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Response to: 'Screening for atrial fibrillation in hospitalised geriatric patients' by Tavernier et al.

Lown M, Shah BN, Corbett SJ, Yue A, Little P, Moore M.

Heart. 2018 Apr;104(7):624. doi: 10.1136/heartjnl-2017-312672. No abstract available.


Multimorbidity and Socioeconomic Deprivation in Primary Care Consultations.

Mercer SW, Zhou Y, Humphris GM, McConnachie A, Bakhshi A, Bikker A, Higgins M, Little P, Fitzpatrick B, Watt GCM.

Ann Fam Med. 2018 Mar;16(2):127-131. doi: 10.1370/afm.2202.


The association between copy number aberration, DNA methylation and gene expression in tumor samples.

Sun W, Bunn P, Jin C, Little P, Zhabotynsky V, Perou CM, Hayes DN, Chen M, Lin DY.

Nucleic Acids Res. 2018 Feb 26. doi: 10.1093/nar/gky131. [Epub ahead of print]


Using an internet intervention to support self-management of low back pain in primary care: findings from a randomised controlled feasibility trial (SupportBack).

Geraghty AWA, Stanford R, Stuart B, Little P, Roberts LC, Foster NE, Hill JC, Hay EM, Turner D, Malakan W, Leigh L, Yardley L.

BMJ Open. 2018 Mar 9;8(3):e016768. doi: 10.1136/bmjopen-2017-016768.


G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors.

Dayati P, Rezaei HB, Sharifat N, Kamato D, Little PJ.

Life Sci. 2018 Mar 3. pii: S0024-3205(18)30102-4. doi: 10.1016/j.lfs.2018.03.004. [Epub ahead of print] Review.


Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness.

Butler CC, Francis NA, Thomas-Jones E, Longo M, Wootton M, Llor C, Little P, Moore M, Bates J, Pickles T, Kirby N, Gillespie D, Rumsby K, Brugman C, Gal M, Hood K, Verheij T.

Br J Gen Pract. 2018 Feb 26. pii: bjgp18X695285. doi: 10.3399/bjgp18X695285. [Epub ahead of print]


Protection of sheep by vaccination against experimental challenge with Leptospira borgpetersenii serovar Hardjo and L. interrogans serovar Pomona.

Clough WJ, Little PR, Hodge A, Chapman VC, Holz DK.

N Z Vet J. 2018 May;66(3):138-143. doi: 10.1080/00480169.2018.1441078. Epub 2018 Mar 8.


Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis.

Afroz R, Cao Y, Rostam MA, Ta H, Xu S, Zheng W, Osman N, Kamato D, Little PJ.

Pharmacol Ther. 2018 Feb 15. pii: S0163-7258(18)30030-5. doi: 10.1016/j.pharmthera.2018.02.005. [Epub ahead of print] Review.


Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries.

Ieven M, Coenen S, Loens K, Lammens C, Coenjaerts F, Vanderstraeten A, Henriques-Normark B, Crook D, Huygen K, Butler CC, Verheij TJM, Little P, Zlateva K, van Loon A, Claas ECJ, Goossens H; GRACE consortium.

Clin Microbiol Infect. 2018 Feb 12. pii: S1198-743X(18)30152-6. doi: 10.1016/j.cmi.2018.02.004. [Epub ahead of print]


Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2.

Rostam MA, Shajimoon A, Kamato D, Mitra P, Piva TJ, Getachew R, Cao Y, Zheng W, Osman N, Little PJ.

J Pharmacol Exp Ther. 2018 Apr;365(1):156-164. doi: 10.1124/jpet.117.244483. Epub 2018 Feb 9.


Effectiveness of general practitioner online training and an information booklet for parents on antibiotic prescribing for children with respiratory tract infection in primary care: a cluster randomized controlled trial.

Dekker ARJ, Verheij TJM, Broekhuizen BDL, Butler CC, Cals JWL, Francis NA, Little P, Sanders EAM, Yardley L, Zuithoff NPA, van der Velden AW.

J Antimicrob Chemother. 2018 Feb 9. doi: 10.1093/jac/dkx542. [Epub ahead of print]


What gives rise to clinician gut feeling, its influence on management decisions and its prognostic value for children with RTI in primary care: a prospective cohort study.

Turnbull S, Lucas PJ, Redmond NM, Christensen H, Thornton H, Cabral C, Blair PS, Delaney BC, Thompson M, Little P, Peters TJ, Hay AD.

BMC Fam Pract. 2018 Feb 5;19(1):25. doi: 10.1186/s12875-018-0716-7.


Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B.

Yan F, Liao R, Lin S, Deng X, Little PJ, Zheng W.

Mol Med Rep. 2018 Feb;17(2):3109-3114. doi: 10.3892/mmr.2017.8215. Epub 2017 Dec 7.


Probiotic capsules and xylitol chewing gum to manage symptoms of pharyngitis: a randomized controlled factorial trial.

Little P, Stuart B, Wingrove Z, Mullee M, Thomas T, Johnson S, Leydon G, Richards-Hall S, Williamson I, Yao L, Zhu S, Moore M.

CMAJ. 2017 Dec 18;189(50):E1543-E1550. doi: 10.1503/cmaj.170599.


Physiotherapy breathing retraining for asthma: a randomised controlled trial.

Bruton A, Lee A, Yardley L, Raftery J, Arden-Close E, Kirby S, Zhu S, Thiruvothiyur M, Webley F, Taylor L, Gibson D, Yao G, Stafford-Watson M, Versnel J, Moore M, George S, Little P, Djukanovic R, Price D, Pavord ID, Holgate ST, Thomas M.

Lancet Respir Med. 2018 Jan;6(1):19-28. doi: 10.1016/S2213-2600(17)30474-5. Epub 2017 Dec 14.


Adverse Effects of Amoxicillin for Acute Lower Respiratory Tract Infection in Primary Care: Secondary and Subgroup Analysis of a Randomised Clinical Trial.

Tandan M, Vellinga A, Bruyndonckx R, Little P, Verheij T, Butler CC, Goossens H, Coenen S.

Antibiotics (Basel). 2017 Dec 13;6(4). pii: E36. doi: 10.3390/antibiotics6040036.


General practitioner and nurse prescriber experiences of prescribing antibiotics for respiratory tract infections in UK primary care out-of-hours services (the UNITE study).

Williams SJ, Halls AV, Tonkin-Crine S, Moore MV, Latter SE, Little P, Eyles C, Postle K, Leydon GM.

J Antimicrob Chemother. 2017 Nov 27. doi: 10.1093/jac/dkx429. [Epub ahead of print]


Qualitative interview study of antibiotics and self-management strategies for respiratory infections in primary care.

McDermott L, Leydon GM, Halls A, Kelly J, Nagle A, White J, Little P; PIPS investigators.

BMJ Open. 2017 Nov 26;7(11):e016903. doi: 10.1136/bmjopen-2017-016903.


Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication cohort study.

Moore M, Stuart B, Little P, Smith S, Thompson MJ, Knox K, van den Bruel A, Lown M, Mant D.

Eur Respir J. 2017 Nov 22;50(5). pii: 1700434. doi: 10.1183/13993003.00434-2017. Print 2017 Nov.


Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study.

Butler CC, Francis N, Thomas-Jones E, Llor C, Bongard E, Moore M, Little P, Bates J, Lau M, Pickles T, Gal M, Wootton M, Kirby N, Gillespie D, Rumbsy K, Brugman C, Hood K, Verheij T.

Br J Gen Pract. 2017 Dec;67(665):e830-e841. doi: 10.3399/bjgp17X693641.


Antibiotics or NSAIDs for uncomplicated urinary tract infection?

Little P.

BMJ. 2017 Nov 8;359:j5037. doi: 10.1136/bmj.j5037. No abstract available.


Amoxicillin for acute lower respiratory tract infection in primary care: subgroup analysis by bacterial and viral aetiology.

Bruyndonckx R, Stuart B, Little P, Hens N, Ieven M, Butler CC, Verheij T, Goossens H, Coenen S; GRACE project group.

Clin Microbiol Infect. 2017 Nov 3. pii: S1198-743X(17)30626-2. doi: 10.1016/j.cmi.2017.10.032. [Epub ahead of print]


'Well, it literally stops me from having a life when it's really bad': a nested qualitative interview study of patient views on the use of self-management treatments for the management of recurrent sinusitis (SNIFS trial).

Leydon GM, McDermott L, Thomas T, Halls A, Holdstock-Brown B, Petley S, Wiseman C, Little P; SNIFS Investigators.

BMJ Open. 2017 Nov 3;7(11):e017130. doi: 10.1136/bmjopen-2017-017130.


Understanding acceptability of and engagement with Web-based interventions aiming to improve quality of life in cancer survivors: A synthesis of current research.

Corbett T, Singh K, Payne L, Bradbury K, Foster C, Watson E, Richardson A, Little P, Yardley L.

Psychooncology. 2018 Jan;27(1):22-33. doi: 10.1002/pon.4566. Epub 2017 Nov 21. Review.


Reducing early career general practitioners' antibiotic prescribing for respiratory tract infections: a pragmatic prospective non-randomised controlled trial.

Magin P, Tapley A, Morgan S, Davis JS, McElduff P, Yardley L, Henderson K, Dallas A, McArthur L, Mulquiney K, Davey A, Little P, Spike N, van Driel ML.

Fam Pract. 2018 Jan 16;35(1):53-60. doi: 10.1093/fampra/cmx070.


Focus on early-career GPs: qualitative evaluation of a multi-faceted educational intervention to improve antibiotic prescribing.

Deckx L, Anthierens S, Magin PJ, Morgan S, McArthur L, Yardley L, Dallas A, Little P, van Driel ML.

Fam Pract. 2018 Jan 16;35(1):99-104. doi: 10.1093/fampra/cmx074.


Corporate Mortality Files and Late Industrial Necropolitics.

Little PC.

Med Anthropol Q. 2017 Oct 5. doi: 10.1111/maq.12417. [Epub ahead of print]


A randomised controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist either by instructional DVD or in face-to-face sessions in the management of asthma in adults.

Thomas M, Bruton A, Little P, Holgate S, Lee A, Yardley L, George S, Raftery J, Versnel J, Price D, Pavord I, Djukanovic R, Moore M, Kirby S, Yao G, Zhu S, Arden-Close E, Thiruvothiyur M, Webley F, Stafford-Watson M, Dixon E, Taylor L.

Health Technol Assess. 2017 Sep;21(53):1-162. doi: 10.3310/hta21530.


Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.

Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY.

Nat Commun. 2017 Sep 21;8(1):653. doi: 10.1038/s41467-017-00413-x.


Qualitative interview study of parents' perspectives, concerns and experiences of the management of lower respiratory tract infections in children in primary care.

Halls A, Van't Hoff C, Little P, Verheij T, Leydon GM.

BMJ Open. 2017 Sep 15;7(9):e015701. doi: 10.1136/bmjopen-2016-015701.


Uva-ursi extract and ibuprofen as alternative treatments of adult female urinary tract infection (ATAFUTI): study protocol for a randomised controlled trial.

Trill J, Simpson C, Webley F, Radford M, Stanton L, Maishman T, Galanopoulou A, Flower A, Eyles C, Willcox M, Hay A, Griffiths G, Little P, Lewith G, Moore M.

Trials. 2017 Sep 8;18(1):421. doi: 10.1186/s13063-017-2145-7.


Effect of Oral Prednisolone on Symptom Duration and Severity in Nonasthmatic Adults With Acute Lower Respiratory Tract Infection: A Randomized Clinical Trial.

Hay AD, Little P, Harnden A, Thompson M, Wang K, Kendrick D, Orton E, Brookes ST, Young GJ, May M, Hollinghurst S, Carroll FE, Downing H, Timmins D, Lafond N, El-Gohary M, Moore M.

JAMA. 2017 Aug 22;318(8):721-730. doi: 10.1001/jama.2017.10572.


FOXO Signaling Pathways as Therapeutic Targets in Cancer.

Farhan M, Wang H, Gaur U, Little PJ, Xu J, Zheng W.

Int J Biol Sci. 2017 Jul 6;13(7):815-827. doi: 10.7150/ijbs.20052. eCollection 2017. Review.


Influence of the duration of penicillin prescriptions on outcomes for acute sore throat in adults: the DESCARTE prospective cohort study in UK general practice.

Moore M, Stuart B, Hobbs FR, Butler CC, Hay AD, Campbell J, Delaney BC, Broomfield S, Barratt P, Hood K, Everitt H, Mullee M, Williamson I, Mant D, Little P; DESCARTE investigators.

Br J Gen Pract. 2017 Sep;67(662):e623-e633. doi: 10.3399/bjgp17X692333. Epub 2017 Aug 14.


Symptom response to antibiotic prescribing strategies in acute sore throat in adults: the DESCARTE prospective cohort study in UK general practice.

Moore M, Stuart B, Hobbs FR, Butler CC, Hay AD, Campbell J, Delaney BC, Broomfield S, Barratt P, Hood K, Everitt HA, Mullee M, Williamson I, Mant D, Little P; DESCARTE investigators.

Br J Gen Pract. 2017 Sep;67(662):e634-e642. doi: 10.3399/bjgp17X692321. Epub 2017 Aug 14.


Comparison between treatment effects in a randomised controlled trial and an observational study using propensity scores in primary care.

Stuart BL, Grebel LE, Butler CC, Hood K, Verheij TJM, Little P.

Br J Gen Pract. 2017 Sep;67(662):e643-e649. doi: 10.3399/bjgp17X692153. Epub 2017 Jul 31.


RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells.

Kamato D, Bhaskarala VV, Mantri N, Oh TG, Ling D, Janke R, Zheng W, Little PJ, Osman N.

PLoS One. 2017 Jul 18;12(7):e0180842. doi: 10.1371/journal.pone.0180842. eCollection 2017.


Biopsychosocial risk factors of persistent fatigue after acute infection: A systematic review to inform interventions.

Hulme K, Hudson JL, Rojczyk P, Little P, Moss-Morris R.

J Psychosom Res. 2017 Aug;99:120-129. doi: 10.1016/j.jpsychores.2017.06.013. Epub 2017 Jun 16. Review.


What techniques might be used to harness placebo effects in non-malignant pain? A literature review and survey to develop a taxonomy.

Bishop FL, Coghlan B, Geraghty AW, Everitt H, Little P, Holmes MM, Seretis D, Lewith G.

BMJ Open. 2017 Jun 30;7(6):e015516. doi: 10.1136/bmjopen-2016-015516.


George Lewith.

Lewith H, Moore M, Little P.

BMJ. 2017 Jun 1;357:j2656. doi: 10.1136/bmj.j2656. No abstract available.


Providing online weight management in Primary Care: a mixed methods process evaluation of healthcare practitioners' experiences of using and supporting patients using POWeR.

Smith E, Bradbury K, Scott L, Steele M, Little P, Yardley L.

Implement Sci. 2017 May 25;12(1):69. doi: 10.1186/s13012-017-0596-6.


Antibiotic prescription strategies and adverse outcome for uncomplicated lower respiratory tract infections: prospective cough complication cohort (3C) study.

Little P, Stuart B, Smith S, Thompson MJ, Knox K, van den Bruel A, Lown M, Moore M, Mant D.

BMJ. 2017 May 22;357:j2148. doi: 10.1136/bmj.j2148.


Feasibility cluster randomised controlled trial of a within-consultation intervention to reduce antibiotic prescribing for children presenting to primary care with acute respiratory tract infection and cough.

Blair PS, Turnbull S, Ingram J, Redmond N, Lucas PJ, Cabral C, Hollinghurst S, Dixon P, Peters T, Horwood J, Little P, Francis NA, Gilbertson A, Jameson C, Hay AD.

BMJ Open. 2017 May 9;7(5):e014506. doi: 10.1136/bmjopen-2016-014506.


Internet-Based Vestibular Rehabilitation for Older Adults With Chronic Dizziness: A Randomized Controlled Trial in Primary Care.

Geraghty AWA, Essery R, Kirby S, Stuart B, Turner D, Little P, Bronstein A, Andersson G, Carlbring P, Yardley L.

Ann Fam Med. 2017 May;15(3):209-216. doi: 10.1370/afm.2070.


Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial.

Hayward GN, Hay AD, Moore MV, Jawad S, Williams N, Voysey M, Cook J, Allen J, Thompson M, Little P, Perera R, Wolstenholme J, Harman K, Heneghan C.

JAMA. 2017 Apr 18;317(15):1535-1543. doi: 10.1001/jama.2017.3417.


The Diagnosis of Urinary Tract Infection in Young Children (DUTY) Study Clinical Rule: Economic Evaluation.

Hollingworth W, Busby J, Butler CC, O'Brien K, Sterne JA, Hood K, Little P, Lawton M, Birnie K, Thomas-Jones E, Harman K, Hay AD; DUTY Study Team.

Value Health. 2017 Apr;20(4):556-566. doi: 10.1016/j.jval.2017.01.003. Epub 2017 Feb 22.


Disease Course of Lower Respiratory Tract Infection With a Bacterial Cause.

Teepe J, Broekhuizen BD, Loens K, Lammens C, Ieven M, Goossens H, Little P, Butler CC, Coenen S, Godycki-Cwirko M, Verheij T; GRACE Consortium.

Ann Fam Med. 2016 Nov;14(6):534-539. doi: 10.1370/afm.1974.


Measuring Vapor Intrusion: From Source Science Politics to a Transdisciplinary Approach.

Little PC, Pennell KG.

Environ Sociol. 2017;3(2):145-154. doi: 10.1080/23251042.2016.1224528. Epub 2016 Oct 12.


Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care.

Gillespie D, Farewell D, Brookes-Howell L, Butler CC, Coenen S, Francis NA, Little P, Stuart B, Verheij T, Hood K.

Patient Prefer Adherence. 2017 Mar 15;11:561-569. doi: 10.2147/PPA.S119256. eCollection 2017.


Clinicians' interpretations of point of care urine culture versus laboratory culture results: analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care.

Hullegie S, Wootton M, Verheij TJM, Thomas-Jones E, Bates J, Hood K, Gal M, Francis NA, Little P, Moore M, Llor C, Pickles T, Gillespie D, Kirby N, Brugman C, Butler CC.

Fam Pract. 2017 Aug 1;34(4):392-399. doi: 10.1093/fampra/cmx009.


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