Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 91


Non-cell-autonomous function of DR6 in Schwann cell proliferation.

Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld T, Lichtenthaler SF.

EMBO J. 2018 Feb 19. pii: e97390. doi: 10.15252/embj.201797390. [Epub ahead of print]


The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.

Brummer T, Pigoni M, Rossello A, Wang H, Noy PJ, Tomlinson MG, Blobel CP, Lichtenthaler SF.

FASEB J. 2018 Feb 7:fj201700823RR. doi: 10.1096/fj.201700823RR. [Epub ahead of print]


An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C.

EMBO Mol Med. 2017 Oct;9(10):1356-1365. doi: 10.15252/emmm.201707672.


PERK activation mitigates tau pathology in vitro and in vivo.

Bruch J, Xu H, Rösler TW, De Andrade A, Kuhn PH, Lichtenthaler SF, Arzberger T, Winklhofer KF, Müller U, Höglinger GU.

EMBO Mol Med. 2017 Mar;9(3):371-384. doi: 10.15252/emmm.201606664.


Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J.

Biol Psychiatry. 2018 Mar 1;83(5):428-437. doi: 10.1016/j.biopsych.2016.12.023. Epub 2016 Dec 26.


MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro.

Baranger K, Bonnet AE, Girard SD, Paumier JM, García-González L, Elmanaa W, Bernard A, Charrat E, Stephan D, Bauer C, Moschke K, Lichtenthaler SF, Roman FS, Checler F, Khrestchatisky M, Rivera S.

Front Mol Neurosci. 2017 Jan 10;9:163. doi: 10.3389/fnmol.2016.00163. eCollection 2016.


Seizure-6 proteins highlight BACE1 functions in neurobiology.

Pigoni M, Gunnersen JM, Lichtenthaler SF.

Oncotarget. 2017 Jan 31;8(5):7214-7215. doi: 10.18632/oncotarget.13801. No abstract available.


An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.

Serdaroglu A, Müller SA, Schepers U, Bräse S, Weichert W, Lichtenthaler SF, Kuhn PH.

Proteomics. 2017 Mar;17(5). doi: 10.1002/pmic.201600423. Epub 2017 Jan 31.


Proteomic Substrate Identification for Membrane Proteases in the Brain.

Müller SA, Scilabra SD, Lichtenthaler SF.

Front Mol Neurosci. 2016 Oct 13;9:96. eCollection 2016. Review.


Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF.

Mol Neurodegener. 2016 Oct 5;11(1):67.


Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

Scilabra SD, Yamamoto K, Pigoni M, Sakamoto K, Müller SA, Papadopoulou A, Lichtenthaler SF, Troeberg L, Nagase H, Kadomatsu K.

Matrix Biol. 2017 May;59:69-79. doi: 10.1016/j.matbio.2016.07.004. Epub 2016 Jul 29.


Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies.

Höfling C, Morawski M, Zeitschel U, Zanier ER, Moschke K, Serdaroglu A, Canneva F, von Hörsten S, De Simoni MG, Forloni G, Jäger C, Kremmer E, Roßner S, Lichtenthaler SF, Kuhn PH.

Aging Cell. 2016 Oct;15(5):953-63. doi: 10.1111/acel.12508. Epub 2016 Jul 29.


Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.

Munro KM, Nash A, Pigoni M, Lichtenthaler SF, Gunnersen JM.

J Mol Neurosci. 2016 Nov;60(3):305-315. Epub 2016 Jul 25. Review.


Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer's Disease Mouse Models.

Biella G, Fusco F, Nardo E, Bernocchi O, Colombo A, Lichtenthaler SF, Forloni G, Albani D.

J Alzheimers Dis. 2016 Jun 30;53(3):1193-207. doi: 10.3233/JAD-151135.


Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.

Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H.

EMBO Mol Med. 2016 May 2;8(5):458-65. doi: 10.15252/emmm.201505952. Print 2016 May.


Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site.

Schönherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU.

Mol Neurodegener. 2016 Feb 19;11:19. doi: 10.1186/s13024-016-0084-5.


BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Barão S, Moechars D, Lichtenthaler SF, De Strooper B.

Trends Neurosci. 2016 Mar;39(3):158-169. doi: 10.1016/j.tins.2016.01.003. Epub 2016 Jan 30. Review.


Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.

Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF.

Elife. 2016 Jan 23;5. pii: e12748. doi: 10.7554/eLife.12748.


Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.

Schulz AM, Stutte S, Hogl S, Luckashenak N, Dudziak D, Leroy C, Forné I, Imhof A, Müller SA, Brakebusch CH, Lichtenthaler SF, Brocker T.

J Cell Biol. 2015 Nov 9;211(3):553-67. doi: 10.1083/jcb.201503128.


The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.

Saftig P, Lichtenthaler SF.

Prog Neurobiol. 2015 Dec;135:1-20. doi: 10.1016/j.pneurobio.2015.10.003. Epub 2015 Oct 29. Review.


Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.

Li S, Dislich B, Brakebusch CH, Lichtenthaler SF, Brocker T.

J Immunol. 2015 Nov 1;195(9):4244-56. doi: 10.4049/jimmunol.1500676. Epub 2015 Sep 25.


iRhoms in the brain - a new frontier?

Lichtenthaler SF, O'Hara BF, Blobel CP.

Cell Cycle. 2015;14(19):3003-4. doi: 10.1080/15384101.2015.1084187. No abstract available.


MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.

Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S.

Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23.


Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.

Dislich B, Wohlrab F, Bachhuber T, Müller SA, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF.

Mol Cell Proteomics. 2015 Oct;14(10):2550-63. doi: 10.1074/mcp.M114.041533. Epub 2015 Jul 2.


γ-Secretase directly sheds the survival receptor BCMA from plasma cells.

Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333.


Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.

Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R.

Mol Cell Proteomics. 2015 Jun;14(6):1584-98. doi: 10.1074/mcp.M115.048298. Epub 2015 Mar 31.


The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.

Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

J Immunol. 2015 Jan 15;194(2):542-52. doi: 10.4049/jimmunol.1402070. Epub 2014 Dec 10.


Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.

Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R.

EMBO J. 2014 Dec 17;33(24):2890-905. doi: 10.15252/embj.201488375. Epub 2014 Oct 29.


Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.

Cox CJ, Choudhry F, Peacey E, Perkinton MS, Richardson JC, Howlett DR, Lichtenthaler SF, Francis PT, Williams RJ.

Neurobiol Aging. 2015 Jan;36(1):178-87. doi: 10.1016/j.neurobiolaging.2014.07.032. Epub 2014 Jul 30.


Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF.

J Neurochem. 2014 Jul;130(1):4-28. doi: 10.1111/jnc.12715. Epub 2014 Apr 19. Review.


The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.

Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D.

EMBO J. 2014 Mar 3;33(5):450-67. doi: 10.1002/embj.201385857. Epub 2013 Dec 19.


Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.

Hachmeister M, Bobowski KD, Hogl S, Dislich B, Fukumori A, Eggert C, Mack B, Kremling H, Sarrach S, Coscia F, Zimmermann W, Steiner H, Lichtenthaler SF, Gires O.

PLoS One. 2013 Aug 29;8(8):e71836. doi: 10.1371/journal.pone.0071836. eCollection 2013.


Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model.

Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E.

Neurobiol Aging. 2014 Jan;35(1):213-22. doi: 10.1016/j.neurobiolaging.2013.07.014. Epub 2013 Aug 15.


A new sandwich immunoassay for detection of the α-secretase cleaved, soluble amyloid-β protein precursor in cerebrospinal fluid and serum.

Taverna M, Straub T, Hampel H, Rujescu D, Lichtenthaler SF.

J Alzheimers Dis. 2013;37(4):667-78. doi: 10.3233/JAD-130509.


QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis.

Ivankov DN, Bogatyreva NS, Hönigschmid P, Dislich B, Hogl S, Kuhn PH, Frishman D, Lichtenthaler SF.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W459-64. doi: 10.1093/nar/gkt436. Epub 2013 May 31.


Between new genetic discoveries and large randomized trials--neurological research in the era of systems medicine.

Misgeld T, Lichtenthaler SF, Dichgans M.

EMBO Rep. 2013 Jun;14(6):489-92. doi: 10.1038/embor.2013.70. Epub 2013 May 14.


Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C.

J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013.


Cell-to-cell propagation of infectious cytosolic protein aggregates.

Hofmann JP, Denner P, Nussbaum-Krammer C, Kuhn PH, Suhre MH, Scheibel T, Lichtenthaler SF, Schätzl HM, Bano D, Vorberg IM.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5951-6. doi: 10.1073/pnas.1217321110. Epub 2013 Mar 18.


Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.

Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B.

Neurobiol Aging. 2013 Jul;34(7):1779-89. doi: 10.1016/j.neurobiolaging.2013.01.020. Epub 2013 Mar 6.


Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4986-91. doi: 10.1073/pnas.1218311110. Epub 2013 Mar 1.


Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.

Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF.

Proteomics. 2013 May;13(9):1519-27. doi: 10.1002/pmic.201200582. Epub 2013 Apr 2.


The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.

Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF.

Mol Cell. 2013 Mar 7;49(5):908-21. doi: 10.1016/j.molcel.2013.01.036. Epub 2013 Feb 28.


iRHOM2 takes control of rheumatoid arthritis.

Lichtenthaler SF.

J Clin Invest. 2013 Feb;123(2):560-2. doi: 10.1172/JCI67548. Epub 2013 Jan 25.


5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

Cochet M, Donneger R, Cassier E, Gaven F, Lichtenthaler SF, Marin P, Bockaert J, Dumuis A, Claeysen S.

ACS Chem Neurosci. 2013 Jan 16;4(1):130-40. doi: 10.1021/cn300095t. Epub 2012 Oct 13.


Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments.

Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C.

J Neurosci. 2012 Dec 12;32(50):18204-14. doi: 10.1523/JNEUROSCI.2681-12.2012.


Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

Kretner B, Fukumori A, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H.

J Neurochem. 2013 Apr;125(1):144-56. doi: 10.1111/jnc.12124. Epub 2013 Jan 15.


Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R.

J Biol Chem. 2012 Dec 21;287(52):43401-9. doi: 10.1074/jbc.M112.371369. Epub 2012 Nov 6.


Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF.

Neurobiol Dis. 2013 Jan;49:137-47. doi: 10.1016/j.nbd.2012.08.011. Epub 2012 Aug 24.


Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF.

EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.


Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.

Augustin R, Endres K, Reinhardt S, Kuhn PH, Lichtenthaler SF, Hansen J, Wurst W, Trümbach D.

BMC Med Genet. 2012 May 17;13:35.

Supplemental Content

Loading ...
Support Center