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Items: 1 to 50 of 121

1.

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.

Cell Metab. 2018 Mar 6;27(3):559-571.e5. doi: 10.1016/j.cmet.2018.01.005. Epub 2018 Feb 15.

PMID:
29456073
2.

Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - an 11-Year Prospective Study.

Lallukka S, Sädevirta S, Kallio MT, Luukkonen PK, Zhou Y, Hakkarainen A, Lundbom N, Orho-Melander M, Yki-Järvinen H.

Sci Rep. 2017 Nov 6;7(1):14561. doi: 10.1038/s41598-017-14706-0.

3.

Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects.

Hua B, Hakkarainen A, Zhou Y, Lundbom N, Yki-Järvinen H.

Dig Liver Dis. 2018 Feb;50(2):168-174. doi: 10.1016/j.dld.2017.08.030. Epub 2017 Aug 23.

PMID:
28964678
4.

Physical activity, cardiorespiratory fitness, and metabolic outcomes in monozygotic twin pairs discordant for body mass index.

Berntzen B, Jukarainen S, Kataja M, Hakkarainen A, Lundbom J, Lundbom N, Tammelin T, Simonen R, Piirilä P, Rissanen A, Kaprio J, Paavonen EJ, Pietiläinen KH.

Scand J Med Sci Sports. 2018 Mar;28(3):1048-1055. doi: 10.1111/sms.12975. Epub 2017 Sep 21.

PMID:
28833625
5.

Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study.

Urrila AS, Hakkarainen A, Castaneda A, Paunio T, Marttunen M, Lundbom N.

Neuropsychobiology. 2017;75(1):21-31. doi: 10.1159/000478861. Epub 2017 Aug 10.

PMID:
28793304
6.

Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study.

Isokuortti E, Zhou Y, Peltonen M, Bugianesi E, Clement K, Bonnefont-Rousselot D, Lacorte JM, Gastaldelli A, Schuppan D, Schattenberg JM, Hakkarainen A, Lundbom N, Jousilahti P, Männistö S, Keinänen-Kiukaanniemi S, Saltevo J, Anstee QM, Yki-Järvinen H.

Diabetologia. 2017 Oct;60(10):1873-1882. doi: 10.1007/s00125-017-4340-1. Epub 2017 Jun 29.

PMID:
28660493
7.

Metabolism of sex steroids is influenced by acquired adiposity-A study of young adult male monozygotic twin pairs.

Vihma V, Naukkarinen J, Turpeinen U, Hämäläinen E, Kaprio J, Rissanen A, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Mikkola TS, Tikkanen MJ, Pietiläinen KH.

J Steroid Biochem Mol Biol. 2017 Sep;172:98-105. doi: 10.1016/j.jsbmb.2017.06.007. Epub 2017 Jun 13.

PMID:
28619249
8.

Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis: A proton decoupled 31P-MRS study.

Hakkarainen A, Puustinen L, Kivisaari R, Boyd S, Nieminen U, Arkkila P, Lundbom N.

Eur J Radiol. 2017 May;90:205-211. doi: 10.1016/j.ejrad.2017.01.008. Epub 2017 Jan 10.

PMID:
28583636
9.

Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity.

Kaye S, Lokki AI, Hanttu A, Nissilä E, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Saarinen L, Tynninen O, Muniandy M, Rissanen A, Kaprio J, Meri S, Pietiläinen KH.

Front Immunol. 2017 May 16;8:545. doi: 10.3389/fimmu.2017.00545. eCollection 2017.

10.

Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity.

Taskinen MR, Söderlund S, Bogl LH, Hakkarainen A, Matikainen N, Pietiläinen KH, Räsänen S, Lundbom N, Björnson E, Eliasson B, Mancina RM, Romeo S, Alméras N, Pepa GD, Vetrani C, Prinster A, Annuzzi G, Rivellese A, Després JP, Borén J.

J Intern Med. 2017 Aug;282(2):187-201. doi: 10.1111/joim.12632. Epub 2017 Jun 27.

PMID:
28548281
11.

Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated with sub-types of obesity.

Muniandy M, Heinonen S, Yki-Järvinen H, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Ollikainen M, Pietiläinen KH.

Int J Obes (Lond). 2017 Aug;41(8):1176-1184. doi: 10.1038/ijo.2017.95. Epub 2017 Apr 25.

PMID:
28439093
12.

Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men.

Matikainen N, Söderlund S, Björnson E, Bogl LH, Pietiläinen KH, Hakkarainen A, Lundbom N, Eliasson B, Räsänen SM, Rivellese A, Patti L, Prinster A, Riccardi G, Després JP, Alméras N, Holst JJ, Deacon CF, Borén J, Taskinen MR.

Nutr Metab Cardiovasc Dis. 2017 Jun;27(6):534-542. doi: 10.1016/j.numecd.2017.03.003. Epub 2017 Mar 18.

PMID:
28428027
13.

31Phosphorus magnetic resonance spectroscopy of the liver for evaluating inflammation and fibrosis in autoimmune hepatitis.

Puustinen L, Hakkarainen A, Kivisaari R, Boyd S, Nieminen U, Färkkilä M, Lundbom N, Arkkila P.

Scand J Gastroenterol. 2017 Aug;52(8):886-892. doi: 10.1080/00365521.2017.1315738. Epub 2017 Apr 17.

PMID:
28415898
14.

Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health-Pooled Analysis of Two Twin Cohorts.

Jukarainen S, Holst R, Dalgård C, Piirilä P, Lundbom J, Hakkarainen A, Lundbom N, Rissanen A, Kaprio J, Kyvik KO, Sørensen TIA, Pietiläinen KH.

J Clin Endocrinol Metab. 2017 May 1;102(5):1520-1528. doi: 10.1210/jc.2016-3435.

PMID:
28324016
15.

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.

Mol Syst Biol. 2017 Mar 2;13(3):916. doi: 10.15252/msb.20167422.

16.

Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans.

Lallukka S, Luukkonen PK, Zhou Y, Isokuortti E, Leivonen M, Juuti A, Hakkarainen A, Orho-Melander M, Lundbom N, Olkkonen VM, Lassila R, Yki-Järvinen H.

Thromb Haemost. 2017 Jan 26;117(2):286-294. doi: 10.1160/TH16-09-0716. Epub 2016 Dec 8.

PMID:
27929200
17.

Liver Fat and Insulin Sensitivity Define Metabolite Profiles During a Glucose Tolerance Test in Young Adult Twins.

Rämö JT, Kaye SM, Jukarainen S, Bogl LH, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Kaprio J, Matikainen N, Pietiläinen KH.

J Clin Endocrinol Metab. 2017 Jan 1;102(1):220-231. doi: 10.1210/jc.2015-3512.

PMID:
27809652
18.

Modified Atkins diet induces subacute selective ragged-red-fiber lysis in mitochondrial myopathy patients.

Ahola S, Auranen M, Isohanni P, Niemisalo S, Urho N, Buzkova J, Velagapudi V, Lundbom N, Hakkarainen A, Muurinen T, Piirilä P, Pietiläinen KH, Suomalainen A.

EMBO Mol Med. 2016 Nov 2;8(11):1234-1247. doi: 10.15252/emmm.201606592. Print 2016 Nov.

19.

Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.

Heinonen S, Muniandy M, Buzkova J, Mardinoglu A, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH.

Diabetologia. 2017 Jan;60(1):169-181. Epub 2016 Oct 12.

PMID:
27734103
20.

Deep subcutaneous adipose tissue lipid unsaturation associates with intramyocellular lipid content.

Lundbom J, Bierwagen A, Bodis K, Szendrödi J, Kaprio J, Rissanen A, Lundbom N, Roden M, Pietiläinen KH.

Metabolism. 2016 Sep;65(9):1230-7. doi: 10.1016/j.metabol.2016.05.010. Epub 2016 May 24.

PMID:
27506730
21.

Eye Movements of Radiologists Reflect Expertise in CT Study Interpretation: A Potential Tool to Measure Resident Development.

Bertram R, Kaakinen J, Bensch F, Helle L, Lantto E, Niemi P, Lundbom N.

Radiology. 2016 Dec;281(3):805-815. Epub 2016 Jul 13.

PMID:
27409563
22.

Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD.

Petäjä EM, Zhou Y, Havana M, Hakkarainen A, Lundbom N, Ihalainen J, Yki-Järvinen H.

Sci Rep. 2016 Apr 19;6:24740. doi: 10.1038/srep24740.

23.

Abdominal obesity and circulating metabolites: A twin study approach.

Bogl LH, Kaye SM, Rämö JT, Kangas AJ, Soininen P, Hakkarainen A, Lundbom J, Lundbom N, Ortega-Alonso A, Rissanen A, Ala-Korpela M, Kaprio J, Pietiläinen KH.

Metabolism. 2016 Mar;65(3):111-21. doi: 10.1016/j.metabol.2015.10.027. Epub 2015 Oct 31.

PMID:
26892522
24.

ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity.

Vergès B, Adiels M, Boren J, Barrett PH, Watts GF, Chan D, Duvillard L, Söderlund S, Matikainen N, Kahri J, Lundbom N, Lundbom J, Hakkarainen A, Aho S, Simoneau-Robin I, Taskinen MR.

J Clin Endocrinol Metab. 2016 Apr;101(4):1398-406. doi: 10.1210/jc.2015-3740. Epub 2016 Feb 2.

PMID:
26835543
25.

Biomarkers and prediction of myocardial triglyceride content in non-diabetic men.

Granér M, Gustavsson S, Nyman K, Siren R, Pentikäinen MO, Lundbom J, Hakkarainen A, Lauerma K, Lundbom N, Borén J, Nieminen MS, Taskinen MR.

Nutr Metab Cardiovasc Dis. 2016 Feb;26(2):134-40. doi: 10.1016/j.numecd.2015.11.002. Epub 2015 Dec 12.

PMID:
26803593
26.

Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue.

Rappou E, Jukarainen S, Rinnankoski-Tuikka R, Kaye S, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Saunavaara V, Rissanen A, Virtanen KA, Pirinen E, Pietiläinen KH.

J Clin Endocrinol Metab. 2016 Mar;101(3):1263-73. doi: 10.1210/jc.2015-3054. Epub 2016 Jan 13.

PMID:
26760174
27.

Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men.

Matikainen N, Björnson E, Söderlund S, Borén C, Eliasson B, Pietiläinen KH, Bogl LH, Hakkarainen A, Lundbom N, Rivellese A, Riccardi G, Després JP, Alméras N, Holst JJ, Deacon CF, Borén J, Taskinen MR.

PLoS One. 2016 Jan 11;11(1):e0145890. doi: 10.1371/journal.pone.0145890. eCollection 2016.

28.

Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.

Jukarainen S, Heinonen S, Rämö JT, Rinnankoski-Tuikka R, Rappou E, Tummers M, Muniandy M, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pirinen E, Pietiläinen KH.

J Clin Endocrinol Metab. 2016 Jan;101(1):275-83. doi: 10.1210/jc.2015-3095. Epub 2015 Nov 17.

PMID:
26574954
29.

DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs.

Pietiläinen KH, Ismail K, Järvinen E, Heinonen S, Tummers M, Bollepalli S, Lyle R, Muniandy M, Moilanen E, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Kaprio J, Ollikainen M.

Int J Obes (Lond). 2016 Apr;40(4):654-61. doi: 10.1038/ijo.2015.221. Epub 2015 Oct 26.

PMID:
26499446
30.

Bone marrow fat unsaturation in young adults is not affected by present or childhood obesity, but increases with age: A pilot study.

Huovinen V, Viljakainen H, Hakkarainen A, Saukkonen T, Toiviainen-Salo S, Lundbom N, Lundbom J, Mäkitie O.

Metabolism. 2015 Nov;64(11):1574-81. doi: 10.1016/j.metabol.2015.08.014. Epub 2015 Aug 28.

PMID:
26388537
31.

Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study.

Borén J, Watts GF, Adiels M, Söderlund S, Chan DC, Hakkarainen A, Lundbom N, Matikainen N, Kahri J, Vergès B, Barrett PH, Taskinen MR.

Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2218-24. doi: 10.1161/ATVBAHA.115.305614. Epub 2015 Aug 27. Erratum in: Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):e57.

32.

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity.

Heinonen S, Buzkova J, Muniandy M, Kaksonen R, Ollikainen M, Ismail K, Hakkarainen A, Lundbom J, Lundbom N, Vuolteenaho K, Moilanen E, Kaprio J, Rissanen A, Suomalainen A, Pietiläinen KH.

Diabetes. 2015 Sep;64(9):3135-45. doi: 10.2337/db14-1937. Epub 2015 May 13.

33.

Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat.

Ollikainen M, Ismail K, Gervin K, Kyllönen A, Hakkarainen A, Lundbom J, Järvinen EA, Harris JR, Lundbom N, Rissanen A, Lyle R, Pietiläinen KH, Kaprio J.

Clin Epigenetics. 2015 Apr 2;7:39. doi: 10.1186/s13148-015-0073-5. eCollection 2015.

34.

Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant.

Mancina RM, Matikainen N, Maglio C, Söderlund S, Lundbom N, Hakkarainen A, Rametta R, Mozzi E, Fargion S, Valenti L, Romeo S, Taskinen MR, Borén J.

J Clin Endocrinol Metab. 2015 May;100(5):E821-5. doi: 10.1210/jc.2014-4464. Epub 2015 Mar 12.

PMID:
25763607
35.

Ectopic fat depots and left ventricular function in nondiabetic men with nonalcoholic fatty liver disease.

Granér M, Nyman K, Siren R, Pentikäinen MO, Lundbom J, Hakkarainen A, Lauerma K, Lundbom N, Nieminen MS, Taskinen MR.

Circ Cardiovasc Imaging. 2014 Dec 30;8(1). pii: e001979. doi: 10.1161/CIRCIMAGING.114.001979. Print 2015 Jan.

36.

Liver fat content and hepatic insulin sensitivity in overweight patients with type 1 diabetes.

Llauradó G, Sevastianova K, Sädevirta S, Hakkarainen A, Lundbom N, Orho-Melander M, Groop PH, Forsblom C, Yki-Järvinen H.

J Clin Endocrinol Metab. 2015 Feb;100(2):607-16. doi: 10.1210/jc.2014-3050. Epub 2014 Nov 18.

PMID:
25405502
37.

Measuring short-term liver metabolism non-invasively: postprandial and post-exercise ¹H and ³¹P MR spectroscopy.

Hakkarainen A, Lundbom J, Tuominen EK, Taskinen MR, Pietiläinen KH, Lundbom N.

MAGMA. 2015 Feb;28(1):57-66. doi: 10.1007/s10334-014-0450-7. Epub 2014 Jun 4.

PMID:
24895090
38.

Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge.

Bondia-Pons I, Maukonen J, Mattila I, Rissanen A, Saarela M, Kaprio J, Hakkarainen A, Lundbom J, Lundbom N, Hyötyläinen T, Pietiläinen KH, Orešič M.

FASEB J. 2014 Sep;28(9):4169-79. doi: 10.1096/fj.14-250167. Epub 2014 May 20.

39.

Cardiac steatosis in patients with dilated cardiomyopathy.

Granér M, Pentikäinen MO, Nyman K, Siren R, Lundbom J, Hakkarainen A, Lauerma K, Lundbom N, Nieminen MS, Petzold M, Taskinen MR.

Heart. 2014 Jul;100(14):1107-12. doi: 10.1136/heartjnl-2013-304961. Epub 2014 Apr 24.

PMID:
24763492
40.

Impact of non-alcoholic fatty liver disease on liver volume in humans.

Bian H, Hakkarainen A, Zhou Y, Lundbom N, Olkkonen VM, Yki-Järvinen H.

Hepatol Res. 2015 Jan;45(2):210-9. doi: 10.1111/hepr.12338. Epub 2014 Jul 18.

PMID:
24698021
41.

Adipocyte morphology and implications for metabolic derangements in acquired obesity.

Heinonen S, Saarinen L, Naukkarinen J, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Vuolteenaho K, Moilanen E, Arner P, Hautaniemi S, Suomalainen A, Kaprio J, Rissanen A, Pietiläinen KH.

Int J Obes (Lond). 2014 Nov;38(11):1423-31. doi: 10.1038/ijo.2014.31. Epub 2014 Feb 19.

PMID:
24549139
42.

Electrocardiographic changes associated with insulin resistance.

Granér M, Pentikäinen MO, Siren R, Nyman K, Lundbom J, Hakkarainen A, Lauerma K, Lundbom N, Nieminen MS, Taskinen MR.

Nutr Metab Cardiovasc Dis. 2014 Mar;24(3):315-20. doi: 10.1016/j.numecd.2013.09.013. Epub 2013 Nov 1.

PMID:
24462049
43.

Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.

Matikainen N, Burza MA, Romeo S, Hakkarainen A, Adiels M, Folkersen L, Eriksson P, Lundbom N, Ehrenborg E, Orho-Melander M, Taskinen MR, Borén J.

PLoS One. 2013 Nov 20;8(11):e79473. doi: 10.1371/journal.pone.0079473. eCollection 2013.

44.

Cardiac steatosis and left ventricular function in men with metabolic syndrome.

Nyman K, Granér M, Pentikäinen MO, Lundbom J, Hakkarainen A, Sirén R, Nieminen MS, Taskinen MR, Lundbom N, Lauerma K.

J Cardiovasc Magn Reson. 2013 Nov 14;15:103. doi: 10.1186/1532-429X-15-103.

45.

Effects of dietary interventions on liver volume in humans.

Bian H, Hakkarainen A, Lundbom N, Yki-Järvinen H.

Obesity (Silver Spring). 2014 Apr;22(4):989-95. doi: 10.1002/oby.20623. Epub 2013 Dec 4.

46.

Characterising metabolically healthy obesity in weight-discordant monozygotic twins.

Naukkarinen J, Heinonen S, Hakkarainen A, Lundbom J, Vuolteenaho K, Saarinen L, Hautaniemi S, Rodriguez A, Frühbeck G, Pajunen P, Hyötyläinen T, Orešič M, Moilanen E, Suomalainen A, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH.

Diabetologia. 2014 Jan;57(1):167-76. doi: 10.1007/s00125-013-3066-y. Epub 2013 Oct 8.

PMID:
24100782
47.

GLP-1 responses are heritable and blunted in acquired obesity with high liver fat and insulin resistance.

Matikainen N, Bogl LH, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Holst JJ, Pietiläinen KH.

Diabetes Care. 2014;37(1):242-51. doi: 10.2337/dc13-1283. Epub 2013 Aug 29.

PMID:
23990519
48.

Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype.

Petäjä EM, Sevastianova K, Hakkarainen A, Orho-Melander M, Lundbom N, Yki-Järvinen H.

Obesity (Silver Spring). 2013 Jun;21(6):1174-9. doi: 10.1002/oby.20114.

49.

Acquired liver fat is a key determinant of serum lipid alterations in healthy monozygotic twins.

Kaye SM, Maranghi M, Bogl LH, Kaprio J, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Taskinen MR, Pietiläinen KH.

Obesity (Silver Spring). 2013 Sep;21(9):1815-22. doi: 10.1002/oby.20228. Epub 2013 May 21.

50.

Cardiac steatosis associates with visceral obesity in nondiabetic obese men.

Granér M, Siren R, Nyman K, Lundbom J, Hakkarainen A, Pentikäinen MO, Lauerma K, Lundbom N, Adiels M, Nieminen MS, Taskinen MR.

J Clin Endocrinol Metab. 2013 Mar;98(3):1189-97. doi: 10.1210/jc.2012-3190. Epub 2013 Feb 15.

PMID:
23418318

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