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Items: 1 to 50 of 643

1.

Cortical superficial siderosis: A prospective observational cohort study.

Moulin S, Casolla B, Kuchcinski G, Boulouis G, Rossi C, Hénon H, Leys D, Cordonnier C.

Neurology. 2018 Jun 8. pii: 10.1212/WNL.0000000000005778. doi: 10.1212/WNL.0000000000005778. [Epub ahead of print]

PMID:
29884737
2.

Intravenous Recombinant Tissue-Type Plasminogen Activator: Influence on Outcome in Anterior Circulation Ischemic Stroke Treated by Mechanical Thrombectomy.

Ferrigno M, Bricout N, Leys D, Estrade L, Cordonnier C, Personnic T, Kyheng M, Henon H.

Stroke. 2018 Jun;49(6):1377-1385. doi: 10.1161/STROKEAHA.118.020490. Epub 2018 May 10.

PMID:
29748424
3.

NADPH-Driven Organohalide Reduction by a Nonrespiratory Reductive Dehalogenase.

Collins FA, Fisher K, Payne KAP, Gaytan Mondragon S, Rigby SEJ, Leys D.

Biochemistry. 2018 Jun 13. doi: 10.1021/acs.biochem.8b00255. [Epub ahead of print]

PMID:
29630828
4.

Influence of on-going treatment with angiotensin-converting enzyme inhibitor or angiotensin receptor blocker on the outcome of patients treated with intravenous rt-PA for ischemic stroke.

Gilliot S, Sibon I, Mas JL, Moulin T, Béjot Y, Cordonnier C, Giroud M, Odou P, Bordet R, Vivien D, Leys D; OPHELIE Investigators.

J Neurol. 2018 May;265(5):1166-1173. doi: 10.1007/s00415-018-8827-6. Epub 2018 Mar 16.

PMID:
29549467
5.

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Björkegren JLM, Codoni V, Civelek M, Smith NL, Trégouët DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M, Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, Hoed MD, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Amin N, Aparicio HS, Arnett DK, Attia J, Beiser AS, Berr C, Buring JE, Bustamante M, Caso V, Cheng YC, Choi SH, Chowhan A, Cullell N, Dartigues JF, Delavaran H, Delgado P, Dörr M, Engström G, Ford I, Gurpreet WS, Hamsten A, Heitsch L, Hozawa A, Ibanez L, Ilinca A, Ingelsson M, Iwasaki M, Jackson RD, Jood K, Jousilahti P, Kaffashian S, Kalra L, Kamouchi M, Kitazono T, Kjartansson O, Kloss M, Koudstaal PJ, Krupinski J, Labovitz DL, Laurie CC, Levi CR, Li L, Lind L, Lindgren CM, Lioutas V, Liu YM, Lopez OL, Makoto H, Martinez-Majander N, Matsuda K, Minegishi N, Montaner J, Morris AP, Muiño E, Müller-Nurasyid M, Norrving B, Ogishima S, Parati EA, Peddareddygari LR, Pedersen NL, Pera J, Perola M, Pezzini A, Pileggi S, Rabionet R, Riba-Llena I, Ribasés M, Romero JR, Roquer J, Rudd AG, Sarin AP, Sarju R, Sarnowski C, Sasaki M, Satizabal CL, Satoh M, Sattar N, Sawada N, Sibolt G, Sigurdsson Á, Smith A, Sobue K, Soriano-Tárraga C, Stanne T, Stine OC, Stott DJ, Strauch K, Takai T, Tanaka H, Tanno K, Teumer A, Tomppo L, Torres-Aguila NP, Touze E, Tsugane S, Uitterlinden AG, Valdimarsson EM, van der Lee SJ, Völzke H, Wakai K, Weir D, Williams SR, Wolfe CDA, Wong Q, Xu H, Yamaji T, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M; AFGen Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; INVENT Consortium; STARNET; BioBank Japan Cooperative Hospital Group; COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International Stroke Genetics Consortium (ISGC); METASTROKE Consortium; Neurology Working Group of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar DNA Study; MEGASTROKE Consortium; MEGASTROKE Consortium:.

Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. Epub 2018 Mar 12.

6.

University education and cervical artery dissection.

Kellert L, Grau A, Pezzini A, Debette S, Leys D, Caso V, Thijs VN, Bersano A, Touzé E, Tatlisumak T, Traenka C, Lyrer PA, Engelter ST, Metso TM, Grond-Ginsbach C, Kloss M; Cervical Artery Dissection and Ischemic Stroke Patients (CADISP)-Study Group.

J Neurol. 2018 May;265(5):1065-1070. doi: 10.1007/s00415-018-8798-7. Epub 2018 Feb 24.

PMID:
29478223
7.

Controlled Education of patients after Stroke (CEOPS)- nurse-led multimodal and long-term interventional program involving a patient's caregiver to optimize secondary prevention of stroke: study protocol for a randomized controlled trial.

Mendyk AM, Duhamel A, Bejot Y, Leys D, Derex L, Dereeper O, Detante O, Garcia PY, Godefroy O, Montoro FM, Neau JP, Richard S, Rosolacci T, Sibon I, Sablot D, Timsit S, Zuber M, Cordonnier C, Bordet R; on the behalf of Strokavenir network.

Trials. 2018 Feb 22;19(1):137. doi: 10.1186/s13063-018-2483-0.

8.

Intravenous thrombolysis and platelet count.

Gensicke H, Al Sultan AS, Strbian D, Hametner C, Zinkstok SM, Moulin S, Bill O, Zini A, Padjen V, Kägi G, Pezzini A, Seiffge DJ, Traenka C, Räty S, Amiri H, Zonneveld TP, Lachenmeier R, Polymeris A, Roos YB, Gumbinger C, Jovanovic DR, Curtze S, Sibolt G, Vandelli L, Ringleb PA, Leys D, Cordonnier C, Michel P, Lyrer PA, Peters N, Tatlisumak T, Nederkoorn PJ, Engelter ST; Thrombolysis in Stroke Patients (TRISP) Collaborators.

Neurology. 2018 Feb 20;90(8):e690-e697. doi: 10.1212/WNL.0000000000004982. Epub 2018 Jan 24.

PMID:
29367438
9.

Heterologous Production and Purification of a Functional Chloroform Reductive Dehalogenase.

Jugder BE, Payne KAP, Fisher K, Bohl S, Lebhar H, Manefield M, Lee M, Leys D, Marquis CP.

ACS Chem Biol. 2018 Mar 16;13(3):548-552. doi: 10.1021/acschembio.7b00846. Epub 2018 Jan 25.

PMID:
29363941
10.

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis.

Bailey SS, Payne KAP, Fisher K, Marshall SA, Cliff MJ, Spiess R, Parker DA, Rigby SEJ, Leys D.

J Biol Chem. 2018 Feb 16;293(7):2272-2287. doi: 10.1074/jbc.RA117.000881. Epub 2017 Dec 19.

11.

Non-office-hours admission affects intravenous thrombolysis treatment times and clinical outcome.

Zonneveld TP, Curtze S, Zinkstok SM, Gensicke H, Moulin S, Scheitz JF, Seiffge DJ, Hametner C, Heldner MR, Traenka C, Erdur H, Baharoglu I, Martinez-Majander N, Pezzini A, Zini A, Padjen V, Correia PN, Strbian D, Michel P, Béjot Y, Arnold M, Leys D, Ringleb PA, Tatlisumak T, Nolte CH, Engelter ST, Nederkoorn PJ; TRISP collaborators.

J Neurol Neurosurg Psychiatry. 2017 Oct 25. pii: jnnp-2017-316791. doi: 10.1136/jnnp-2017-316791. [Epub ahead of print] No abstract available.

PMID:
29070647
12.

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes.

Weise NJ, Ahmed ST, Parmeggiani F, Galman JL, Dunstan MS, Charnock SJ, Leys D, Turner NJ.

Sci Rep. 2017 Oct 20;7(1):13691. doi: 10.1038/s41598-017-13990-0.

13.

Hippocampal Deformations and Entorhinal Cortex Atrophy as an Anatomical Signature of Long-Term Cognitive Impairment: from the MCAO Rat Model to the Stroke Patient.

Delattre C, Bournonville C, Auger F, Lopes R, Delmaire C, Henon H, Mendyk AM, Bombois S, Devedjian JC, Leys D, Cordonnier C, Bordet R, Bastide M.

Transl Stroke Res. 2018 Jun;9(3):294-305. doi: 10.1007/s12975-017-0576-9. Epub 2017 Oct 16.

PMID:
29034421
14.

Topographic distribution of brain iron deposition and small cerebrovascular lesions in amyotrophic lateral sclerosis and in frontotemporal lobar degeneration: a post-mortem 7.0-tesla magnetic resonance imaging study with neuropathological correlates.

De Reuck J, Devos D, Moreau C, Auger F, Durieux N, Deramecourt V, Pasquier F, Maurage CA, Cordonnier C, Leys D, Bordet R.

Acta Neurol Belg. 2017 Dec;117(4):873-878. doi: 10.1007/s13760-017-0832-5. Epub 2017 Oct 7.

PMID:
28988390
15.

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.

Karuppiah V, Ranaghan KE, Leferink NGH, Johannissen LO, Shanmugam M, Ní Cheallaigh A, Bennett NJ, Kearsey LJ, Takano E, Gardiner JM, van der Kamp MW, Hay S, Mulholland AJ, Leys D, Scrutton NS.

ACS Catal. 2017 Sep 1;7(9):6268-6282. doi: 10.1021/acscatal.7b01924. Epub 2017 Aug 9.

16.

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides.

Wood AJL, Weise NJ, Frampton JD, Dunstan MS, Hollas MA, Derrington SR, Lloyd RC, Quaglia D, Parmeggiani F, Leys D, Turner NJ, Flitsch SL.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14498-14501. doi: 10.1002/anie.201707918. Epub 2017 Oct 11.

PMID:
28940631
17.

Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase.

Payer SE, Marshall SA, Bärland N, Sheng X, Reiter T, Dordic A, Steinkellner G, Wuensch C, Kaltwasser S, Fisher K, Rigby SEJ, Macheroux P, Vonck J, Gruber K, Faber K, Himo F, Leys D, Pavkov-Keller T, Glueck SM.

Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13893-13897. doi: 10.1002/anie.201708091. Epub 2017 Oct 2.

18.

Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets: S2TOP-BLEED.

Hilkens NA, Algra A, Diener HC, Reitsma JB, Bath PM, Csiba L, Hacke W, Kappelle LJ, Koudstaal PJ, Leys D, Mas JL, Sacco RL, Amarenco P, Sissani L, Greving JP; Cerebrovascular Antiplatelet Trialists' Collaborative Group.

Neurology. 2017 Aug 29;89(9):936-943. doi: 10.1212/WNL.0000000000004289. Epub 2017 Aug 2.

19.

The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN).

Marshall SA, Payne KAP, Leys D.

Arch Biochem Biophys. 2017 Oct 15;632:209-221. doi: 10.1016/j.abb.2017.07.014. Epub 2017 Jul 25. Review.

PMID:
28754323
20.

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.

Gahloth D, Dunstan MS, Quaglia D, Klumbys E, Lockhart-Cairns MP, Hill AM, Derrington SR, Scrutton NS, Turner NJ, Leys D.

Nat Chem Biol. 2017 Sep;13(9):975-981. doi: 10.1038/nchembio.2434. Epub 2017 Jul 17.

21.

In-hospital ischaemic stroke treated with intravenous thrombolysis or mechanical thrombectomy.

Caparros F, Ferrigno M, Decourcelle A, Hochart A, Moulin S, Dequatre N, Bodenant M, Hénon H, Cordonnier C, Leys D.

J Neurol. 2017 Aug;264(8):1804-1810. doi: 10.1007/s00415-017-8570-4. Epub 2017 Jul 15.

PMID:
28712001
22.

Structural insights into the ene-reductase synthesis of profens.

Waller J, Toogood HS, Karuppiah V, Rattray NJW, Mansell DJ, Leys D, Gardiner JM, Fryszkowska A, Ahmed ST, Bandichhor R, Reddy GP, Scrutton NS.

Org Biomol Chem. 2017 May 23;15(20):4440-4448. doi: 10.1039/c7ob00163k.

PMID:
28485453
23.

Cerebrovascular Lesions in Mixed Neurodegenerative Dementia: A Neuropathological and Magnetic Resonance Study.

De Reuck JL, Deramecourt V, Auger F, Durieux N, Maurage CA, Pasquier F, Cordonnier C, Leys D, Bordet R.

Eur Neurol. 2017;78(1-2):1-5. doi: 10.1159/000476032. Epub 2017 May 6.

PMID:
28478439
24.

Are the results of intravenous thrombolysis trials reproduced in clinical practice? Comparison of observed and expected outcomes with the stroke-thrombolytic predictive instrument (STPI).

Decourcelle A, Moulin S, Dequatre-Ponchelle N, Bodenant M, Rossi C, Girot M, Hénon H, Wiel E, Bordet R, Goldstein P, Pruvo JP, Cordonnier C, Leys D.

Rev Neurol (Paris). 2017 Jun;173(6):381-387. doi: 10.1016/j.neurol.2017.03.023. Epub 2017 Apr 25.

PMID:
28454980
25.

Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates.

De Reuck J, Auger F, Durieux N, Deramecourt V, Maurage CA, Cordonnier C, Pasquier F, Leys D, Bordet R.

Folia Neuropathol. 2017;55(1):31-37. doi: 10.5114/fn.2017.66711.

26.

Genetic Imbalance in Patients with Cervical Artery Dissection.

Grond-Ginsbach C, Chen B, Krawczak M, Pjontek R, Ginsbach P, Jiang Y, Abboud S, Arnold ML, Bersano A, Brandt T, Caso V, Debette S, Dichgans M, Geschwendtner A, Giacalone G, Martin JJ, Metso AJ, Metso TM, Grau AJ, Kloss M, Lichy C, Pezzini A, Traenka C, Schreiber S, Thijs V, Touzé E, Del Zotto E, Tatlisumak T, Leys D, Lyrer PA, Engelter ST; CADISP group.

Curr Genomics. 2017 Apr;18(2):206-213. doi: 10.2174/1389202917666160805152627.

27.

Cervical artery dissection in patients ≥60 years: Often painless, few mechanical triggers.

Traenka C, Dougoud D, Simonetti BG, Metso TM, Debette S, Pezzini A, Kloss M, Grond-Ginsbach C, Majersik JJ, Worrall BB, Leys D, Baumgartner R, Caso V, Béjot Y, Compter A, Reiner P, Thijs V, Southerland AM, Bersano A, Brandt T, Gensicke H, Touzé E, Martin JJ, Chabriat H, Tatlisumak T, Lyrer P, Arnold M, Engelter ST; CADISP-Plus Study Group.

Neurology. 2017 Apr 4;88(14):1313-1320. doi: 10.1212/WNL.0000000000003788. Epub 2017 Mar 3.

PMID:
28258079
28.

Stroke occurring in patients with cognitive impairment or dementia.

Moulin S, Leys D.

Arq Neuropsiquiatr. 2017 Feb;75(2):117-121. doi: 10.1590/0004-282X20160187. Review.

29.

A common mechanism for coenzyme cobalamin-dependent reductive dehalogenases.

Johannissen LO, Leys D, Hay S.

Phys Chem Chem Phys. 2017 Feb 22;19(8):6090-6094. doi: 10.1039/c6cp08659d.

PMID:
28191552
30.

[The management of acute cerebral ischaemia is now just a matter of organization. For spontaneous intracerebral hemorrhage, all has still to be done…].

Leys D.

Presse Med. 2017 Jan;46(1):1-3. doi: 10.1016/j.lpm.2017.01.006. French. No abstract available.

PMID:
28164842
31.

Vascular Cognitive Impairment.

Dichgans M, Leys D.

Circ Res. 2017 Feb 3;120(3):573-591. doi: 10.1161/CIRCRESAHA.116.308426. Review.

32.

Production of alkenes and novel secondary products by P450 OleTJE using novel H2 O2 -generating fusion protein systems.

Matthews S, Tee KL, Rattray NJ, McLean KJ, Leys D, Parker DA, Blankley RT, Munro AW.

FEBS Lett. 2017 Mar;591(5):737-750. doi: 10.1002/1873-3468.12581. Epub 2017 Feb 21.

33.

Sex Differences and Functional Outcome After Intravenous Thrombolysis.

Spaander FH, Zinkstok SM, Baharoglu IM, Gensicke H, Polymeris A, Traenka C, Hametner C, Ringleb P, Curtze S, Martinez-Majander N, Aarnio K, Nolte CH, Scheitz JF, Leys D, Hochart A, Padjen V, Kägi G, Pezzini A, Michel P, Bill O, Zini A, Engelter ST, Nederkoorn PJ; Thrombolysis in Ischemic Stroke Patients Collaborators (TrISP).

Stroke. 2017 Mar;48(3):699-703. doi: 10.1161/STROKEAHA.116.014739. Epub 2017 Jan 31. Erratum in: Stroke. 2017 Mar;48(3):e97.

34.

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.

Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk AM, Gelé P, Deplanque D, Bae HJ, Lim JS, Brodtmann A, Werden E, Cumming T, Köhler S, Verhey FR, Dong YH, Tan HH, Chen C, Xin X, Kalaria RN, Allan LM, Akinyemi RO, Ogunniyi A, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee BC, Yu KH, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VC, Wong A, Lam BY, Leys D, Hénon H, Bombois S, Lipnicki DM, Kochan NA; STROKOG.

Alzheimers Dement (Amst). 2016 Nov 18;7:11-23. doi: 10.1016/j.dadm.2016.10.006. eCollection 2017.

35.

Post-stroke dementia - a comprehensive review.

Mijajlović MD, Pavlović A, Brainin M, Heiss WD, Quinn TJ, Ihle-Hansen HB, Hermann DM, Assayag EB, Richard E, Thiel A, Kliper E, Shin YI, Kim YH, Choi S, Jung S, Lee YB, Sinanović O, Levine DA, Schlesinger I, Mead G, Milošević V, Leys D, Hagberg G, Ursin MH, Teuschl Y, Prokopenko S, Mozheyko E, Bezdenezhnykh A, Matz K, Aleksić V, Muresanu D, Korczyn AD, Bornstein NM.

BMC Med. 2017 Jan 18;15(1):11. doi: 10.1186/s12916-017-0779-7. Review.

36.

Oxidative Maturation and Structural Characterization of Prenylated FMN Binding by UbiD, a Decarboxylase Involved in Bacterial Ubiquinone Biosynthesis.

Marshall SA, Fisher K, Ní Cheallaigh A, White MD, Payne KA, Parker DA, Rigby SE, Leys D.

J Biol Chem. 2017 Mar 17;292(11):4623-4637. doi: 10.1074/jbc.M116.762732. Epub 2017 Jan 5.

37.

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE.

Matthews S, Belcher JD, Tee KL, Girvan HM, McLean KJ, Rigby SE, Levy CW, Leys D, Parker DA, Blankley RT, Munro AW.

J Biol Chem. 2017 Mar 24;292(12):5128-5143. doi: 10.1074/jbc.M116.762336. Epub 2017 Jan 4.

38.

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW.

J Biol Chem. 2017 Jan 27;292(4):1310-1329. doi: 10.1074/jbc.M116.748822. Epub 2016 Dec 8.

39.

An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.

Ortmayer M, Lafite P, Menon BR, Tralau T, Fisher K, Denkhaus L, Scrutton NS, Rigby SE, Munro AW, Hay S, Leys D.

Nature. 2016 Nov 24;539(7630):593-597. doi: 10.1038/nature20159. Epub 2016 Nov 16.

PMID:
27851736
40.

Management of acute cerebral ischaemia.

Moulin S, Leys D.

Presse Med. 2016 Dec;45(12 Pt 2):e451-e455. doi: 10.1016/j.lpm.2016.10.008. Epub 2016 Nov 2.

PMID:
27816339
41.

Proportion of single-chain recombinant tissue plasminogen activator and outcome after stroke.

Leys D, Hommet Y, Jacquet C, Moulin S, Sibon I, Mas JL, Moulin T, Giroud M, Sagnier S, Cordonnier C, Medeiros de Bustos E, Turc G, Ronzière T, Bejot Y, Detante O, Ouk T, Mendyk AM, Favrole P, Zuber M, Triquenot-Bagan A, Ozkul-Wermester O, Montoro FM, Lamy C, Faivre A, Lebouvier L, Potey C, Poli M, Hénon H, Renou P, Dequatre-Ponchelle N, Bodenant M, Debruxelles S, Rossi C, Bordet R, Vivien D; OPHELIE investigators and the STROKAVENIR network.

Neurology. 2016 Dec 6;87(23):2416-2426. Epub 2016 Nov 4.

PMID:
27815401
42.

Cognitive status after intracerebral haemorrhage - Authors' reply.

Moulin S, Leys D, Bombois S, Cordonnier C.

Lancet Neurol. 2016 Nov;15(12):1206-1207. doi: 10.1016/S1474-4422(16)30239-3. Epub 2016 Oct 11. No abstract available.

PMID:
27751546
43.

Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes.

Menon BR, Latham J, Dunstan MS, Brandenburger E, Klemstein U, Leys D, Karthikeyan C, Greaney MF, Shepherd SA, Micklefield J.

Org Biomol Chem. 2016 Oct 4;14(39):9354-9361.

PMID:
27714222
44.

Lobar intracerebral haematomas: Neuropathological and 7.0-tesla magnetic resonance imaging evaluation.

De Reuck J, Cordonnier C, Deramecourt V, Auger F, Durieux N, Leys D, Pasquier F, Maurage CA, Bordet R.

J Neurol Sci. 2016 Oct 15;369:121-125. doi: 10.1016/j.jns.2016.08.012. Epub 2016 Aug 5.

PMID:
27653876
45.

Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases.

Lygidakis A, Karuppiah V, Hoeven R, Ní Cheallaigh A, Leys D, Gardiner JM, Toogood HS, Scrutton NS.

Angew Chem Weinheim Bergstr Ger. 2016 Aug 8;128(33):9748-9752. Epub 2016 Jul 13.

46.

The role of ADP-ribosylation in regulating DNA interstrand crosslink repair.

Gunn AR, Banos-Pinero B, Paschke P, Sanchez-Pulido L, Ariza A, Day J, Emrich M, Leys D, Ponting CP, Ahel I, Lakin ND.

J Cell Sci. 2016 Oct 15;129(20):3845-3858. Epub 2016 Sep 1.

47.

Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.

Girvan HM, Bradley JM, Cheesman MR, Kincaid JR, Liu Y, Czarnecki K, Fisher K, Leys D, Rigby SE, Munro AW.

Biochemistry. 2016 Sep 13;55(36):5073-83. doi: 10.1021/acs.biochem.6b00204. Epub 2016 Sep 1.

PMID:
27546061
48.

The topography of cortical microbleeds in frontotemporal lobar degeneration: a post-mortem 7.0-tesla magnetic resonance study.

De Reuck J, Auger F, Durieux N, Deramecourt V, Maurage CA, Lebert F, Leys D, Cordonnier C, Pasquier F, Bordet R.

Folia Neuropathol. 2016;54(2):149-55.

49.

Author Response.

Leys D, Maestrini I, Moulin S, Tatlisumak T.

Neurology. 2016 Mar 15;86(11):1077. No abstract available.

PMID:
27427561
50.

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding.

Beveridge R, Migas LG, Payne KA, Scrutton NS, Leys D, Barran PE.

Nat Commun. 2016 Jul 15;7:12163. doi: 10.1038/ncomms12163.

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