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Items: 1 to 50 of 73

1.

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress.

Qin P, Arabacilar P, Bernard RE, Bao W, Olzinski AR, Guo Y, Lal H, Eisennagel SH, Platchek MC, Xie W, Del Rosario J, Nayal M, Lu Q, Roethke T, Schnackenberg CG, Wright F, Quaile MP, Halsey WS, Hughes AM, Sathe GM, Livi GP, Kirkpatrick RB, Qu XA, Rajpal DK, Faelth Savitski M, Bantscheff M, Joberty G, Bergamini G, Force TL, Gatto GJ Jr, Hu E, Willette RN.

J Am Heart Assoc. 2017 May 9;6(5). pii: e004453. doi: 10.1161/JAHA.116.004453.

2.

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes.

Zhao W, Beers DR, Hooten KG, Sieglaff DH, Zhang A, Kalyana-Sundaram S, Traini CM, Halsey WS, Hughes AM, Sathe GM, Livi GP, Fan GH, Appel SH.

JAMA Neurol. 2017 Jun 1;74(6):677-685. doi: 10.1001/jamaneurol.2017.0357.

PMID:
28437540
3.

Applications of CRISPR genome editing technology in drug target identification and validation.

Lu Q, Livi GP, Modha S, Yusa K, MacarrĂ³n R, Dow DJ.

Expert Opin Drug Discov. 2017 Jun;12(6):541-552. doi: 10.1080/17460441.2017.1317244. Epub 2017 Apr 23. Review.

PMID:
28388235
4.

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models.

Rajpal DK, Klein JL, Mayhew D, Boucheron J, Spivak AT, Kumar V, Ingraham K, Paulik M, Chen L, Van Horn S, Thomas E, Sathe G, Livi GP, Holmes DJ, Brown JR.

PLoS One. 2015 Dec 28;10(12):e0145499. doi: 10.1371/journal.pone.0145499. eCollection 2015.

5.

Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase.

Arat S, Spivak A, Van Horn S, Thomas E, Traini C, Sathe G, Livi GP, Ingraham K, Jones L, Aubart K, Holmes DJ, Naderer O, Brown JR.

Antimicrob Agents Chemother. 2015 Feb;59(2):1182-92. doi: 10.1128/AAC.04506-14. Epub 2014 Dec 8.

6.

Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.

O'Dwyer K, Spivak AT, Ingraham K, Min S, Holmes DJ, Jakielaszek C, Rittenhouse S, Kwan AL, Livi GP, Sathe G, Thomas E, Van Horn S, Miller LA, Twynholm M, Tomayko J, Dalessandro M, Caltabiano M, Scangarella-Oman NE, Brown JR.

Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. doi: 10.1128/AAC.03774-14. Epub 2014 Oct 27.

7.

UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms.

Bassil AK, Bourdu S, Townson KA, Wheeldon A, Jarvie EM, Zebda N, Abuin A, Grau E, Livi GP, Punter L, Latcham J, Grimes AM, Hurp DP, Downham KM, Sanger GJ, Winchester WJ, Morrison AD, Moore GB.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G923-30. doi: 10.1152/ajpgi.90363.2008. Epub 2009 Jan 22.

8.

DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.

Bogacheva O, Bogachev O, Menon M, Dev A, Houde E, Valoret EI, Prosser HM, Creasy CL, Pickering SJ, Grau E, Rance K, Livi GP, Karur V, Erickson-Miller CL, Wojchowski DM.

J Biol Chem. 2008 Dec 26;283(52):36665-75. doi: 10.1074/jbc.M807844200. Epub 2008 Oct 14.

9.

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.

Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, Brandner S, Schulz JB, Mak T, Downward J.

Mol Cell Biol. 2004 Nov;24(22):9848-62.

10.

Mutation of charged residues in the TR3 death domain does not perturb interaction with TRADD.

Tunbridge E, Dingwall C, Edge C, Konduri M, DeMarini DJ, Livi GP, Maycox PR.

Protein Eng. 2002 Oct;15(10):811-5.

PMID:
12468715
11.

Cloning, expression, and initial characterization of a novel cytokine-like gene family.

Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR.

Genomics. 2002 Aug;80(2):144-50.

PMID:
12160727
12.

The ARO4 gene of Candida albicans encodes a tyrosine-sensitive DAHP synthase: evolution, functional conservation and phenotype of Aro3p-, Aro4p-deficient mutants.

Sousa S, McLaughlin MM, Pereira SA, VanHorn S, Knowlton R, Brown JR, Nicholas RO, Livi GP.

Microbiology. 2002 May;148(Pt 5):1291-303.

PMID:
11988503
13.

Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.

Freeman K, Tsui P, Moore D, Emson PC, Vawter L, Naheed S, Lane P, Bawagan H, Herrity N, Murphy K, Sarau HM, Ames RS, Wilson S, Livi GP, Chambers JK.

Genomics. 2001 Dec;78(3):124-8.

PMID:
11735218
14.

EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes.

Robert P, Tsui P, Laville MP, Livi GP, Sarau HM, Bril A, Berrebi-Bertrand I.

J Mol Cell Cardiol. 2001 Sep;33(9):1589-606.

PMID:
11549339
15.
16.

Oligonucleotide-mediated, PCR-independent cloning by homologous recombination.

DeMarini DJ, Creasy CL, Lu Q, Mao J, Sheardown SA, Sathe GM, Livi GP.

Biotechniques. 2001 Mar;30(3):520-3.

PMID:
11252788
17.

A G protein-coupled receptor for UDP-glucose.

Chambers JK, Macdonald LE, Sarau HM, Ames RS, Freeman K, Foley JJ, Zhu Y, McLaughlin MM, Murdock P, McMillan L, Trill J, Swift A, Aiyar N, Taylor P, Vawter L, Naheed S, Szekeres P, Hervieu G, Scott C, Watson JM, Murphy AJ, Duzic E, Klein C, Bergsma DJ, Wilson S, Livi GP.

J Biol Chem. 2000 Apr 14;275(15):10767-71.

18.

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL.

Eur J Biochem. 2000 Sep;267(18):5699-710.

19.
20.

Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor.

Truneh A, Sharma S, Silverman C, Khandekar S, Reddy MP, Deen KC, McLaughlin MM, Srinivasula SM, Livi GP, Marshall LA, Alnemri ES, Williams WV, Doyle ML.

J Biol Chem. 2000 Jul 28;275(30):23319-25.

21.

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket.

Gum RJ, McLaughlin MM, Kumar S, Wang Z, Bower MJ, Lee JC, Adams JL, Livi GP, Goldsmith EJ, Young PR.

J Biol Chem. 1998 Jun 19;273(25):15605-10.

22.

Role of conserved histidines in catalytic activity and inhibitor binding of human recombinant phosphodiesterase 4A.

Jacobitz S, Ryan MD, McLaughlin MM, Livi GP, DeWolf WE Jr, Torphy TJ.

Mol Pharmacol. 1997 Jun;51(6):999-1006.

23.

Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site.

Young PR, McLaughlin MM, Kumar S, Kassis S, Doyle ML, McNulty D, Gallagher TF, Fisher S, McDonnell PC, Carr SA, Huddleston MJ, Seibel G, Porter TG, Livi GP, Adams JL, Lee JC.

J Biol Chem. 1997 May 2;272(18):12116-21.

24.

Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.

Jacobitz S, McLaughlin MM, Livi GP, Burman M, Torphy TJ.

Mol Pharmacol. 1996 Oct;50(4):891-9.

PMID:
8863835
25.

Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis.

Cheung PP, Xu H, McLaughlin MM, Ghazaleh FA, Livi GP, Colman RW.

Blood. 1996 Aug 15;88(4):1321-9.

26.

Missense mutations at the FKBP12-rapamycin-binding site of TOR1.

Freeman K, Livi GP.

Gene. 1996 Jun 12;172(1):143-7.

PMID:
8654975
27.

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.

McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR.

J Biol Chem. 1996 Apr 5;271(14):8488-92.

28.
29.

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B.

Manning CD, McLaughlin MM, Livi GP, Cieslinski LB, Torphy TJ, Barnette MS.

J Pharmacol Exp Ther. 1996 Feb;276(2):810-8.

PMID:
8632354
30.

Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast.

Kumar S, McLaughlin MM, McDonnell PC, Lee JC, Livi GP, Young PR.

J Biol Chem. 1995 Dec 8;270(49):29043-6.

31.

Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells.

Amegadzie BY, Hanning CR, McLaughlin MM, Burman M, Cieslinski LB, Livi GP, Torphy TJ.

Cell Biol Int. 1995 Jun;19(6):477-84.

PMID:
7640661
32.

Candida albicans ALS1: domains related to a Saccharomyces cerevisiae sexual agglutinin separated by a repeating motif.

Hoyer LL, Scherer S, Shatzman AR, Livi GP.

Mol Microbiol. 1995 Jan;15(1):39-54.

PMID:
7752895
33.

A GCN-like response in Candida albicans.

Pereira SA, Livi GP.

Cell Biol Int. 1995 Jan;19(1):65-9.

PMID:
7613513
34.

The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.

Eng WK, Faucette L, McLaughlin MM, Cafferkey R, Koltin Y, Morris RA, Young PR, Johnson RK, Livi GP.

Gene. 1994 Dec 30;151(1-2):61-71.

PMID:
7530227
35.

Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.

Stan R, McLaughlin MM, Cafferkey R, Johnson RK, Rosenberg M, Livi GP.

J Biol Chem. 1994 Dec 23;269(51):32027-30.

36.

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.

Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, Strickler JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL, Young PR.

Nature. 1994 Dec 22-29;372(6508):739-46.

PMID:
7997261
37.

A Candida albicans cyclic nucleotide phosphodiesterase: cloning and expression in Saccharomyces cerevisiae and biochemical characterization of the recombinant enzyme.

Hoyer LL, Cieslinski LB, McLaughlin MM, Torphy TJ, Shatzman AR, Livi GP.

Microbiology. 1994 Jul;140 ( Pt 7):1533-42.

PMID:
8075796
38.

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs.

Cafferkey R, McLaughlin MM, Young PR, Johnson RK, Livi GP.

Gene. 1994 Apr 8;141(1):133-6.

PMID:
8163165
39.

Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to Leu.

Bossard MJ, Bergsma DJ, Brandt M, Livi GP, Eng WK, Johnson RK, Levy MA.

Biochem J. 1994 Jan 15;297 ( Pt 2):365-72.

40.
41.

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

Cafferkey R, Young PR, McLaughlin MM, Bergsma DJ, Koltin Y, Sathe GM, Faucette L, Eng WK, Johnson RK, Livi GP.

Mol Cell Biol. 1993 Oct;13(10):6012-23.

42.

The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding.

Koser PL, Eng WK, Bossard MJ, McLaughlin MM, Cafferkey R, Sathe GM, Faucette L, Levy MA, Johnson RK, Bergsma DJ, Livi GP.

Gene. 1993 Jul 30;129(2):159-65.

PMID:
8325502
43.

Expression of dopamine beta-hydroxylase in Drosophila Schneider 2 cells. Evidence for a mechanism of membrane binding other than uncleaved signal peptide.

Gibson KR, Vanek PG, Kaloss WD, Collier GB, Connaughton JF, Angelichio M, Livi GP, Fleming PJ.

J Biol Chem. 1993 May 5;268(13):9490-5.

45.

Biochemical characteristics and cellular regulation of phosphodiesterase IV.

Torphy TJ, DeWolf WE Jr, Green DW, Livi GP.

Agents Actions Suppl. 1993;43:51-71. Review.

PMID:
8396319
46.

Recombinant human secretory phospholipase A2: purification and characterization of the enzyme for active site studies.

Stadel JM, Jones C, Livi GP, Hoyle K, Kurdyla J, Roshak A, McLaughlin MM, Pfarr DA, Comer S, Strickler J, et al.

J Mol Recognit. 1992 Dec;5(4):145-53.

PMID:
1339483
47.
48.

The yeast cyclophilin multigene family: purification, cloning and characterization of a new isoform.

McLaughlin MM, Bossard MJ, Koser PL, Cafferkey R, Morris RA, Miles LM, Strickler J, Bergsma DJ, Levy MA, Livi GP.

Gene. 1992 Feb 1;111(1):85-92.

PMID:
1547957
49.

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

Torphy TJ, Stadel JM, Burman M, Cieslinski LB, McLaughlin MM, White JR, Livi GP.

J Biol Chem. 1992 Jan 25;267(3):1798-804.

50.

Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma.

Torphy TJ, Livi GP, Balcarek JM, White JR, Chilton FH, Undem BJ.

Adv Second Messenger Phosphoprotein Res. 1992;25:289-305. Review. No abstract available.

PMID:
1372813

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