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Items: 1 to 50 of 70

1.

The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.

Billatos E, Vick JL, Lenburg ME, Spira AE.

Clin Cancer Res. 2018 Feb 20. pii: clincanres.3187.2017. doi: 10.1158/1078-0432.CCR-16-3187. [Epub ahead of print]

PMID:
29463557
2.

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M.

Respir Res. 2017 Dec 21;18(1):213. doi: 10.1186/s12931-017-0696-5.

3.

Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts.

Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA.

PLoS One. 2017 Sep 14;12(9):e0183815. doi: 10.1371/journal.pone.0183815. eCollection 2017.

4.

Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.

Pavel AB, Campbell JD, Liu G, Elashoff D, Dubinett S, Smith K, Whitney D, Lenburg ME, Spira A; AEGIS Study Team.

Cancer Prev Res (Phila). 2017 Nov;10(11):651-659. doi: 10.1158/1940-6207.CAPR-17-0098. Epub 2017 Sep 6.

PMID:
28877936
5.

The cellular and molecular determinants of emphysematous destruction in COPD.

Suzuki M, Sze MA, Campbell JD, Brothers JF 2nd, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC.

Sci Rep. 2017 Aug 25;7(1):9562. doi: 10.1038/s41598-017-10126-2.

6.

Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression.

Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Buncio AD, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE.

Clin Cancer Res. 2017 Sep 1;23(17):5091-5100. doi: 10.1158/1078-0432.CCR-16-2540. Epub 2017 May 22.

PMID:
28533227
7.

Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.

Hu Z, Mao JH, Curtis C, Huang G, Gu S, Heiser L, Lenburg ME, Korkola JE, Bayani N, Samarajiwa S, Seoane JA, Dane MA, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, Wood KW, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, Gray JW.

Breast Cancer Res. 2017 Feb 9;19(1):17. doi: 10.1186/s13058-017-0809-6. No abstract available.

8.

Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium.

Moses E, Wang T, Corbett S, Jackson GR, Drizik E, Perdomo C, Perdomo C, Kleerup E, Brooks D, O'Connor G, Dubinett S, Hayden P, Lenburg ME, Spira A.

Toxicol Sci. 2017 Jan;155(1):248-257. doi: 10.1093/toxsci/kfw198. Epub 2016 Oct 3.

9.

A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia.

Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild A, Lenburg ME, Ionescu DN, Mayo J, Yi JE, Tazelaar H, Harmsen WS, Smith J, Spira AE, Beane J, Limburg PJ, Szabo E; Cancer Prevention Network.

Cancer Prev Res (Phila). 2016 Dec;9(12):906-914. Epub 2016 Sep 22.

10.

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.

Hu Z, Mao JH, Curtis C, Huang G, Gu S, Heiser L, Lenburg ME, Korkola JE, Bayani N, Samarajiwa S, Seoane JA, Dane MA, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, W Wood K, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, Gray JW.

Breast Cancer Res. 2016 Jul 1;18(1):70. doi: 10.1186/s13058-016-0728-y. Erratum in: Breast Cancer Res. 2017 Feb 9;19(1):17.

11.

Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal.

Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, Rothman N, Spira A, Lan Q.

Carcinogenesis. 2015 Dec;36(12):1494-501. doi: 10.1093/carcin/bgv150. Epub 2015 Oct 14.

12.

A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.

Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A; AEGIS Study Team.

N Engl J Med. 2015 Jul 16;373(3):243-51. doi: 10.1056/NEJMoa1504601. Epub 2015 May 17.

13.

Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease.

Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, Hogg JC.

Am J Respir Crit Care Med. 2015 Aug 15;192(4):438-45. doi: 10.1164/rccm.201502-0223OC.

14.

Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy.

Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A.

BMC Med Genomics. 2015 May 6;8:18. doi: 10.1186/s12920-015-0091-3.

15.

Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.

Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):758-66. doi: 10.1164/rccm.201408-1458OC.

16.

Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data.

Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, Johnson WE, Monti S, Spira A, Beane J, Lenburg ME.

RNA. 2015 Feb;21(2):164-71. doi: 10.1261/rna.046060.114. Epub 2014 Dec 17.

17.

Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction.

Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME, Spira A, Paré PD, Nickle D, Sin DD, Postma DS.

Thorax. 2014 Nov;69(11):997-1004. doi: 10.1136/thoraxjnl-2014-205630. Epub 2014 Sep 2.

PMID:
25182044
18.

Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis.

Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN.

Cancer Prev Res (Phila). 2014 May;7(5):487-95. doi: 10.1158/1940-6207.CAPR-13-0372. Epub 2014 Mar 11.

19.

Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity.

Wolf DM, Lenburg ME, Yau C, Boudreau A, van 't Veer LJ.

PLoS One. 2014 Feb 7;9(2):e88309. doi: 10.1371/journal.pone.0088309. eCollection 2014.

20.

PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC.

Krysan K, Kusko R, Grogan T, O'Hearn J, Reckamp KL, Walser TC, Garon EB, Lenburg ME, Sharma S, Spira AE, Elashoff D, Dubinett SM.

Mol Cancer Res. 2014 May;12(5):765-74. doi: 10.1158/1541-7786.MCR-13-0377. Epub 2014 Jan 27.

21.

DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways.

Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, Macaulay CE, Lam S, Lam WL.

Am J Respir Cell Mol Biol. 2014 May;50(5):912-22. doi: 10.1165/rcmb.2013-0304OC.

22.

Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung.

Steiling K, Lenburg ME, Spira A.

Ann Am Thorac Soc. 2013 Dec;10 Suppl:S190-6. doi: 10.1513/AnnalsATS.201306-190AW. Review.

23.

MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis.

Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18946-51. doi: 10.1073/pnas.1220319110. Epub 2013 Oct 24.

24.

Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity.

van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS.

Thorax. 2014 Jan;69(1):14-23. doi: 10.1136/thoraxjnl-2012-202878. Epub 2013 Aug 7.

25.

Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays.

Zhang X, Lenburg ME, Spira A.

ScientificWorldJournal. 2013;2013:951416. doi: 10.1155/2013/951416. Epub 2013 Feb 17.

26.

A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment.

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME.

Am J Respir Crit Care Med. 2013 May 1;187(9):933-42. doi: 10.1164/rccm.201208-1449OC.

27.

SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.

Beane J, Cheng L, Soldi R, Zhang X, Liu G, Anderlind C, Lenburg ME, Spira A, Bild AH.

Cancer Res. 2012 Nov 15;72(22):5702-11. doi: 10.1158/0008-5472.CAN-12-1043. Epub 2012 Sep 17.

28.

A single-sample microarray normalization method to facilitate personalized-medicine workflows.

Piccolo SR, Sun Y, Campbell JD, Lenburg ME, Bild AH, Johnson WE.

Genomics. 2012 Dec;100(6):337-44. doi: 10.1016/j.ygeno.2012.08.003. Epub 2012 Aug 19.

29.

A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.

Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A.

Genome Med. 2012 Aug 31;4(8):67. doi: 10.1186/gm367. eCollection 2012.

30.

FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice.

Lee SY, Meier R, Furuta S, Lenburg ME, Kenny PA, Xu R, Bissell MJ.

J Clin Invest. 2012 Sep;122(9):3211-20. doi: 10.1172/JCI60498. Epub 2012 Aug 13.

31.

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.

Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A.

J Exp Med. 2012 Apr 9;209(4):679-96. doi: 10.1084/jem.20111512. Epub 2012 Mar 19.

32.

Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657).

Esserman LJ, Berry DA, Cheang MC, Yau C, Perou CM, Carey L, DeMichele A, Gray JW, Conway-Dorsey K, Lenburg ME, Buxton MB, Davis SE, van't Veer LJ, Hudis C, Chin K, Wolf D, Krontiras H, Montgomery L, Tripathy D, Lehman C, Liu MC, Olopade OI, Rugo HS, Carpenter JT, Livasy C, Dressler L, Chhieng D, Singh B, Mies C, Rabban J, Chen YY, Giri D, Au A, Hylton N; I-SPY 1 TRIAL Investigators.

Breast Cancer Res Treat. 2012 Apr;132(3):1049-62. doi: 10.1007/s10549-011-1895-2. Epub 2011 Dec 25.

33.

Discovering biological connections between experimental conditions based on common patterns of differential gene expression.

Gower AC, Spira A, Lenburg ME.

BMC Bioinformatics. 2011 Sep 27;12:381. doi: 10.1186/1471-2105-12-381.

34.

Transcriptomic studies of the airway field of injury associated with smoking-related lung disease.

Gower AC, Steiling K, Brothers JF 2nd, Lenburg ME, Spira A.

Proc Am Thorac Soc. 2011 May;8(2):173-9. doi: 10.1513/pats.201011-066MS.

35.

Applying gene expression microarrays to pulmonary disease.

Campbell JD, Spira A, Lenburg ME.

Respirology. 2011 Apr;16(3):407-18. doi: 10.1111/j.1440-1843.2011.01942.x. Review.

PMID:
21299687
36.

A chronic obstructive pulmonary disease related signature in squamous cell lung cancer.

Boelens MC, Gustafson AM, Postma DS, Kok K, van der Vries G, van der Vlies P, Spira A, Lenburg ME, Geerlings M, Sietsma H, Timens W, van den Berg A, Groen HJ.

Lung Cancer. 2011 May;72(2):177-83. doi: 10.1016/j.lungcan.2010.08.014. Epub 2010 Sep 15.

PMID:
20832896
37.

Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer.

Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, Walser TC, Wallace WD, Dubinett SM, Goodglick L, Gomperts BN.

Cancer Res. 2010 Aug 15;70(16):6639-48. doi: 10.1158/0008-5472.CAN-10-0455.

38.

Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia.

Panchenko MP, Siddiquee Z, Dombkowski DM, Alekseyev YO, Lenburg ME, Walker JD, Macgillivray TE, Preffer FI, Stone JR.

Am J Pathol. 2010 Sep;177(3):1562-72. doi: 10.2353/ajpath.2010.100327. Epub 2010 Aug 9.

39.

Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer.

Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME, Thompson EW.

J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):235-52. doi: 10.1007/s10911-010-9175-z. Epub 2010 Jun 4. Review.

PMID:
20521089
40.

Airway PI3K pathway activation is an early and reversible event in lung cancer development.

Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, Bild AH, Spira A.

Sci Transl Med. 2010 Apr 7;2(26):26ra25. doi: 10.1126/scitranslmed.3000251.

41.

The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer.

Hu Z, Huang G, Sadanandam A, Gu S, Lenburg ME, Pai M, Bayani N, Blakely EA, Gray JW, Mao JH.

Breast Cancer Res. 2010;12(2):R18. doi: 10.1186/bcr2487. Epub 2010 Mar 8.

42.

Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model.

Salisbury Palomares KT, Gerstenfeld LC, Wigner NA, Lenburg ME, Einhorn TA, Morgan EF.

Arthritis Rheum. 2010 Apr;62(4):1108-18. doi: 10.1002/art.27343.

43.

Aging, depot origin, and preadipocyte gene expression.

Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):242-51. doi: 10.1093/gerona/glp213. Epub 2010 Jan 27.

44.

Airway gene expression in chronic obstructive pulmonary disease.

Steiling K, Lenburg ME, Spira A.

Proc Am Thorac Soc. 2009 Dec;6(8):697-700. doi: 10.1513/pats.200907-076DP. Review.

45.

Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium.

Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A.

Physiol Genomics. 2010 Mar 3;41(1):1-8. doi: 10.1152/physiolgenomics.00167.2009. Epub 2009 Dec 1.

46.

Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers.

Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A.

PLoS One. 2009;4(4):e5043. doi: 10.1371/journal.pone.0005043. Epub 2009 Apr 9.

47.

Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.

Zhou J, Huang W, Tao R, Ibaragi S, Lan F, Ido Y, Wu X, Alekseyev YO, Lenburg ME, Hu GF, Luo Z.

Oncogene. 2009 May 7;28(18):1993-2002. doi: 10.1038/onc.2009.63. Epub 2009 Apr 6.

48.

The UCSC Cancer Genomics Browser.

Zhu J, Sanborn JZ, Benz S, Szeto C, Hsu F, Kuhn RM, Karolchik D, Archie J, Lenburg ME, Esserman LJ, Kent WJ, Haussler D, Wang T.

Nat Methods. 2009 Apr;6(4):239-40. doi: 10.1038/nmeth0409-239. No abstract available.

49.

MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium.

Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2319-24. doi: 10.1073/pnas.0806383106. Epub 2009 Jan 23.

50.

A prediction model for lung cancer diagnosis that integrates genomic and clinical features.

Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A.

Cancer Prev Res (Phila). 2008 Jun;1(1):56-64. doi: 10.1158/1940-6207.CAPR-08-0011. Epub 2008 Mar 31.

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