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Items: 1 to 50 of 444

1.

An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage.

Kuser-Abali G, Gong L, Yan J, Liu Q, Zeng W, Williamson A, Lim CB, Molloy ME, Little JB, Huang L, Yuan ZM.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3452-3457. doi: 10.1073/pnas.1719532115. Epub 2018 Mar 14.

PMID:
29540569
2.

A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation.

Gong L, Pan X, Lim CB, de Polo A, Little JB, Yuan ZM.

Oncogene. 2018 Apr;37(16):2150-2164. doi: 10.1038/s41388-017-0117-8. Epub 2018 Jan 26.

PMID:
29371679
3.

Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells.

Nagasawa H, Lin YF, Kato TA, Brogan JR, Shih HY, Kurimasa A, Bedford JS, Chen BP, Little JB.

Radiat Res. 2017 Feb;187(2):259-267. doi: 10.1667/RR14679.1. Epub 2017 Jan 24.

4.

AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex.

de Polo A, Luo Z, Gerarduzzi C, Chen X, Little JB, Yuan ZM.

J Mol Cell Biol. 2017 Apr 1;9(2):154-165. doi: 10.1093/jmcb/mjw045.

PMID:
27927748
5.

Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.

Gerarduzzi C, de Polo A, Liu XS, El Kharbili M, Little JB, Yuan ZM.

J Biol Chem. 2016 Dec 9;291(50):25937-25949. Epub 2016 Oct 24.

6.

UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity.

Qi M, Ganapathy S, Zeng W, Zhang J, Little JB, Yuan ZM.

Oncotarget. 2015 Jul 10;6(19):17584-93.

7.

Glycolytic metabolism influences global chromatin structure.

Liu XS, Little JB, Yuan ZM.

Oncotarget. 2015 Feb 28;6(6):4214-25.

8.

Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.

Lin YF, Nagasawa H, Little JB, Kato TA, Shih HY, Xie XJ, Wilson PF Jr, Brogan JR, Kurimasa A, Chen DJ, Bedford JS, Chen BP.

PLoS One. 2014 Apr 8;9(4):e93579. doi: 10.1371/journal.pone.0093579. eCollection 2014.

9.

First metatarsophalangeal joint arthrodesis in the treatment of hallux valgus.

Little JB.

Clin Podiatr Med Surg. 2014 Apr;31(2):281-9. doi: 10.1016/j.cpm.2013.12.009. Epub 2014 Feb 26. Review.

PMID:
24685193
10.

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.

Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM.

Cell Death Differ. 2014 May;21(5):836-44. doi: 10.1038/cdd.2014.24. Epub 2014 Feb 28.

11.

A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection.

Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM.

J Biol Chem. 2014 Feb 21;289(8):5340-7. doi: 10.1074/jbc.M113.531020. Epub 2014 Jan 3.

12.

A tale of two forests: addressing postnuclear radiation at Chernobyl and Fukushima.

Bird WA, Little JB.

Environ Health Perspect. 2013 Mar;121(3):A78-85. doi: 10.1289/ehp.121-a78. No abstract available.

13.

Plight of the condors.

Little JB.

Sci Am. 2012 Jan;306(1):18. No abstract available.

PMID:
22279825
14.

Sequentially-induced responses define tumour cell radiosensitivity.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Dicello JF, Little JB.

Int J Radiat Biol. 2011 Jun;87(6):628-43. doi: 10.3109/09553002.2011.568573. Epub 2011 Apr 18.

PMID:
21501033
15.

The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells.

Autsavapromporn N, de Toledo SM, Little JB, Jay-Gerin JP, Harris AL, Azzam EI.

Radiat Res. 2011 Mar;175(3):347-57. doi: 10.1667/RR2372.1. Epub 2011 Jan 10.

16.

Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.

Nagasawa H, Little JB, Lin YF, So S, Kurimasa A, Peng Y, Brogan JR, Chen DJ, Bedford JS, Chen BP.

Radiat Res. 2011 Jan;175(1):83-9. doi: 10.1667/RR2092.1. Epub 2010 Nov 17.

17.

Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Dicello JF, Slater JM, Little JB.

Radiat Oncol. 2010 Aug 12;5:71. doi: 10.1186/1748-717X-5-71.

18.

Clean energy from filthy water.

Little JB.

Sci Am. 2010 Jul;303(1):64-9. No abstract available.

PMID:
20583669
19.

Some unsolved problems and unresolved issues in radiation cytogenetics: a review and new data on roles of homologous recombination and non-homologous end joining.

Nagasawa H, Brogan JR, Peng Y, Little JB, Bedford JS.

Mutat Res. 2010 Aug 14;701(1):12-22. doi: 10.1016/j.mrgentox.2010.03.003. Epub 2010 Mar 16. Review.

PMID:
20298803
20.

G2-phase chromosomal radiosensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls.

Wilson PF, Nagasawa H, Fitzek MM, Little JB, Bedford JS.

Radiat Res. 2010 Jan;173(1):62-70. doi: 10.1667/RR1943.1.

21.

Variations in radiosensitivity among individuals: a potential impact on risk assessment?

Kato TA, Wilson PF, Nagasaw H, Peng Y, Weil MM, Little JB, Bedford JS.

Health Phys. 2009 Nov;97(5):470-80. doi: 10.1097/HP.0b013e3181b08eee. Review.

PMID:
19820456
22.

Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant.

Tsai KK, Stuart J, Chuang YY, Little JB, Yuan ZM.

Radiat Res. 2009 Sep;172(3):306-13. doi: 10.1667/RR1764.1.

23.

Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Little JB.

Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):909-17. doi: 10.1016/j.ijrobp.2008.06.1928. Review.

PMID:
19014780
24.
25.

A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Russell J, Slater JS, Little JB.

Int J Radiat Biol. 2008 Apr;84(4):253-64. doi: 10.1080/09553000801953342. Review.

PMID:
18386191
26.

Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution.

Williams JR, Zhang Y, Zhou H, Russell J, Gridley DS, Koch CJ, Little JB.

Int J Radiat Biol. 2008 Feb;84(2):151-64. doi: 10.1080/09553000701797021.

PMID:
18246483
27.

Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination.

Nagasawa H, Wilson PF, Chen DJ, Thompson LH, Bedford JS, Little JB.

DNA Repair (Amst). 2008 Mar 1;7(3):515-22. doi: 10.1016/j.dnarep.2007.11.014. Epub 2008 Jan 7.

PMID:
18182331
28.

DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation.

Guo Z, Tsai MH, Shiao YH, Chen LH, Wei ML, Lv X, Gius D, Little JB, Mitchell JB, Chuang EY.

J Biomed Sci. 2008 Mar;15(2):163-8. Epub 2007 Nov 24.

PMID:
18038118
29.

[Nontargeted effects of ionizing radiation: implications for low-dose exposures].

Little JB.

Radiats Biol Radioecol. 2007 May-Jun;47(3):262-72. Russian.

PMID:
17867493
30.

Regulation of normal cell cycle progression by flavin-containing oxidases.

Venkatachalam P, de Toledo SM, Pandey BN, Tephly LA, Carter AB, Little JB, Spitz DR, Azzam EI.

Oncogene. 2008 Jan 3;27(1):20-31. Epub 2007 Jul 16.

PMID:
17637756
31.

Human tumor cells segregate into radiosensitivity groups that associate with ATM and TP53 status.

Williams JR, Zhang Y, Russell J, Koch C, Little JB.

Acta Oncol. 2007;46(5):628-38.

PMID:
17562439
32.

Serendipity and chance in one's life and scientific career.

Little JB.

Cancer Biol Ther. 2007 Feb;6(2):295-300. Epub 2007 Feb 19. No abstract available.

PMID:
17361095
33.

A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans.

Kato TA, Wilson PF, Nagasawa H, Fitzek MM, Weil MM, Little JB, Bedford JS.

DNA Repair (Amst). 2007 Jun 1;6(6):818-29. Epub 2007 Mar 6.

PMID:
17339135
34.

Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure.

Urashima T, Nagasawa H, Wang K, Adelstein SJ, Little JB, Kassis AI.

Nucl Med Biol. 2006 Nov;33(8):1055-63.

35.
37.

gamma-H2AX foci after low-dose-rate irradiation reveal atm haploinsufficiency in mice.

Kato TA, Nagasawa H, Weil MM, Genik PC, Little JB, Bedford JS.

Radiat Res. 2006 Jul;166(1 Pt 1):47-54.

PMID:
16808619
38.

Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma.

Chuang EY, Chen X, Tsai MH, Yan H, Li CY, Mitchell JB, Nagasawa H, Wilson PF, Peng Y, Fitzek MM, Bedford JS, Little JB.

Cancer Res. 2006 Apr 1;66(7):3428-33.

39.

Cellular radiation effects and the bystander response.

Little JB.

Mutat Res. 2006 May 11;597(1-2):113-8. Epub 2006 Jan 18. Review.

PMID:
16413041
40.

Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations.

Travis LB, Rabkin CS, Brown LM, Allan JM, Alter BP, Ambrosone CB, Begg CB, Caporaso N, Chanock S, DeMichele A, Figg WD, Gospodarowicz MK, Hall EJ, Hisada M, Inskip P, Kleinerman R, Little JB, Malkin D, Ng AK, Offit K, Pui CH, Robison LL, Rothman N, Shields PG, Strong L, Taniguchi T, Tucker MA, Greene MH.

J Natl Cancer Inst. 2006 Jan 4;98(1):15-25. Review.

PMID:
16391368
41.

Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment.

Tsai KK, Chuang EY, Little JB, Yuan ZM.

Cancer Res. 2005 Aug 1;65(15):6734-44.

42.

Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations.

Nagasawa H, Peng Y, Wilson PF, Lio YC, Chen DJ, Bedford JS, Little JB.

Radiat Res. 2005 Aug;164(2):141-7.

PMID:
16038585
43.

A scientific, moral and diplomatic misstep.

Adelstein SJ, Fry RJ, Little JB, Sinclair WK.

Radiat Res. 2004 Jun;161(6):621. No abstract available.

PMID:
15161359
44.

The radiation-induced bystander effect: evidence and significance.

Azzam EI, Little JB.

Hum Exp Toxicol. 2004 Feb;23(2):61-5. Review.

PMID:
15070061
45.
46.

Stress signaling from irradiated to non-irradiated cells.

Azzam EI, de Toledo SM, Little JB.

Curr Cancer Drug Targets. 2004 Feb;4(1):53-64. Review.

PMID:
14965267
47.

Low dose ionizing radiation-induced activation of connexin 43 expression.

Glover D, Little JB, Lavin MF, Gueven N.

Int J Radiat Biol. 2003 Dec;79(12):955-64.

PMID:
14713573
48.

Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation.

Mamon HJ, Dahlberg W, Azzam EI, Nagasawa H, Muto MG, Little JB.

Int J Radiat Biol. 2003 Oct;79(10):817-29.

PMID:
14630541
49.

Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses.

Azzam EI, de Toledo SM, Little JB.

Cancer Res. 2003 Nov 1;63(21):7128-35.

50.

Cancer risks attributable to low doses of ionizing radiation: assessing what we really know.

Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, Lubin JH, Preston DL, Preston RJ, Puskin JS, Ron E, Sachs RK, Samet JM, Setlow RB, Zaider M.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13761-6. Epub 2003 Nov 10.

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