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Items: 1 to 50 of 290

1.

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.

Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B.

Autophagy. 2018 Jan 3:1-51. doi: 10.1080/15548627.2017.1422850. [Epub ahead of print]

PMID:
29297744
2.

The cartilage-specific lectin C-type lectin domain family 3 member A (CLEC3A) enhances tissue plasminogen activator-mediated plasminogen activation.

Lau D, Elezagic D, Hermes G, Mörgelin M, Wohl AP, Koch M, Hartmann U, Höllriegl S, Wagener R, Paulsson M, Streichert T, Klatt AR.

J Biol Chem. 2018 Jan 5;293(1):203-214. doi: 10.1074/jbc.M117.818930. Epub 2017 Nov 16.

PMID:
29146595
3.

Haemophilus Protein F Orthologs of Pathogens Infecting the Airways: Exploiting Host Laminin at Heparin-Binding Sites for Maximal Adherence to Epithelial Cells.

Su YC, Halang P, Fleury C, Jalalvand F, Mörgelin M, Riesbeck K.

J Infect Dis. 2017 Dec 5;216(10):1303-1307. doi: 10.1093/infdis/jix467.

PMID:
28968674
4.

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis.

Sonesson A, Przybyszewska K, Eriksson S, Mörgelin M, Kjellström S, Davies J, Potempa J, Schmidtchen A.

Sci Rep. 2017 Aug 18;7(1):8689. doi: 10.1038/s41598-017-08046-2.

5.

Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria.

Hansen FC, Strömdahl AC, Mörgelin M, Schmidtchen A, van der Plas MJA.

Front Immunol. 2017 Jul 21;8:843. doi: 10.3389/fimmu.2017.00843. eCollection 2017.

6.

Syncytiotrophoblast derived extracellular vesicles transfer functional placental miRNAs to primary human endothelial cells.

Cronqvist T, Tannetta D, Mörgelin M, Belting M, Sargent I, Familari M, Hansson SR.

Sci Rep. 2017 Jul 4;7(1):4558. doi: 10.1038/s41598-017-04468-0.

7.

Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism.

Petrlova J, Hansen FC, van der Plas MJA, Huber RG, Mörgelin M, Malmsten M, Bond PJ, Schmidtchen A.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4213-E4222. doi: 10.1073/pnas.1619609114. Epub 2017 May 4.

8.

Rac1 regulates sepsis-induced formation of platelet-derived microparticles and thrombin generation.

Wang Y, Luo L, Mörgelin M, Thorlacius H.

Biochem Biophys Res Commun. 2017 Jun 10;487(4):887-891. doi: 10.1016/j.bbrc.2017.04.147. Epub 2017 Apr 29.

PMID:
28465231
9.

Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation.

Purhonen J, Rajendran J, Mörgelin M, Uusi-Rauva K, Katayama S, Krjutskov K, Einarsdottir E, Velagapudi V, Kere J, Jauhiainen M, Fellman V, Kallijärvi J.

Sci Rep. 2017 Apr 19;7(1):957. doi: 10.1038/s41598-017-01109-4.

10.

Platelet-derived microparticles regulates thrombin generation via phophatidylserine in abdominal sepsis.

Wang Y, Zhang S, Luo L, Norström E, Braun OÖ, Mörgelin M, Thorlacius H.

J Cell Physiol. 2018 Feb;233(2):1051-1060. doi: 10.1002/jcp.25959. Epub 2017 Jun 6.

PMID:
28409836
11.

Heparin-Binding Protein (HBP): A Causative Marker and Potential Target for Heparin Treatment of Human Sepsis-Induced Acute Kidney Injury.

Fisher J, Russell JA, Bentzer P, Parsons D, Secchia S, Mörgelin M, Walley KR, Boyd JH, Linder A.

Shock. 2017 Sep;48(3):313-320. doi: 10.1097/SHK.0000000000000862.

PMID:
28319494
12.

Antibacterial and antibiofilm effects of sodium hypochlorite against Staphylococcus aureus isolates derived from patients with atopic dermatitis.

Eriksson S, van der Plas MJA, Mörgelin M, Sonesson A.

Br J Dermatol. 2017 Aug;177(2):513-521. doi: 10.1111/bjd.15410. Epub 2017 Jul 3.

PMID:
28238217
13.

Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney.

Tati R, Kristoffersson AC, Manea Hedström M, Mörgelin M, Wieslander J, van Kooten C, Karpman D.

EBioMedicine. 2017 Feb;16:302-311. doi: 10.1016/j.ebiom.2017.01.032. Epub 2017 Jan 24.

14.

Erratum to: Heparin-binding protein is important for vascular leak in sepsis.

Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA, Linder A.

Intensive Care Med Exp. 2017 Dec;5(1):6. doi: 10.1186/s40635-017-0119-4. Epub 2017 Jan 20. No abstract available.

15.

Microvesicle transfer of kinin B1-receptors is a novel inflammatory mechanism in vasculitis.

Kahn R, Mossberg M, Ståhl AL, Johansson K, Lopatko Lindman I, Heijl C, Segelmark M, Mörgelin M, Leeb-Lundberg LM, Karpman D.

Kidney Int. 2017 Jan;91(1):96-105. doi: 10.1016/j.kint.2016.09.023. Epub 2016 Dec 1.

PMID:
27914700
16.
17.

DNA-fragmentation is a source of bactericidal activity against Pseudomonas aeruginosa.

Bhongir RK, Kasetty G, Papareddy P, Mörgelin M, Herwald H, Egesten A.

Biochem J. 2017 Feb 1;474(3):411-425. doi: 10.1042/BCJ20160706. Epub 2016 Oct 26.

PMID:
27784762
18.

Heparin-binding protein is important for vascular leak in sepsis.

Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA, Linder A.

Intensive Care Med Exp. 2016 Dec;4(1):33. Epub 2016 Oct 4. Erratum in: Intensive Care Med Exp. 2017 Dec;5(1):6.

19.

Biofilm in group A streptococcal necrotizing soft tissue infections.

Siemens N, Chakrakodi B, Shambat SM, Morgan M, Bergsten H, Hyldegaard O, Skrede S, Arnell P, Madsen MB, Johansson L; INFECT Study Group, Juarez J, Bosnjak L, Mörgelin M, Svensson M, Norrby-Teglund A.

JCI Insight. 2016 Jul 7;1(10):e87882.

20.

The Tyrosine Sulfate Domain of Fibromodulin Binds Collagen and Enhances Fibril Formation.

Tillgren V, Mörgelin M, Önnerfjord P, Kalamajski S, Aspberg A.

J Biol Chem. 2016 Nov 4;291(45):23744-23755. Epub 2016 Sep 15.

21.

High Presence of Extracellular Hemoglobin in the Periventricular White Matter Following Preterm Intraventricular Hemorrhage.

Ley D, Romantsik O, Vallius S, Sveinsdóttir K, Sveinsdóttir S, Agyemang AA, Baumgarten M, Mörgelin M, Lutay N, Bruschettini M, Holmqvist B, Gram M.

Front Physiol. 2016 Aug 3;7:330. doi: 10.3389/fphys.2016.00330. eCollection 2016.

22.

Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion.

Wollein Waldetoft K, Mohanty T, Karlsson C, Mörgelin M, Frick IM, Malmström J, Björck L.

Infect Immun. 2016 Sep 19;84(10):2813-23. doi: 10.1128/IAI.00307-16. Print 2016 Oct.

23.

Acetic acid as a decontamination method for sink drains in a nosocomial outbreak of metallo-β-lactamase-producing Pseudomonas aeruginosa.

Stjärne Aspelund A, Sjöström K, Olsson Liljequist B, Mörgelin M, Melander E, Påhlman LI.

J Hosp Infect. 2016 Sep;94(1):13-20. doi: 10.1016/j.jhin.2016.05.009. Epub 2016 May 24.

24.

CD14 Is a Co-Receptor for TLR4 in the S100A9-Induced Pro-Inflammatory Response in Monocytes.

He Z, Riva M, Björk P, Swärd K, Mörgelin M, Leanderson T, Ivars F.

PLoS One. 2016 May 26;11(5):e0156377. doi: 10.1371/journal.pone.0156377. eCollection 2016.

25.

Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses.

van der Plas MJ, Bhongir RK, Kjellström S, Siller H, Kasetty G, Mörgelin M, Schmidtchen A.

Nat Commun. 2016 May 16;7:11567. doi: 10.1038/ncomms11567.

26.

Modulation of Hemostatic and Inflammatory Responses by Leptospira Spp.

Vieira ML, Naudin C, Mörgelin M, Romero EC, Nascimento AL, Herwald H.

PLoS Negl Trop Dis. 2016 May 11;10(5):e0004713. doi: 10.1371/journal.pntd.0004713. eCollection 2016 May.

27.

The Respiratory Pathogen Moraxella catarrhalis Targets Collagen for Maximal Adherence to Host Tissues.

Singh B, Alvarado-Kristensson M, Johansson M, Hallgren O, Westergren-Thorsson G, Mörgelin M, Riesbeck K.

MBio. 2016 Mar 22;7(2):e00066. doi: 10.1128/mBio.00066-16.

28.

The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles.

Happonen KE, Tran S, Mörgelin M, Prince R, Calzavarini S, Angelillo-Scherrer A, Dahlbäck B.

J Biol Chem. 2016 May 13;291(20):10586-601. doi: 10.1074/jbc.M115.699058. Epub 2016 Mar 22.

29.

Platelet-Derived S100A8/A9 and Cardiovascular Disease in Systemic Lupus Erythematosus.

Lood C, Tydén H, Gullstrand B, Jönsen A, Källberg E, Mörgelin M, Kahn R, Gunnarsson I, Leanderson T, Ivars F, Svenungsson E, Bengtsson AA.

Arthritis Rheumatol. 2016 Aug;68(8):1970-80. doi: 10.1002/art.39656.

30.

Heterogeneity of Collagen VI Microfibrils: STRUCTURAL ANALYSIS OF NON-COLLAGENOUS REGIONS.

Maaß T, Bayley CP, Mörgelin M, Lettmann S, Bonaldo P, Paulsson M, Baldock C, Wagener R.

J Biol Chem. 2016 Mar 4;291(10):5247-58. doi: 10.1074/jbc.M115.705160. Epub 2016 Jan 7.

31.

Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics.

Gela A, Bhongir RK, Mori M, Keenan P, Mörgelin M, Erjefält JS, Herwald H, Egesten A, Kasetty G.

PLoS One. 2016 Jan 5;11(1):e0146192. doi: 10.1371/journal.pone.0146192. eCollection 2016.

32.

Vesicular Location and Transport of S100A8 and S100A9 Proteins in Monocytoid Cells.

Chakraborty P, Bjork P, Källberg E, Olsson A, Riva M, Mörgelin M, Liberg D, Ivars F, Leanderson T.

PLoS One. 2015 Dec 14;10(12):e0145217. doi: 10.1371/journal.pone.0145217. eCollection 2015.

33.

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

Westman J, Papareddy P, Dahlgren MW, Chakrakodi B, Norrby-Teglund A, Smeds E, Linder A, Mörgelin M, Johansson-Lindbom B, Egesten A, Herwald H.

PLoS Pathog. 2015 Dec 8;11(12):e1005319. doi: 10.1371/journal.ppat.1005319. eCollection 2015 Dec.

34.

LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).

Svensson D, Wilk L, Mörgelin M, Herwald H, Nilsson BO.

Biochem J. 2016 Jan 1;473(1):87-98. doi: 10.1042/BJ20150798. Epub 2015 Oct 27.

PMID:
26508735
35.

NLF20: an antimicrobial peptide with therapeutic potential against invasive Pseudomonas aeruginosa infection.

Papareddy P, Kasetty G, Kalle M, Bhongir RK, Mörgelin M, Schmidtchen A, Malmsten M.

J Antimicrob Chemother. 2016 Jan;71(1):170-80. doi: 10.1093/jac/dkv322. Epub 2015 Oct 26.

PMID:
26503666
36.

Vigilant keratinocytes trigger pathogen-associated molecular pattern signaling in response to streptococcal M1 protein.

Persson ST, Wilk L, Mörgelin M, Herwald H.

Infect Immun. 2015 Dec;83(12):4673-81. doi: 10.1128/IAI.00887-15. Epub 2015 Sep 28.

37.

Osteopontin binds and modulates functions of eosinophil-recruiting chemokines.

Gela A, Kasetty G, Mörgelin M, Bergqvist A, Erjefält JS, Pease JE, Egesten A.

Allergy. 2016 Jan;71(1):58-67. doi: 10.1111/all.12771. Epub 2015 Oct 20.

38.

Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis.

Merza M, Hartman H, Rahman M, Hwaiz R, Zhang E, Renström E, Luo L, Mörgelin M, Regner S, Thorlacius H.

Gastroenterology. 2015 Dec;149(7):1920-1931.e8. doi: 10.1053/j.gastro.2015.08.026. Epub 2015 Aug 22.

PMID:
26302488
39.

A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa.

Mohanty T, Sjögren J, Kahn F, Abu-Humaidan AH, Fisker N, Assing K, Mörgelin M, Bengtsson AA, Borregaard N, Sørensen OE.

Blood. 2015 Oct 29;126(18):2128-37. doi: 10.1182/blood-2015-04-641142. Epub 2015 Aug 4.

40.

Platelet-Dependent Neutrophil Function Is Dysregulated by M Protein from Streptococcus pyogenes.

Hurley SM, Kahn F, Nordenfelt P, Mörgelin M, Sørensen OE, Shannon O.

Infect Immun. 2015 Sep;83(9):3515-25. doi: 10.1128/IAI.00508-15. Epub 2015 Jun 22.

41.

A fusion protein derived from Moraxella catarrhalis and Neisseria meningitidis aimed for immune modulation of human B cells.

Mukherjee O, Singh B, Bayrak B, Jonsson AB, Mörgelin M, Riesbeck K.

Hum Vaccin Immunother. 2015;11(9):2223-7. doi: 10.1080/21645515.2015.1034917. Epub 2015 Jun 4.

42.

Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes.

Naudin C, Hurley SM, Malmström E, Plug T, Shannon O, Meijers JC, Mörgelin M, Björck L, Herwald H.

Thromb Haemost. 2015 Oct;114(4):717-26. doi: 10.1160/TH15-02-0127. Epub 2015 May 21.

PMID:
25994766
43.

The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA.

Jovic S, Linge HM, Shikhagaie MM, Olin AI, Lannefors L, Erjefält JS, Mörgelin M, Egesten A.

Mucosal Immunol. 2016 Jan;9(1):112-23. doi: 10.1038/mi.2015.43. Epub 2015 May 20.

PMID:
25993443
44.

A1M Ameliorates Preeclampsia-Like Symptoms in Placenta and Kidney Induced by Cell-Free Fetal Hemoglobin in Rabbit.

Nääv Å, Erlandsson L, Axelsson J, Larsson I, Johansson M, Wester-Rosenlöf L, Mörgelin M, Casslén V, Gram M, Åkerström B, Hansson SR.

PLoS One. 2015 May 8;10(5):e0125499. doi: 10.1371/journal.pone.0125499. eCollection 2015.

45.

Collagen VI Is Upregulated in COPD and Serves Both as an Adhesive Target and a Bactericidal Barrier for Moraxella catarrhalis.

Abdillahi SM, Bober M, Nordin S, Hallgren O, Baumgarten M, Erjefält J, Westergren-Thorsson G, Bjermer L, Riesbeck K, Egesten A, Mörgelin M.

J Innate Immun. 2015;7(5):506-17. doi: 10.1159/000381213. Epub 2015 Apr 25.

46.

The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes.

Hansen FC, Kalle-Brune M, van der Plas MJ, Strömdahl AC, Malmsten M, Mörgelin M, Schmidtchen A.

J Immunol. 2015 Jun 1;194(11):5397-406. doi: 10.4049/jimmunol.1403009. Epub 2015 Apr 24.

47.

Anti-endotoxic and antibacterial effects of a dermal substitute coated with host defense peptides.

Kasetty G, Kalle M, Mörgelin M, Brune JC, Schmidtchen A.

Biomaterials. 2015;53:415-25. doi: 10.1016/j.biomaterials.2015.02.111. Epub 2015 Mar 18.

48.

A novel mechanism of bacterial toxin transfer within host blood cell-derived microvesicles.

Ståhl AL, Arvidsson I, Johansson KE, Chromek M, Rebetz J, Loos S, Kristoffersson AC, Békássy ZD, Mörgelin M, Karpman D.

PLoS Pathog. 2015 Feb 26;11(2):e1004619. doi: 10.1371/journal.ppat.1004619. eCollection 2015 Feb.

49.

Staphylococcus aureus-induced clotting of plasma is an immune evasion mechanism for persistence within the fibrin network.

Loof TG, Goldmann O, Naudin C, Mörgelin M, Neumann Y, Pils MC, Foster SJ, Medina E, Herwald H.

Microbiology. 2015 Mar;161(Pt 3):621-627. doi: 10.1099/mic.0.000019. Epub 2014 Dec 22.

PMID:
25533444
50.

Osteopontin is increased in cystic fibrosis and can skew the functional balance between ELR-positive and ELR-negative CXC-chemokines.

Jovic S, Shikhagaie M, Mörgelin M, Erjefält JS, Kjellström S, Egesten A.

J Cyst Fibros. 2015 Jul;14(4):453-63. doi: 10.1016/j.jcf.2014.11.010. Epub 2014 Dec 6.

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