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Items: 1 to 50 of 306

1.

Transcriptional regulatory networks underlying gene expression changes in Huntington's disease.

Ament SA, Pearl JR, Cantle JP, Bragg RM, Skene PJ, Coffey SR, Bergey DE, Wheeler VC, MacDonald ME, Baliga NS, Rosinski J, Hood LE, Carroll JB, Price ND.

Mol Syst Biol. 2018 Mar 26;14(3):e7435. doi: 10.15252/msb.20167435.

2.

Relational ethics of delirium care: Findings from a hospice ethnography.

Wright DK, Brajtman S, Macdonald ME.

Nurs Inq. 2018 Mar 24:e12234. doi: 10.1111/nin.12234. [Epub ahead of print]

PMID:
29573054
3.

HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction.

Kovalenko M, Milnerwood A, Giordano J, St Claire J, Guide JR, Stromberg M, Gillis T, Sapp E, DiFiglia M, MacDonald ME, Carroll JB, Lee JM, Tappan S, Raymond L, Wheeler VC.

J Huntingtons Dis. 2018;7(1):17-33. doi: 10.3233/JHD-170282.

4.

Gas-free calibrated fMRI with a correction for vessel-size sensitivity.

Berman AJL, Mazerolle EL, MacDonald ME, Blockley NP, Luh WM, Pike GB.

Neuroimage. 2018 Apr 1;169:176-188. doi: 10.1016/j.neuroimage.2017.12.047. Epub 2017 Dec 15.

PMID:
29253657
5.

Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

Handley RR, Reid SJ, Brauning R, Maclean P, Mears ER, Fourie I, Patassini S, Cooper GJS, Rudiger SR, McLaughlan CJ, Verma PJ, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RLM, Snell RG.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11293-E11302. doi: 10.1073/pnas.1711243115. Epub 2017 Dec 11.

6.

Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.

Yu P, Xiong T, Tenedero CB, Lebeau P, Ni R, MacDonald ME, Gross PL, Austin RC, Trigatti BL.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):26-39. doi: 10.1161/ATVBAHA.117.305140. Epub 2017 Nov 21.

7.

The Making of Informed Choice in Midwifery: A Feminist Experiment in Care.

MacDonald ME.

Cult Med Psychiatry. 2017 Nov 15. doi: 10.1007/s11013-017-9560-9. [Epub ahead of print]

PMID:
29143236
8.

HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner.

Durham KK, Chathely KM, Mak KC, Momen A, Thomas CT, Zhao YY, MacDonald ME, Curtis JM, Husain M, Trigatti BL.

Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H31-H44. doi: 10.1152/ajpheart.00521.2016. Epub 2017 Oct 6.

PMID:
28986362
9.

A modifier of Huntington's disease onset at the MLH1 locus.

Lee JM, Chao MJ, Harold D, Abu Elneel K, Gillis T, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF.

Hum Mol Genet. 2017 Oct 1;26(19):3859-3867. doi: 10.1093/hmg/ddx286.

PMID:
28934397
10.

The conceptualization of childhood in North American pediatric dentistry texts: a discursive case study analysis.

Makansi N, Carnevale FA, Macdonald ME.

Int J Paediatr Dent. 2018 Mar;28(2):189-197. doi: 10.1111/ipd.12325. Epub 2017 Aug 25.

PMID:
28840947
11.

Haplotype-based stratification of Huntington's disease.

Chao MJ, Gillis T, Atwal RS, Mysore JS, Arjomand J, Harold D, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM.

Eur J Hum Genet. 2017 Nov;25(11):1202-1209. doi: 10.1038/ejhg.2017.125. Epub 2017 Aug 23.

PMID:
28832564
12.

Reconciling disparate data to determine the right answer: A grounded theory of meta analysts' reasoning in meta-analysis.

Chan L, Macdonald ME, Carnevale FA, Steele RJ, Shrier I.

Res Synth Methods. 2018 Mar;9(1):25-40. doi: 10.1002/jrsm.1258. Epub 2017 Sep 3.

PMID:
28741808
13.

A randomized phase II trial of geriatric assessment and management for older cancer patients.

Puts MTE, Sattar S, Kulik M, MacDonald ME, McWatters K, Lee K, Brennenstuhl S, Jang R, Amir E, Krzyzanowska MK, Joshua AM, Monette J, Wan-Chow-Wah D, Alibhai SMH.

Support Care Cancer. 2018 Jan;26(1):109-117. doi: 10.1007/s00520-017-3820-7. Epub 2017 Jul 25.

PMID:
28741175
14.

'I'm only dealing with the acute issues': How medical ward 'busyness' constrains care of the dying.

Chan LS, Macdonald ME, Carnevale FA, Cohen SR.

Health (London). 2017 May 1:1363459317708822. doi: 10.1177/1363459317708822. [Epub ahead of print]

PMID:
28552003
15.

Erratum to: The concept of 'vulnerability' in research ethics: an in-depth analysis of policies and guidelines.

Bracken-Roche D, Bell E, Macdonald ME, Racine E.

Health Res Policy Syst. 2017 Apr 3;15(1):29. doi: 10.1186/s12961-017-0186-8. No abstract available.

16.

Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.

Bragg RM, Coffey SR, Weston RM, Ament SA, Cantle JP, Minnig S, Funk CC, Shuttleworth DD, Woods EL, Sullivan BR, Jones L, Glickenhaus A, Anderson JS, Anderson MD, Dunnett SB, Wheeler VC, MacDonald ME, Brooks SP, Price ND, Carroll JB.

Sci Rep. 2017 Mar 28;7:44960. doi: 10.1038/srep44960. No abstract available.

17.

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.

Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME, Carlson G, Wheeler VC, Price ND, Hood LE.

Hum Mol Genet. 2017 Mar 1;26(5):913-922. doi: 10.1093/hmg/ddx006.

PMID:
28334820
18.

Inuit interpreters engaged in end-of-life care in Nunavik, Northern Quebec.

Hordyk SR, Macdonald ME, Brassard P.

Int J Circumpolar Health. 2017;76(1):1291868. doi: 10.1080/22423982.2017.1291868.

19.

End-of-Life Care in Nunavik, Quebec: Inuit Experiences, Current Realities, and Ways Forward.

Hordyk SR, Macdonald ME, Brassard P.

J Palliat Med. 2017 Jun;20(6):647-655. doi: 10.1089/jpm.2016.0256. Epub 2017 Feb 8.

PMID:
28177857
20.

Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.

Bragg RM, Coffey SR, Weston RM, Ament SA, Cantle JP, Minnig S, Funk CC, Shuttleworth DD, Woods EL, Sullivan BR, Jones L, Glickenhaus A, Anderson JS, Anderson MD, Dunnett SB, Wheeler VC, MacDonald ME, Brooks SP, Price ND, Carroll JB.

Sci Rep. 2017 Feb 8;7:41570. doi: 10.1038/srep41570.

21.

The concept of 'vulnerability' in research ethics: an in-depth analysis of policies and guidelines.

Bracken-Roche D, Bell E, Macdonald ME, Racine E.

Health Res Policy Syst. 2017 Feb 7;15(1):8. doi: 10.1186/s12961-016-0164-6. Erratum in: Health Res Policy Syst. 2017 Apr 3;15(1):29.

22.

Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.

Shin JW, Kim KH, Chao MJ, Atwal RS, Gillis T, MacDonald ME, Gusella JF, Lee JM.

Hum Mol Genet. 2016 Oct 15;25(20):4566-4576. doi: 10.1093/hmg/ddw286.

PMID:
28172889
23.

Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels.

Shin A, Shin B, Shin JW, Kim KH, Atwal RS, Hope JM, Gillis T, Leszyk JD, Shaffer SA, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS, Lee JM.

Hum Mol Genet. 2017 Apr 1;26(7):1258-1267. doi: 10.1093/hmg/ddx033.

PMID:
28165127
24.

Potential molecular consequences of transgene integration: The R6/2 mouse example.

Jacobsen JC, Erdin S, Chiang C, Hanscom C, Handley RR, Barker DD, Stortchevoi A, Blumenthal I, Reid SJ, Snell RG, MacDonald ME, Morton AJ, Ernst C, Gusella JF, Talkowski ME.

Sci Rep. 2017 Jan 25;7:41120. doi: 10.1038/srep41120.

25.

Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening.

Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ.

Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33.

26.

Patient participation in palliative care decisions: An ethnographic discourse analysis.

Bélanger E, Rodríguez C, Groleau D, Légaré F, MacDonald ME, Marchand R.

Int J Qual Stud Health Well-being. 2016 Nov 22;11:32438. doi: 10.3402/qhw.v11.32438. eCollection 2016.

27.

Chemotherapy treatment decision-making experiences of older adults with cancer, their family members, oncologists and family physicians: a mixed methods study.

Puts MT, Sattar S, McWatters K, Lee K, Kulik M, MacDonald ME, Jang R, Amir E, Krzyzanowska MK, Leighl N, Fitch M, Joshua AM, Warde P, Tourangeau AE, Alibhai SM.

Support Care Cancer. 2017 Mar;25(3):879-886. doi: 10.1007/s00520-016-3476-8. Epub 2016 Nov 9.

28.

Suffering and medicalization at the end of life: The case of physician-assisted dying.

Karsoho H, Fishman JR, Wright DK, Macdonald ME.

Soc Sci Med. 2016 Dec;170:188-196. doi: 10.1016/j.socscimed.2016.10.010. Epub 2016 Oct 12.

29.

The oral health of refugees and asylum seekers: a scoping review.

Keboa MT, Hiles N, Macdonald ME.

Global Health. 2016 Oct 7;12(1):59. Review.

30.

Flow and pressure measurements in aneurysms and arteriovenous malformations with phase contrast MR imaging.

MacDonald ME, Dolati P, Mitha AP, Wong JH, Frayne R.

Magn Reson Imaging. 2016 Nov;34(9):1322-1328. doi: 10.1016/j.mri.2016.07.007. Epub 2016 Jul 25.

PMID:
27469312
31.

Correction: RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH.

PLoS One. 2016 Jul 25;11(7):e0160295. doi: 10.1371/journal.pone.0160295. eCollection 2016.

32.

Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.

Alexandrov V, Brunner D, Menalled LB, Kudwa A, Watson-Johnson J, Mazzella M, Russell I, Ruiz MC, Torello J, Sabath E, Sanchez A, Gomez M, Filipov I, Cox K, Kwan M, Ghavami A, Ramboz S, Lager B, Wheeler VC, Aaronson J, Rosinski J, Gusella JF, MacDonald ME, Howland D, Kwak S.

Nat Biotechnol. 2016 Aug;34(8):838-44. doi: 10.1038/nbt.3587. Epub 2016 Jul 4.

PMID:
27376585
33.

The emergency department as a 'last resort': why parents seek care for their child's nontraumatic dental problems in the emergency room.

Mostajer Haqiqi A, Bedos C, Macdonald ME.

Community Dent Oral Epidemiol. 2016 Oct;44(5):493-503. doi: 10.1111/cdoe.12239. Epub 2016 Jun 10.

PMID:
27283335
34.

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group.

Wickwire EM, Williams SG, Roth T, Capaldi VF, Jaffe M, Moline M, Motamedi GK, Morgan GW, Mysliwiec V, Germain A, Pazdan RM, Ferziger R, Balkin TJ, MacDonald ME, Macek TA, Yochelson MR, Scharf SM, Lettieri CJ.

Neurotherapeutics. 2016 Apr;13(2):403-17. doi: 10.1007/s13311-016-0429-3.

35.

Low-income working immigrant families in Quebec: Exploring their challenges to well-being.

Pitt RS, Sherman J, Macdonald ME.

Can J Public Health. 2016 Mar 16;106(8):e539-45. doi: 10.17269/cjph.106.5028.

PMID:
26986917
36.

Phase Error Correction in Time-Averaged 3D Phase Contrast Magnetic Resonance Imaging of the Cerebral Vasculature.

MacDonald ME, Forkert ND, Pike GB, Frayne R.

PLoS One. 2016 Feb 24;11(2):e0149930. doi: 10.1371/journal.pone.0149930. eCollection 2016.

37.

An open letter to The BMJ editors on qualitative research.

Greenhalgh T, Annandale E, Ashcroft R, Barlow J, Black N, Bleakley A, Boaden R, Braithwaite J, Britten N, Carnevale F, Checkland K, Cheek J, Clark A, Cohn S, Coulehan J, Crabtree B, Cummins S, Davidoff F, Davies H, Dingwall R, Dixon-Woods M, Elwyn G, Engebretsen E, Ferlie E, Fulop N, Gabbay J, Gagnon MP, Galasinski D, Garside R, Gilson L, Griffiths P, Hawe P, Helderman JK, Hodges B, Hunter D, Kearney M, Kitzinger C, Kitzinger J, Kuper A, Kushner S, Le May A, Legare F, Lingard L, Locock L, Maben J, Macdonald ME, Mair F, Mannion R, Marshall M, May C, Mays N, McKee L, Miraldo M, Morgan D, Morse J, Nettleton S, Oliver S, Pearce W, Pluye P, Pope C, Robert G, Roberts C, Rodella S, Rycroft-Malone J, Sandelowski M, Shekelle P, Stevenson F, Straus S, Swinglehurst D, Thorne S, Tomson G, Westert G, Wilkinson S, Williams B, Young T, Ziebland S.

BMJ. 2016 Feb 10;352:i563. doi: 10.1136/bmj.i563. No abstract available. Erratum in: BMJ. 2016;352:i957.

38.

Metabolic disruption identified in the Huntington's disease transgenic sheep model.

Handley RR, Reid SJ, Patassini S, Rudiger SR, Obolonkin V, McLaughlan CJ, Jacobsen JC, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RL, Snell RG.

Sci Rep. 2016 Feb 11;6:20681. doi: 10.1038/srep20681.

39.

The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease.

Keum JW, Shin A, Gillis T, Mysore JS, Abu Elneel K, Lucente D, Hadzi T, Holmans P, Jones L, Orth M, Kwak S, MacDonald ME, Gusella JF, Lee JM.

Am J Hum Genet. 2016 Feb 4;98(2):287-98. doi: 10.1016/j.ajhg.2015.12.018.

40.

Understanding How Bereaved Parents Cope With Their Grief to Inform the Services Provided to Them.

Stevenson M, Achille M, Liben S, Proulx MC, Humbert N, Petti A, Macdonald ME, Cohen SR.

Qual Health Res. 2017 Apr;27(5):649-664. doi: 10.1177/1049732315622189. Epub 2016 Jul 9.

PMID:
26848080
41.

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH.

PLoS One. 2015 Dec 4;10(12):e0143563. doi: 10.1371/journal.pone.0143563. eCollection 2015. Erratum in: PLoS One. 2016;11(7):e0160295.

42.

Resident Role Modeling: "It Just Happens".

Sternszus R, Macdonald ME, Steinert Y.

Acad Med. 2016 Mar;91(3):427-32. doi: 10.1097/ACM.0000000000000996.

PMID:
26579795
43.

Promoting an ethic of engagement in pediatric palliative care research.

Rahimzadeh V, Bartlett G, Longo C, Crimi L, Macdonald ME, Jabado N, Ells C.

BMC Palliat Care. 2015 Oct 16;14:50. doi: 10.1186/s12904-015-0048-5.

44.

The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease.

Correia K, Harold D, Kim KH, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM.

J Huntingtons Dis. 2015;4(3):279-84. doi: 10.3233/JHD-150169.

45.

Physicians and euthanasia: a Canadian print-media discourse analysis of physician perspectives.

Wright DK, Fishman JR, Karsoho H, Sandham S, Macdonald ME.

CMAJ Open. 2015 Apr 2;3(2):E134-9. doi: 10.9778/cmajo.20140071. eCollection 2015 Apr-Jun.

46.

Sequence-Level Analysis of the Major European Huntington Disease Haplotype.

Lee JM, Kim KH, Shin A, Chao MJ, Abu Elneel K, Gillis T, Mysore JS, Kaye JA, Zahed H, Kratter IH, Daub AC, Finkbeiner S, Li H, Roach JC, Goodman N, Hood L, Myers RH, MacDonald ME, Gusella JF.

Am J Hum Genet. 2015 Sep 3;97(3):435-44. doi: 10.1016/j.ajhg.2015.07.017. Epub 2015 Aug 27.

47.

HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.

Carroll JB, Deik A, Fossale E, Weston RM, Guide JR, Arjomand J, Kwak S, Clish CB, MacDonald ME.

PLoS One. 2015 Aug 21;10(8):e0134465. doi: 10.1371/journal.pone.0134465. eCollection 2015.

48.

Why physicians teach: giving back by paying it forward.

Steinert Y, Macdonald ME.

Med Educ. 2015 Aug;49(8):773-82. doi: 10.1111/medu.12782.

PMID:
26152489
49.
50.

Promoting Cultural Awareness: A Faculty Development Workshop on Cultural Competency.

Carnevale FA, Macdonald ME, Razack S, Steinert Y.

Can J Nurs Res. 2015 Jun;47(2):18-40. doi: 10.1177/084456211504700203. English, French.

PMID:
29509442

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