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Items: 16


Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1.

Sankhala RS, Lokareddy RK, Begum S, Pumroy RA, Gillilan RE, Cingolani G.

Nat Commun. 2017 Oct 17;8(1):979. doi: 10.1038/s41467-017-01057-7.


Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms.

Wu W, Sankhala RS, Florio TJ, Zhou L, Nguyen NLT, Lokareddy RK, Cingolani G, Panté N.

Sci Rep. 2017 Sep 12;7(1):11381. doi: 10.1038/s41598-017-11018-1.


A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly.

Motwani T, Lokareddy RK, Dunbar CA, Cortines JR, Jarrold MF, Cingolani G, Teschke CM.

Sci Adv. 2017 Jul 26;3(7):e1700423. doi: 10.1126/sciadv.1700423. eCollection 2017 Jul.


Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation.

Lokareddy RK, Sankhala RS, Roy A, Afonine PV, Motwani T, Teschke CM, Parent KN, Cingolani G.

Nat Commun. 2017 Jan 30;8:14310. doi: 10.1038/ncomms14310.


Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.

Sankhala RS, Lokareddy RK, Cingolani G.

J Biol Chem. 2016 May 20;291(21):11420-33. doi: 10.1074/jbc.M116.724393. Epub 2016 Mar 31.


A Greasy Aid to Capsid Assembly: Lessons from a Salty Virus.

Sankhala RS, Lokareddy RK, Cingolani G.

Structure. 2015 Oct 6;23(10):1777-9. doi: 10.1016/j.str.2015.09.002.


Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

McNulty R, Lokareddy RK, Roy A, Yang Y, Lander G, Heck AJ, Johnson JE, Cingolani G.

J Mol Biol. 2015 Oct 9;427(20):3285-3299. doi: 10.1016/j.jmb.2015.08.013. Epub 2015 Aug 21.


The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD.

Sun J, Siroy A, Lokareddy RK, Speer A, Doornbos KS, Cingolani G, Niederweis M.

Nat Struct Mol Biol. 2015 Sep;22(9):672-8. doi: 10.1038/nsmb.3064. Epub 2015 Aug 3.


Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins.

Kralt A, Jagalur NB, van den Boom V, Lokareddy RK, Steen A, Cingolani G, Fornerod M, Veenhoff LM.

Mol Biol Cell. 2015 Sep 15;26(18):3301-12. doi: 10.1091/mbc.E15-03-0184. Epub 2015 Jul 15.


Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.

Lokareddy RK, Hapsari RA, van Rheenen M, Pumroy RA, Bhardwaj A, Steen A, Veenhoff LM, Cingolani G.

Structure. 2015 Jul 7;23(7):1305-1316. doi: 10.1016/j.str.2015.04.017. Epub 2015 Jun 4.


Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.

Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT.

Mol Cancer Ther. 2015 Aug;14(8):1777-93. doi: 10.1158/1535-7163.MCT-14-0883. Epub 2015 May 29.


The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.

Lieu KG, Shim EH, Wang J, Lokareddy RK, Tao T, Cingolani G, Zambetti GP, Jans DA.

J Cell Biol. 2014 May 12;205(3):301-12. doi: 10.1083/jcb.201304055.


Structure of human PIR1, an atypical dual-specificity phosphatase.

Sankhala RS, Lokareddy RK, Cingolani G.

Biochemistry. 2014 Feb 11;53(5):862-71. doi: 10.1021/bi401240x. Epub 2014 Jan 31.


Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase.

Lokareddy RK, Bhardwaj A, Cingolani G.

Biochemistry. 2013 Feb 5;52(5):938-48. doi: 10.1021/bi301476m. Epub 2013 Jan 18.


Combination of two separate binding domains defines stoichiometry between type III secretion system chaperone IpgC and translocator protein IpaB.

Lokareddy RK, Lunelli M, Eilers B, Wolter V, Kolbe M.

J Biol Chem. 2010 Dec 17;285(51):39965-75. doi: 10.1074/jbc.M110.135616. Epub 2010 Oct 11.


IpaB-IpgC interaction defines binding motif for type III secretion translocator.

Lunelli M, Lokareddy RK, Zychlinsky A, Kolbe M.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9661-6. doi: 10.1073/pnas.0812900106. Epub 2009 May 28.

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