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Items: 44

1.

A transcription factor network represses CFTR gene expression in airway epithelial cells.

Mutolo MJ, Leir SH, Fossum SL, Browne JA, Harris A.

Biochem J. 2018 Apr 16;475(7):1323-1334. doi: 10.1042/BCJ20180044.

PMID:
29572268
2.

Molecular characterization of gene regulatory networks in primary human tracheal and bronchial epithelial cells.

Gillen AE, Yang R, Cotton CU, Perez A, Randell SH, Leir SH, Harris A.

J Cyst Fibros. 2018 Feb 17. pii: S1569-1993(18)30012-2. doi: 10.1016/j.jcf.2018.01.009. [Epub ahead of print]

PMID:
29459038
3.

Region-specific innate antiviral responses of the human epididymis.

Browne JA, Leir SH, Eggener SE, Harris A.

Mol Cell Endocrinol. 2018 Jan 13. pii: S0303-7207(18)30004-2. doi: 10.1016/j.mce.2018.01.004. [Epub ahead of print]

PMID:
29339104
4.

Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity.

Stolzenburg LR, Yang R, Kerschner JL, Fossum S, Xu M, Hoffmann A, Lamar KM, Ghosh S, Wachtel S, Leir SH, Harris A.

Nucleic Acids Res. 2017 Sep 6;45(15):8773-8784. doi: 10.1093/nar/gkx482.

5.

Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease.

Fossum SL, Mutolo MJ, Tugores A, Ghosh S, Randell SH, Jones LC, Leir SH, Harris A.

J Biol Chem. 2017 Jun 30;292(26):10938-10949. doi: 10.1074/jbc.M117.775304. Epub 2017 May 1.

PMID:
28461336
6.

Erratum to "HNF1 regulates critical processes in the human epididymis epithelium" [Mol. Cell. Endocrinol. 425 (2016) 94-102].

Browne JA, Yang R, Eggener SE, Leir SH, Harris A.

Mol Cell Endocrinol. 2016 Jun 15;428:174. doi: 10.1016/j.mce.2016.04.018. No abstract available.

PMID:
27147477
7.

HNF1 regulates critical processes in the human epididymis epithelium.

Browne JA, Yang R, Eggener SE, Leir SH, Harris A.

Mol Cell Endocrinol. 2016 Apr 15;425:94-102. doi: 10.1016/j.mce.2016.01.021. Epub 2016 Jan 22.

8.

Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus.

Yang R, Kerschner JL, Gosalia N, Neems D, Gorsic LK, Safi A, Crawford GE, Kosak ST, Leir SH, Harris A.

Nucleic Acids Res. 2016 Apr 20;44(7):3082-94. doi: 10.1093/nar/gkv1358. Epub 2015 Dec 15.

9.

Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions.

Browne JA, Yang R, Leir SH, Eggener SE, Harris A.

Mol Hum Reprod. 2016 Feb;22(2):69-82. doi: 10.1093/molehr/gav066. Epub 2015 Nov 26.

10.

Characterization of primary cultures of adult human epididymis epithelial cells.

Leir SH, Browne JA, Eggener SE, Harris A.

Fertil Steril. 2015 Mar;103(3):647-54.e1. doi: 10.1016/j.fertnstert.2014.11.022. Epub 2014 Dec 24.

11.

Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells.

Fossum SL, Mutolo MJ, Yang R, Dang H, O'Neal WK, Knowles MR, Leir SH, Harris A.

Nucleic Acids Res. 2014 Dec 16;42(22):13588-98. doi: 10.1093/nar/gku1146. Epub 2014 Nov 20.

12.

Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element.

Zhang Z, Leir SH, Harris A.

Am J Respir Cell Mol Biol. 2015 Mar;52(3):387-96. doi: 10.1165/rcmb.2014-0263OC.

13.

Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function.

Browne JA, Yang R, Song L, Crawford GE, Leir SH, Harris A.

Mol Hum Reprod. 2014 Dec;20(12):1198-207. doi: 10.1093/molehr/gau075. Epub 2014 Sep 1.

14.

An optimized protocol for isolating primary epithelial cell chromatin for ChIP.

Browne JA, Harris A, Leir SH.

PLoS One. 2014 Jun 27;9(6):e100099. doi: 10.1371/journal.pone.0100099. eCollection 2014.

15.

Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells.

Kerschner JL, Gosalia N, Leir SH, Harris A.

Epigenetics. 2014 Apr;9(4):557-65. doi: 10.4161/epi.27696. Epub 2014 Jan 17.

16.

Collagen XV inhibits epithelial to mesenchymal transition in pancreatic adenocarcinoma cells.

Clementz AG, Mutolo MJ, Leir SH, Morris KJ, Kucybala K, Harris H, Harris A.

PLoS One. 2013 Aug 22;8(8):e72250. doi: 10.1371/journal.pone.0072250. eCollection 2013.

17.

Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer.

Zhang Z, Leir SH, Harris A.

Mol Cell Biol. 2013 Aug;33(15):2843-53. doi: 10.1128/MCB.00003-13. Epub 2013 May 20.

18.

Nucleosome mapping across the CFTR locus identifies novel regulatory factors.

Yigit E, Bischof JM, Zhang Z, Ott CJ, Kerschner JL, Leir SH, Buitrago-Delgado E, Zhang Q, Wang JP, Widom J, Harris A.

Nucleic Acids Res. 2013 Mar 1;41(5):2857-68. doi: 10.1093/nar/gks1462. Epub 2013 Jan 15.

19.

Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5.

Gosalia N, Leir SH, Harris A.

J Biol Chem. 2013 Mar 1;288(9):6717-25. doi: 10.1074/jbc.M112.437400. Epub 2013 Jan 9.

20.

Tumor suppression by collagen XV is independent of the restin domain.

Mutolo MJ, Morris KJ, Leir SH, Caffrey TC, Lewandowska MA, Hollingsworth MA, Harris A.

Matrix Biol. 2012 Jun;31(5):285-9. doi: 10.1016/j.matbio.2012.03.003. Epub 2012 Apr 16.

21.

A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function.

Bischof JM, Ott CJ, Leir SH, Gosalia N, Song L, London D, Furey TS, Cotton CU, Crawford GE, Harris A.

Thorax. 2012 May;67(5):385-91. doi: 10.1136/thoraxjnl-2011-200880. Epub 2011 Dec 14.

22.

Nucleosome occupancy reveals regulatory elements of the CFTR promoter.

Ott CJ, Bischof JM, Unti KM, Gillen AE, Leir SH, Harris A.

Nucleic Acids Res. 2012 Jan;40(2):625-37. doi: 10.1093/nar/gkr754. Epub 2011 Sep 24.

23.

Molecular mechanisms controlling CFTR gene expression in the airway.

Zhang Z, Ott CJ, Lewandowska MA, Leir SH, Harris A.

J Cell Mol Med. 2012 Jun;16(6):1321-30. doi: 10.1111/j.1582-4934.2011.01439.x.

24.

MUC6 mucin expression inhibits tumor cell invasion.

Leir SH, Harris A.

Exp Cell Res. 2011 Oct 15;317(17):2408-19. doi: 10.1016/j.yexcr.2011.07.021. Epub 2011 Aug 5.

PMID:
21851820
25.

MicroRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene.

Gillen AE, Gosalia N, Leir SH, Harris A.

Biochem J. 2011 Aug 15;438(1):25-32. doi: 10.1042/BJ20110672.

26.

The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice.

Gouyer V, Leir SH, Tetaert D, Liu Y, Gottrand F, Harris A, Desseyn JL.

Histochem Cell Biol. 2010 May;133(5):517-25. doi: 10.1007/s00418-010-0688-8. Epub 2010 Mar 23.

PMID:
20309575
27.

Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus.

Ott CJ, Blackledge NP, Kerschner JL, Leir SH, Crawford GE, Cotton CU, Harris A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19934-9. doi: 10.1073/pnas.0900946106. Epub 2009 Nov 6.

28.

Novel regulatory mechanisms for the CFTR gene.

Ott CJ, Blackledge NP, Leir SH, Harris A.

Biochem Soc Trans. 2009 Aug;37(Pt 4):843-8. doi: 10.1042/BST0370843. Review.

29.

N-Glycosylation of the MUC1 mucin in epithelial cells and secretions.

Parry S, Hanisch FG, Leir SH, Sutton-Smith M, Morris HR, Dell A, Harris A.

Glycobiology. 2006 Jul;16(7):623-34. Epub 2006 Apr 3.

PMID:
16585136
30.

The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins.

Palmai-Pallag T, Khodabukus N, Kinarsky L, Leir SH, Sherman S, Hollingsworth MA, Harris A.

FEBS J. 2005 Jun;272(11):2901-11.

31.

Evaluation of MUC6 mucin tandem repeats.

Parry S, Sutton-Smith M, Heal P, Leir SH, Palmai-Pallag T, Morris HR, Hollingsworth MA, Dell A, Harris A.

Biochim Biophys Acta. 2005 Feb 11;1722(1):77-83. Epub 2004 Dec 8.

PMID:
15716126
32.

Mucin glycosylation and sulphation in airway epithelial cells is not influenced by cystic fibrosis transmembrane conductance regulator expression.

Leir SH, Parry S, Palmai-Pallag T, Evans J, Morris HR, Dell A, Harris A.

Am J Respir Cell Mol Biol. 2005 May;32(5):453-61. Epub 2005 Jan 27.

PMID:
15677769
33.

In vivo glycosylation of MUC1 in airway epithelial cells.

Silverman HS, Sutton-Smith M, Heal P, Parry S, Palmai-Pallag T, Leir SH, Morris HR, Dell A, Harris A.

Glycoconj J. 2002 Jul;19(6):379-84.

PMID:
14707484
34.

CD44 isoform expression on colonic epithelium mediates lamina propria lymphocyte adhesion and is controlled by Th1 and Th2 cytokines.

Macdonald DC, Leir SH, Brooks C, Sanders E, Lackie P, Rosenberg W.

Eur J Gastroenterol Hepatol. 2003 Oct;15(10):1101-10.

PMID:
14501619
35.

Inflammatory cytokines can enhance CD44-mediated airway epithelial cell adhesion independently of CD44 expression.

Leir SH, Holgate ST, Lackie PM.

Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1305-11. Epub 2003 Aug 8.

36.

The contribution of tandem repeat number to the O-glycosylation of mucins.

Silverman HS, Sutton-Smith M, McDermott K, Heal P, Leir SH, Morris HR, Hollingsworth MA, Dell A, Harris A.

Glycobiology. 2003 Apr;13(4):265-77. Epub 2002 Dec 17.

PMID:
12626424
37.

Matrix metalloproteinase-2 from bronchial epithelial cells induces the proliferation of subepithelial fibroblasts.

Xu J, Benyon RC, Leir SH, Zhang S, Holgate ST, Lackie PM.

Clin Exp Allergy. 2002 Jun;32(6):881-8.

PMID:
12047435
38.

Rhinoviruses infect the lower airways.

Papadopoulos NG, Bates PJ, Bardin PG, Papi A, Leir SH, Fraenkel DJ, Meyer J, Lackie PM, Sanderson G, Holgate ST, Johnston SL.

J Infect Dis. 2000 Jun;181(6):1875-84. Epub 2000 Jun 5.

PMID:
10837165
39.

Increased CD44 expression in human bronchial epithelial repair after damage or plating at low cell densities.

Leir SH, Baker JE, Holgate ST, Lackie PM.

Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1129-37.

40.

Expression of c-erbB receptors and ligands in human bronchial mucosa.

Polosa R, Prosperini G, Leir SH, Holgate ST, Lackie PM, Davies DE.

Am J Respir Cell Mol Biol. 1999 May;20(5):914-23.

PMID:
10226061
41.

Antigen-induced anaphylactic death in mice.

Lei HY, Lee SH, Leir SH.

Int Arch Allergy Immunol. 1996 Apr;109(4):407-12.

PMID:
8634527
42.

Involvement of histamine or tumor necrosis factor in early-type hypersensitivity.

Lei HY, Shun CY, Wang JY, Hsiue TR, Leir SH.

Immunopharmacology. 1995 Mar;29(2):167-73.

PMID:
7775159
43.
44.

Antigen-specific tachycardia and hypotension in rodents.

Lei HY, Chen HI, Chan SH, Leir SS, Lin SB, Wing LY.

Clin Exp Allergy. 1992 Aug;22(8):767-73.

PMID:
1525696

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