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Items: 14


Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.

Shen J, Frye M, Lee BL, Reinardy JL, McClung JM, Ding K, Kojima M, Xia H, Seidel C, Lima e Silva R, Dong A, Hackett SF, Wang J, Howard BW, Vestweber D, Kontos CD, Peters KG, Campochiaro PA.

J Clin Invest. 2014 Oct;124(10):4564-76. doi: 10.1172/JCI74527. Epub 2014 Sep 2.


Sustained delivery of a HIF-1 antagonist for ocular neovascularization.

Iwase T, Fu J, Yoshida T, Muramatsu D, Miki A, Hashida N, Lu L, Oveson B, Lima e Silva R, Seidel C, Yang M, Connelly S, Shen J, Han B, Wu M, Semenza GL, Hanes J, Campochiaro PA.

J Control Release. 2013 Dec 28;172(3):625-33. doi: 10.1016/j.jconrel.2013.10.008. Epub 2013 Oct 12.


Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide.

Shmueli RB, Ohnaka M, Miki A, Pandey NB, Lima e Silva R, Koskimaki JE, Kim J, Popel AS, Campochiaro PA, Green JJ.

Biomaterials. 2013 Oct;34(30):7544-51. doi: 10.1016/j.biomaterials.2013.06.044. Epub 2013 Jul 10.


Topical pazopanib blocks VEGF-induced vascular leakage and neovascularization in the mouse retina but is ineffective in the rabbit.

Iwase T, Oveson BC, Hashida N, Lima e Silva R, Shen J, Krauss AH, Gale DC, Adamson P, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2013 Jan 21;54(1):503-11. doi: 10.1167/iovs.12-10473.


Agents that bind annexin A2 suppress ocular neovascularization.

Lima e Silva R, Shen J, Gong YY, Seidel CP, Hackett SF, Kesavan K, Jacoby DB, Campochiaro PA.

J Cell Physiol. 2010 Nov;225(3):855-64. doi: 10.1002/jcp.22296.


Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.

Kiuchi K, Matsuoka M, Wu JC, Lima e Silva R, Kengatharan M, Verghese M, Ueno S, Yokoi K, Khu NH, Cooke JP, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1705-11. doi: 10.1167/iovs.07-0089.


The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization.

Lima e Silva R, Shen J, Hackett SF, Kachi S, Akiyama H, Kiuchi K, Yokoi K, Hatara MC, Lauer T, Aslam S, Gong YY, Xiao WH, Khu NH, Thut C, Campochiaro PA.

FASEB J. 2007 Oct;21(12):3219-30. Epub 2007 May 23.


Trans-scleral delivery of polyamine analogs for ocular neovascularization.

Lima e Silva R, Kachi S, Akiyama H, Shen J, Hatara MC, Aslam S, Gong YY, Khu NH, Lauer TW, Hackett SF, Marton LJ, Campochiaro PA.

Exp Eye Res. 2006 Nov;83(5):1260-7. Epub 2006 Sep 6.


Recombinant non-collagenous domain of alpha2(IV) collagen causes involution of choroidal neovascularization by inducing apoptosis.

Lima E Silva R, Kachi S, Akiyama H, Shen J, Aslam S, Yuan Gong Y, Khu NH, Hatara MC, Boutaud A, Peterson R, Campochiaro PA.

J Cell Physiol. 2006 Jul;208(1):161-6.


Suppression and regression of choroidal neovascularization by polyamine analogues.

Lima e Silva R, Saishin Y, Saishin Y, Akiyama H, Kachi S, Aslam S, Rogers B, Deering T, Gong YY, Hackett SF, Lai H, Frydman BJ, Valasinas A, Marton LJ, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3323-30.


VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier.

Saishin Y, Saishin Y, Takahashi K, Lima e Silva R, Hylton D, Rudge JS, Wiegand SJ, Campochiaro PA.

J Cell Physiol. 2003 May;195(2):241-8.


Effect in vitro of cyclic nucleotides-elevating agents on nitric oxide production by human granulocytes from type 2-diabetic patients.

Nogueira-Machado JA, Lima E Silva FC, Lima E Silva R, Medina LO, Costa DC, Chaves MM.

Diabetes Metab. 2002 Feb;28(1):45-50.


Increase of reactive oxygen (ROS) and nitrogen (RNS) species generated by phagocyting granulocytes related to age.

Martins Chaves M, Rocha-Vieira E, Pereira dos Reis A, de Lima e Silva R, Gerzstein NC, Nogueira-Machado JA.

Mech Ageing Dev. 2000 Oct 20;119(1-2):1-8.


Host defenses in the aged: evaluation of the balance between oxidizing species generation and reducing power in phagocyting human granulocytes.

Chaves MM, Rocha-Vieira E, de Lima e Silva R, Pereira dos Reis A, Nogueira-Machado JA.

Mech Ageing Dev. 1998 Aug 1;104(1):103-9.


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