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Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.

Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg HT, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, Schmuck G, Solecki R, Terron A, Monnet-Tschudi F, Wilks MF, Witters H, Zurich MG, Bal-Price A.

Toxicol Appl Pharmacol. 2018 Feb 12. pii: S0041-008X(18)30043-7. doi: 10.1016/j.taap.2018.02.004. [Epub ahead of print]


Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.

Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ, Harony-Nicolas H, Buxbaum JD, Ellegood J, Lerch JP, Wöhr M, Silverman JL.

Autism Res. 2018 Jan 29. doi: 10.1002/aur.1925. [Epub ahead of print]


Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls.

Chen X, Walter KM, Miller GW, Lein PJ, Puschner B.

Biomed Chromatogr. 2018 Jan 3. doi: 10.1002/bmc.4185. [Epub ahead of print]


Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.

Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ.

J Neuroinflammation. 2018 Jan 6;15(1):7. doi: 10.1186/s12974-017-1050-z.


Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11).

Sethi S, Keil KP, Lein PJ.

Toxics. 2017 Dec 23;6(1). pii: E4. doi: 10.3390/toxics6010004.


Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95.

Frank DF, Miller GW, Connon RE, Geist J, Lein PJ.

PeerJ. 2017 Nov 29;5:e4106. doi: 10.7717/peerj.4106. eCollection 2017.


A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.

Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR.

Neurotoxicology. 2017 Nov 26. pii: S0161-813X(17)30232-2. doi: 10.1016/j.neuro.2017.11.009. [Epub ahead of print]


In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons.

Keil KP, Sethi S, Wilson MD, Chen H, Lein PJ.

Sci Rep. 2017 Aug 16;7(1):8486. doi: 10.1038/s41598-017-08459-z.


A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling.

Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD.

Aquat Toxicol. 2017 Sep;190:1-10. doi: 10.1016/j.aquatox.2017.06.019. Epub 2017 Jun 21.


Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance.

Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E.

Adv Funct Mater. 2017 Jan 19;27(3). pii: 1604631. doi: 10.1002/adfm.201604631. Epub 2016 Dec 12.


Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons.

Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler HJ, Puschner B, Lein PJ.

Toxicol Sci. 2017 Aug 1;158(2):401-411. doi: 10.1093/toxsci/kfx100.


Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.

Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ.

Toxicol Sci. 2017 Jul 1;158(1):101-115. doi: 10.1093/toxsci/kfx071.


Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity.

Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E.

Sci Rep. 2017 Mar 27;7(1):427. doi: 10.1038/s41598-017-00447-7.


Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.

Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ.

Toxicol Sci. 2017 Jun 1;157(2):330-341. doi: 10.1093/toxsci/kfx048.


From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.

Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ.

Toxicol Sci. 2017 Jun 1;157(2):342-353. doi: 10.1093/toxsci/kfx049.


BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action.

Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E.

Sci Rep. 2017 Mar 20;7:44861. doi: 10.1038/srep44861.


Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds.

Voorhees JR, Rohlman DS, Lein PJ, Pieper AA.

Front Neurosci. 2017 Jan 18;10:590. doi: 10.3389/fnins.2016.00590. eCollection 2016. Review.


Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models.

Wilson MD, Sethi S, Lein PJ, Keil KP.

J Neurosci Methods. 2017 Mar 1;279:33-43. doi: 10.1016/j.jneumeth.2017.01.003. Epub 2017 Jan 16. Review.


Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns.

Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM.

Stem Cells. 2017 Apr;35(4):981-988. doi: 10.1002/stem.2563. Epub 2017 Jan 19.


From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms.

Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ.

Toxicol Sci. 2017 Apr 1;156(2):375-386. doi: 10.1093/toxsci/kfw259.


Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces.

Chapman CA, Chen H, Stamou M, Lein PJ, Seker E.

Cell Mol Bioeng. 2016 Sep;9(3):433-442. Epub 2016 May 31.


Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication.

Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ.

J Neuroinflammation. 2016 Oct 12;13(1):267.


Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.

Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ.

Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review.


Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.

Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink RH, Zimmer B, Lein PJ.

ALTEX. 2017;34(1):49-74. doi: 10.14573/altex.1604201. Epub 2016 Jul 25.


Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity.

Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek MEB.

Neurotoxicology. 2017 Mar;59:240-255. doi: 10.1016/j.neuro.2016.05.010. Epub 2016 May 17. Review.


DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

Keil KP, Lein PJ.

Environ Epigenet. 2016 Mar;2(1). pii: dvv012. Epub 2016 Jan 30.


Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity.

Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V.

J Org Chem. 2016 Mar 4;81(5):1870-6. doi: 10.1021/acs.joc.5b02665. Epub 2016 Feb 18.


Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides.

Lee YS, Lewis JA, Ippolito DL, Hussainzada N, Lein PJ, Jackson DA, Stallings JD.

Toxicology. 2016 Jan 18;340:53-62. doi: 10.1016/j.tox.2016.01.001. Epub 2016 Jan 13.


BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.

Courter LA, Shaffo FC, Ghogha A, Parrish DJ, Lorentz CU, Habecker BA, Lein PJ.

Dev Neurobiol. 2016 Sep;76(9):1003-13. doi: 10.1002/dneu.22371. Epub 2016 Jan 22.


Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio.

Bui-Nguyen TM, Baer CE, Lewis JA, Yang D, Lein PJ, Jackson DA.

BMC Genomics. 2015 Oct 24;16:853. doi: 10.1186/s12864-015-1941-2.


Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.

Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ.

Toxicology. 2015 Dec 2;338:59-68. doi: 10.1016/j.tox.2015.10.002. Epub 2015 Oct 14.


Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice.

Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler HJ.

Chem Res Toxicol. 2015 Sep 21;28(9):1774-83. doi: 10.1021/acs.chemrestox.5b00241. Epub 2015 Aug 13.


Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.

Chandrasekaran V, Lea C, Sosa JC, Higgins D, Lein PJ.

Mol Cell Neurosci. 2015 Jul;67:116-25. doi: 10.1016/j.mcn.2015.06.007. Epub 2015 Jun 14.


The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity.

Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):738-47. doi: 10.1165/rcmb.2014-0444OC.


Using the Morris water maze to assess spatial learning and memory in weanling mice.

Barnhart CD, Yang D, Lein PJ.

PLoS One. 2015 Apr 17;10(4):e0124521. doi: 10.1371/journal.pone.0124521. eCollection 2015.


Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.

Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ.

Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14.


Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury.

Li Y, Lein PJ, Ford GD, Liu C, Stovall KC, White TE, Bruun DA, Tewolde T, Gates AS, Distel TJ, Surles-Zeigler MC, Ford BD.

J Neuroinflammation. 2015 Apr 2;12:64. doi: 10.1186/s12974-015-0283-y.


Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons.

Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ.

Mol Brain. 2015 Feb 15;8:10. doi: 10.1186/s13041-015-0099-9.


Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size.

Chapman CA, Chen H, Stamou M, Biener J, Biener MM, Lein PJ, Seker E.

ACS Appl Mater Interfaces. 2015 Apr 8;7(13):7093-100. doi: 10.1021/acsami.5b00410. Epub 2015 Mar 2.


Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior.

Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ.

Curr Neurobiol. 2014 Dec 1;5(1-2):1-10.


Putative adverse outcome pathways relevant to neurotoxicity.

Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, van Thriel C, Whelan M, Fritsche E.

Crit Rev Toxicol. 2015 Jan;45(1):83-91. doi: 10.3109/10408444.2014.981331. Review.


Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.

Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN.

Mol Pharmacol. 2015 Apr;87(4):595-605. doi: 10.1124/mol.114.096701. Epub 2015 Jan 12.


A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression.

Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F.

J Pharmacol Exp Ther. 2015 Mar;352(3):438-47. doi: 10.1124/jpet.114.220186. Epub 2014 Dec 23.


Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers.

Singleton ST, Lein PJ, Dadson OA, McGarrigle BP, Farahat FM, Farahat T, Bonner MR, Fenske RA, Galvin K, Lasarev MR, Anger WK, Rohlman DS, Olson JR.

Int J Hyg Environ Health. 2015 Mar;218(2):203-11. doi: 10.1016/j.ijheh.2014.10.005. Epub 2014 Nov 7.


Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication.

Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ.

Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94. doi: 10.1016/j.taap.2014.10.001. Epub 2014 Oct 14.


Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine.

Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ.

Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45. doi: 10.1016/ Epub 2014 Nov 8.


High abundant protein removal from rodent blood for biomarker discovery.

Haudenschild DR, Eldridge A, Lein PJ, Chromy BA.

Biochem Biophys Res Commun. 2014 Dec 5;455(1-2):84-9.


Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice.

Wu X, Barnhart C, Lein PJ, Lehmler HJ.

Environ Sci Technol. 2015 Jan 6;49(1):616-25. doi: 10.1021/es504766p. Epub 2014 Dec 10.


Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron.

Moore CE, Lein PJ, Puschner B.

Toxins (Basel). 2014 Jun 10;6(6):1813-36. doi: 10.3390/toxins6061813.


The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.

Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA.

J Neurosci. 2014 Jan 15;34(3):717-25. doi: 10.1523/JNEUROSCI.2884-13.2014.

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