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Items: 43


Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function.

Stiff A, Trikha P, Mundy-Bosse B, McMichael E, Mace TA, Benner B, Kendra K, Campbell A, Gautam S, Abood D, Landi I, Hsu V, Duggan M, Wesolowski R, Old M, Howard JH, Yu L, Stasik N, Olencki T, Muthusamy N, Tridandapani S, Byrd JC, Caligiuri M, Carson WE.

Clin Cancer Res. 2018 Jan 23. doi: 10.1158/1078-0432.CCR-17-0691. [Epub ahead of print]


Circulating myeloid-derived suppressor cells increase in patients undergoing neo-adjuvant chemotherapy for breast cancer.

Wesolowski R, Duggan MC, Stiff A, Markowitz J, Trikha P, Levine KM, Schoenfield L, Abdel-Rasoul M, Layman R, Ramaswamy B, Macrae ER, Lustberg MB, Reinbolt RE, Mrozek E, Byrd JC, Caligiuri MA, Mace TA, Carson WE 3rd.

Cancer Immunol Immunother. 2017 Nov;66(11):1437-1447. doi: 10.1007/s00262-017-2038-3. Epub 2017 Jul 7.


Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.

Komar HM, Serpa G, Kerscher C, Schwoegl E, Mace TA, Jin M, Yang MC, Chen CS, Bloomston M, Ostrowski MC, Hart PA, Conwell DL, Lesinski GB.

Sci Rep. 2017 May 11;7(1):1787. doi: 10.1038/s41598-017-01973-0.


Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment.

Gomez-Chou SB, Swidnicka-Siergiejko AK, Badi N, Chavez-Tomar M, Lesinski GB, Bekaii-Saab T, Farren MR, Mace TA, Schmidt C, Liu Y, Deng D, Hwang RF, Zhou L, Moore T, Chatterjee D, Wang H, Leng X, Arlinghaus RB, Logsdon CD, Cruz-Monserrate Z.

Cancer Res. 2017 May 15;77(10):2647-2660. doi: 10.1158/0008-5472.CAN-16-1986. Epub 2017 Mar 1.


Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.

Talbert EE, Yang J, Mace TA, Farren MR, Farris AB, Young GS, Elnaggar O, Che Z, Timmers CD, Rajasekera P, Maskarinec JM, Bloomston M, Bekaii-Saab T, Guttridge DC, Lesinski GB.

Mol Cancer Ther. 2017 Feb;16(2):344-356. doi: 10.1158/1535-7163.MCT-16-0337. Epub 2016 Nov 3.


IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.

Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E, Cruz-Monserrate Z, Yu L, Young G, Zhong X, Zimmers TA, Ostrowski MC, Ludwig T, Bloomston M, Bekaii-Saab T, Lesinski GB.

Gut. 2018 Feb;67(2):320-332. doi: 10.1136/gutjnl-2016-311585. Epub 2016 Oct 21.


Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.

Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC.

Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006.


Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5.

Eng JW, Mace TA, Sharma R, Twum DYF, Peng P, Gibbs JF, Pitoniak R, Reed CB, Abrams SI, Repasky EA, Hylander BL.

J Immunother Cancer. 2016 Jun 21;4:33. doi: 10.1186/s40425-016-0136-y. eCollection 2016.


Randomized Phase 2 Trial of the Oncolytic Virus Pelareorep (Reolysin) in Upfront Treatment of Metastatic Pancreatic Adenocarcinoma.

Noonan AM, Farren MR, Geyer SM, Huang Y, Tahiri S, Ahn D, Mikhail S, Ciombor KK, Pant S, Aparo S, Sexton J, Marshall JL, Mace TA, Wu CS, El-Rayes B, Timmers CD, Zwiebel J, Lesinski GB, Villalona-Calero MA, Bekaii-Saab TS.

Mol Ther. 2016 Jun;24(6):1150-1158. doi: 10.1038/mt.2016.66. Epub 2016 Apr 4.


Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment.

Stiff A, Trikha P, Wesolowski R, Kendra K, Hsu V, Uppati S, McMichael E, Duggan M, Campbell A, Keller K, Landi I, Zhong Y, Dubovsky J, Howard JH, Yu L, Harrington B, Old M, Reiff S, Mace T, Tridandapani S, Muthusamy N, Caligiuri MA, Byrd JC, Carson WE 3rd.

Cancer Res. 2016 Apr 15;76(8):2125-36. doi: 10.1158/0008-5472.CAN-15-1490. Epub 2016 Feb 15.


Systemic Immune Activity Predicts Overall Survival in Treatment-Naïve Patients with Metastatic Pancreatic Cancer.

Farren MR, Mace TA, Geyer S, Mikhail S, Wu C, Ciombor K, Tahiri S, Ahn D, Noonan AM, Villalona-Calero M, Bekaii-Saab T, Lesinski GB.

Clin Cancer Res. 2016 May 15;22(10):2565-74. doi: 10.1158/1078-0432.CCR-15-1732. Epub 2015 Dec 30.


Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.

Mace TA, Shakya R, Elnaggar O, Wilson K, Komar HM, Yang J, Pitarresi JR, Young GS, Ostrowski MC, Ludwig T, Bekaii-Saab T, Bloomston M, Lesinski GB.

Oncotarget. 2015 Dec 29;6(42):44509-22. doi: 10.18632/oncotarget.6332.


Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced proinflammatory cytokines and immunosuppressive cells.

Lesinski GB, Reville PK, Mace TA, Young GS, Ahn-Jarvis J, Thomas-Ahner J, Vodovotz Y, Ameen Z, Grainger E, Riedl K, Schwartz S, Clinton SK.

Cancer Prev Res (Phila). 2015 Nov;8(11):1036-44. doi: 10.1158/1940-6207.CAPR-14-0464. Epub 2015 Aug 14.


The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells.

Martin del Campo SE, Levine KM, Mundy-Bosse BL, Grignol VP, Fairchild ET, Campbell AR, Trikha P, Mace TA, Paul BK, Jaime-Ramirez AC, Markowitz J, Kondadasula SV, Guenterberg KD, McClory S, Karpa VI, Pan X, Olencki TE, Monk JP, Mortazavi A, Tridandapani S, Lesinski GB, Byrd JC, Caligiuri MA, Shah MH, Carson WE 3rd.

J Immunol. 2015 Sep 1;195(5):1995-2005. doi: 10.4049/jimmunol.1400084. Epub 2015 Aug 3.


A role for the thermal environment in defining co-stimulation requirements for CD4(+) T cell activation.

Zynda ER, Grimm MJ, Yuan M, Zhong L, Mace TA, Capitano M, Ostberg JR, Lee KP, Pralle A, Repasky EA.

Cell Cycle. 2015;14(14):2340-54. doi: 10.1080/15384101.2015.1049782.


A phase I trial of single-agent reolysin in patients with relapsed multiple myeloma.

Sborov DW, Nuovo GJ, Stiff A, Mace T, Lesinski GB, Benson DM Jr, Efebera YA, Rosko AE, Pichiorri F, Grever MR, Hofmeister CC.

Clin Cancer Res. 2014 Dec 1;20(23):5946-55. doi: 10.1158/1078-0432.CCR-14-1404. Epub 2014 Oct 7.


Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling.

Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GB.

Cancer Immunol Immunother. 2014 Sep;63(9):889-900. doi: 10.1007/s00262-014-1564-5. Epub 2014 Jun 4.


Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice.

Gutierrez-Orozco F, Thomas-Ahner JM, Berman-Booty LD, Galley JD, Chitchumroonchokchai C, Mace T, Suksamrarn S, Bailey MT, Clinton SK, Lesinski GB, Failla ML.

Mol Nutr Food Res. 2014 Jun;58(6):1226-38. doi: 10.1002/mnfr.201300771. Epub 2014 Feb 17.


A phase I study of high-dose interleukin-2 with sorafenib in patients with metastatic renal cell carcinoma and melanoma.

Monk P, Lam E, Mortazavi A, Kendra K, Lesinski GB, Mace TA, Geyer S, Carson WE 3rd, Tahiri S, Bhinder A, Clinton SK, Olencki T.

J Immunother. 2014 Apr;37(3):180-6. doi: 10.1097/CJI.0000000000000023.


Performance of high-resolution SEM/EDX systems equipped with transmission mode (TSEM) for imaging and measurement of size and size distribution of spherical nanoparticles.

Hodoroaba VD, Motzkus C, Macé T, Vaslin-Reimann S.

Microsc Microanal. 2014 Apr;20(2):602-12. doi: 10.1017/S1431927614000014. Epub 2014 Feb 19.


β-Sitosterol modulates TLR4 receptor expression and intracellular MyD88-dependent pathway activation in J774A.1 murine macrophages.

Valerio MS, Minderman H, Mace T, Awad AB.

Cell Immunol. 2013 Sep-Oct;285(1-2):76-83. doi: 10.1016/j.cellimm.2013.08.007. Epub 2013 Sep 7.


Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment.

Mace TA, Bloomston M, Lesinski GB.

Oncoimmunology. 2013 Jul 1;2(7):e24891. Epub 2013 May 7.


Iron (III) isomaltoside 1000.

Mace TA, Syed A, Bhandari S.

Expert Rev Hematol. 2013 Jun;6(3):239-46. doi: 10.1586/ehm.13.15.


Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells.

Mace TA, Collins AL, Wojcik SE, Croce CM, Lesinski GB, Bloomston M.

J Surg Res. 2013 Oct;184(2):855-60. doi: 10.1016/j.jss.2013.04.061. Epub 2013 May 18.


Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.

Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, Fuchs JR, Eubank TD, Frankel WL, Bekaii-Saab T, Bloomston M, Lesinski GB.

Cancer Res. 2013 May 15;73(10):3007-18. doi: 10.1158/0008-5472.CAN-12-4601. Epub 2013 Mar 20.


Identifying attributes required by Foundation Year 1 doctors in multidisciplinary teams: a tool for performance evaluation.

McGettigan P, McKendree J, Reed N, Holborow S, Walsh CD, Mace T.

BMJ Qual Saf. 2013 Mar;22(3):225-32. doi: 10.1136/bmjqs-2012-001418. Epub 2013 Jan 29.


Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.

Bill MA, Nicholas C, Mace TA, Etter JP, Li C, Schwartz EB, Fuchs JR, Young GS, Lin L, Lin J, He L, Phelps M, Li PK, Lesinski GB.

PLoS One. 2012;7(8):e40724. doi: 10.1371/journal.pone.0040724. Epub 2012 Aug 10.


Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.

Capitano ML, Nemeth MJ, Mace TA, Salisbury-Ruf C, Segal BH, McCarthy PL, Repasky EA.

Blood. 2012 Sep 27;120(13):2600-9. Epub 2012 Jul 17.


Elevation in body temperature to fever range enhances and prolongs subsequent responsiveness of macrophages to endotoxin challenge.

Lee CT, Zhong L, Mace TA, Repasky EA.

PLoS One. 2012;7(1):e30077. doi: 10.1371/journal.pone.0030077. Epub 2012 Jan 10.


Effector CD8+ T cell IFN-γ production and cytotoxicity are enhanced by mild hyperthermia.

Mace TA, Zhong L, Kokolus KM, Repasky EA.

Int J Hyperthermia. 2012;28(1):9-18. doi: 10.3109/02656736.2011.616182.


UV light B-mediated inhibition of skin catalase activity promotes Gr-1+ CD11b+ myeloid cell expansion.

Sullivan NJ, Tober KL, Burns EM, Schick JS, Riggenbach JA, Mace TA, Bill MA, Young GS, Oberyszyn TM, Lesinski GB.

J Invest Dermatol. 2012 Mar;132(3 Pt 1):695-702. doi: 10.1038/jid.2011.329. Epub 2011 Oct 27.


At-sea detection of marine debris: overview of technologies, processes, issues, and options.

Mace TH.

Mar Pollut Bull. 2012;65(1-3):23-7. doi: 10.1016/j.marpolbul.2011.08.042. Epub 2011 Sep 21. Review.


Differentiation of CD8+ T cells into effector cells is enhanced by physiological range hyperthermia.

Mace TA, Zhong L, Kilpatrick C, Zynda E, Lee CT, Capitano M, Minderman H, Repasky EA.

J Leukoc Biol. 2011 Nov;90(5):951-62. doi: 10.1189/jlb.0511229. Epub 2011 Aug 26.


A new certified reference material for benzene measurement in air on a sorbent tube: development and proficiency testing.

Caurant A, Lalère B, Schbath MC, Stumpf C, Sutour C, Mace T, Quisefit JP, Doussin JF, Vaslin-Reimann S.

Anal Bioanal Chem. 2010 Nov;398(5):2265-77. doi: 10.1007/s00216-010-4123-8. Epub 2010 Sep 12.


Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?

Lee CT, Mace T, Repasky EA.

Int J Hyperthermia. 2010;26(3):232-46. doi: 10.3109/02656731003601745. Review.


The potential of the tumor microenvironment to influence Apo2L/TRAIL induced apoptosis.

Mace TA, Yamane N, Cheng J, Hylander BL, Repasky EA.

Immunol Invest. 2006;35(3-4):279-96. Review.


Parentage and relatedness in polyandrous comb-crested jacanas using ISSRs.

Haig SM, Mace TR, Mullins TD.

J Hered. 2003 Jul-Aug;94(4):302-9.


Effects of severe hypoxemia on mesenteric blood flow in neonatal piglets.

Mace TP, Azar GJ, Lee RD, Choe EU, Burgess RS, Cork RC, Flint LM, Ferrara JJ.

J Surg Res. 1998 Dec;80(2):287-94.


Dopexamine maintains mesenteric blood flow during systemic hypoxemia in the neonatal piglet.

Thomas TV, Mace TP, Choe EU, Flint LM, Ferrara JJ.

J Gastrointest Surg. 1997 Jul-Aug;1(4):362-9; discussion 370.


Pruritus in psoriasis. A prospective study of some psychiatric and dermatologic correlates.

Gupta MA, Gupta AK, Kirkby S, Weiner HK, Mace TM, Schork NJ, Johnson EH, Ellis CN, Voorhees JJ.

Arch Dermatol. 1988 Jul;124(7):1052-7.


Octomacrum microconfibula (Monogenea: Polyopisthocotylea) from a British Columbia lake.

Shepard CD, Mace TF.

J Parasitol. 1980 Dec;66(6):913. No abstract available.


Development of the giant kidney worm, Dioctophyma renale (Goeze, 1782) (Nematoda: Dioctophymatoidea).

Mace TF, Anderson RC.

Can J Zool. 1975 Nov;53(11):1552-68. No abstract available.


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