, Dümpelmann M, Korinthenberg R, Schulze-Bonhage A.

Epilepsy Res. 2014 Dec;108(10):1758-69. doi: 10.1016/j.eplepsyres.2014.09.022. Epub 2014 Sep 28.


Assessing the strength of directed influences among neural signals: an approach to noisy data.

Sommerlade L, Thiel M, Mader M, Mader W, Timmer J, Platt B, Schelter B.

J Neurosci Methods. 2015 Jan 15;239:47-64. doi: 10.1016/j.jneumeth.2014.09.007. Epub 2014 Sep 23.


Statistical evaluation of forecasts.

Mader M, Mader W, Gluckman BJ, Timmer J, Schelter B.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Aug;90(2):022133. Epub 2014 Aug 26.


[Adjusting to the needs of over 65-year-old patients].

Gerber FS, Shaha M, Mäder MB.

Krankenpfl Soins Infirm. 2014;107(7):32-3. German. No abstract available.


Optimized spectral estimation for nonlinear synchronizing systems.

Sommerlade L, Mader M, Mader W, Timmer J, Thiel M, Grebogi C, Schelter B.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Mar;89(3):032912. Epub 2014 Mar 14.


FISH Oracle 2: a web server for integrative visualization of genomic data in cancer research.

Mader M, Simon R, Kurtz S.

J Clin Bioinforma. 2014 Mar 31;4(1):5. doi: 10.1186/2043-9113-4-5.


Safety and blood sample volume and quality of a refined retro-orbital bleeding technique in rats using a lateral approach.

Sharma A, Fish BL, Moulder JE, Medhora M, Baker JE, Mader M, Cohen EP.

Lab Anim (NY). 2014 Feb;43(2):63-6. doi: 10.1038/laban.432.


Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity.

Campbell RM, Anderson BD, Brooks NA, Brooks HB, Chan EM, De Dios A, Gilmour R, Graff JR, Jambrina E, Mader M, McCann D, Na S, Parsons SH, Pratt SE, Shih C, Stancato LF, Starling JJ, Tate C, Velasco JA, Wang Y, Ye XS.

Mol Cancer Ther. 2014 Feb;13(2):364-74. doi: 10.1158/1535-7163.MCT-13-0513. Epub 2013 Dec 19.


Block-bootstrapping for noisy data.

Mader M, Mader W, Sommerlade L, Timmer J, Schelter B.

J Neurosci Methods. 2013 Oct 15;219(2):285-91. doi: 10.1016/j.jneumeth.2013.07.022. Epub 2013 Aug 8.


High bacterial load in negative pressure wound therapy (NPWT) foams used in the treatment of chronic wounds.

Yusuf E, Jordan X, Clauss M, Borens O, Mäder M, Trampuz A.

Wound Repair Regen. 2013 Sep-Oct;21(5):677-81. doi: 10.1111/wrr.12088. Epub 2013 Aug 8.


Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species-studies in white blood cells and in animal models.

Kröller-Schön S, Steven S, Kossmann S, Scholz A, Daub S, Oelze M, Xia N, Hausding M, Mikhed Y, Zinssius E, Mader M, Stamm P, Treiber N, Scharffetter-Kochanek K, Li H, Schulz E, Wenzel P, Münzel T, Daiber A.

Antioxid Redox Signal. 2014 Jan 10;20(2):247-66. doi: 10.1089/ars.2012.4953. Epub 2013 Aug 17.


[We have to learn to argue more intelligently (interview by Martina Camenzind)].

Mäder M.

Krankenpfl Soins Infirm. 2013;106(6):30-1. German. No abstract available.


Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers.

Krohn A, Seidel A, Burkhardt L, Bachmann F, Mader M, Grupp K, Eichenauer T, Becker A, Adam M, Graefen M, Huland H, Kurtz S, Steurer S, Tsourlakis MC, Minner S, Michl U, Schlomm T, Sauter G, Simon R, Sirma H.

J Pathol. 2013 Sep;231(1):130-41. doi: 10.1002/path.4223.


[Officer in charge, that unknown being - an explorative, qualitative study of unconscious fears, wishes, and defense mechanisms].

Beck T, Kumnig M, Breuss M, Mitmansgruber H, Schusser S, Andreatta P, Mader M, Schüßler G.

Z Psychosom Med Psychother. 2013;59(2):198-208. German.


Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial.

Lawitz E, Lalezari JP, Hassanein T, Kowdley KV, Poordad FF, Sheikh AM, Afdhal NH, Bernstein DE, Dejesus E, Freilich B, Nelson DR, Dieterich DT, Jacobson IM, Jensen D, Abrams GA, Darling JM, Rodriguez-Torres M, Reddy KR, Sulkowski MS, Bzowej NH, Hyland RH, Mo H, Lin M, Mader M, Hindes R, Albanis E, Symonds WT, Berrey MM, Muir A.

Lancet Infect Dis. 2013 May;13(5):401-8. doi: 10.1016/S1473-3099(13)70033-1. Epub 2013 Mar 15.


CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer.

Burkhardt L, Fuchs S, Krohn A, Masser S, Mader M, Kluth M, Bachmann F, Huland H, Steuber T, Graefen M, Schlomm T, Minner S, Sauter G, Sirma H, Simon R.

Cancer Res. 2013 May 1;73(9):2795-805. doi: 10.1158/0008-5472.CAN-12-1342. Epub 2013 Mar 14.


Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer.

Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jäger N, Gu L, Bogatyrova O, Stütz AM, Claus R, Eils J, Eils R, Gerhäuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Haß T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, Schlomm T.

Cancer Cell. 2013 Feb 11;23(2):159-70. doi: 10.1016/j.ccr.2013.01.002.

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