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Chondroprotective Effects and Mechanisms of Dextromethorphan: Repurposing Antitussive Medication for Osteoarthritis Treatment.

Chen LW, Liu FC, Hung LF, Huang CY, Lien SB, Lin LC, Lai JH, Ho LJ.

Int J Mol Sci. 2018 Mar 12;19(3). pii: E825. doi: 10.3390/ijms19030825.


Functional outcomes and quality of life after a 6-month early intervention program for oral cancer survivors: a single-arm clinical trial.

Chen YH, Liang WA, Hsu CY, Guo SL, Lien SH, Tseng HJ, Chao YH.

PeerJ. 2018 Feb 21;6:e4419. doi: 10.7717/peerj.4419. eCollection 2018.


Life-stage-associated remodelling of lipid metabolism regulation in Atlantic salmon.

Gillard G, Harvey TN, Gjuvsland A, Jin Y, Thomassen M, Lien S, Leaver M, Torgersen JS, Hvidsten TR, Vik JO, Sandve SR.

Mol Ecol. 2018 Feb 12. doi: 10.1111/mec.14533. [Epub ahead of print]


Unravelling genetic variation underlying de novo-synthesis of bovine milk fatty acids.

Knutsen TM, Olsen HG, Tafintseva V, Svendsen M, Kohler A, Kent MP, Lien S.

Sci Rep. 2018 Feb 1;8(1):2179. doi: 10.1038/s41598-018-20476-0.


Ancient chromosomal rearrangement associated with local adaptation of a postglacially colonized population of Atlantic Cod in the northwest Atlantic.

Sinclair-Waters M, Bradbury IR, Morris CJ, Lien S, Kent MP, Bentzen P.

Mol Ecol. 2017 Nov 28. doi: 10.1111/mec.14442. [Epub ahead of print]


Mapping of quantitative trait loci associated with size, shape, and parr mark traits using first- and second-generation backcrosses between European and North American Atlantic salmon (Salmo salar).

Pedersen S, Liu L, Glebe B, Leadbeater S, Lien S, Boulding EG.

Genome. 2018 Jan;61(1):33-42. doi: 10.1139/gen-2017-0026. Epub 2017 Oct 16.


Exploiting whole genome sequence data to fine map and characterize candidate genes within a quantitative trait loci region affecting androstenone on porcine chromosome 5.

van Son M, Agarwal R, Kent MP, Grove H, Grindflek E, Lien S.

Anim Genet. 2017 Dec;48(6):653-659. doi: 10.1111/age.12615. Epub 2017 Oct 16.


Fine mapping of a QTL affecting levels of skatole on pig chromosome 7.

van Son M, Kent MP, Grove H, Agarwal R, Hamland H, Lien S, Grindflek E.

BMC Genet. 2017 Oct 11;18(1):85. doi: 10.1186/s12863-017-0549-8.


Simultaneous Stiles-Bunnell Tendon Transfer Enhances Intrinsic Function of Second-Toe Transplantations.

Lin YT, Loh CYY, Lien SH, Lin CH, Wei FC.

Plast Reconstr Surg. 2017 Dec;140(6):1229-1234. doi: 10.1097/PRS.0000000000003861.


Low Cost Local Contact Opening by Using Polystyrene Spheres Spin-Coating Method for PERC Solar Cells.

Hsu CH, Yang CH, Wang YH, Huang CW, Lien SY, Kung CY, Lou JC.

Materials (Basel). 2016 Jul 8;9(7). pii: E549. doi: 10.3390/ma9070549.


Thin-Film Coated Plastic Wrap for Food Packaging.

Wu HY, Liu TX, Hsu CH, Cho YS, Xu ZJ, Liao SC, Zeng BH, Jiang YL, Lien SY.

Materials (Basel). 2017 Jul 18;10(7). pii: E821. doi: 10.3390/ma10070821.


Genetic differences between wild and hatchery-bred brown trout (Salmo trutta L.) in single nucleotide polymorphisms linked to selective traits.

Linløkken AN, Haugen TO, Kent MP, Lien S.

Ecol Evol. 2017 May 30;7(13):4963-4972. doi: 10.1002/ece3.3070. eCollection 2017 Jul.


Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture.

Macqueen DJ, Primmer CR, Houston RD, Nowak BF, Bernatchez L, Bergseth S, Davidson WS, Gallardo-Escárate C, Goldammer T, Guiguen Y, Iturra P, Kijas JW, Koop BF, Lien S, Maass A, Martin SAM, McGinnity P, Montecino M, Naish KA, Nichols KM, Ólafsson K, Omholt SW, Palti Y, Plastow GS, Rexroad CE Rd, Rise ML, Ritchie RJ, Sandve SR, Schulte PM, Tello A, Vidal R, Vik JO, Wargelius A, Yáñez JM; FAASG Consortium.

BMC Genomics. 2017 Jun 27;18(1):484. doi: 10.1186/s12864-017-3862-8.


SalmoBase: an integrated molecular data resource for Salmonid species.

Samy JKA, Mulugeta TD, Nome T, Sandve SR, Grammes F, Kent MP, Lien S, Våge DI.

BMC Genomics. 2017 Jun 26;18(1):482. doi: 10.1186/s12864-017-3877-1.


The genomic mosaicism of hybrid speciation.

Elgvin TO, Trier CN, Tørresen OK, Hagen IJ, Lien S, Nederbragt AJ, Ravinet M, Jensen H, Sætre GP.

Sci Adv. 2017 Jun 14;3(6):e1602996. doi: 10.1126/sciadv.1602996. eCollection 2017 Jun.


Lineage-specific rediploidization is a mechanism to explain time-lags between genome duplication and evolutionary diversification.

Robertson FM, Gundappa MK, Grammes F, Hvidsten TR, Redmond AK, Lien S, Martin SAM, Holland PWH, Sandve SR, Macqueen DJ.

Genome Biol. 2017 Jun 14;18(1):111. doi: 10.1186/s13059-017-1241-z.


Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.

Lai JH, Luo SF, Hung LF, Huang CY, Lien SB, Lin LC, Liu FC, Yen BL, Ho LJ.

Sci Rep. 2017 May 24;7(1):2359. doi: 10.1038/s41598-017-02640-0.


Genome-wide association study confirm major QTL for backfat fatty acid composition on SSC14 in Duroc pigs.

van Son M, Enger EG, Grove H, Ros-Freixedes R, Kent MP, Lien S, Grindflek E.

BMC Genomics. 2017 May 11;18(1):369. doi: 10.1186/s12864-017-3752-0.


Sex difference determined the role of sex hormone-binding globulin in obese children during short-term weight reduction program.

Wang FM, Lin CM, Lien SH, Wu LW, Huang CF, Chu DM.

Medicine (Baltimore). 2017 May;96(19):e6834. doi: 10.1097/MD.0000000000006834.


Surface Passivation of Silicon Using HfO2 Thin Films Deposited by Remote Plasma Atomic Layer Deposition System.

Zhang XY, Hsu CH, Lien SY, Chen SY, Huang W, Yang CH, Kung CY, Zhu WZ, Xiong FB, Meng XG.

Nanoscale Res Lett. 2017 Dec;12(1):324. doi: 10.1186/s11671-017-2098-5. Epub 2017 May 4.


Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer.

Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, Lawn S, Gleave ME, Gregory-Evans CY, McIntosh LP, Cox ME, Rennie PS, Cherkasov A.

Oncotarget. 2017 Jun 27;8(26):42438-42454. doi: 10.18632/oncotarget.17124.


A genome scan for selection signatures comparing farmed Atlantic salmon with two wild populations: Testing colocalization among outlier markers, candidate genes, and quantitative trait loci for production traits.

Liu L, Ang KP, Elliott JA, Kent MP, Lien S, MacDonald D, Boulding EG.

Evol Appl. 2016 Dec 29;10(3):276-296. doi: 10.1111/eva.12450. eCollection 2017 Mar.


Genome-wide association mapping for milk fat composition and fine mapping of a QTL for de novo synthesis of milk fatty acids on bovine chromosome 13.

Olsen HG, Knutsen TM, Kohler A, Svendsen M, Gidskehaug L, Grove H, Nome T, Sodeland M, Sundsaasen KK, Kent MP, Martens H, Lien S.

Genet Sel Evol. 2017 Feb 13;49(1):20. doi: 10.1186/s12711-017-0294-5.


An improved genome assembly uncovers prolific tandem repeats in Atlantic cod.

Tørresen OK, Star B, Jentoft S, Reinar WB, Grove H, Miller JR, Walenz BP, Knight J, Ekholm JM, Peluso P, Edvardsen RB, Tooming-Klunderud A, Skage M, Lien S, Jakobsen KS, Nederbragt AJ.

BMC Genomics. 2017 Jan 18;18(1):95. doi: 10.1186/s12864-016-3448-x.


Customizing Extensor Reconstruction in Vascularized Toe Joint Transfers to Finger Proximal Interphalangeal Joints: A Strategic Approach for Correcting Extensor Lag.

Loh CY, Hsu CC, Lin CH, Chen SH, Lien SH, Lin CH, Wei FC, Lin YT.

Plast Reconstr Surg. 2017 Apr;139(4):915-922. doi: 10.1097/PRS.0000000000003153.


Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations.

Lien SA, Young L, Gau BS, K Shiao SP.

Oncotarget. 2017 Jan 17;8(3):4387-4398. doi: 10.18632/oncotarget.13876.


Controlling for P-value inflation in allele frequency change in experimental evolution and artificial selection experiments.

Kemppainen P, Rønning B, Kvalnes T, Hagen IJ, Ringsby TH, Billing AM, Pärn H, Lien S, Husby A, Saether BE, Jensen H.

Mol Ecol Resour. 2017 Jul;17(4):770-782. doi: 10.1111/1755-0998.12631. Epub 2016 Nov 25.


Fine mapping of a QTL on bovine chromosome 6 using imputed full sequence data suggests a key role for the group-specific component (GC) gene in clinical mastitis and milk production.

Olsen HG, Knutsen TM, Lewandowska-Sabat AM, Grove H, Nome T, Svendsen M, Arnyasi M, Sodeland M, Sundsaasen KK, Dahl SR, Heringstad B, Hansen HH, Olsaker I, Kent MP, Lien S.

Genet Sel Evol. 2016 Oct 19;48(1):79.


Endoscopy-assisted subfascial anterior transposition of the ulnar nerve for the treatment of cubital tunnel syndrome.

Wong JK, Hsu CC, Lin CH, Lien SH, Lin YT.

J Plast Reconstr Aesthet Surg. 2016 Dec;69(12):1704-1710. doi: 10.1016/j.bjps.2016.09.004. Epub 2016 Sep 16.


Single nucleotide polymorphisms to discriminate different classes of hybrid between wild Atlantic salmon and aquaculture escapees.

Pritchard VL, Erkinaro J, Kent MP, Niemelä E, Orell P, Lien S, Primmer CR.

Evol Appl. 2016 Aug 18;9(8):1017-31. doi: 10.1111/eva.12407. eCollection 2016 Sep.


SNP Arrays for Species Identification in Salmonids.

Wenne R, Drywa A, Kent M, Sundsaasen KK, Lien S.

Methods Mol Biol. 2016;1452:97-111. doi: 10.1007/978-1-4939-3774-5_6.


Combined Innovative Portal Arthroscopy and Fluoroscopy-Assisted Reduction and Fixation in Subtle Injury of the Lisfranc Joint Complex: Analysis of 10 Cases.

Lien SB, Shen HC, Lin LC.

J Foot Ankle Surg. 2017 Jan - Feb;56(1):142-147. doi: 10.1053/j.jfas.2016.05.003. Epub 2016 Jun 21.


The Atlantic salmon genome provides insights into rediploidization.

Lien S, Koop BF, Sandve SR, Miller JR, Kent MP, Nome T, Hvidsten TR, Leong JS, Minkley DR, Zimin A, Grammes F, Grove H, Gjuvsland A, Walenz B, Hermansen RA, von Schalburg K, Rondeau EB, Di Genova A, Samy JK, Olav Vik J, Vigeland MD, Caler L, Grimholt U, Jentoft S, Våge DI, de Jong P, Moen T, Baranski M, Palti Y, Smith DR, Yorke JA, Nederbragt AJ, Tooming-Klunderud A, Jakobsen KS, Jiang X, Fan D, Hu Y, Liberles DA, Vidal R, Iturra P, Jones SJ, Jonassen I, Maass A, Omholt SW, Davidson WS.

Nature. 2016 May 12;533(7602):200-5. doi: 10.1038/nature17164. Epub 2016 Apr 18.


"Islands of Divergence" in the Atlantic Cod Genome Represent Polymorphic Chromosomal Rearrangements.

Sodeland M, Jorde PE, Lien S, Jentoft S, Berg PR, Grove H, Kent MP, Arnyasi M, Olsen EM, Knutsen H.

Genome Biol Evol. 2016 Apr 11;8(4):1012-22. doi: 10.1093/gbe/evw057.


A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes.

Lee CC, Lo Y, Ho LJ, Lai JH, Lien SB, Lin LC, Chen CL, Chen TC, Liu FC, Huang HS.

PLoS One. 2016 Mar 10;11(3):e0149317. doi: 10.1371/journal.pone.0149317. eCollection 2016. Erratum in: PLoS One. 2016;11(4):e0154067.


Two adjacent inversions maintain genomic differentiation between migratory and stationary ecotypes of Atlantic cod.

Kirubakaran TG, Grove H, Kent MP, Sandve SR, Baranski M, Nome T, De Rosa MC, Righino B, Johansen T, Otterå H, Sonesson A, Lien S, Andersen Ø.

Mol Ecol. 2016 May;25(10):2130-43. doi: 10.1111/mec.13592. Epub 2016 Apr 20.


Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon.

Barson NJ, Aykanat T, Hindar K, Baranski M, Bolstad GH, Fiske P, Jacq C, Jensen AJ, Johnston SE, Karlsson S, Kent M, Moen T, Niemelä E, Nome T, Næsje TF, Orell P, Romakkaniemi A, Sægrov H, Urdal K, Erkinaro J, Lien S, Primmer CR.

Nature. 2015 Dec 17;528(7582):405-8. doi: 10.1038/nature16062. Epub 2015 Nov 4.


Entry into vocational rehabilitation program following work-related hand injury: Potential candidates.

Chen YH, Hsu CY, Lien SH, Yu SJ, Chang JM, Su SW, Chao YH.

Int J Occup Med Environ Health. 2016;29(1):101-11. doi: 10.13075/ijomeh.1896.00419.


A ddRAD Based Linkage Map of the Cultivated Strawberry, Fragaria xananassa.

Davik J, Sargent DJ, Brurberg MB, Lien S, Kent M, Alsheikh M.

PLoS One. 2015 Sep 23;10(9):e0137746. doi: 10.1371/journal.pone.0137746. eCollection 2015.


Biochemical and Immunological Characterization of Truncated Fragments of the Receptor-Binding Domains of C. difficile Toxin A.

Huang JH, Shen ZQ, Lien SP, Hsiao KN, Leng CH, Chen CC, Siu LK, Chong PC.

PLoS One. 2015 Aug 13;10(8):e0135045. doi: 10.1371/journal.pone.0135045. eCollection 2015.


Recombinant lipoprotein-based vaccine candidates against C. difficile infections.

Huang JH, Wu CW, Lien SP, Leng CH, Hsiao KN, Liu SJ, Chen HW, Siu LK, Chong P.

J Biomed Sci. 2015 Aug 7;22:65. doi: 10.1186/s12929-015-0171-x.


Identification of quantitative genetic components of fitness variation in farmed, hybrid and native salmon in the wild.

Besnier F, Glover KA, Lien S, Kent M, Hansen MM, Shen X, Skaala Ø.

Heredity (Edinb). 2015 Jul;115(1):47-55. doi: 10.1038/hdy.2015.15. Epub 2015 Mar 18.


Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon.

Moen T, Torgersen J, Santi N, Davidson WS, Baranski M, Ødegård J, Kjøglum S, Velle B, Kent M, Lubieniecki KP, Isdal E, Lien S.

Genetics. 2015 Aug;200(4):1313-26. doi: 10.1534/genetics.115.175406. Epub 2015 Jun 2.


Adaptation to Low Salinity Promotes Genomic Divergence in Atlantic Cod (Gadus morhua L.).

Berg PR, Jentoft S, Star B, Ring KH, Knutsen H, Lien S, Jakobsen KS, André C.

Genome Biol Evol. 2015 May 20;7(6):1644-63. doi: 10.1093/gbe/evv093.


Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar).

Gonen S, Baranski M, Thorland I, Norris A, Grove H, Arnesen P, Bakke H, Lien S, Bishop SC, Houston RD.

Heredity (Edinb). 2015 Nov;115(5):405-14. doi: 10.1038/hdy.2015.37. Epub 2015 May 20.


Restitution and genetic differentiation of salmon populations in the southern Baltic genotyped with the Atlantic salmon 7K SNP array.

Poćwierz-Kotus A, Bernaś R, Kent MP, Lien S, Leliűna E, Dębowski P, Wenne R.

Genet Sel Evol. 2015 May 6;47:39. doi: 10.1186/s12711-015-0121-9.


Investigation on the passivated Si/Al2O3 interface fabricated by non-vacuum spatial atomic layer deposition system.

Lien SY, Yang CH, Wu KC, Kung CY.

Nanoscale Res Lett. 2015 Feb 28;10:93. doi: 10.1186/s11671-015-0803-9. eCollection 2015.


Unilateral Cleft Lip Repair Using the Anatomical Subunit Approximation: Modifications and Analysis of Early Results in 100 Consecutive Cases.

Tse R, Lien S.

Plast Reconstr Surg. 2015 Jul;136(1):119-30. doi: 10.1097/PRS.0000000000001369.


Contraction of abdominal wall muscles influences size and occurrence of incisional hernia.

Lien SC, Hu Y, Wollstein A, Franz MG, Patel SP, Kuzon WM Jr, Urbanchek MG.

Surgery. 2015 Jul;158(1):278-88. doi: 10.1016/j.surg.2015.01.023. Epub 2015 Mar 25.

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