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Items: 1 to 50 of 235

1.

Proliferative Cartilaginous Lesions in the Calcaneal Tendons of huNOG Mice.

MacLeod AM, Treuting PM, Carlson CS.

Toxicol Pathol. 2017 Oct;45(7):952-956. doi: 10.1177/0192623317734822. Epub 2017 Oct 3.

PMID:
28974149
2.

A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.

Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y.

Nat Chem Biol. 2016 Jun;12(6):444-51. doi: 10.1038/nchembio.2069. Epub 2016 Apr 25.

3.

Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections.

MacLeod AM, Mitchell DR, Palmer NJ, Van de Poël H, Conrath K, Andrews M, Leyssen P, Neyts J.

ACS Med Chem Lett. 2013 May 8;4(7):585-9. doi: 10.1021/ml400095m. eCollection 2013 Jul 11.

4.

Evaluation of an advanced-practice physical therapist in a specialty shoulder clinic: diagnostic agreement and effect on wait times.

Razmjou H, Robarts S, Kennedy D, McKnight C, Macleod AM, Holtby R.

Physiother Can. 2013 Winter;65(1):46-55. doi: 10.3138/ptc.2011-56.

5.

A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

van der Schaar HM, Leyssen P, Thibaut HJ, de Palma A, van der Linden L, Lanke KH, Lacroix C, Verbeken E, Conrath K, Macleod AM, Mitchell DR, Palmer NJ, van de Poël H, Andrews M, Neyts J, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. doi: 10.1128/AAC.01175-13. Epub 2013 Jul 29.

6.

Global differences in dialysis modality mix: the role of patient characteristics, macroeconomics and renal service indicators.

van de Luijtgaarden MW, Jager KJ, Stel VS, Kramer A, Cusumano A, Elliott RF, Geue C, MacLeod AM, Stengel B, Covic A, Caskey FJ.

Nephrol Dial Transplant. 2013 May;28(5):1264-75. doi: 10.1093/ndt/gft053. Epub 2013 Mar 29.

PMID:
23543592
7.

Exploring the association between macroeconomic indicators and dialysis mortality.

Kramer A, Stel VS, Caskey FJ, Stengel B, Elliott RF, Covic A, Geue C, Cusumano A, Macleod AM, Jager KJ.

Clin J Am Soc Nephrol. 2012 Oct;7(10):1655-63. doi: 10.2215/CJN.10461011. Epub 2012 Jul 26.

8.

Translating chronic kidney disease epidemiology into patient care--the individual/public health risk paradox.

Marks A, Black C, Fluck N, Smith WC, Prescott GJ, Clark LE, Ali TZ, Simpson WG, MacLeod AM.

Nephrol Dial Transplant. 2012 Oct;27 Suppl 3:iii65-72. doi: 10.1093/ndt/gfr746. Epub 2012 Apr 24.

PMID:
22532617
9.

Global variation in renal replacement therapy for end-stage renal disease.

Caskey FJ, Kramer A, Elliott RF, Stel VS, Covic A, Cusumano A, Geue C, Macleod AM, Zwinderman AH, Stengel B, Jager KJ.

Nephrol Dial Transplant. 2011 Aug;26(8):2604-10. doi: 10.1093/ndt/gfq781. Epub 2011 Jan 18.

PMID:
21245131
10.

Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.

Blackaby WP, Lewis RT, Thomson JL, Jennings AS, Goodacre SC, Street LJ, MacLeod AM, Pike A, Wood S, Thomas S, Brown TA, Smith A, Pillai G, Almond S, Guscott MR, Burns HD, Eng W, Ryan C, Cook J, Hamill TG.

ACS Med Chem Lett. 2010 Jun 25;1(7):350-4. doi: 10.1021/ml1001085. eCollection 2010 Oct 14.

11.

Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.

Ladduwahetty T, Gilligan M, Humphries A, Merchant KJ, Fish R, McAlister G, Ivarsson M, Dominguez M, O'Connor D, MacLeod AM.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12. doi: 10.1016/j.bmcl.2010.04.090. Epub 2010 Apr 24.

PMID:
20493697
12.

The EVEREST study: an international collaboration.

Caskey FJ, Stel VS, Elliott RF, Jager KJ, Covic A, Cusumano A, Geue C, Kramer A, Stengel B, MacLeod AM.

NDT Plus. 2010 Feb;3(1):28-36. doi: 10.1093/ndtplus/sfp146. Epub 2009 Oct 19.

13.

In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.

Atack JR, Maubach KA, Wafford KA, O'Connor D, Rodrigues AD, Evans DC, Tattersall FD, Chambers MS, MacLeod AM, Eng WS, Ryan C, Hostetler E, Sanabria SM, Gibson RE, Krause S, Burns HD, Hargreaves RJ, Agrawal NG, McKernan RM, Murphy MG, Gingrich K, Dawson GR, Musson DG, Petty KJ.

J Pharmacol Exp Ther. 2009 Nov;331(2):470-84. doi: 10.1124/jpet.109.157636. Epub 2009 Aug 24.

14.

Systematic review of antimicrobials for the prevention of haemodialysis catheter-related infections.

Rabindranath KS, Bansal T, Adams J, Das R, Shail R, MacLeod AM, Moore C, Besarab A.

Nephrol Dial Transplant. 2009 Dec;24(12):3763-74. doi: 10.1093/ndt/gfp327. Epub 2009 Jul 10. Review.

PMID:
19592599
15.
16.

Toward a joint health and disease management program. Toronto hospitals partner to provide system leadership.

Macleod AM, Gollish J, Kennedy D, McGlasson R, Waddell J.

Healthc Q. 2009;12(2):56-65.

PMID:
19369812
17.

Mid-infrared (2.75-6.0-microm) second-harmonic generation in LiInS(2).

Knippels GM, van der Meer AF, Macleod AM, Yelisseyev A, Isaenko L, Lobanov S, Thènot I, Zondy JJ.

Opt Lett. 2001 May 1;26(9):617-9.

PMID:
18040401
18.

Benchmarking of electro-optic monitors for femtosecond electron bunches.

Berden G, Gillespie WA, Jamison SP, Knabbe EA, MacLeod AM, van der Meer AF, Phillips PJ, Schlarb H, Schmidt B, Schmüser P, Steffen B.

Phys Rev Lett. 2007 Oct 19;99(16):164801. Epub 2007 Oct 17.

PMID:
17995259
19.

Automated vs continuous ambulatory peritoneal dialysis: a systematic review of randomized controlled trials.

Rabindranath KS, Adams J, Ali TZ, Daly C, Vale L, Macleod AM.

Nephrol Dial Transplant. 2007 Oct;22(10):2991-8. Epub 2007 Sep 17. Review.

PMID:
17875571
20.

Intermittent versus continuous renal replacement therapy for acute renal failure in adults.

Rabindranath K, Adams J, Macleod AM, Muirhead N.

Cochrane Database Syst Rev. 2007 Jul 18;(3):CD003773. Review.

PMID:
17636735
21.

A prospective national study of acute renal failure treated with RRT: incidence, aetiology and outcomes.

Prescott GJ, Metcalfe W, Baharani J, Khan IH, Simpson K, Smith WC, MacLeod AM.

Nephrol Dial Transplant. 2007 Sep;22(9):2513-9. Epub 2007 May 21.

PMID:
17517795
22.

Continuous ambulatory peritoneal dialysis versus automated peritoneal dialysis for end-stage renal disease.

Rabindranath KS, Adams J, Ali TZ, MacLeod AM, Vale L, Cody J, Wallace SA, Daly C.

Cochrane Database Syst Rev. 2007 Apr 18;(2):CD006515. Review.

PMID:
17443624
23.

2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands.

Wilson KJ, van Niel MB, Cooper L, Bloomfield D, O'Connor D, Fish LR, MacLeod AM.

Bioorg Med Chem Lett. 2007 May 1;17(9):2643-8. Epub 2007 Feb 2.

PMID:
17314044
24.

Achieving team consensus on best practice rehabilitation guidelines following primary total hip replacement (THR) surgery.

O'Donnell S, Kennedy D, MacLeod AM, Kilroy C, Gollish J.

Healthc Q. 2006;9(4):60-4.

PMID:
17076378
25.

Haemodiafiltration, haemofiltration and haemodialysis for end-stage kidney disease.

Rabindranath KS, Strippoli GF, Daly C, Roderick PJ, Wallace S, MacLeod AM.

Cochrane Database Syst Rev. 2006 Oct 18;(4):CD006258. Review. Update in: Cochrane Database Syst Rev. 2015;5:CD006258.

PMID:
17054289
26.

Temporally resolved electro-optic effect.

Jamison SP, MacLeod AM, Berden G, Jaroszynski DA, Gillespie WA.

Opt Lett. 2006 Jun 1;31(11):1753-5.

PMID:
16688284
27.

Aldehyde oxidase and its contribution to the metabolism of a structurally novel, functionally selective GABAA alpha5-subtype inverse agonist.

O'Connor D, Jones P, Chambers MS, Maxey R, Szekeres HJ, Szeto N, Scott-Stevens P, Macleod AM, Braun M, Cato B.

Xenobiotica. 2006 Apr;36(4):315-30.

PMID:
16684711
28.

A new class of selective, non-basic 5-HT2A receptor antagonists.

Ladduwahetty T, Boase AL, Mitchinson A, Quin C, Patel S, Chapman K, MacLeod AM.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3201-4. Epub 2006 May 2.

PMID:
16632354
29.

An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA, Reynolds DS, Seabrook GR, Atack JR.

J Pharmacol Exp Ther. 2006 Mar;316(3):1335-45. Epub 2005 Dec 2.

30.

Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.

Jones P, Atack JR, Braun MP, Cato BP, Chambers MS, O'Connor D, Cook SM, Hobbs SC, Maxey R, Szekeres HJ, Szeto N, Wafford KA, MacLeod AM.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):872-5. Epub 2005 Nov 21.

PMID:
16303300
31.

A new pyridazine series of GABAA alpha5 ligands.

van Niel MB, Wilson K, Adkins CH, Atack JR, Castro JL, Clarke DE, Fletcher S, Gerhard U, Mackey MM, Malpas S, Maubach K, Newman R, O'Connor D, Pillai GV, Simpson PB, Thomas SR, MacLeod AM.

J Med Chem. 2005 Sep 22;48(19):6004-11.

PMID:
16162003
32.

Psychosocial interventions for depression in dialysis patients.

Rabindranath KS, Daly C, Butler JA, Roderick PJ, Wallace S, Macleod AM.

Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004542. Review.

PMID:
16034936
33.

Cellulose, modified cellulose and synthetic membranes in the haemodialysis of patients with end-stage renal disease.

Macleod AM, Campbell M, Cody JD, Daly C, Donaldson C, Grant A, Khan I, Rabindranath KS, Vale L, Wallace S.

Cochrane Database Syst Rev. 2005 Jul 20;(3):CD003234. Review.

PMID:
16034894
34.

4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.

Fish LR, Gilligan MT, Humphries AC, Ivarsson M, Ladduwahetty T, Merchant KJ, O'Connor D, Patel S, Philipps E, Vargas HM, Hutson PH, MacLeod AM.

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3665-9.

PMID:
15993598
35.

Physical measures for treating depression in dialysis patients.

Rabindranath KS, Butler JA, Macleod AM, Roderick P, Wallace SA, Daly C.

Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004541. Review. Update in: Cochrane Database Syst Rev. 2016;(5):CD004541.

PMID:
15846720
36.

Comparison of hemodialysis, hemofiltration, and acetate-free biofiltration for ESRD: systematic review.

Rabindranath KS, Strippoli GF, Roderick P, Wallace SA, MacLeod AM, Daly C.

Am J Kidney Dis. 2005 Mar;45(3):437-47. Review.

PMID:
15754266
37.

An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.

Chambers MS, Atack JR, Carling RW, Collinson N, Cook SM, Dawson GR, Ferris P, Hobbs SC, O'connor D, Marshall G, Rycroft W, Macleod AM.

J Med Chem. 2004 Nov 18;47(24):5829-32.

PMID:
15537339
38.

Electro-optic technique with improved time resolution for real-time, nondestructive, single-shot measurements of femtosecond electron bunch profiles.

Berden G, Jamison SP, MacLeod AM, Gillespie WA, Redlich B, van der Meer AF.

Phys Rev Lett. 2004 Sep 10;93(11):114802. Epub 2004 Sep 9.

PMID:
15447346
39.

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

Street LJ, Sternfeld F, Jelley RA, Reeve AJ, Carling RW, Moore KW, McKernan RM, Sohal B, Cook S, Pike A, Dawson GR, Bromidge FA, Wafford KA, Seabrook GR, Thompson SA, Marshall G, Pillai GV, Castro JL, Atack JR, MacLeod AM.

J Med Chem. 2004 Jul 1;47(14):3642-57.

PMID:
15214791
40.

3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.

Szekeres HJ, Atack JR, Chambers MS, Cook SM, Macaulay AJ, Pillai GV, MacLeod AM.

Bioorg Med Chem Lett. 2004 Jun 7;14(11):2871-5.

PMID:
15125950
41.

Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.

Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, Collinson N, Dawson GR, Castro JL, MacLeod AM.

J Med Chem. 2004 Apr 22;47(9):2176-9.

PMID:
15084116
42.

Hospitalization in the first year of renal replacement therapy for end-stage renal disease.

Metcalfe W, Khan IH, Prescott GJ, Simpson K, Macleod AM.

QJM. 2003 Dec;96(12):899-909.

PMID:
14631056
43.

End-stage renal disease in Scotland: outcomes and standards of care.

Metcalfe W, Khan IH, Prescott GJ, Simpson K, Macleod AM; Scottish Renal Registry.

Kidney Int. 2003 Nov;64(5):1808-16.

44.

High-temporal-resolution, single-shot characterization of terahertz pulses.

Jamison SP, Shen J, MacLeod AM, Gillespie WA, Jaroszynski DA.

Opt Lett. 2003 Sep 15;28(18):1710-2.

PMID:
13677545
45.

End-stage renal disease in Indo-Asians in the North-West of England.

Trehan A, Winterbottom J, Lane B, Foley R, Venning M, Coward R, MacLeod AM, Gokal R.

QJM. 2003 Jul;96(7):499-504.

PMID:
12881592
46.

Early referral and planned initiation of dialysis: what impact on quality of life?

Caskey FJ, Wordsworth S, Ben T, de Charro FT, Delcroix C, Dobronravov V, van Hamersvelt H, Henderson I, Kokolina E, Khan IH, Ludbrook A, Luman M, Prescott GJ, Tsakiris D, Barbullushi M, MacLeod AM; EURODICE group.

Nephrol Dial Transplant. 2003 Jul;18(7):1330-8.

PMID:
12808170
47.

Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.

Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, Pillai GV, Reeve AJ, MacLeod AM.

J Med Chem. 2003 May 22;46(11):2227-40.

PMID:
12747794
48.

Acute renal failure requiring renal replacement therapy: incidence and outcome.

Metcalfe W, Simpson M, Khan IH, Prescott GJ, Simpson K, Smith WC, MacLeod AM; Scottish Renal Registry.

QJM. 2002 Sep;95(9):579-83.

PMID:
12205335
49.

Incomplete excision of basal cell carcinomas: a retrospective audit.

Dieu T, Macleod AM.

ANZ J Surg. 2002 Mar;72(3):219-21.

PMID:
12071456
50.

Single-shot electron-beam bunch length measurements.

Wilke I, MacLeod AM, Gillespie WA, Berden G, Knippels GM, van der Meer AF.

Phys Rev Lett. 2002 Mar 25;88(12):124801. Epub 2002 Mar 6.

PMID:
11909465

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