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Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis.

Sun Q, Lesperance J, Wettersten H, Luterstein E, DeRose YS, Welm A, Cheresh DA, Desgrosellier JS.

J Clin Invest. 2018 Jan 2;128(1):531-544. doi: 10.1172/JCI93707. Epub 2017 Dec 11.


Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers.

Seguin L, Camargo MF, Wettersten HI, Kato S, Desgrosellier JS, von Schalscha T, Elliott KC, Cosset E, Lesperance J, Weis SM, Cheresh DA.

Cancer Discov. 2017 Dec;7(12):1464-1479. doi: 10.1158/2159-8290.CD-17-0539. Epub 2017 Sep 11.


Results of a randomized clinical trial of external beam radiation to prevent restenosis after superficial femoral artery stenting.

Therasse E, Donath D, Elkouri S, Lespérance J, Giroux MF, Oliva VL, Guertin MC, Bouchard L, Perreault P, Gilbert P, Soulez G.

J Vasc Surg. 2016 Jun;63(6):1531-40. doi: 10.1016/j.jvs.2016.02.023. Epub 2016 Mar 23.


Effects of P-Selectin Antagonist Inclacumab in Patients Undergoing Coronary Artery Bypass Graft Surgery: SELECT-CABG Trial.

Stähli BE, Tardif JC, Carrier M, Gallo R, Emery RW, Robb S, Cournoyer D, Blondeau L, Johnson D, Mann J, Lespérance J, Guertin MC, L'Allier PL.

J Am Coll Cardiol. 2016 Jan 26;67(3):344-6. doi: 10.1016/j.jacc.2015.10.071. No abstract available.


Value of C-Arm Computed Tomography to Evaluate Stent Deployment During Femoro-Popliteal Revascularization.

Gahide G, Hadjadj S, Therasse E, Kauffmann C, Gilbert P, Oliva VL, Tardif JC, Lespérance J, Cloutier G, Soulez G.

Cardiovasc Intervent Radiol. 2015 Dec;38(6):1458-67. doi: 10.1007/s00270-015-1108-1. Epub 2015 May 12.


Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland.

Desgrosellier JS, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA.

Dev Cell. 2014 Aug 11;30(3):295-308. doi: 10.1016/j.devcel.2014.06.005.


Elevated alkaline phosphatase velocity strongly predicts overall survival and the risk of bone metastases in castrate-resistant prostate cancer.

Metwalli AR, Rosner IL, Cullen J, Chen Y, Brand T, Brassell SA, Lesperance J, Porter C, Sterbis J, McLeod DG.

Urol Oncol. 2014 Aug;32(6):761-8. doi: 10.1016/j.urolonc.2014.03.024. Epub 2014 Jun 11.


Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial.

Tardif JC, Ballantyne CM, Barter P, Dasseux JL, Fayad ZA, Guertin MC, Kastelein JJ, Keyserling C, Klepp H, Koenig W, L'Allier PL, Lespérance J, Lüscher TF, Paolini JF, Tawakol A, Waters DD; Can HDL Infusions Significantly QUicken Atherosclerosis REgression (CHI-SQUARE) Investigators.

Eur Heart J. 2014 Dec 7;35(46):3277-86. doi: 10.1093/eurheartj/ehu171. Epub 2014 Apr 29.


An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.

Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier JS, Anand S, Weis SM, Cheresh DA.

Nat Cell Biol. 2014 May;16(5):457-68. doi: 10.1038/ncb2953. Epub 2014 Apr 20.


Rectal cultures before transrectal ultrasound-guided prostate biopsy reduce post-prostatic biopsy infection rates.

Duplessis CA, Bavaro M, Simons MP, Marguet C, Santomauro M, Auge B, Collard DA, Fierer J, Lesperance J.

Urology. 2012 Mar;79(3):556-61. doi: 10.1016/j.urology.2011.09.057.


Oncogenic Ras/Src cooperativity in pancreatic neoplasia.

Shields DJ, Murphy EA, Desgrosellier JS, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA.

Oncogene. 2011 May 5;30(18):2123-34. doi: 10.1038/onc.2010.589. Epub 2011 Jan 17.


Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo.

Hebbard LW, Maurer J, Miller A, Lesperance J, Hassell J, Oshima RG, Terskikh AV.

Cancer Res. 2010 Nov 1;70(21):8863-73. doi: 10.1158/0008-5472.CAN-10-1295. Epub 2010 Sep 22.


RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.

Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2189-94. doi: 10.1073/pnas.0911646107. Epub 2009 Dec 28.


Evaluation of coronary atheroma by 64-slice multidetector computed tomography: Comparison with intravascular ultrasound and angiography.

Ugolini P, Pressacco J, Lespérance J, Berry C, L'Allier PL, Ibrahim R, Grégoire J, Ouellet R, Heinonen T, Levesque S, Guertin MC, Tardif JC.

Can J Cardiol. 2009 Nov;25(11):641-7.


A forme fruste of Shone's anomaly in a 65 year-old patient.

Moustafa SE, Lesperance J, Rouleau JL, Gosselin G.

Mcgill J Med. 2008 Jan;11(1):19-21.


Plexus network between internal mammary graft and pulmonary vasculature after coronary bypass grafting.

Moustafa SE, Lesperance J, Gosselin G.

Heart Lung Circ. 2009 Apr;18(2):147-9. doi: 10.1016/j.hlc.2007.10.016. Epub 2008 Feb 21.


Efficient propagation of single cells Accutase-dissociated human embryonic stem cells.

Bajpai R, Lesperance J, Kim M, Terskikh AV.

Mol Reprod Dev. 2008 May;75(5):818-27.


A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature.

Vervoort VS, Lu M, Valencia F, Lesperance J, Breier G, Oshima R, Pasquale EB.

Transgenic Res. 2008 Jun;17(3):403-15. Epub 2007 Nov 20.


Percutaneous coronary intervention on a single coronary artery: case report.

Moustafa SE, Lesperance J, Gosselin G.

Int J Cardiol. 2009 Jan 24;131(3):e118-9. Epub 2007 Oct 22.


Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progression.

Berry C, L'Allier PL, Grégoire J, Lespérance J, Levesque S, Ibrahim R, Tardif JC.

Circulation. 2007 Apr 10;115(14):1851-7. Epub 2007 Mar 26.


Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial.

Tardif JC, Grégoire J, L'Allier PL, Ibrahim R, Lespérance J, Heinonen TM, Kouz S, Berry C, Basser R, Lavoie MA, Guertin MC, Rodés-Cabau J; Effect of rHDL on Atherosclerosis-Safety and Efficacy (ERASE) Investigators.

JAMA. 2007 Apr 18;297(15):1675-82. Epub 2007 Mar 26.


Role of Gab2 in mammary tumorigenesis and metastasis.

Ke Y, Wu D, Princen F, Nguyen T, Pang Y, Lesperance J, Muller WJ, Oshima RG, Feng GS.

Oncogene. 2007 Jul 26;26(34):4951-60. Epub 2007 Feb 19.


Importance of collateral circulation in coronary heart disease.

Berry C, Balachandran KP, L'Allier PL, Lespérance J, Bonan R, Oldroyd KG.

Eur Heart J. 2007 Feb;28(3):278-91. Epub 2007 Jan 11. Review.


Accuracy and rate of coronary artery segment visualization with CT angiography for the non-invasive detection of coronary artery stenoses.

Bordeleau E, Lamonde A, Prenovault J, Belblidia A, Coté G, Lespérance J, Soulez G, Chartrand-Lefebvre C.

Int J Cardiovasc Imaging. 2007 Dec;23(6):771-80. Epub 2007 Jan 10.


Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial.

Tardif JC, Grégoire J, L'Allier PL, Ibrahim R, Anderson TJ, Reeves F, Title LM, Schampaert E, LeMay M, Lespérance J, Scott R, Guertin MC, Brennan ML, Hazen SL, Bertrand OF; CART-2 Investigators.

Atherosclerosis. 2008 Mar;197(1):480-6. Epub 2007 Jan 9.


Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes.

Frasure-Smith N, Lespérance F, Irwin MR, Sauvé C, Lespérance J, Théroux P.

Biol Psychiatry. 2007 Aug 15;62(4):302-8. Epub 2007 Jan 8.


Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.

Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS.

J Biol Chem. 2006 Nov 10;281(45):34374-80. Epub 2006 Sep 7.


Role of angiography for the assessment of coronary artery disease in patients with diabetes mellitus.

L'Allier PL, Lespérance J.

Can J Cardiol. 2006 Feb;22 Suppl A:34A-37A. Review.


Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer.

Liu M, Howes A, Lesperance J, Stallcup WB, Hauser CA, Kadoya K, Oshima RG, Abraham RT.

Cancer Res. 2005 Jun 15;65(12):5325-36.


External beam radiation to prevent restenosis after superficial femoral artery balloon angioplasty.

Therasse E, Donath D, Lespérance J, Tardif JC, Guertin MC, Oliva VL, Soulez G.

Circulation. 2005 Jun 21;111(24):3310-5. Epub 2005 Jun 13.


Sustained elevation of serum CD40 ligand levels one month after coronary angioplasty predicts angiographic restenosis.

L'Allier PL, Tardif JC, Grégoire J, Joyal M, Lespérance J, Fortier A, Guertin MC.

Can J Cardiol. 2005 May 1;21(6):495-500.


Effect of cholesterol lowering and cardiovascular risk factors on the progression of aortoiliac arteriosclerosis: a quantitative cineangiography study.

Campeau L, Lespérance J, Bilodeau L, Fortier A, Guertin MC, Knatterud GL.

Angiology. 2005 Mar-Apr;56(2):191-9.


Long-term safety of intravascular ultrasound in nontransplant, nonintervened, atherosclerotic coronary arteries.

Guédès A, Keller PF, L'Allier PL, Lespérance J, Grégoire J, Tardif JC.

J Am Coll Cardiol. 2005 Feb 15;45(4):559-64.


Angiographic and clinical outcomes of polytetrafluoroethylene-covered stent use in significant coronary perforations.

Ly H, Awaida JP, Lespérance J, Bilodeau L.

Am J Cardiol. 2005 Jan 15;95(2):244-6.


Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions.

Tardif JC, Grégoire J, L'Allier PL, Anderson TJ, Bertrand O, Reeves F, Title LM, Alfonso F, Schampaert E, Hassan A, McLain R, Pressler ML, Ibrahim R, Lespérance J, Blue J, Heinonen T, Rodés-Cabau J; Avasimibe and Progression of Lesions on UltraSound (A-PLUS) Investigators.

Circulation. 2004 Nov 23;110(21):3372-7. Epub 2004 Nov 8.


Native coronary disease progression exceeds failed revascularization as cause of angina after five years in the Bypass Angioplasty Revascularization Investigation (BARI).

Alderman EL, Kip KE, Whitlow PL, Bashore T, Fortin D, Bourassa MG, Lesperance J, Schwartz L, Stadius M; Bypass Angioplasty Revascularization Investigation.

J Am Coll Cardiol. 2004 Aug 18;44(4):766-74.


Early quantitative coronary angiography of saphenous vein grafts for coronary artery bypass grafting harvested by means of open versus endoscopic saphenectomy: a prospective randomized trial.

Perrault LP, Jeanmart H, Bilodeau L, Lespérance J, Tanguay JF, Bouchard D, Pagé P, Carrier M.

J Thorac Cardiovasc Surg. 2004 May;127(5):1402-7.


Angiogenic acceleration of Neu induced mammary tumor progression and metastasis.

Oshima RG, Lesperance J, Munoz V, Hebbard L, Ranscht B, Sharan N, Muller WJ, Hauser CA, Cardiff RD.

Cancer Res. 2004 Jan 1;64(1):169-79.


Effect of increasing metabolic syndrome score on atherosclerotic risk profile and coronary artery disease angiographic severity.

Solymoss BC, Bourassa MG, Campeau L, Sniderman A, Marcil M, Lespérance J, Lévesque S, Varga S.

Am J Cardiol. 2004 Jan 15;93(2):159-64.


Ets2-dependent stromal regulation of mouse mammary tumors.

Man AK, Young LJ, Tynan JA, Lesperance J, Egeblad M, Werb Z, Hauser CA, Muller WJ, Cardiff RD, Oshima RG.

Mol Cell Biol. 2003 Dec;23(23):8614-25.


Incidence, coronary risk profile and angiographic characteristics of prediabetic and diabetic patients in a population with ischemic heart disease.

Solymoss BC, Bourassa MG, Campeau L, Lespérance J, Marcil M, Varga S.

Can J Cardiol. 2003 Sep;19(10):1155-60.


Incidence and clinical characteristics of the metabolic syndrome in patients with coronary artery disease.

Solymoss BC, Bourassa MG, Lespérance J, Levesque S, Marcil M, Varga S, Campeau L.

Coron Artery Dis. 2003 May;14(3):207-12.


Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategies.

Bourassa MG, Butnaru A, Lespérance J, Tardif JC.

J Am Coll Cardiol. 2003 Feb 5;41(3):351-9. Review.


Effects of AGI-1067 and probucol after percutaneous coronary interventions.

Tardif JC, Grégoire J, Schwartz L, Title L, Laramée L, Reeves F, Lespérance J, Bourassa MG, L'Allier PL, Glass M, Lambert J, Guertin MC; Canadian Antioxidant Restenosis Trial (CART-1) Investigators.

Circulation. 2003 Feb 4;107(4):552-8.


In vivo measurement of coronary circulation angiotensin-converting enzyme activity in humans.

Staniloae C, Schwab AJ, Simard A, Gallo R, Dyrda I, Gosselin G, Lesperance J, Ryan JW, Dupuis J.

Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H17-22.


Design features of the Avasimibe and Progression of coronary Lesions assessed by intravascular UltraSound (A-PLUS) clinical trial.

Tardif JC, Grégoire J, Lespérance J, Lambert J, L'Allier PL, Rodés J, Anderson T, Blue JW, Imus J, Heinonen T.

Am Heart J. 2002 Oct;144(4):589-96.


Two-year angiographic follow-up of intracoronary Sr90 therapy for restenosis prevention after balloon angioplasty.

Meerkin D, Joyal M, Tardif JC, Lespérance J, Arsenault A, Lucier G, Bonan R.

Circulation. 2002 Jul 30;106(5):539-43.


One core laboratory at two international sites, is that feasible? An inter-core laboratory and intra-observer variability study.

Tuinenburg JC, Koning G, Hekking E, Desjardins C, Harel F, Bilodeau L, van Weert AW, Lespérance J, Reiber JH.

Catheter Cardiovasc Interv. 2002 Jul;56(3):333-40.


Effects of plaque composition on vascular remodelling after angioplasty in the MultiVitamins and Probucol (MVP) trial.

Lee HS, Tardif JC, Harel F, Côté G, Joyal M, Gosselin G, L'Allier PL, Doucet S, de Guise P, Lespérance J, Grégoire JC, Couturier A.

Can J Cardiol. 2002 Mar;18(3):271-5.


Stent placement to prevent restenosis after angioplasty in small coronary arteries.

Doucet S, Schalij MJ, Vrolix MC, Hilton D, Chenu P, de Bruyne B, Udayachalerm W, Seth A, Bilodeau L, Reiber JH, Harel F, Lespérance J; Stent In Small Arteries(SISA) Trial Investigators.

Circulation. 2001 Oct 23;104(17):2029-33.

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