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Items: 1 to 50 of 170

1.

Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases.

Szabo A, Sumegi K, Fekete K, Hocsak E, Debreceni B, Setalo G Jr., Kovacs K, Deres L, Kengyel A, Kovacs D, Mandl J, Nyitrai M, Febbraio MA, Gallyas F Jr., Sumegi B.

Biochem Pharmacol. 2018 Apr;150:86-96. doi: 10.1016/j.bcp.2018.01.038. Epub 2018 Feb 3.

2.

Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells.

Hoppe-Seyler K, Mändl J, Adrian S, Kuhn BJ, Hoppe-Seyler F.

Viruses. 2017 Jul 5;9(7). pii: E174. doi: 10.3390/v9070174. Review.

3.

Alterations in the Thymic Selection Threshold Skew the Self-Reactivity of the TCR Repertoire in Neonates.

Dong M, Artusa P, Kelly SA, Fournier M, Baldwin TA, Mandl JN, Melichar HJ.

J Immunol. 2017 Aug 1;199(3):965-973. doi: 10.4049/jimmunol.1602137. Epub 2017 Jun 28.

PMID:
28659353
4.

Weakly self-reactive T-cell clones can homeostatically expand when present at low numbers.

Vrisekoop N, Artusa P, Monteiro JP, Mandl JN.

Eur J Immunol. 2017 Jan;47(1):68-73. doi: 10.1002/eji.201646540. Epub 2016 Nov 18.

5.

The Reticular Cell Network: A Robust Backbone for Immune Responses.

Textor J, Mandl JN, de Boer RJ.

PLoS Biol. 2016 Oct 11;14(10):e2000827. doi: 10.1371/journal.pbio.2000827. eCollection 2016 Oct.

6.

IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity.

Lippens C, Duraes FV, Dubrot J, Brighouse D, Lacroix M, Irla M, Aubry-Lachainaye JP, Reith W, Mandl JN, Hugues S.

J Autoimmun. 2016 Dec;75:39-49. doi: 10.1016/j.jaut.2016.07.004. Epub 2016 Jul 26.

7.

Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes.

Simon-Szabó L, Kokas M, Greff Z, Boros S, Bánhegyi P, Zsákai L, Szántai-Kis C, Vantus T, Mandl J, Bánhegyi G, Vályi-Nagy I, Őrfi L, Ullrich A, Csala M, Kéri G.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):424-428. doi: 10.1016/j.bmcl.2015.11.099. Epub 2015 Nov 28.

PMID:
26704265
8.

The Level of ALR is Regulated by the Quantity of Mitochondrial DNA.

Balogh T, Lőrincz T, Stiller I, Mandl J, Bánhegyi G, Szarka A.

Pathol Oncol Res. 2016 Apr;22(2):431-7. doi: 10.1007/s12253-015-0020-y. Epub 2015 Nov 19.

PMID:
26584568
9.

Ferroptosis is Involved in Acetaminophen Induced Cell Death.

Lőrincz T, Jemnitz K, Kardon T, Mandl J, Szarka A.

Pathol Oncol Res. 2015 Sep;21(4):1115-21. doi: 10.1007/s12253-015-9946-3. Epub 2015 May 12.

PMID:
25962350
10.

Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy).

Grassmann F, Bergholz R, Mändl J, Jägle H, Ruether K, Weber BH.

BMC Ophthalmol. 2015 Mar 6;15:18. doi: 10.1186/s12886-015-0008-0.

11.

Robust and sustained immune activation in human Ebola virus infection.

Mandl JN, Feinberg MB.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4518-9. doi: 10.1073/pnas.1503864112. Epub 2015 Apr 7. No abstract available.

12.

On the role of 4-hydroxynonenal in health and disease.

Csala M, Kardon T, Legeza B, Lizák B, Mandl J, Margittai É, Puskás F, Száraz P, Szelényi P, Bánhegyi G.

Biochim Biophys Acta. 2015 May;1852(5):826-38. doi: 10.1016/j.bbadis.2015.01.015. Epub 2015 Jan 30. Review.

13.

Reservoir host immune responses to emerging zoonotic viruses.

Mandl JN, Ahmed R, Barreiro LB, Daszak P, Epstein JH, Virgin HW, Feinberg MB.

Cell. 2015 Jan 15;160(1-2):20-35. doi: 10.1016/j.cell.2014.12.003. Epub 2014 Dec 18. Review.

14.

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.

Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, Mandl JN, Grodick RA, Jing H, Chandler-Brown DB, Lenardo TE, Crawford G, Matthews HF, Freeman AF, Cornall RJ, Germain RN, Mueller SN, Su HC.

J Exp Med. 2014 Dec 15;211(13):2549-66. doi: 10.1084/jem.20141307. Epub 2014 Nov 24.

15.

Revisiting thymic positive selection and the mature T cell repertoire for antigen.

Vrisekoop N, Monteiro JP, Mandl JN, Germain RN.

Immunity. 2014 Aug 21;41(2):181-90. doi: 10.1016/j.immuni.2014.07.007.

16.

Random migration and signal integration promote rapid and robust T cell recruitment.

Textor J, Henrickson SE, Mandl JN, von Andrian UH, Westermann J, de Boer RJ, Beltman JB.

PLoS Comput Biol. 2014 Aug 7;10(8):e1003752. doi: 10.1371/journal.pcbi.1003752. eCollection 2014 Aug.

17.

Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells.

Simon-Szabó L, Kokas M, Mandl J, Kéri G, Csala M.

PLoS One. 2014 Jun 4;9(6):e97868. doi: 10.1371/journal.pone.0097868. eCollection 2014.

18.

Focusing in on T cell cross-reactivity.

Mandl JN, Germain RN.

Cell. 2014 May 22;157(5):1006-8. doi: 10.1016/j.cell.2014.05.002.

19.

Visualization and dynamic analysis of host-pathogen interactions.

Mandl JN, Torabi-Parizi P, Germain RN.

Curr Opin Immunol. 2014 Aug;29:8-15. doi: 10.1016/j.coi.2014.03.002. Epub 2014 Apr 3. Review.

PMID:
24705104
20.

Detection of Mycobacterium avium subsp. paratuberculosis in faeces using different procedures of pre-treatment for real-time PCR in comparison to culture.

Sting R, Hrubenja M, Mandl J, Seemann G, Salditt A, Waibel S.

Vet J. 2014 Jan;199(1):138-42. doi: 10.1016/j.tvjl.2013.08.033. Epub 2013 Sep 7.

PMID:
24280588
21.

5'-AMP impacts lymphocyte recirculation through activation of A2B receptors.

Bouma HR, Mandl JN, Strijkstra AM, Boerema AS, Kok JW, van Dam A, Ijzerman A, Kroese FG, Henning RH.

J Leukoc Biol. 2013 Jul;94(1):89-98. doi: 10.1189/jlb.1212613. Epub 2013 May 16.

22.

Synergic insulin sensitizing effect of rimonabant and BGP-15 in Zucker-obese rats.

Literati-Nagy Z, Tory K, Literáti-Nagy B, Bajza A, Vígh L Jr, Vígh L, Mandl J, Szilvássy Z.

Pathol Oncol Res. 2013 Jul;19(3):571-5. doi: 10.1007/s12253-013-9620-6. Epub 2013 May 3.

PMID:
23640247
23.

Inhibition of microsomal cortisol production by (-)-epigallocatechin-3-gallate through a redox shift in the endoplasmic reticulum--a potential new target for treating obesity-related diseases.

Szelényi P, Révész K, Konta L, Tüttõ A, Mandl J, Kereszturi É, Csala M.

Biofactors. 2013 Sep-Oct;39(5):534-41. doi: 10.1002/biof.1095. Epub 2013 Mar 29.

PMID:
23554216
24.

Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase.

Kálmán FS, Lizák B, Nagy SK, Mészáros T, Zámbó V, Mandl J, Csala M, Kereszturi E.

Biochimie. 2013 Jul;95(7):1403-10. doi: 10.1016/j.biochi.2013.03.004. Epub 2013 Mar 19.

PMID:
23523930
25.

Minireview: endoplasmic reticulum stress: control in protein, lipid, and signal homeostasis.

Mandl J, Mészáros T, Bánhegyi G, Csala M.

Mol Endocrinol. 2013 Mar;27(3):384-93. doi: 10.1210/me.2012-1317. Epub 2013 Jan 24. Review.

26.

T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.

Mandl JN, Monteiro JP, Vrisekoop N, Germain RN.

Immunity. 2013 Feb 21;38(2):263-274. doi: 10.1016/j.immuni.2012.09.011. Epub 2013 Jan 3.

27.

Luminal accumulation of newly synthesized morphine-3-glucuronide in rat liver microsomal vesicles.

Révész K, Tóth B, Staines AG, Coughtrie MW, Mandl J, Csala M.

Biofactors. 2013 May-Jun;39(3):271-8. doi: 10.1002/biof.1067. Epub 2012 Dec 22.

PMID:
23281118
28.

A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis.

Kapuy O, Vinod PK, Mandl J, Bánhegyi G.

Mol Biosyst. 2013 Feb 2;9(2):296-306. doi: 10.1039/c2mb25261a. Epub 2012 Dec 7.

PMID:
23223525
29.

Pathology in euthermic bats with white nose syndrome suggests a natural manifestation of immune reconstitution inflammatory syndrome.

Meteyer CU, Barber D, Mandl JN.

Virulence. 2012 Nov 15;3(7):583-8. doi: 10.4161/viru.22330. Epub 2012 Nov 15.

30.

Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells.

Mandl JN, Liou R, Klauschen F, Vrisekoop N, Monteiro JP, Yates AJ, Huang AY, Germain RN.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18036-41. doi: 10.1073/pnas.1211717109. Epub 2012 Oct 15.

31.

Keratinocyte ATP binding cassette transporter expression is regulated by ultraviolet light.

Markó L, Paragh G, Ugocsai P, Boettcher A, Vogt T, Schling P, Balogh A, Tarabin V, Orsó E, Wikonkál N, Mandl J, Remenyik E, Schmitz G.

J Photochem Photobiol B. 2012 Nov 5;116:79-88. doi: 10.1016/j.jphotobiol.2012.06.007. Epub 2012 Jun 25.

PMID:
22982209
32.

Hydroximic acid derivatives: pleiotropic HSP co-inducers restoring homeostasis and robustness.

Crul T, Toth N, Piotto S, Literati-Nagy P, Tory K, Haldimann P, Kalmar B, Greensmith L, Torok Z, Balogh G, Gombos I, Campana F, Concilio S, Gallyas F, Nagy G, Berente Z, Gungor B, Peter M, Glatz A, Hunya A, Literati-Nagy Z, Vigh L Jr, Hoogstra-Berends F, Heeres A, Kuipers I, Loen L, Seerden JP, Zhang D, Meijering RA, Henning RH, Brundel BJ, Kampinga HH, Koranyi L, Szilvassy Z, Mandl J, Sumegi B, Febbraio MA, Horvath I, Hooper PL, Vigh L.

Curr Pharm Des. 2013;19(3):309-46. Review.

PMID:
22920902
33.

The race for the prize: T-cell trafficking strategies for optimal surveillance.

Lee M, Mandl JN, Germain RN, Yates AJ.

Blood. 2012 Aug 16;120(7):1432-8. doi: 10.1182/blood-2012-04-424655. Epub 2012 Jul 6.

34.

A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychotics.

Literati-Nagy Z, Tory K, Literáti-Nagy B, Kolonics A, Vígh L Jr, Vígh L, Mandl J, Szilvássy Z.

Pathol Oncol Res. 2012 Oct;18(4):1071-6. Epub 2012 Jun 30.

PMID:
22743983
35.

G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome.

Czegle I, Csala M, Mandl J, Benedetti A, Karádi I, Bánhegyi G.

World J Hepatol. 2012 Apr 27;4(4):129-38. doi: 10.4254/wjh.v4.i4.129.

36.

Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules.

Borbély G, Huszár M, Varga A, Futosi K, Mócsai A, Orfi L, Idei M, Mandl J, Kéri G, Vántus T.

Med Chem. 2012 Mar;8(2):174-81.

PMID:
22385185
37.

The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics.

Literáti-Nagy Z, Tory K, Literáti-Nagy B, Kolonics A, Török Z, Gombos I, Balogh G, Vígh L Jr, Horváth I, Mandl J, Sümegi B, Hooper PL, Vígh L.

Cell Stress Chaperones. 2012 Jul;17(4):517-21. doi: 10.1007/s12192-012-0327-5. Epub 2012 Feb 10.

38.

Inhibition of glycoprotein synthesis in the endoplasmic reticulum as a novel anticancer mechanism of (-)-epigallocatechin-3-gallate.

Konta L, Száraz P, Magyar JÉ, Révész K, Bánhegyi G, Mandl J, Csala M.

Biofactors. 2011 Nov-Dec;37(6):468-76. doi: 10.1002/biof.189. Epub 2011 Dec 8.

PMID:
22162335
39.

The endoplasmic reticulum as the extracellular space inside the cell: role in protein folding and glycosylation.

Csala M, Kereszturi É, Mandl J, Bánhegyi G.

Antioxid Redox Signal. 2012 May 15;16(10):1100-8. doi: 10.1089/ars.2011.4227. Epub 2012 Feb 23. Review.

PMID:
22149109
40.

Crosstalk and barriers between the electron carriers of the endoplasmic reticulum.

Bánhegyi G, Margittai E, Szarka A, Mandl J, Csala M.

Antioxid Redox Signal. 2012 Apr 15;16(8):772-80. doi: 10.1089/ars.2011.4437. Epub 2012 Jan 18. Review.

PMID:
22142307
41.

N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation.

Chatterjee J, Laufer B, Beck JG, Helyes Z, Pintér E, Szolcsányi J, Horvath A, Mandl J, Reubi JC, Kéri G, Kessler H.

ACS Med Chem Lett. 2011 Apr 4;2(7):509-14. doi: 10.1021/ml200032v. eCollection 2011 Jul 14.

42.

[Complementary therapies--based on the principles of evidence-based medicine. Position statement of the Medical Sciences Section of the Hungarian Academy of Sciences].

Medical Sciences Section, Hungarian Academy of Sciences, Dobozy A, Kerpel-Fronius S, Komoly S, Kovács L G, Mandl J, Muszbek L, Petrányi G, Sótonyi P, Udvardy M, Varró A, Vécsei L.

Orv Hetil. 2011 Jul 24;152(30):1197-204. doi: 10.1556/OH.2011.29171. Hungarian. No abstract available.

PMID:
21733793
43.

Distinctive TLR7 signaling, type I IFN production, and attenuated innate and adaptive immune responses to yellow fever virus in a primate reservoir host.

Mandl JN, Akondy R, Lawson B, Kozyr N, Staprans SI, Ahmed R, Feinberg MB.

J Immunol. 2011 Jun 1;186(11):6406-16. doi: 10.4049/jimmunol.1001191. Epub 2011 Apr 22.

44.

Beneficial effect of the insulin sensitizer (HSP inducer) BGP-15 on olanzapine-induced metabolic disorders.

Literáti-Nagy B, Péterfai E, Kulcsár E, Literáti-Nagy Z, Buday B, Tory K, Mandl J, Sümegi B, Fleming A, Roth J, Korányi L.

Brain Res Bull. 2010 Nov 20;83(6):340-4. doi: 10.1016/j.brainresbull.2010.09.005. Epub 2010 Sep 16.

PMID:
20849938
45.

Contribution of fructose-6-phosphate to glucocorticoid activation in the endoplasmic reticulum: possible implication in the metabolic syndrome.

Senesi S, Legeza B, Balázs Z, Csala M, Marcolongo P, Kereszturi E, Szelényi P, Egger C, Fulceri R, Mandl J, Giunti R, Odermatt A, Bánhegyi G, Benedetti A.

Endocrinology. 2010 Oct;151(10):4830-9. doi: 10.1210/en.2010-0614. Epub 2010 Sep 8.

PMID:
20826560
46.

Cold ischemia contributes to the development of chronic rejection and mitochondrial injury after cardiac transplantation.

Schneeberger S, Amberger A, Mandl J, Hautz T, Renz O, Obrist P, Meusburger H, Brandacher G, Mark W, Strobl D, Troppmair J, Pratschke J, Margreiter R, Kuznetsov AV.

Transpl Int. 2010 Dec;23(12):1282-92. doi: 10.1111/j.1432-2277.2010.01126.x.

47.

Comparative characterization of experimental and calculated lipophilicity and anti-tumour activity of isochromanone derivatives.

Huszár M, Varga A, Horváth A, Loránd T, Agócs A, Idei M, Mandl J, Vántus T, Kéri G.

Curr Med Chem. 2010;17(4):321-33.

PMID:
20015044
48.

Whole genome transcriptional profiling identifies novel differentiation regulated genes in keratinocytes.

Paragh G, Ugocsai P, Vogt T, Schling P, Kel AE, Tarabin V, Liebisch G, Orsó E, Markó L, Balogh A, Köbling T, Remenyik E, Wikonkál NM, Mandl J, Farwick M, Schmitz G.

Exp Dermatol. 2010 Mar;19(3):297-301. doi: 10.1111/j.1600-0625.2009.00920.x. Epub 2009 Dec 2.

PMID:
19961536
49.

Life and death as a T lymphocyte: from immune protection to HIV pathogenesis.

Vrisekoop N, Mandl JN, Germain RN.

J Biol. 2009;8(10):91. doi: 10.1186/jbiol198. Review.

50.

BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury.

Nagy G, Szarka A, Lotz G, Dóczi J, Wunderlich L, Kiss A, Jemnitz K, Veres Z, Bánhegyi G, Schaff Z, Sümegi B, Mandl J.

Toxicol Appl Pharmacol. 2010 Feb 15;243(1):96-103. doi: 10.1016/j.taap.2009.11.017. Epub 2009 Nov 26.

PMID:
19931551

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