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Items: 40

1.

Multidrug Resistance Protein 1 (MRP1/ABCC1)-mediated cellular protection and transport of methylated arsenic metabolites differs between human cell lines.

Banerjee M, Kaur G, Whitlock BD, Carew MW, Le XC, Leslie EM.

Drug Metab Dispos. 2018 May 11. pii: dmd.117.079640. doi: 10.1124/dmd.117.079640. [Epub ahead of print]

PMID:
29752257
2.

Experiences of police contact among young adult recreational drug users: A qualitative study.

Leslie EM, Cherney A, Smirnov A, Kemp R, Najman JM.

Int J Drug Policy. 2018 Mar 30;56:64-72. doi: 10.1016/j.drugpo.2018.03.010. [Epub ahead of print]

PMID:
29609152
3.

Metabolism of a Phenylarsenical in Human Hepatic Cells and Identification of a New Arsenic Metabolite.

Liu Q, Leslie EM, Moe B, Zhang H, Douglas DN, Kneteman NM, Le XC.

Environ Sci Technol. 2018 Feb 6;52(3):1386-1392. doi: 10.1021/acs.est.7b05081. Epub 2018 Jan 17.

4.

Multidrug Resistance Protein 4 (MRP4/ABCC4) Protects Cells from the Toxic Effects of Halobenzoquinones.

Li J, Bauer M, Moe B, Leslie EM, Li XF.

Chem Res Toxicol. 2017 Oct 16;30(10):1815-1822. doi: 10.1021/acs.chemrestox.7b00156. Epub 2017 Sep 22.

PMID:
28885828
5.

Simultaneous use of alcohol with methamphetamine but not ecstasy linked with aggression among young adult stimulant users.

Leslie EM, Smirnov A, Cherney A, Wells H, Legosz M, Kemp R, Najman JM.

Addict Behav. 2017 Jul;70:27-34. doi: 10.1016/j.addbeh.2017.01.036. Epub 2017 Feb 2.

PMID:
28182965
6.

Cellular arsenic transport pathways in mammals.

Roggenbeck BA, Banerjee M, Leslie EM.

J Environ Sci (China). 2016 Nov;49:38-58. doi: 10.1016/j.jes.2016.10.001. Epub 2016 Oct 29. Review.

PMID:
28007179
7.

Accumulation and Transport of Roxarsone, Arsenobetaine, and Inorganic Arsenic Using the Human Immortalized Caco-2 Cell Line.

Liu Q, Leslie EM, Le XC.

J Agric Food Chem. 2016 Nov 23;64(46):8902-8908. Epub 2016 Nov 8.

PMID:
27790904
8.

Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.

Banerjee M, Marensi V, Conseil G, Le XC, Cole SP, Leslie EM.

Biochem Pharmacol. 2016 Nov 15;120:72-82. doi: 10.1016/j.bcp.2016.09.016. Epub 2016 Sep 19.

PMID:
27659809
9.

Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23.

Shukalek CB, Swanlund DP, Rousseau RK, Weigl KE, Marensi V, Cole SP, Leslie EM.

Mol Pharmacol. 2016 Aug;90(2):127-39. doi: 10.1124/mol.116.103648. Epub 2016 Jun 13.

10.

Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors.

Kaur G, Leslie EM, Tillman H, Lee WM, Swanlund DP, Karvellas CJ; US Acute Liver Failure Study Group.

PLoS One. 2015 Sep 25;10(9):e0139299. doi: 10.1371/journal.pone.0139299. eCollection 2015.

11.

Characterization of arsenic hepatobiliary transport using sandwich-cultured human hepatocytes.

Roggenbeck BA, Carew MW, Charrois GJ, Douglas DN, Kneteman NM, Lu X, Le XC, Leslie EM.

Toxicol Sci. 2015 Jun;145(2):307-20. doi: 10.1093/toxsci/kfv051. Epub 2015 Mar 9.

PMID:
25752797
12.

A novel pathway for arsenic elimination: human multidrug resistance protein 4 (MRP4/ABCC4) mediates cellular export of dimethylarsinic acid (DMAV) and the diglutathione conjugate of monomethylarsonous acid (MMAIII).

Banerjee M, Carew MW, Roggenbeck BA, Whitlock BD, Naranmandura H, Le XC, Leslie EM.

Mol Pharmacol. 2014 Aug;86(2):168-79. doi: 10.1124/mol.113.091314. Epub 2014 May 28.

13.

Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*.

Possamai LA, McPhail MJ, Quaglia A, Zingarelli V, Abeles RD, Tidswell R, Puthucheary Z, Rawal J, Karvellas CJ, Leslie EM, Hughes RD, Ma Y, Jassem W, Shawcross DL, Bernal W, Dharwan A, Heaton ND, Thursz M, Wendon JA, Mitry RR, Antoniades CG.

Crit Care Med. 2013 Nov;41(11):2543-50. doi: 10.1097/CCM.0b013e31829791a2.

14.

Arsenic-glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs).

Leslie EM.

J Inorg Biochem. 2012 Mar;108:141-9. doi: 10.1016/j.jinorgbio.2011.11.009. Epub 2011 Nov 22. Review.

PMID:
22197475
15.

Monomethylarsenic diglutathione transport by the human multidrug resistance protein 1 (MRP1/ABCC1).

Carew MW, Naranmandura H, Shukalek CB, Le XC, Leslie EM.

Drug Metab Dispos. 2011 Dec;39(12):2298-304. doi: 10.1124/dmd.111.041673. Epub 2011 Sep 14.

16.

Comparative toxicity of arsenic metabolites in human bladder cancer EJ-1 cells.

Naranmandura H, Carew MW, Xu S, Lee J, Leslie EM, Weinfeld M, Le XC.

Chem Res Toxicol. 2011 Sep 19;24(9):1586-96. doi: 10.1021/tx200291p. Epub 2011 Aug 16.

PMID:
21815631
17.

Glutathione transferase P1 interacts strongly with the inner leaflet of the plasma membrane.

Qazi SS, Osoria Pérez A, Sam M, Leslie EM.

Drug Metab Dispos. 2011 Jul;39(7):1122-6. doi: 10.1124/dmd.111.039362. Epub 2011 Apr 1.

18.
19.

Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies.

Ghibellini G, Leslie EM, Pollack GM, Brouwer KL.

Pharm Res. 2008 Aug;25(8):1851-60. doi: 10.1007/s11095-008-9597-0. Epub 2008 May 30.

20.

Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity.

Lee JK, Leslie EM, Zamek-Gliszczynski MJ, Brouwer KL.

Toxicol Appl Pharmacol. 2008 Apr 1;228(1):17-23. doi: 10.1016/j.taap.2007.11.020. Epub 2007 Dec 3.

21.

Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity.

Marion TL, Leslie EM, Brouwer KL.

Mol Pharm. 2007 Nov-Dec;4(6):911-8. Epub 2007 Oct 27.

PMID:
17963355
22.
23.
24.

In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

Ghibellini G, Vasist LS, Leslie EM, Heizer WD, Kowalsky RJ, Calvo BF, Brouwer KL.

Clin Pharmacol Ther. 2007 Mar;81(3):406-13. Epub 2007 Jan 18.

PMID:
17235333
25.

Methods to evaluate biliary excretion of drugs in humans: an updated review.

Ghibellini G, Leslie EM, Brouwer KL.

Mol Pharm. 2006 May-Jun;3(3):198-211. Review.

26.

Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake.

Leslie EM, Liu J, Klaassen CD, Waalkes MP.

Mol Pharmacol. 2006 Feb;69(2):629-39. Epub 2005 Nov 10.

27.

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense.

Leslie EM, Deeley RG, Cole SP.

Toxicol Appl Pharmacol. 2005 May 1;204(3):216-37. Review.

PMID:
15845415
28.

Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required.

Leslie EM, Haimeur A, Waalkes MP.

J Biol Chem. 2004 Jul 30;279(31):32700-8. Epub 2004 May 25.

30.
31.

CFTR directly mediates nucleotide-regulated glutathione flux.

Kogan I, Ramjeesingh M, Li C, Kidd JF, Wang Y, Leslie EM, Cole SP, Bear CE.

EMBO J. 2003 May 1;22(9):1981-9.

32.

Structural requirements for functional interaction of glutathione tripeptide analogs with the human multidrug resistance protein 1 (MRP1).

Leslie EM, Bowers RJ, Deeley RG, Cole SP.

J Pharmacol Exp Ther. 2003 Feb;304(2):643-53. Erratum in: J Pharmacol Exp Ther. 2003 May;305(2):798.

33.
34.

A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance.

Conrad S, Kauffmann HM, Ito K, Leslie EM, Deeley RG, Schrenk D, Cole SP.

Pharmacogenetics. 2002 Jun;12(4):321-30.

PMID:
12042670
35.

Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

Leslie EM, Deeley RG, Cole SP.

Toxicology. 2001 Oct 5;167(1):3-23. Review.

PMID:
11557126
37.
38.

ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells.

Mao Q, Leslie EM, Deeley RG, Cole SP.

Biochim Biophys Acta. 1999 Nov 9;1461(1):69-82.

40.

Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

Hipfner DR, Almquist KC, Leslie EM, Gerlach JH, Grant CE, Deeley RG, Cole SP.

J Biol Chem. 1997 Sep 19;272(38):23623-30.

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