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Items: 1 to 50 of 67

1.

Mathematical modeling predicts response to chemotherapy and drug combinations in ovarian cancer.

Kozłowska E, Färkkilä A, Vallius T, Carpén O, Kemppainen J, Grénman S, Lehtonen R, Hynninen J, Hietanen S, Hautaniemi S.

Cancer Res. 2018 May 16. pii: canres.3746.2017. doi: 10.1158/0008-5472.CAN-17-3746. [Epub ahead of print]

PMID:
29769198
2.

MicroRNAs regulate key cell survival pathways and mediate chemosensitivity during progression of diffuse large B-cell lymphoma.

Leivonen SK, Icay K, Jäntti K, Siren I, Liu C, Alkodsi A, Cervera A, Ludvigsen M, Hamilton-Dutoit SJ, d'Amore F, Karjalainen-Lindsberg ML, Delabie J, Holte H, Lehtonen R, Hautaniemi S, Leppä S.

Blood Cancer J. 2017 Dec 15;7(12):654. doi: 10.1038/s41408-017-0033-8.

3.

Alternative splicing discriminates molecular subtypes and has prognostic impact in diffuse large B-cell lymphoma.

Leivonen SK, Taskinen M, Cervera A, Karjalainen-Lindsberg ML, Delabie J, Holte H, Lehtonen R, Hautaniemi S, Leppä S.

Blood Cancer J. 2017 Aug 25;7(8):e596. doi: 10.1038/bcj.2017.71.

4.

Genetic effects on life-history traits in the Glanville fritillary butterfly.

Duplouy A, Wong SC, Corander J, Lehtonen R, Hanski I.

PeerJ. 2017 May 25;5:e3371. doi: 10.7717/peerj.3371. eCollection 2017.

5.

Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei.

Saarinen L, Nummela P, Thiel A, Lehtonen R, Järvinen P, Järvinen H, Aaltonen LA, Lepistö A, Hautaniemi S, Ristimäki A.

PLoS One. 2017 Apr 20;12(4):e0174898. doi: 10.1371/journal.pone.0174898. eCollection 2017.

6.

PerPAS: Topology-Based Single Sample Pathway Analysis Method.

Liu C, Lehtonen R, Hautaniemi S.

IEEE/ACM Trans Comput Biol Bioinform. 2017 Mar 8. doi: 10.1109/TCBB.2017.2679745. [Epub ahead of print]

PMID:
28287981
7.

Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma.

Meriranta L, Pasanen A, Louhimo R, Cervera A, Alkodsi A, Autio M, Taskinen M, Rantanen V, Karjalainen-Lindsberg ML, Holte H, Delabie J, Lehtonen R, Hautaniemi S, Leppä S.

Haematologica. 2017 May;102(5):e195-e198. doi: 10.3324/haematol.2016.157495. Epub 2017 Feb 9. No abstract available.

8.

Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene.

Känsäkoski J, Jääskeläinen J, Jääskeläinen T, Tommiska J, Saarinen L, Lehtonen R, Hautaniemi S, Frilander MJ, Palvimo JJ, Toppari J, Raivio T.

Sci Rep. 2016 Sep 9;6:32819. doi: 10.1038/srep32819.

9.

Data integration to prioritize drugs using genomics and curated data.

Louhimo R, Laakso M, Belitskin D, Klefström J, Lehtonen R, Hautaniemi S.

BioData Min. 2016 May 26;9:21. doi: 10.1186/s13040-016-0097-1. eCollection 2016.

10.

SePIA: RNA and small RNA sequence processing, integration, and analysis.

Icay K, Chen P, Cervera A, Rantanen V, Lehtonen R, Hautaniemi S.

BioData Min. 2016 May 20;9:20. doi: 10.1186/s13040-016-0099-z. eCollection 2016.

11.

Expressional profiling of prostate cancer risk SNPs at 11q13.5 identifies DGAT2 as a new target gene.

Nurminen R, Rantapero T, Wong SC, Fischer D, Lehtonen R, Tammela TL, Nykter M, Visakorpi T, Wahlfors T, Schleutker J.

Genes Chromosomes Cancer. 2016 Aug;55(8):661-73. doi: 10.1002/gcc.22368. Epub 2016 May 24.

PMID:
27113481
12.

Predictable allele frequency changes due to habitat fragmentation in the Glanville fritillary butterfly.

Fountain T, Nieminen M, Sirén J, Wong SC, Lehtonen R, Hanski I.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2678-83. doi: 10.1073/pnas.1600951113. Epub 2016 Feb 22. Erratum in: Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5363. Lehtonen, Rainer [added}.

13.

Effects of ambient and preceding temperatures and metabolic genes on flight metabolism in the Glanville fritillary butterfly.

Wong SC, Oksanen A, Mattila AL, Lehtonen R, Niitepõld K, Hanski I.

J Insect Physiol. 2016 Feb;85:23-31. doi: 10.1016/j.jinsphys.2015.11.015. Epub 2015 Dec 3.

14.

Temperature- and sex-related effects of serine protease alleles on larval development in the Glanville fritillary butterfly.

Ahola V, Koskinen P, Wong SC, Kvist J, Paulin L, Auvinen P, Saastamoinen M, Frilander MJ, Lehtonen R, Hanski I.

J Evol Biol. 2015 Dec;28(12):2224-35. doi: 10.1111/jeb.12745. Epub 2015 Sep 22.

15.

Flight-induced changes in gene expression in the Glanville fritillary butterfly.

Kvist J, Mattila AL, Somervuo P, Ahola V, Koskinen P, Paulin L, Salmela L, Fountain T, Rastas P, Ruokolainen A, Taipale M, Holm L, Auvinen P, Lehtonen R, Frilander MJ, Hanski I.

Mol Ecol. 2015 Oct;24(19):4886-900. doi: 10.1111/mec.13359.

PMID:
26331775
16.

Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum-Taxane Chemotherapy.

Chen P, Huhtinen K, Kaipio K, Mikkonen P, Aittomäki V, Lindell R, Hynninen J, Auranen A, Grénman S, Lehtonen R, Carpén O, Hautaniemi S.

Cancer Res. 2015 Aug 1;75(15):2987-98. doi: 10.1158/0008-5472.CAN-14-3242. Epub 2015 Jun 29.

17.

Identification of sample-specific regulations using integrative network level analysis.

Liu C, Louhimo R, Laakso M, Lehtonen R, Hautaniemi S.

BMC Cancer. 2015 Apr 28;15:319. doi: 10.1186/s12885-015-1265-2.

18.

Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry.

Nummela P, Saarinen L, Thiel A, Järvinen P, Lehtonen R, Lepistö A, Järvinen H, Aaltonen LA, Hautaniemi S, Ristimäki A.

Int J Cancer. 2015 Mar 1;136(5):E282-9. doi: 10.1002/ijc.29245. Epub 2014 Oct 13.

19.

The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera.

Ahola V, Lehtonen R, Somervuo P, Salmela L, Koskinen P, Rastas P, Välimäki N, Paulin L, Kvist J, Wahlberg N, Tanskanen J, Hornett EA, Ferguson LC, Luo S, Cao Z, de Jong MA, Duplouy A, Smolander OP, Vogel H, McCoy RC, Qian K, Chong WS, Zhang Q, Ahmad F, Haukka JK, Joshi A, Salojärvi J, Wheat CW, Grosse-Wilde E, Hughes D, Katainen R, Pitkänen E, Ylinen J, Waterhouse RM, Turunen M, Vähärautio A, Ojanen SP, Schulman AH, Taipale M, Lawson D, Ukkonen E, Mäkinen V, Goldsmith MR, Holm L, Auvinen P, Frilander MJ, Hanski I.

Nat Commun. 2014 Sep 5;5:4737. doi: 10.1038/ncomms5737.

20.

Phenotypic plasticity in thermal tolerance in the Glanville fritillary butterfly.

Luo S, Chong Wong S, Xu C, Hanski I, Wang R, Lehtonen R.

J Therm Biol. 2014 May;42:33-9. doi: 10.1016/j.jtherbio.2014.02.018. Epub 2014 Mar 7.

PMID:
24802146
21.

Cytochrome P450 gene CYP337 and heritability of fitness traits in the Glanville fritillary butterfly.

de Jong MA, Wong SC, Lehtonen R, Hanski I.

Mol Ecol. 2014 Apr;23(8):1994-2005. doi: 10.1111/mec.12697. Epub 2014 Apr 5.

PMID:
24552294
22.

Lep-MAP: fast and accurate linkage map construction for large SNP datasets.

Rastas P, Paulin L, Hanski I, Lehtonen R, Auvinen P.

Bioinformatics. 2013 Dec 15;29(24):3128-34. doi: 10.1093/bioinformatics/btt563. Epub 2013 Sep 26.

23.

Fine mapping of 11q13.5 identifies regions associated with prostate cancer and prostate cancer death.

Nurminen R, Lehtonen R, Auvinen A, Tammela TL, Wahlfors T, Schleutker J.

Eur J Cancer. 2013 Oct;49(15):3335-43. doi: 10.1016/j.ejca.2013.06.006. Epub 2013 Jul 2.

PMID:
23830236
24.

Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.

Ngeow J, Heald B, Rybicki LA, Orloff MS, Chen JL, Liu X, Yerian L, Willis J, Lehtonen HJ, Lehtonen R, Mester JL, Moline J, Burke CA, Church J, Aaltonen LA, Eng C.

Gastroenterology. 2013 Jun;144(7):1402-9, 1409.e1-5. doi: 10.1053/j.gastro.2013.02.001. Epub 2013 Feb 8.

25.

Nationwide registry-based analysis of cancer clustering detects strong familial occurrence of Kaposi sarcoma.

Kaasinen E, Aavikko M, Vahteristo P, Patama T, Li Y, Saarinen S, Kilpivaara O, Pitkänen E, Knekt P, Laaksonen M, Artama M, Lehtonen R, Aaltonen LA, Pukkala E.

PLoS One. 2013;8(1):e55209. doi: 10.1371/journal.pone.0055209. Epub 2013 Jan 24.

26.

Plastic larval development in a butterfly has complex environmental and genetic causes and consequences for population dynamics.

Saastamoinen M, Ikonen S, Wong SC, Lehtonen R, Hanski I.

J Anim Ecol. 2013 May;82(3):529-39. doi: 10.1111/1365-2656.12034. Epub 2013 Jan 24.

PMID:
23347450
27.

SNP design from 454 sequencing of Podosphaera plantaginis transcriptome reveals a genetically diverse pathogen metapopulation with high levels of mixed-genotype infection.

Tollenaere C, Susi H, Nokso-Koivisto J, Koskinen P, Tack A, Auvinen P, Paulin L, Frilander MJ, Lehtonen R, Laine AL.

PLoS One. 2012;7(12):e52492. doi: 10.1371/journal.pone.0052492. Epub 2012 Dec 27.

28.

High genetic load in an old isolated butterfly population.

Mattila AL, Duplouy A, Kirjokangas M, Lehtonen R, Rastas P, Hanski I.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2496-505. doi: 10.1073/pnas.1205789109. Epub 2012 Aug 20.

29.

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer.

Saarinen S, Vahteristo P, Lehtonen R, Aittomäki K, Launonen V, Kiviluoto T, Aaltonen LA.

Fam Cancer. 2012 Sep;11(3):525-8. doi: 10.1007/s10689-012-9532-8.

PMID:
22638770
30.

Rule-based induction method for haplotype comparison and identification of candidate disease loci.

Karinen S, Saarinen S, Lehtonen R, Rastas P, Vahteristo P, Aaltonen LA, Hautaniemi S.

Genome Med. 2012 Mar 19;4(3):21.

31.

Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma.

Saarinen S, Aavikko M, Aittomäki K, Launonen V, Lehtonen R, Franssila K, Lehtonen HJ, Kaasinen E, Broderick P, Tarkkanen J, Bain BJ, Bauduer F, Ünal A, Swerdlow AJ, Cooke R, Mäkinen MJ, Houlston R, Vahteristo P, Aaltonen LA.

Blood. 2011 Jul 21;118(3):493-8. doi: 10.1182/blood-2011-03-341560. Epub 2011 May 11.

32.

Analysis of KLHDC8B in familial nodular lymphocyte predominant Hodgkin lymphoma.

Saarinen S, Vahteristo P, Launonen V, Franssila K, Kivirikko S, Lehtonen R, Bain BJ, Bauduer F, Ünal A, Aaltonen LA, Aittomäki K.

Br J Haematol. 2011 Aug;154(3):413-5. doi: 10.1111/j.1365-2141.2010.08528.x. Epub 2011 Apr 22. No abstract available.

PMID:
21517803
33.

Computational identification of cancer susceptibility loci.

Laakso M, Karinen S, Lehtonen R, Hautaniemi S.

Methods Mol Biol. 2010;653:87-103. doi: 10.1007/978-1-60761-759-4_6. Review.

PMID:
20721739
34.

Mutations in the circadian gene CLOCK in colorectal cancer.

Alhopuro P, Björklund M, Sammalkorpi H, Turunen M, Tuupanen S, Biström M, Niittymäki I, Lehtonen HJ, Kivioja T, Launonen V, Saharinen J, Nousiainen K, Hautaniemi S, Nuorva K, Mecklin JP, Järvinen H, Orntoft T, Arango D, Lehtonen R, Karhu A, Taipale J, Aaltonen LA.

Mol Cancer Res. 2010 Jul;8(7):952-60. doi: 10.1158/1541-7786.MCR-10-0086. Epub 2010 Jun 15.

35.

Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1).

Kaasinen E, Aittomäki K, Eronen M, Vahteristo P, Karhu A, Mecklin JP, Kajantie E, Aaltonen LA, Lehtonen R.

Hum Mol Genet. 2010 Jul 15;19(14):2747-53. doi: 10.1093/hmg/ddq164. Epub 2010 Apr 22.

PMID:
20413652
36.

No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome.

Vahteristo P, Koski TA, Näätsaari L, Kiuru M, Karhu A, Herva R, Sallinen SL, Vierimaa O, Björck E, Richard S, Gardie B, Bessis D, Van Glabeke E, Blanco I, Houlston R, Senter L, Hietala M, Aittomäki K, Aaltonen LA, Launonen V, Lehtonen R.

Fam Cancer. 2010 Jun;9(2):245-51. doi: 10.1007/s10689-009-9312-2.

PMID:
20091131
37.

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

Tuupanen S, Turunen M, Lehtonen R, Hallikas O, Vanharanta S, Kivioja T, Björklund M, Wei G, Yan J, Niittymäki I, Mecklin JP, Järvinen H, Ristimäki A, Di-Bernardo M, East P, Carvajal-Carmona L, Houlston RS, Tomlinson I, Palin K, Ukkonen E, Karhu A, Taipale J, Aaltonen LA.

Nat Genet. 2009 Aug;41(8):885-90. doi: 10.1038/ng.406. Epub 2009 Jun 28.

PMID:
19561604
38.

Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer.

Koski TA, Lehtonen HJ, Jee KJ, Ninomiya S, Joosse SA, Vahteristo P, Kiuru M, Karhu A, Sammalkorpi H, Vanharanta S, Lehtonen R, Edgren H, Nederlof PM, Hietala M, Aittomäki K, Herva R, Knuutila S, Aaltonen LA, Launonen V.

Genes Chromosomes Cancer. 2009 Jul;48(7):544-51. doi: 10.1002/gcc.20663.

PMID:
19373782
39.

BMPR2 mutation in a patient with pulmonary arterial hypertension and suspected hereditary hemorrhagic telangiectasia.

Rigelsky CM, Jennings C, Lehtonen R, Minai OA, Eng C, Aldred MA.

Am J Med Genet A. 2008 Oct 1;146A(19):2551-6. doi: 10.1002/ajmg.a.32468.

PMID:
18792970
40.

Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer.

Ahvenainen T, Lehtonen HJ, Lehtonen R, Vahteristo P, Aittomäki K, Baynam G, Dommering C, Eng C, Gruber SB, Grönberg H, Harvima R, Herva R, Hietala M, Kujala M, Kääriäinen H, Sunde L, Vierimaa O, Pollard PJ, Tomlinson IP, Björck E, Aaltonen LA, Launonen V.

Cancer Genet Cytogenet. 2008 Jun;183(2):83-8. doi: 10.1016/j.cancergencyto.2008.01.010.

PMID:
18503824
41.

Stress-induced expression of a novel variant of human fumarate hydratase (FH).

Lehtonen HJ, Ylisaukko-Oja SK, Kiuru M, Karhu A, Lehtonen R, Vanharanta S, Jalanko A, Aaltonen LA, Launonen V.

Gene Expr. 2007;14(2):59-69.

PMID:
18257390
42.

Background mutation frequency in microsatellite-unstable colorectal cancer.

Sammalkorpi H, Alhopuro P, Lehtonen R, Tuimala J, Mecklin JP, Järvinen HJ, Jiricny J, Karhu A, Aaltonen LA.

Cancer Res. 2007 Jun 15;67(12):5691-8.

43.

Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays.

Laakso M, Tuupanen S, Karhu A, Lehtonen R, Aaltonen LA, Hautaniemi S.

Bioinformatics. 2007 Aug 1;23(15):1952-61. Epub 2007 May 17.

PMID:
17510170
44.

Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region.

Vanharanta S, Wortham NC, Langford C, El-Bahrawy M, van der Spuy Z, Sjöberg J, Lehtonen R, Karhu A, Tomlinson IP, Aaltonen LA.

Genes Chromosomes Cancer. 2007 May;46(5):451-8.

PMID:
17285575
45.

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.

Kokko A, Laiho P, Lehtonen R, Korja S, Carvajal-Carmona LG, Järvinen H, Mecklin JP, Eng C, Schleutker J, Tomlinson IP, Vahteristo P, Aaltonen LA.

BMC Cancer. 2006 Jun 1;6:145.

46.

Pituitary adenoma predisposition caused by germline mutations in the AIP gene.

Vierimaa O, Georgitsi M, Lehtonen R, Vahteristo P, Kokko A, Raitila A, Tuppurainen K, Ebeling TM, Salmela PI, Paschke R, Gündogdu S, De Menis E, Mäkinen MJ, Launonen V, Karhu A, Aaltonen LA.

Science. 2006 May 26;312(5777):1228-30.

47.

Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma.

Ylisaukko-oja SK, Cybulski C, Lehtonen R, Kiuru M, Matyjasik J, Szymañska A, Szymañska-Pasternak J, Dyrskjot L, Butzow R, Orntoft TF, Launonen V, Lubiñski J, Aaltonen LA.

Eur J Hum Genet. 2006 Jul;14(7):880-3. Epub 2006 Apr 26.

48.

Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients.

Ylisaukko-oja SK, Kiuru M, Lehtonen HJ, Lehtonen R, Pukkala E, Arola J, Launonen V, Aaltonen LA.

Int J Cancer. 2006 Jul 15;119(2):283-7.

49.

Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.

Yki-Järvinen H, Kauppinen-Mäkelin R, Tiikkainen M, Vähätalo M, Virtamo H, Nikkilä K, Tulokas T, Hulme S, Hardy K, McNulty S, Hänninen J, Levänen H, Lahdenperä S, Lehtonen R, Ryysy L.

Diabetologia. 2006 Mar;49(3):442-51. Epub 2006 Feb 3.

PMID:
16456680
50.

Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.

Sweet K, Willis J, Zhou XP, Gallione C, Sawada T, Alhopuro P, Khoo SK, Patocs A, Martin C, Bridgeman S, Heinz J, Pilarski R, Lehtonen R, Prior TW, Frebourg T, Teh BT, Marchuk DA, Aaltonen LA, Eng C.

JAMA. 2005 Nov 16;294(19):2465-73.

PMID:
16287957

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