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Agonist-Dependent and -Independent κ Opioid Receptor Phosphorylation: Distinct Phosphorylation Patterns and Different Cellular Outcomes.

Chiu YT, Chen C, Yu D, Schulz S, Liu-Chen LY.

Mol Pharmacol. 2017 Nov;92(5):588-600. doi: 10.1124/mol.117.108555. Epub 2017 Sep 11.


Synthetic cathinones and stereochemistry: S enantiomer of mephedrone reduces anxiety- and depressant-like effects in cocaine- or MDPV-abstinent rats.

Philogene-Khalid HL, Hicks C, Reitz AB, Liu-Chen LY, Rawls SM.

Drug Alcohol Depend. 2017 Sep 1;178:119-125. doi: 10.1016/j.drugalcdep.2017.04.024. Epub 2017 Jun 13.


Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors.

Lee DYW, Liu J, Zhang S, Huang P, Liu-Chen LY.

Bioorg Med Chem Lett. 2017 Mar 15;27(6):1437-1440. doi: 10.1016/j.bmcl.2017.01.090. Epub 2017 Jan 31.


Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists.

Xu W, Wang X, Tocker AM, Huang P, Reith ME, Liu-Chen LY, Smith AB 3rd, Kortagere S.

ACS Chem Neurosci. 2017 Mar 15;8(3):486-500. doi: 10.1021/acschemneuro.6b00221. Epub 2016 Nov 23.


Development and validation of a high performance liquid chromatography quantification method of levo-tetrahydropalmatine and its metabolites in plasma and brain tissues: application to a pharmacokinetic study.

Abdallah IA, Huang P, Liu J, Lee DY, Liu-Chen LY, Hassan HE.

Biomed Chromatogr. 2017 Apr;31(4). doi: 10.1002/bmc.3850. Epub 2016 Oct 9.


T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice.

Wang XF, Barbier E, Chiu YT, He Y, Zhan J, Bi GH, Zhang HY, Feng B, Liu-Chen LY, Wang JB, Xi ZX.

J Neurosci. 2016 Oct 5;36(40):10392-10403. Erratum in: J Neurosci. 2017 Mar 15;37(11):3102.


Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation.

Kutlu MG, Oliver C, Huang P, Liu-Chen LY, Gould TJ.

Neuropharmacology. 2016 Oct;109:341-348. doi: 10.1016/j.neuropharm.2016.06.032. Epub 2016 Jul 1.


Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.

Huang P, Tunis J, Parry C, Tallarida R, Liu-Chen LY.

Eur J Pharmacol. 2016 Jun 15;781:53-9. doi: 10.1016/j.ejphar.2016.03.061. Epub 2016 Apr 1.


Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests.

Huang P, Yakovleva T, Aldrich JV, Tunis J, Parry C, Liu-Chen LY.

Neurosci Lett. 2016 Feb 26;615:15-20. doi: 10.1016/j.neulet.2016.01.017. Epub 2016 Jan 15.


Determination of sites of U50,488H-promoted phosphorylation of the mouse κ opioid receptor (KOPR): disconnect between KOPR phosphorylation and internalization.

Chen C, Chiu YT, Wu W, Huang P, Mann A, Schulz S, Liu-Chen LY.

Biochem J. 2016 Feb 15;473(4):497-508. doi: 10.1042/BJ20141471. Epub 2015 Dec 3.


Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists.

Lee DY, Deng G, Ma Z, Xu W, Yang L, Liu J, Dai R, Liu-Chen LY.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4689-92. doi: 10.1016/j.bmcl.2015.06.092. Epub 2015 Jul 3.


Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors.

DiMattio KM, Ehlert FJ, Liu-Chen LY.

Eur J Pharmacol. 2015 Aug 15;761:235-44. doi: 10.1016/j.ejphar.2015.05.054. Epub 2015 Jun 6.


K303⁶·⁵⁸ in the μ opioid (MOP) receptor is important in conferring selectivity for covalent binding of β-funaltrexamine (β-FNA).

DiMattio KM, Chen C, Shi L, Liu-Chen LY.

Eur J Pharmacol. 2015 Feb 5;748:93-100. doi: 10.1016/j.ejphar.2014.11.028. Epub 2014 Dec 4.


Identification and verification of proteins interacting with the kappa opioid receptor (KOPR).

Chen C, Huang P, Liu-Chen LY.

Methods Mol Biol. 2015;1230:129-40. doi: 10.1007/978-1-4939-1708-2_10.


Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice.

Dimattio KM, Yakovleva TV, Aldrich JV, Cowan A, Liu-Chen LY.

Neurosci Lett. 2014 Mar 20;563:155-9. doi: 10.1016/j.neulet.2014.01.022. Epub 2014 Feb 3.


Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity.

Munro TA, Xu W, Ho DM, Liu-Chen LY, Cohen BM.

Beilstein J Org Chem. 2013 Dec 20;9:2916-24. doi: 10.3762/bjoc.9.328. eCollection 2013 Dec 20.


L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors.

Xu W, Wang Y, Ma Z, Chiu YT, Huang P, Rasakham K, Unterwald E, Lee DY, Liu-Chen LY.

Drug Alcohol Depend. 2013 Dec 1;133(2):693-703. doi: 10.1016/j.drugalcdep.2013.08.021. Epub 2013 Sep 2.


A G protein-coupled receptor (GPCR) in red: live cell imaging of the kappa opioid receptor-tdTomato fusion protein (KOPR-tdT) in neuronal cells.

Huang P, Chiu YT, Chen C, Wang Y, Liu-Chen LY.

J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):340-5. doi: 10.1016/j.vascn.2013.07.002. Epub 2013 Jul 12.


PKA and ERK1/2 are involved in dopamine D₁ receptor-induced heterologous desensitization of the δ opioid receptor.

Xu W, Chen C, Li JG, Dimattio K, Wang Y, Unterwald E, Liu-Chen LY.

Life Sci. 2013 Jun 21;92(23):1101-9. doi: 10.1016/j.lfs.2013.04.006. Epub 2013 Apr 26.


Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity.

Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA Jr.

Neuropsychopharmacology. 2013 Jul;38(8):1585-97. doi: 10.1038/npp.2013.58. Epub 2013 Feb 27.


Ligand directed signaling differences between rodent and human κ-opioid receptors.

Schattauer SS, Miyatake M, Shankar H, Zietz C, Levin JR, Liu-Chen LY, Gurevich VV, Rieder MJ, Chavkin C.

J Biol Chem. 2012 Dec 7;287(50):41595-607. doi: 10.1074/jbc.M112.381368. Epub 2012 Oct 19.


14-3-3ζ Protein regulates anterograde transport of the human κ-opioid receptor (hKOPR).

Li JG, Chen C, Huang P, Wang Y, Liu-Chen LY.

J Biol Chem. 2012 Nov 2;287(45):37778-92. doi: 10.1074/jbc.M112.359679. Epub 2012 Sep 18.


Sex differences in U50,488H-induced phosphorylation of p44/42 mitogen-activated protein kinase in the guinea pig brain.

Rasakham K, McGillivray KL, Liu-Chen LY.

Neuroscience. 2012 Oct 25;223:447-56. doi: 10.1016/j.neuroscience.2012.07.040. Epub 2012 Jul 31.


Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G.

Wang YJ, Huang P, Blendy JA, Liu-Chen LY.

Addict Biol. 2014 May;19(3):354-61. doi: 10.1111/j.1369-1600.2012.00484.x. Epub 2012 Aug 2.


6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment.

Rives ML, Rossillo M, Liu-Chen LY, Javitch JA.

J Biol Chem. 2012 Aug 3;287(32):27050-4. doi: 10.1074/jbc.C112.387332. Epub 2012 Jun 26.


Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation.

Lisek R, Xu W, Yuvasheva E, Chiu YT, Reitz AB, Liu-Chen LY, Rawls SM.

Drug Alcohol Depend. 2012 Nov 1;126(1-2):257-62. doi: 10.1016/j.drugalcdep.2012.04.021. Epub 2012 May 29.


Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G.

Wang YJ, Huang P, Ung A, Blendy JA, Liu-Chen LY.

Neuroscience. 2012 Mar 15;205:178-84. doi: 10.1016/j.neuroscience.2011.12.033. Epub 2012 Jan 3.


Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.

Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA Jr, Cohen BM.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1023-6. doi: 10.1016/j.bmcl.2011.11.128. Epub 2011 Dec 7.


A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.

Huang P, Chen C, Mague SD, Blendy JA, Liu-Chen LY.

Biochem J. 2012 Jan 1;441(1):379-86. doi: 10.1042/BJ20111050.


Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig.

Wang YJ, Rasakham K, Huang P, Chudnovskaya D, Cowan A, Liu-Chen LY.

J Pharmacol Exp Ther. 2011 Nov;339(2):438-50. doi: 10.1124/jpet.111.183905. Epub 2011 Aug 12.


Methylphenidate and μ opioid receptor interactions: a pharmacological target for prevention of stimulant abuse.

Zhu J, Spencer TJ, Liu-Chen LY, Biederman J, Bhide PG.

Neuropharmacology. 2011 Jul-Aug;61(1-2):283-92. doi: 10.1016/j.neuropharm.2011.04.015. Epub 2011 Apr 23.


Sex differences in kappa opioid pharmacology.

Rasakham K, Liu-Chen LY.

Life Sci. 2011 Jan 3;88(1-2):2-16. doi: 10.1016/j.lfs.2010.10.007. Epub 2010 Oct 14. Review.


Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A.

Lee DY, Yang L, Xu W, Deng G, Guo L, Liu-Chen LY.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5749-52. doi: 10.1016/j.bmcl.2010.08.001. Epub 2010 Aug 5.


Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze.

Huang P, Liu-Chen LY, Kirby LG.

Neurosci Lett. 2010 May 21;475(3):165-8. doi: 10.1016/j.neulet.2010.03.071. Epub 2010 Apr 2.


Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice.

Huang P, Liu-Chen LY, Unterwald EM, Cowan A.

Neurosci Lett. 2009 Nov 6;465(1):66-70. doi: 10.1016/j.neulet.2009.08.073. Epub 2009 Sep 3.


Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.

Mague SD, Isiegas C, Huang P, Liu-Chen LY, Lerman C, Blendy JA.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10847-52. doi: 10.1073/pnas.0901800106. Epub 2009 Jun 15.


Detection of the endogenous mu opioid receptor (mopr) in brain

Huang P, Liu-Chen LY.

Front Biosci (Elite Ed). 2009 Jun 1;1:220-7. Review.


Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.

Wang Q, Liu-Chen LY, Traynor JR.

J Biol Chem. 2009 Jul 3;284(27):18357-67. doi: 10.1074/jbc.M109.015453. Epub 2009 May 5.


C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro.

Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ.

Neuroscience. 2009 Mar 17;159(2):492-500.


Chaperone-like effects of cell-permeant ligands on opioid receptors.

Chen Y, Liu-Chen LY.

Front Biosci (Landmark Ed). 2009 Jan 1;14:634-43. Review.


Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A.

Yang L, Xu W, Chen F, Liu-Chen LY, Ma Z, Lee DY.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1301-4. doi: 10.1016/j.bmcl.2009.01.078. Epub 2009 Feb 9.


Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.

Béguin C, Duncan KK, Munro TA, Ho DM, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM.

Bioorg Med Chem. 2009 Feb 1;17(3):1370-80. doi: 10.1016/j.bmc.2008.12.012. Epub 2008 Dec 14.


Effects of acute agonist treatment on subcellular distribution of kappa opioid receptor in rat spinal cord.

Wang Y, Xu W, Huang P, Chavkin C, Van Bockstaele EJ, Liu-Chen LY.

J Neurosci Res. 2009 May 15;87(7):1695-702. doi: 10.1002/jnr.21971.


GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect.

Chen Y, Chen C, Kotsikorou E, Lynch DL, Reggio PH, Liu-Chen LY.

J Biol Chem. 2009 Jan 16;284(3):1673-85. doi: 10.1074/jbc.M808303200. Epub 2008 Nov 11.


Young and older good learners have higher levels of brain nicotinic receptor binding.

Woodruff-Pak DS, Lehr MA, Li JG, Liu-Chen LY.

Neurobiol Aging. 2010 Jun;31(6):1032-43. doi: 10.1016/j.neurobiolaging.2008.09.002. Epub 2008 Oct 23.


In vivo trafficking of endogenous opioid receptors.

Wang Y, Van Bockstaele EJ, Liu-Chen LY.

Life Sci. 2008 Nov 21;83(21-22):693-9. doi: 10.1016/j.lfs.2008.09.023. Epub 2008 Oct 5. Review.


Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A.

Inan S, Lee DY, Liu-Chen LY, Cowan A.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Mar;379(3):263-70. doi: 10.1007/s00210-008-0358-8. Epub 2008 Oct 17.


Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor.

Ma ZZ, Xu W, Jensen NH, Roth BL, Liu-Chen LY, Lee DY.

Molecules. 2008 Sep 25;13(9):2303-12.

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